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Last Name

profileRaymond J. Kelleher III, M.D.,PH.D.

TitleAssistant Professor of Neurology
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Ctr. for Human Genetic Research, Simches Building 6234
185 Cambridge St
Boston MA 02114
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K24NS093185     (KELLEHER, RAYMOND J)Apr 1, 2016 - Mar 31, 2021
Research Mentoring in Neurology and Translational Research on Alzheimers Disease
Role: Principal Investigator

R01NS075346     (KELLEHER, RAYMOND J)Jul 1, 2011 - Jun 30, 2021
Mechanisms of brain phenotypes caused by FAD-linked Presenilin-1 Mutations
Role: Principal Investigator

K02MH087796     (KELLEHER, RAYMOND J)Dec 14, 2009 - Nov 30, 2014
MicroRNAs in Synaptic Plasticity and Behaviors Relevant to Autism
Role: Principal Investigator

R01MH080430     (KELLEHER, RAYMOND J)Apr 1, 2007 - Mar 31, 2013
MicroRNAs in Synaptic Plasticity and Cognitive Function
Role: Principal Investigator

K02NS048274     (KELLEHER, RAYMOND J)Dec 15, 2004 - Aug 31, 2010
Translational Control in Long-Term Synaptic Plasticity
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Carrette LLG, Wang CY, Wei C, Press W, Ma W, Kelleher RJ, Lee JT. A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders. Proc Natl Acad Sci U S A. 2018 Jan 23; 115(4):E668-E675. PMID: 29282321.
    View in: PubMed
  2. Kelleher RJ, Shen J. Presenilin-1 mutations and Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 Jan 24; 114(4):629-631. PMID: 28082723.
    View in: PubMed
  3. Xia D, Kelleher RJ, Shen J. Loss of Aß43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain. Neuron. 2016 04 20; 90(2):417-22. PMID: 27100200; PMCID: PMC4840410 [Available on 04/20/17].
  4. Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ. Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Neuron. 2015 Mar 04; 85(5):967-81. PMID: 25741723; PMCID: PMC4358812.
  5. Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ, Cooper JD, Slaugenhaupt SA. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathol Commun. 2014 Sep 09; 2:133. PMID: 25200117; PMCID: PMC4173007.
  6. Heilig EA, Gutti U, Tai T, Shen J, Kelleher RJ. Trans-dominant negative effects of pathogenic PSEN1 mutations on ?-secretase activity and Aß production. J Neurosci. 2013 Jul 10; 33(28):11606-17. PMID: 23843529; PMCID: PMC3724549.
  7. Kelleher RJ, Geigenmüller U, Hovhannisyan H, Trautman E, Pinard R, Rathmell B, Carpenter R, Margulies D. High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism. PLoS One. 2012; 7(4):e35003. PMID: 22558107; PMCID: PMC3338748.
  8. Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci. 2012 Apr 11; 32(15):5085-96. PMID: 22496554; PMCID: PMC3340902.
  9. Lehman HK, Simpson-Abelson MR, Conway TF, Kelleher RJ, Bernstein JM, Bankert RB. Memory T cells in the chronic inflammatory microenvironment of nasal polyposis are hyporesponsive to signaling through the T cell receptor. J Assoc Res Otolaryngol. 2012 Jun; 13(3):423-35. PMID: 22310933; PMCID: PMC3346897.
  10. Bankert RB, Balu-Iyer SV, Odunsi K, Shultz LD, Kelleher RJ, Barnas JL, Simpson-Abelson M, Parsons R, Yokota SJ. Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis. PLoS One. 2011; 6(9):e24420. PMID: 21935406; PMCID: PMC3174163.
  11. Anguera MC, Ma W, Clift D, Namekawa S, Kelleher RJ, Lee JT. Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. PLoS Genet. 2011 Sep; 7(9):e1002248. PMID: 21912526; PMCID: PMC3164691.
  12. Kelleher RJ, Shen J. Genetics. Gamma-secretase and human disease. Science. 2010 Nov 19; 330(6007):1055-6. PMID: 21097925; PMCID: PMC4556372.
  13. Barnas JL, Simpson-Abelson MR, Brooks SP, Kelleher RJ, Bankert RB. Reciprocal functional modulation of the activation of T lymphocytes and fibroblasts derived from human solid tumors. J Immunol. 2010 Sep 01; 185(5):2681-92. PMID: 20686130.
    View in: PubMed
  14. Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem. 2010 Jul 16; 285(29):22350-9. PMID: 20460383; PMCID: PMC2903357.
  15. Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9879-84. PMID: 20457918; PMCID: PMC2906862.
  16. Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ, Shen J. Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS One. 2010 Apr 15; 5(4):e10195. PMID: 20419112; PMCID: PMC2855368.
  17. Barnas JL, Simpson-Abelson MR, Yokota SJ, Kelleher RJ, Bankert RB. T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets. Cancer Microenviron. 2010 Mar 31; 3(1):29-47. PMID: 21209773; PMCID: PMC2990491.
  18. Simpson-Abelson MR, Purohit VS, Pang WM, Iyer V, Odunsi K, Demmy TL, Yokota SJ, Loyall JL, Kelleher RJ, Balu-Iyer S, Bankert RB. IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments. Clin Immunol. 2009 Jul; 132(1):71-82. PMID: 19395317; PMCID: PMC2693480.
  19. Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ, Shen J. Indirect regulation of presenilins in CREB-mediated transcription. J Biol Chem. 2009 May 15; 284(20):13705-13. PMID: 19289467; PMCID: PMC2679472.
  20. Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, Fisher RI, Kelleher RJ, Bankert RB, Bernstein SH. Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab. Blood. 2009 Apr 16; 113(16):3809-12. PMID: 19196657; PMCID: PMC2670795.
  21. Kelleher RJ, Bear MF. The autistic neuron: troubled translation? Cell. 2008 Oct 31; 135(3):401-6. PMID: 18984149.
    View in: PubMed
  22. Simpson-Abelson MR, Sonnenberg GF, Takita H, Yokota SJ, Conway TF, Kelleher RJ, Shultz LD, Barcos M, Bankert RB. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol. 2008 May 15; 180(10):7009-18. PMID: 18453623.
    View in: PubMed
  23. Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ, Yokota SJ, Bankert RB. Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol. 2007 May 01; 178(9):5552-62. PMID: 17442937.
    View in: PubMed
  24. Shen J, Kelleher RJ. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):403-9. PMID: 17197420; PMCID: PMC1766397.
  25. Govindarajan A, Kelleher RJ, Tonegawa S. A clustered plasticity model of long-term memory engrams. Nat Rev Neurosci. 2006 Jul; 7(7):575-83. PMID: 16791146.
    View in: PubMed
  26. Lou Q, Conway TF, Egilmez NK, Loyall JL, Bernstein SH, Kelleher RJ, Bankert RB. B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells. Clin Immunol. 2006 Jan; 118(1):66-76. PMID: 16185929.
    View in: PubMed
  27. Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ, Bankert RB. Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol. 2005 Jan 15; 174(2):898-906. PMID: 15634912.
    View in: PubMed
  28. Kelleher RJ, Govindarajan A, Tonegawa S. Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron. 2004 Sep 30; 44(1):59-73. PMID: 15450160.
    View in: PubMed
  29. Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 2004 Apr 08; 42(1):23-36. PMID: 15066262.
    View in: PubMed
  30. Lou Q, Kelleher RJ, Sette A, Loyall J, Southwood S, Bankert RB, Bernstein SH. Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific immune response without altering the response potential of normal B cells. Blood. 2004 Aug 01; 104(3):752-9. PMID: 15054043.
    View in: PubMed
  31. Kelleher RJ, Govindarajan A, Jung HY, Kang H, Tonegawa S. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell. 2004 Feb 06; 116(3):467-79. PMID: 15016380.
    View in: PubMed
  32. Sugano M, Conway TF, Kelleher RJ, Sugiyama Y, Chen FA, Bankert RB, Bernstein SH. Human dendritic cells pulsed with autologous Epstein-Barr virus transformed B-cell lymphoblastoid cell (BCL) lysate elicit a BCL specific MHC-class II restricted T-cell response. J Exp Clin Cancer Res. 2001 Jun; 20(2):175-82. PMID: 11484971.
    View in: PubMed
  33. Stephen FD, Kelleher RJ, Langner M, Repasky EA. Dietary fatty acids alter the adhesion properties of lymphocytes to extracellular matrix proteins. Adv Exp Med Biol. 1997; 400B:775-88. PMID: 9547629.
    View in: PubMed
  34. Kim TK, Hashimoto S, Kelleher RJ, Flanagan PM, Kornberg RD, Horikoshi M, Roeder RG. Effects of activation-defective TBP mutations on transcription initiation in yeast. Nature. 1994 May 19; 369(6477):252-5. PMID: 8183347.
    View in: PubMed
  35. Flanagan PM, Kelleher RJ, Tschochner H, Sayre MH, Kornberg RD. Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7659-63. PMID: 1502179; PMCID: PMC49770.
  36. Flanagan PM, Kelleher RJ, Sayre MH, Tschochner H, Kornberg RD. A mediator required for activation of RNA polymerase II transcription in vitro. Nature. 1991 Apr 04; 350(6317):436-8. PMID: 2011193.
    View in: PubMed
  37. Kelleher RJ, Flanagan PM, Kornberg RD. A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell. 1990 Jun 29; 61(7):1209-15. PMID: 2163759.
    View in: PubMed
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