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Cesar Martin Castro, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kim SJ, Wang C, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K. Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep. 2018 Nov 19; 8(1):17003. PMID: 30451953.
    View in: PubMed
  2. Huber S, Min C, Staat C, Oh J, Castro CM, Haase A, Weissleder R, Gleich B, Lee H. Multichannel digital heteronuclear magnetic resonance biosensor. Biosens Bioelectron. 2019 Feb 01; 126:240-248. PMID: 30445298.
    View in: PubMed
  3. Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel JM, Castro CM, Weissleder R, Lee H. Computational Optics Enables Breast Cancer Profiling in Point-of-Care Settings. ACS Nano. 2018 Sep 25; 12(9):9081-9090. PMID: 30113824.
    View in: PubMed
  4. Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble B, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R. Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast-enhanced microholography and machine learning. Nat Biomed Eng. 2018 Sep; 2(9):666-674. PMID: 30555750.
    View in: PubMed
  5. Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H. Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis. ACS Nano. 2018 Apr 24; 12(4):3378-3384. PMID: 29533646.
    View in: PubMed
  6. Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H. New Technologies for Analysis of Extracellular Vesicles. Chem Rev. 2018 Feb 28; 118(4):1917-1950. PMID: 29384376.
    View in: PubMed
  7. Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H. Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip. 2017 11 21; 17(23):4000-4007. PMID: 29067383.
    View in: PubMed
  8. Park J, Im H, Hong S, Castro CM, Weissleder R, Lee H. Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System. ACS Photonics. 2018 Feb 21; 5(2):487-494. PMID: 29805987.
    View in: PubMed
  9. Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi T, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR. Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. ACS Nano. 2017 11 28; 11(11):11041-11046. PMID: 29053921.
    View in: PubMed
  10. Oza AM, Tinker AV, Oaknin A, Shapira-Frommer R, McNeish IA, Swisher EM, Ray-Coquard I, Bell-McGuinn K, Coleman RL, O'Malley DM, Leary A, Chen LM, Provencher D, Ma L, Brenton JD, Konecny GE, Castro CM, Giordano H, Maloney L, Goble S, Lin KK, Sun J, Raponi M, Rolfe L, Kristeleit RS. Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. Gynecol Oncol. 2017 11; 147(2):267-275. PMID: 28882436.
    View in: PubMed
  11. Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H. Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection. ACS Nano. 2017 10 24; 11(10):10062-10069. PMID: 28792732.
    View in: PubMed
  12. Im H, Lee K, Weissleder R, Lee H, Castro CM. Novel nanosensing technologies for exosome detection and profiling. Lab Chip. 2017 08 22; 17(17):2892-2898. PMID: 28745363.
    View in: PubMed
  13. Yang KS, Im H, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R. Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Sci Transl Med. 2017 05 24; 9(391). PMID: 28539469.
    View in: PubMed
  14. Hong S, Park KS, Weissleder R, Castro CM, Lee H. Facile silicification of plastic surface for bioassays. Chem Commun (Camb). 2017 Feb 09; 53(13):2134-2137. PMID: 28134385.
    View in: PubMed
  15. Castro CM. Good to the last "emulsified" drop. Sci Transl Med. 2017 Jan 18; 9(373). PMID: 28100835.
    View in: PubMed
  16. Im H, Yang K, Lee H, Castro CM. Characterization of Extracellular Vesicles by Surface Plasmon Resonance. Methods Mol Biol. 2017; 1660:133-141. PMID: 28828653.
    View in: PubMed
  17. Castro CM. Taking cancer drug screening very personally. Sci Transl Med. 2016 11 30; 8(367):367ec190. PMID: 27903858.
    View in: PubMed
  18. Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R. Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing. Bioconjug Chem. 2017 01 18; 28(1):33-37. PMID: 27792877.
    View in: PubMed
  19. Pathania D, Im H, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM. Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics. 2016; 6(10):1603-10. PMID: 27446494; PMCID: PMC4955059.
  20. Sosulski A, Horn H, Zhang L, Coletti C, Vathipadiekal V, Castro CM, Birrer MJ, Nagano O, Saya H, Lage K, Donahoe PK, Pépin D. CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis. PLoS One. 2016; 11(6):e0156595. PMID: 27253518; PMCID: PMC4890777.
  21. Park KS, Huang CH, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H. Rapid identification of health care-associated infections with an integrated fluorescence anisotropy system. Sci Adv. 2016 05; 2(5):e1600300. PMID: 28861468.
    View in: PubMed
  22. Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H. Digital diffraction detection of protein markers for avian influenza. Lab Chip. 2016 Apr 21; 16(8):1340-5. PMID: 26980325; PMCID: PMC4829473 [Available on 04/12/17].
  23. Penson RT, Sales E, Sullivan L, Borger DR, Krasner CN, Goodman AK, del Carmen MG, Growdon WB, Schorge JO, Boruta DM, Castro CM, Dizon DS, Birrer MJ. A SNaPshot of potentially personalized care: Molecular diagnostics in gynecologic cancer. Gynecol Oncol. 2016 Apr; 141(1):108-12. PMID: 27016236.
    View in: PubMed
  24. Im H, Lee H, Castro CM. Challenges influencing next generation technologies for precision medicine. Expert Rev Precis Med Drug Dev. 2016; 1(2):121-123. PMID: 28008420.
    View in: PubMed
  25. Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H. Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano. 2016 Feb 23; 10(2):1802-9. PMID: 26808216; PMCID: PMC4802494 [Available on 02/23/17].
  26. Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, Coletti CM, Yu A, Castro CM, Birrer MJ, Gao G, Donahoe PK. AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4418-27. PMID: 26216943; PMCID: PMC4538667.
  27. Im H, Shao H, Weissleder R, Castro CM, Lee H. Nano-plasmonic exosome diagnostics. Expert Rev Mol Diagn. 2015 Jun; 15(6):725-33. PMID: 25936957; PMCID: PMC4675626.
  28. Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R. On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics. 2015; 5(8):796-804. PMID: 26000053; PMCID: PMC4440438.
  29. Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R, Lee H. Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A. 2015 May 05; 112(18):5613-8. PMID: 25870273.
    View in: PubMed
  30. Castro CM, Im H, Le C, Lee H, Weissleder R, Birrer MJ. Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategies. Cancer Metastasis Rev. 2015 Mar; 34(1):75-82. PMID: 25543192.
    View in: PubMed
  31. Im H, Shao H, Park YI, Peterson VM, Castro CM, Weissleder R, Lee H. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol. 2014 May; 32(5):490-5. PMID: 24752081; PMCID: PMC4356947.
  32. Ullal AV, Peterson V, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R. Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates. Sci Transl Med. 2014 Jan 15; 6(219):219ra9. PMID: 24431113; PMCID: PMC4063286.
  33. Peterson VM, Castro CM, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R. Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):E4978-86. PMID: 24297935; PMCID: PMC3870756.
  34. Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H. Magnetic nanosensor for detection and profiling of erythrocyte-derived microvesicles. ACS Nano. 2013 Dec 23; 7(12):11227-33. PMID: 24295203; PMCID: PMC3898036.
  35. Ghazani AA, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R. Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance. Nanomedicine. 2014 Apr; 10(3):661-8. PMID: 24200523; PMCID: PMC3966960.
  36. Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H. Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells. Lab Chip. 2014 Jan 07; 14(1):14-23. PMID: 23835814; PMCID: PMC3844052.
  37. Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R. Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia. 2013 Jul; 15(7):684-93. PMID: 23814481; PMCID: PMC3689232.
  38. Chung HJ, Castro CM, Im H, Lee H, Weissleder R. A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria. Nat Nanotechnol. 2013 May; 8(5):369-75. PMID: 23644570; PMCID: PMC3711657.
  39. Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM. Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and a miniaturized micro-NMR system. Nanomedicine. 2013 Oct; 9(7):1009-17. PMID: 23570873; PMCID: PMC4330975.
  40. Issadore D, Chung J, Shao H, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee H. Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med. 2012 Jul 04; 4(141):141ra92. PMID: 22764208; PMCID: PMC3603277.
  41. Ghazani AA, Castro CM, Gorbatov R, Lee H, Weissleder R. Sensitive and direct detection of circulating tumor cells by multimarker µ-nuclear magnetic resonance. Neoplasia. 2012 May; 14(5):388-95. PMID: 22745585; PMCID: PMC3384426.
  42. Peterson VM, Castro CM, Lee H, Weissleder R. Orthogonal amplification of nanoparticles for improved diagnostic sensing. ACS Nano. 2012 Apr 24; 6(4):3506-13. PMID: 22424443; PMCID: PMC3337350.
  43. Weissleder R, Castro C. Interview: Nanomedicine in oncology: miniaturized means to an enormous end. Interviewed by Cara Sutton. Nanomedicine (Lond). 2011 Nov; 6(9):1495-8. PMID: 22077461.
    View in: PubMed
  44. Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for rapid molecular analysis of human tumor samples. Sci Transl Med. 2011 Feb 23; 3(71):71ra16. PMID: 21346169; PMCID: PMC3086073.
  45. Perez DL, Diamond EL, Castro CM, Diaz A, Buonanno F, Nogueira RG, Sheth K. Factor XIII deficiency related recurrent spontaneous intracerebral hemorrhage: a case and literature review. Clin Neurol Neurosurg. 2011 Feb; 113(2):142-5. PMID: 20950938.
    View in: PubMed
  46. Penson RT, Castro CM, Seiden MV, Chabner BA, Lynch TJ. Complementary, alternative, integrative, or unconventional medicine? Oncologist. 2001; 6(5):463-73. PMID: 11675526.
    View in: PubMed
  47. Castro CM, Yang Y, Zhang Z, Linnoila RI. Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein. Lab Invest. 2000 Oct; 80(10):1533-40. PMID: 11045570.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.