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Last Name

profileNavid Madani, Ph.D.

TitleResearch Associate in Microbiology and Immunobiology
InstitutionDana-Farber Cancer Institute
DepartmentMicrobiology and Immunobiology
AddressDana Farber Cancer Institute
JFB 608, Cancer Immunol/Aids
44 Binney St
Boston MA 02115
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Collapse Mentoring 
Collapse completed student projects
Knowledge and Attitude of Iranian Dental Students towards HIV/AIDS in Tehran Universities
International, 06/19/06 - 08/15/06

Collapse Research 
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AI134494     (MADANI, NAVID)Jul 14, 2017 - Jun 30, 2022
Prevention of HIV-1 transmission by small-molecule CD4-mimetic entry inhibitors
Role: Principal Investigator

R56AI090682     (MADANI, NAVID)Sep 3, 2010 - May 31, 2012
Design of dendrimeric HIV-1 transmission inhibitors targeting gp120 Phe-43 cavity
Role: Principal Investigator

F32NS043260     (MADANI, NAVID)Aug 1, 2001
Biophysical characterization of chemokine receptors
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Madani N. Gender equality is crucial to the fight for better HIV treatment access and outcomes in the MENA region. J Int AIDS Soc. 2018 Mar; 21(3). PMID: 29504249.
    View in: PubMed
  2. Karamouzian M, Madani N, Doroudi F, Haghdoost AA. Tackling HIV in MENA: Talk Is Not Enough-It Is Time for Bold Actions: A Response to Recent Commentaries. Int J Health Policy Manag. 2017 09 10; 7(2):199-200. PMID: 29524947.
    View in: PubMed
  3. Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, Louder MK, Rawi R, Soumana DI, Finzi A, Herschhorn A, Madani N, Sodroski J, Freire E, Langley DR, Mascola JR, McDermott AB, Kwong PD. Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nat Chem Biol. 2017 Oct; 13(10):1115-1122. PMID: 28825711.
    View in: PubMed
  4. Johnson J, Zhai Y, Salimi H, Espy N, Eichelberger N, DeLeon O, O'Malley Y, Courter J, Smith AB, Madani N, Sodroski J, Haim H. Induction of a Tier-1-Like Phenotype in Diverse Tier-2 Isolates by Agents That Guide HIV-1 Env to Perturbation-Sensitive, Nonnative States. J Virol. 2017 Aug 01; 91(15). PMID: 28490588.
    View in: PubMed
  5. Nguyen HT, Madani N, Ding H, Elder E, Princiotto A, Gu C, Darby P, Alin J, Herschhorn A, Kappes JC, Mao Y, Sodroski JG. Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein. Virol J. 2017 02 16; 14(1):33. PMID: 28209172.
    View in: PubMed
  6. Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB, Sodroski J, Finzi A. Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors. J Virol. 2017 Mar 01; 91(5). PMID: 28003492.
    View in: PubMed
  7. Madani N, Princiotto AM, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, Melillo B, Smith AB, Sodroski J. Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds. J Virol. 2017 Feb 01; 91(3). PMID: 27881646.
    View in: PubMed
  8. Ding S, Verly MM, Princiotto A, Melillo B, Moody AM, Bradley T, Easterhoff D, Roger M, Hahn BH, Madani N, Smith AB, Haynes BF, Sodroski J, Finzi A. Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates. AIDS Res Hum Retroviruses. 2017 05; 33(5):428-431. PMID: 27846736.
    View in: PubMed
  9. Ahani R, Roohvand F, Cohan RA, Etemadzadeh MH, Mohajel N, Behdani M, Shahosseini Z, Madani N, Azadmanesh K. Sindbis Virus-Pseudotyped Lentiviral Vectors Carrying VEGFR2-Specific Nanobody for Potential Transductional Targeting of Tumor Vasculature. Mol Biotechnol. 2016 Nov; 58(11):738-747. PMID: 27647452.
    View in: PubMed
  10. Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF. Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity. EBioMedicine. 2016 Oct; 12:196-207. PMID: 27612593.
    View in: PubMed
  11. Karamouzian M, Madani N, Doroudi F, Haghdoost AA. Improving the Quality and Quantity of HIV Data in the Middle East and North Africa: Key Challenges and Ways Forward. Int J Health Policy Manag. 2016 Aug 23; 6(2):65-69. PMID: 28812781.
    View in: PubMed
  12. Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB, Karlsson Hedestam GB, Haynes B, Sodroski J. Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds. J Virol. 2016 05 15; 90(10):5031-46. PMID: 26962221; PMCID: PMC4859707 [Available on 10/29/16].
  13. Gökengin D, Madani N. Response to letter to the editor re 'HIV Trends: Defining "The Middle East'. Int J Infect Dis. 2016 07; 48:124. PMID: 27109106.
    View in: PubMed
  14. Gökengin D, Doroudi F, Tohme J, Collins B, Madani N. HIV/AIDS: trends in the Middle East and North Africa region. Int J Infect Dis. 2016 Mar; 44:66-73. PMID: 26948920.
    View in: PubMed
  15. Himmich H, Madani N. The state of harm reduction in the Middle East and North Africa: A focus on Iran and Morocco. Int J Drug Policy. 2016 05; 31:184-9. PMID: 27012581.
    View in: PubMed
  16. Melillo B, Liang S, Park J, Schön A, Courter JR, LaLonde JM, Wendler DJ, Princiotto AM, Seaman MS, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB. Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. ACS Med Chem Lett. 2016 Mar 10; 7(3):330-4. PMID: 26985324; PMCID: PMC4789667 [Available on 03/10/17].
  17. Madani N. Visa rules imperil collaboration. Science. 2016 Jan 15; 351(6270):234. PMID: 26816368.
    View in: PubMed
  18. Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A. CD4 mimetics sensitize HIV-1-infected cells to ADCC. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2687-94. PMID: 25941367; PMCID: PMC4443331.
  19. Tuyishime M, Danish M, Princiotto A, Mankowski MK, Lawrence R, Lombart HG, Esikov K, Berniac J, Liang K, Ji J, Ptak RG, Madani N, Cocklin S. Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement. Bioorg Med Chem Lett. 2014 Dec 01; 24(23):5439-45. PMID: 25454268; PMCID: PMC4355043.
  20. Pancera M, Druz A, Zhou T, O'Dell S, Louder M, Madani N, Herschhorn A, Sodroski J, Mascola JR, Kwong PD. Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A151. PMID: 25357424.
    View in: PubMed
  21. Madani N, Princiotto AM, Schön A, LaLonde J, Feng Y, Freire E, Park J, Courter JR, Jones DM, Robinson J, Liao HX, Moody MA, Permar S, Haynes B, Smith AB, Wyatt R, Sodroski J. CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies. J Virol. 2014 Jun; 88(12):6542-55. PMID: 24696475; PMCID: PMC4054336.
  22. Chahil-Graf R, Madani N. Women, culture and the HIV epidemic in MENA. J Int AIDS Soc. 2014; 17:19074. PMID: 24629846; PMCID: PMC3955763.
  23. Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, LaLonde JM, Smith AB. Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist. Acc Chem Res. 2014 Apr 15; 47(4):1228-37. PMID: 24502450; PMCID: PMC3993944.
  24. Lalonde JM, Le-Khac M, Jones DM, Courter JR, Park J, Schön A, Princiotto AM, Wu X, Mascola JR, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB. Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med Chem Lett. 2013 Mar 14; 4(3):338-343. PMID: 23667716.
    View in: PubMed
  25. Modjarrad K, Mohraz M, Madani N. AIDS epidemic: Iran needs global support to fight HIV. Nature. 2013 Feb 21; 494(7437):314. PMID: 23426315.
    View in: PubMed
  26. Tuzer F, Madani N, Kamanna K, Zentner I, LaLonde J, Holmes A, Upton E, Rajagopal S, McFadden K, Contarino M, Sodroski J, Chaiken I. HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism. Proteins. 2013 Feb; 81(2):271-90. PMID: 23011758; PMCID: PMC3731144.
  27. Choi WT, Kumar S, Madani N, Han X, Tian S, Dong CZ, Liu D, Duggineni S, Yuan J, Sodroski JG, Huang Z, An J. A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry. Biochemistry. 2012 Sep 11; 51(36):7078-86. PMID: 22897429; PMCID: PMC3476724.
  28. Kortagere S, Madani N, Mankowski MK, Schön A, Zentner I, Swaminathan G, Princiotto A, Anthony K, Oza A, Sierra LJ, Passic SR, Wang X, Jones DM, Stavale E, Krebs FC, Martín-García J, Freire E, Ptak RG, Sodroski J, Cocklin S, Smith AB. Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid. J Virol. 2012 Aug; 86(16):8472-81. PMID: 22647699; PMCID: PMC3421734.
  29. LaLonde JM, Kwon YD, Jones DM, Sun AW, Courter JR, Soeta T, Kobayashi T, Princiotto AM, Wu X, Schön A, Freire E, Kwong PD, Mascola JR, Sodroski J, Madani N, Smith AB. Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors. J Med Chem. 2012 May 10; 55(9):4382-96. PMID: 22497421; PMCID: PMC3376652.
  30. Dong CZ, Tian S, Madani N, Choi WT, Kumar S, Liu D, Sodroski JG, Huang Z, An J. Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1a probed by a novel synthetically and modularly modified-chemokine analog. Exp Biol Med (Maywood). 2011 Dec; 236(12):1413-9. PMID: 22101518; PMCID: PMC3752462.
  31. Malavia NK, Zurakowski D, Schroeder A, Princiotto AM, Laury AR, Barash HE, Sodroski J, Langer R, Madani N, Kohane DS. Liposomes for HIV prophylaxis. Biomaterials. 2011 Nov; 32(33):8663-8. PMID: 21862123; PMCID: PMC3263404.
  32. Haim H, Strack B, Kassa A, Madani N, Wang L, Courter JR, Princiotto A, McGee K, Pacheco B, Seaman MS, Smith AB, Sodroski J. Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity. PLoS Pathog. 2011 Jun; 7(6):e1002101. PMID: 21731494; PMCID: PMC3121797.
  33. Schön A, Madani N, Smith AB, Lalonde JM, Freire E. Some binding-related drug properties are dependent on thermodynamic signature. Chem Biol Drug Des. 2011 Mar; 77(3):161-5. PMID: 21288305; PMCID: PMC3079564.
  34. Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schön A, Freire E, Sodroski J, Smith AB. Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening. Bioorg Med Chem. 2011 Jan 01; 19(1):91-101. PMID: 21169023; PMCID: PMC3049263.
  35. Zhukovsky MA, Basmaciogullari S, Pacheco B, Wang L, Madani N, Haim H, Sodroski J. Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes. PLoS One. 2010 Oct 13; 5(10):e13249. PMID: 20967243; PMCID: PMC2954141.
  36. Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD. Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14093-8. PMID: 20660316; PMCID: PMC2922607.
  37. Kassa A, Madani N, Schön A, Haim H, Finzi A, Xiang SH, Wang L, Princiotto A, Pancera M, Courter J, Smith AB, Freire E, Kwong PD, Sodroski J. Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain. J Virol. 2009 Sep; 83(17):8364-78. PMID: 19535453; PMCID: PMC2738180.
  38. Haim H, Si Z, Madani N, Wang L, Courter JR, Princiotto A, Kassa A, DeGrace M, McGee-Estrada K, Mefford M, Gabuzda D, Smith AB, Sodroski J. Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathog. 2009 Apr; 5(4):e1000360. PMID: 19343205; PMCID: PMC2655723.
  39. Madani N, Schön A, Princiotto AM, Lalonde JM, Courter JR, Soeta T, Ng D, Wang L, Brower ET, Xiang SH, Kwon YD, Huang CC, Wyatt R, Kwong PD, Freire E, Smith AB, Sodroski J. Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120. Structure. 2008 Nov 12; 16(11):1689-701. PMID: 19000821; PMCID: PMC2597202.
  40. Gopi H, Umashankara M, Pirrone V, LaLonde J, Madani N, Tuzer F, Baxter S, Zentner I, Cocklin S, Jawanda N, Miller SR, Schön A, Klein JC, Freire E, Krebs FC, Smith AB, Sodroski J, Chaiken I. Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1. J Med Chem. 2008 May 08; 51(9):2638-47. PMID: 18402432; PMCID: PMC2921370.
  41. Liu D, Madani N, Li Y, Cao R, Choi WT, Kawatkar SP, Lim MY, Kumar S, Dong CZ, Wang J, Russell JD, Lefebure CR, An J, Wilson S, Gao YG, Pallansch LA, Sodroski JG, Huang Z. Crystal structure and structural mechanism of a novel anti-human immunodeficiency virus and D-amino acid-containing chemokine. J Virol. 2007 Oct; 81(20):11489-98. PMID: 17686848; PMCID: PMC2045531.
  42. Schön A, Madani N, Klein JC, Hubicki A, Ng D, Yang X, Smith AB, Sodroski J, Freire E. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12; 45(36):10973-80. PMID: 16953583; PMCID: PMC2504686.
  43. Madani N, Hubicki AM, Perdigoto AL, Springer M, Sodroski J. Inhibition of human immunodeficiency virus envelope glycoprotein- mediated single cell lysis by low-molecular-weight antagonists of viral entry. J Virol. 2007 Jan; 81(2):532-8. PMID: 16943294; PMCID: PMC1797463.
  44. Kumar S, Choi WT, Dong CZ, Madani N, Tian S, Liu D, Wang Y, Pesavento J, Wang J, Fan X, Yuan J, Fritzsche WR, An J, Sodroski JG, Richman DD, Huang Z. SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development. Chem Biol. 2006 Jan; 13(1):69-79. PMID: 16426973.
    View in: PubMed
  45. Dong CZ, Kumar S, Choi WT, Madani N, Tian S, An J, Sodroski JG, Huang Z. Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand. J Med Chem. 2005 Dec 15; 48(25):7923-4. PMID: 16335916.
    View in: PubMed
  46. Choi WT, Tian S, Dong CZ, Kumar S, Liu D, Madani N, An J, Sodroski JG, Huang Z. Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors. J Virol. 2005 Dec; 79(24):15398-404. PMID: 16306611; PMCID: PMC1316031.
  47. Xiang SH, Farzan M, Si Z, Madani N, Wang L, Rosenberg E, Robinson J, Sodroski J. Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody. J Virol. 2005 May; 79(10):6068-77. PMID: 15857992; PMCID: PMC1091675.
  48. Madani N, Perdigoto AL, Srinivasan K, Cox JM, Chruma JJ, LaLonde J, Head M, Smith AB, Sodroski JG. Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155. J Virol. 2004 Apr; 78(7):3742-52. PMID: 15016894; PMCID: PMC371073.
  49. Si Z, Madani N, Cox JM, Chruma JJ, Klein JC, Schön A, Phan N, Wang L, Biorn AC, Cocklin S, Chaiken I, Freire E, Smith AB, Sodroski JG. Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):5036-41. PMID: 15051887; PMCID: PMC387369.
  50. Biorn AC, Cocklin S, Madani N, Si Z, Ivanovic T, Samanen J, Van Ryk DI, Pantophlet R, Burton DR, Freire E, Sodroski J, Chaiken IM. Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions. Biochemistry. 2004 Feb 24; 43(7):1928-38. PMID: 14967033.
    View in: PubMed
  51. LaBonte JA, Madani N, Sodroski J. Cytolysis by CCR5-using human immunodeficiency virus type 1 envelope glycoproteins is dependent on membrane fusion and can be inhibited by high levels of CD4 expression. J Virol. 2003 Jun; 77(12):6645-59. PMID: 12767984; PMCID: PMC156190.
  52. Madani N, Millette R, Platt EJ, Marin M, Kozak SL, Bloch DB, Kabat D. Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1. J Virol. 2002 Nov; 76(21):11133-8. PMID: 12368356; PMCID: PMC136615.
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