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profileCalum Archibald MacRae, Ph.D., M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Cardiovascular Disease, Medicine, Thorn 1127A
75 Francis St
Boston MA 02115
Phone857/307-0301
Fax856/307-0300
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
Development of a new zebrafish model for studying cell-autonomous connexin mutants linked to atrial fibrillation
Summer, 06/05/15 - 08/15/15

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lloyd KC, Robinson PN, MacRae CA. Animal-based studies will be essential for precision medicine. Sci Transl Med. 2016 Aug 17; 8(352):352ed12. PMID: 27535618.
    View in: PubMed
  2. Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, Widjaja AA, Schafer S, Yusoff P, Choksi PK, Ko NS, Singh MK, Epstein D, Guan Y, Houštek J, Mracek T, Nuskova H, Mikell B, Tan J, Pesce F, Kolar F, Bottolo L, Mancini M, Hubner N, Pravenec M, Petretto E, MacRae C, Cook SA. Wars2 is a determinant of angiogenesis. Nat Commun. 2016; 7:12061. PMID: 27389904.
    View in: PubMed
  3. MacRae CA, Vasan RS. The Future of Genetics and Genomics: Closing the Phenotype Gap in Precision Medicine. Circulation. 2016 Jun 21; 133(25):2634-9. PMID: 27324359.
    View in: PubMed
  4. MacRae CA, Roden DM, Loscalzo J. The Future of Cardiovascular Therapeutics. Circulation. 2016 Jun 21; 133(25):2610-7. PMID: 27324356.
    View in: PubMed
  5. MacRae CA, Loscalzo J. The Future of Cardiovascular Biomedicine. Circulation. 2016 Jun 21; 133(25):2601-2. PMID: 27324354.
    View in: PubMed
  6. Brown DW, MacRae CA, Gardner TJ. The Future of Cardiovascular Education and Training. Circulation. 2016 Jun 21; 133(25):2734-42. PMID: 27324367.
    View in: PubMed
  7. Carreras ET, Chatzizisis YS, Mauri L, MacRae C. Acute Coronary Syndrome in a 52-Year-Old Woman With Scleroderma. Circulation. 2016 Jun 14; 133(24):2576-82. PMID: 27297349.
    View in: PubMed
  8. Shah SH, Arnett D, Houser SR, Ginsburg GS, MacRae C, Mital S, Loscalzo J, Hall JL. Opportunities for the Cardiovascular Community in the Precision Medicine Initiative. Circulation. 2016 Jan 12; 133(2):226-31. PMID: 27028435.
    View in: PubMed
  9. Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci U S A. 2015 Dec 8; 112(49):E6780-9. PMID: 26598680.
    View in: PubMed
  10. Antman EM, Benjamin EJ, Harrington RA, Houser SR, Peterson ED, Bauman MA, Brown N, Bufalino V, Califf RM, Creager MA, Daugherty A, Demets DL, Dennis BP, Ebadollahi S, Jessup M, Lauer MS, Lo B, MacRae CA, McConnell MV, McCray AT, Mello MM, Mueller E, Newburger JW, Okun S, Packer M, Philippakis A, Ping P, Prasoon P, Roger VL, Singer S, Temple R, Turner MB, Vigilante K, Warner J, Wayte P. Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015. J Am Heart Assoc. 2015; 4(11). PMID: 26541391.
    View in: PubMed
  11. Cullere X, Plovie E, Bennett PM, MacRae CA, Mayadas TN. The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14284-9. PMID: 26540726; PMCID: PMC4655542 [Available on 05/17/16].
  12. MacRae CA, Pollak MR. Effect Size Does Matter: The Long Road to Mechanistic Insight From Genome-Wide Association. Circulation. 2015 Nov 24; 132(21):1943-5. PMID: 26487758.
    View in: PubMed
  13. Musso G, Mosimann C, Panáková D, Burger A, Zhou Y, Zon LI, MacRae CA. Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genom Data. 2015 Dec; 6:199-201. PMID: 26697374.
    View in: PubMed
  14. MacRae CA, Peterson RT. Zebrafish as tools for drug discovery. Nat Rev Drug Discov. 2015 Oct; 14(10):721-31. PMID: 26361349.
    View in: PubMed
  15. MacRae CA. In vitro and in vivo reprogramming for the conduction system. Trends Cardiovasc Med. 2016 Jan; 26(1):21-2. PMID: 26632016.
    View in: PubMed
  16. Treggiari D, Zoccatelli G, Molesini B, Degan M, Rotino GL, Sala T, Cavallini C, MacRae CA, Minuz P, Pandolfini T. A cystine-knot miniprotein from tomato fruit inhibits endothelial cell migration and angiogenesis by affecting vascular endothelial growth factor receptor (VEGFR) activation and nitric oxide production. Mol Nutr Food Res. 2015 Nov; 59(11):2255-66. PMID: 26255647.
    View in: PubMed
  17. Mosimann C, Panáková D, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015; 6:8146. PMID: 26306682; PMCID: PMC4560818.
  18. MacRae CA. A Critical Need for Clinical Context in the Genomic Era. Circulation. 2015 Sep 15; 132(11):992-3. PMID: 26276888.
    View in: PubMed
  19. Mahmoud AI, O'Meara CC, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi WY, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, Lee RT. Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. Dev Cell. 2015 Aug 24; 34(4):387-99. PMID: 26256209; PMCID: PMC4550513 [Available on 08/24/16].
  20. Rider SA, Mullins LJ, Verdon RF, MacRae CA, Mullins JJ. Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium. Am J Physiol Renal Physiol. 2015 Sep 15; 309(6):F531-9. PMID: 26202224; PMCID: PMC4572395 [Available on 09/15/16].
  21. Can A, Xu J, Volovici V, Dammers R, Dirven CM, MacRae CA, Du R. Fusiform Aneurysms Are Associated with Aortic Root Dilatation in Patients with Subarachnoid Hemorrhage. World Neurosurg. 2015 Dec; 84(6):1681-5. PMID: 26183134.
    View in: PubMed
  22. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2015; 6:7485. PMID: 26108372; PMCID: PMC4491176.
  23. Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2015 May; 7(5):688. PMID: 25940533; PMCID: PMC4492824.
  24. Korf B, Ahmadian R, Allanson J, Aoki Y, Bakker A, Wright EB, Denger B, Elgersma Y, Gelb BD, Gripp KW, Kerr B, Kontaridis M, Lazaro C, Linardic C, Lozano R, MacRae CA, Messiaen L, Mulero-Navarro S, Neel B, Plotkin S, Rauen KA, Roberts A, Silva AJ, Sittampalam SG, Zhang C, Schoyer L. The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach. Am J Med Genet A. 2015 Aug; 167A(8):1741-6. PMID: 25900621; PMCID: PMC4515140.
  25. Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 2015 May 12; 131(19):1715-36. PMID: 25882488.
    View in: PubMed
  26. Vassy JL, McLaughlin HM, McLaughlin HL, MacRae CA, Seidman CE, Lautenbach D, Krier JB, Lane WJ, Kohane IS, Murray MF, McGuire AL, Rehm HL, Green RC. A one-page summary report of genome sequencing for the healthy adult. Public Health Genomics. 2015; 18(2):123-9. PMID: 25612602; PMCID: PMC4348325 [Available on 01/21/16].
  27. MacRae CA. A new phenotypic lexicon for accelerated translation: rise of the machines. Circulation. 2015 Jan 20; 131(3):234-6. PMID: 25601949.
    View in: PubMed
  28. Tasan M, Musso G, Hao T, Vidal M, MacRae CA, Roth FP. Selecting causal genes from genome-wide association studies via functionally coherent subnetworks. Nat Methods. 2015 Feb; 12(2):154-9. PMID: 25532137; PMCID: PMC4480866 [Available on 02/01/16].
  29. McLaughlin HM, Ceyhan-Birsoy O, Christensen KD, Kohane IS, Krier J, Lane WJ, Lautenbach D, Lebo MS, Machini K, MacRae CA, Azzariti DR, Murray MF, Seidman CE, Vassy JL, Green RC, Rehm HL. A systematic approach to the reporting of medically relevant findings from whole genome sequencing. BMC Med Genet. 2014; 15:134. PMID: 25714468; PMCID: PMC4342199.
  30. Deo RC, Musso G, Tasan M, Tang P, Poon A, Yuan C, Felix JF, Vasan RS, Beroukhim R, De Marco T, Kwok PY, MacRae CA, Roth FP. Prioritizing causal disease genes using unbiased genomic features. Genome Biol. 2014; 15(12):534. PMID: 25633252; PMCID: PMC4279789.
  31. Sun H, Al-Romaih KI, MacRae CA, Pollak MR. Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus. EBioMedicine. 2014 Dec; 1(2-3):107-15. PMID: 26086034; PMCID: PMC4457406.
  32. Kong SW, Lee IH, Leshchiner I, Krier J, Kraft P, Rehm HL, Green RC, Kohane IS, MacRae CA. Summarizing polygenic risks for complex diseases in a clinical whole-genome report. Genet Med. 2015 Jul; 17(7):536-44. PMID: 25341114; PMCID: PMC4547452.
  33. Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2014 Nov; 6(11):1493-507. PMID: 25319546; PMCID: PMC4237473.
  34. Roder K, Werdich AA, Li W, Liu M, Kim TY, Organ-Darling LE, Moshal KS, Hwang JM, Lu Y, Choi BR, MacRae CA, Koren G. RING finger protein RNF207, a novel regulator of cardiac excitation. J Biol Chem. 2014 Dec 5; 289(49):33730-40. PMID: 25281747; PMCID: PMC4256309 [Available on 12/05/15].
  35. Hariharan V, Asimaki A, Michaelson JE, Plovie E, MacRae CA, Saffitz JE, Huang H. Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion. Cardiovasc Res. 2014 Nov 1; 104(2):280-9. PMID: 25253076; PMCID: PMC4296114.
  36. Kim AD, Melick CH, Clements WK, Stachura DL, Distel M, Panáková D, MacRae C, Mork LA, Crump JG, Traver D. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16; 33(20):2363-73. PMID: 25230933; PMCID: PMC4253525.
  37. Stitziel NO, MacRae CA. A clinical approach to inherited premature coronary artery disease. Circ Cardiovasc Genet. 2014 Aug; 7(4):558-64. PMID: 25140063; PMCID: PMC4403638.
  38. Triedman JK, MacRae C. Searching for a Rosetta Stone: genetic data and clinical patient management. Heart Rhythm. 2014 Oct; 11(10):1714-5. PMID: 25046859.
    View in: PubMed
  39. Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kléber AG, Saffitz JE. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Sci Transl Med. 2014 Jun 11; 6(240):240ra74. PMID: 24920660; PMCID: PMC4471875.
  40. Pieperhoff S, Wilson KS, Baily J, de Mora K, Maqsood S, Vass S, Taylor J, Del-Pozo J, MacRae CA, Mullins JJ, Denvir MA. Heart on a plate: histological and functional assessment of isolated adult zebrafish hearts maintained in culture. PLoS One. 2014; 9(5):e96771. PMID: 24824845; PMCID: PMC4019527.
  41. Arndt AK, MacRae CA. Genetic testing in cardiovascular diseases. Curr Opin Cardiol. 2014 May; 29(3):235-40. PMID: 24717670; PMCID: PMC4129647.
  42. Abrams DJ, Macrae CA. Long QT syndrome. Circulation. 2014 Apr 8; 129(14):1524-9. PMID: 24709866.
    View in: PubMed
  43. Vassy JL, Lautenbach DM, McLaughlin HM, Kong SW, Christensen KD, Krier J, Kohane IS, Feuerman LZ, Blumenthal-Barby J, Roberts JS, Lehmann LS, Ho CY, Ubel PA, MacRae CA, Seidman CE, Murray MF, McGuire AL, Rehm HL, Green RC. The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine. Trials. 2014; 15:85. PMID: 24645908; PMCID: PMC4113228.
  44. MacRae CA, Vasan RS. Clinically relevant functional annotation of genotype. Circ Cardiovasc Genet. 2014 Feb; 7(1):2-3. PMID: 24550428; PMCID: PMC4188549.
  45. Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, MacRae CA, Lee RT, Burns CG, Burns CE. Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1403-8. PMID: 24474765; PMCID: PMC3910613.
  46. Arndt AK, Macrae CA, Klaassen S. Reponse to De Leeuw and Houge. Am J Hum Genet. 2014 Jan 2; 94(1):154-5. PMID: 24387996; PMCID: PMC3882908.
  47. Musso G, Tasan M, Mosimann C, Beaver JE, Plovie E, Carr LA, Chua HN, Dunham J, Zuberi K, Rodriguez H, Morris Q, Zon L, Roth FP, MacRae CA. Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014 Jan; 141(1):224-35. PMID: 24346703; PMCID: PMC3865760.
  48. Becker JR, Chatterjee S, Robinson TY, Bennett JS, Panáková D, Galindo CL, Zhong L, Shin JT, Coy SM, Kelly AE, Roden DM, Lim CC, MacRae CA. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014 Jan; 141(2):335-45. PMID: 24353062; PMCID: PMC3879815.
  49. MacRae CA. Mendelian forms of structural cardiovascular disease. Curr Cardiol Rep. 2013 Oct; 15(10):399. PMID: 24046092; PMCID: PMC3884814.
  50. Icli B, Wara AK, Moslehi J, Sun X, Plovie E, Cahill M, Marchini JF, Schissler A, Padera RF, Shi J, Cheng HW, Raghuram S, Arany Z, Liao R, Croce K, MacRae C, Feinberg MW. MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res. 2013 Nov 8; 113(11):1231-41. PMID: 24047927; PMCID: PMC4068743.
  51. Kapur S, Macrae CA. The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm. Front Physiol. 2013; 4:221. PMID: 24062689; PMCID: PMC3771314.
  52. Guan J, Mishra S, Shi J, Plovie E, Qiu Y, Cao X, Gianni D, Jiang B, Del Monte F, Connors LH, Seldin DC, Lavatelli F, Rognoni P, Palladini G, Merlini G, Falk RH, Semigran MJ, Dec GW, Macrae CA, Liao R. Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity. Basic Res Cardiol. 2013 Sep; 108(5):378. PMID: 23982491; PMCID: PMC3914405.
  53. Huang CJ, Wilson V, Pennings S, MacRae CA, Mullins J. Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis. Dev Biol. 2013 Dec 15; 384(2):290-300. PMID: 23860396.
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  54. Arndt AK, Schafer S, Drenckhahn JD, Sabeh MK, Plovie ER, Caliebe A, Klopocki E, Musso G, Werdich AA, Kalwa H, Heinig M, Padera RF, Wassilew K, Bluhm J, Harnack C, Martitz J, Barton PJ, Greutmann M, Berger F, Hubner N, Siebert R, Kramer HH, Cook SA, MacRae CA, Klaassen S. Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet. 2013 Jul 11; 93(1):67-77. PMID: 23768516; PMCID: PMC3710750.
  55. Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT. An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 2013 Jul 9; 128(2):152-61. PMID: 23757312; PMCID: PMC3753575.
  56. Macrae C. The author's reply. Heart. 2013 Sep; 99(18):1374. PMID: 23716569.
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  57. Valente AM, Lakdawala NK, Powell AJ, Evans SP, Cirino AL, Orav EJ, MacRae CA, Colan SD, Ho CY. Comparison of echocardiographic and cardiac magnetic resonance imaging in hypertrophic cardiomyopathy sarcomere mutation carriers without left ventricular hypertrophy. Circ Cardiovasc Genet. 2013 Jun; 6(3):230-7. PMID: 23690394; PMCID: PMC3974911.
  58. Mishra S, Guan J, Plovie E, Seldin DC, Connors LH, Merlini G, Falk RH, MacRae CA, Liao R. Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish. Am J Physiol Heart Circ Physiol. 2013 Jul 1; 305(1):H95-103. PMID: 23624626; PMCID: PMC3727100.
  59. Kolpa HJ, Peal DS, Lynch SN, Giokas AC, Ghatak S, Misra S, Norris RA, Macrae CA, Markwald RR, Ellinor P, Bischoff J, Milan DJ. miR-21 represses Pdcd4 during cardiac valvulogenesis. Development. 2013 May; 140(10):2172-80. PMID: 23578931; PMCID: PMC3640220.
  60. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. PMID: 23345455; PMCID: PMC3633825.
  61. MacRae CA. Recent advances in in vivo screening for antiarrhythmic drugs. Expert Opin Drug Discov. 2013 Feb; 8(2):131-41. PMID: 23311759.
    View in: PubMed
  62. MacRae CA. Action and the actionability in exome variation. Circ Cardiovasc Genet. 2012 Dec; 5(6):597-8. PMID: 23250897; PMCID: PMC3834266.
  63. Jin S, Sarkar KS, Jin YN, Liu Y, Kokel D, Van Ham TJ, Roberts LD, Gerszten RE, Macrae CA, Peterson RT. An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. J Biomol Screen. 2013 Jan; 18(1):108-15. PMID: 22960781; PMCID: PMC4053346.
  64. MacRae CA. Pattern recognition: combining informatics and genetics to re-evaluate conduction disease. Heart. 2012 Sep; 98(17):1263-4. PMID: 22875820.
    View in: PubMed
  65. Werdich AA, Brzezinski A, Jeyaraj D, Khaled Sabeh M, Ficker E, Wan X, McDermott BM, Macrae CA, Rosenbaum DS. The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart. Prog Biophys Mol Biol. 2012 Oct-Nov; 110(2-3):154-65. PMID: 22835662; PMCID: PMC3663588.
  66. Rothman RD, Baggish AL, O'Callaghan C, Lowry PA, Bhatt AB, MacRae CA, Yannekis G, Sanborn DM, Mela T, Yeh RW, Palacios I, Vlahakes GJ, Fifer MA. Management strategy in 249 consecutive patients with obstructive hypertrophic cardiomyopathy referred to a dedicated program. Am J Cardiol. 2012 Oct 15; 110(8):1169-74. PMID: 22766229.
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  67. Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ, Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, Towbin JA, Van Eyk J, Worrall BB. Genetics and cardiovascular disease: a policy statement from the American Heart Association. Circulation. 2012 Jul 3; 126(1):142-57. PMID: 22645291; PMCID: PMC3721666.
  68. Guo W, Schafer S, Greaser ML, Radke MH, Liss M, Govindarajan T, Maatz H, Schulz H, Li S, Parrish AM, Dauksaite V, Vakeel P, Klaassen S, Gerull B, Thierfelder L, Regitz-Zagrosek V, Hacker TA, Saupe KW, Dec GW, Ellinor PT, MacRae CA, Spallek B, Fischer R, Perrot A, Özcelik C, Saar K, Hubner N, Gotthardt M. RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med. 2012 May; 18(5):766-73. PMID: 22466703; PMCID: PMC3569865.
  69. Sabeh MK, Kekhia H, Macrae CA. Optical mapping in the developing zebrafish heart. Pediatr Cardiol. 2012 Aug; 33(6):916-22. PMID: 22460358.
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  70. Rider SA, Tucker CS, del-Pozo J, Rose KN, MacRae CA, Bailey MA, Mullins JJ. Techniques for the in vivo assessment of cardio-renal function in zebrafish (Danio rerio) larvae. J Physiol. 2012 Apr 15; 590(Pt 8):1803-9. PMID: 22331420; PMCID: PMC3573304.
  71. Becker JR, Robinson TY, Sachidanandan C, Kelly AE, Coy S, Peterson RT, MacRae CA. In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovasc Res. 2012 Mar 1; 93(3):463-70. PMID: 22198505; PMCID: PMC3410427.
  72. Lee MS, Macrae CA. Revisiting risk stratification in hypertrophic cardiomyopathy: do we need to start from scratch? Heart Rhythm. 2012 Jan; 9(1):64-5. PMID: 22019864.
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  73. Peterson RT, Macrae CA. Systematic approaches to toxicology in the zebrafish. Annu Rev Pharmacol Toxicol. 2012; 52:433-53. PMID: 22017682.
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  74. Refaat MM, Lubitz SA, Makino S, Islam Z, Frangiskakis JM, Mehdi H, Gutmann R, Zhang ML, Bloom HL, MacRae CA, Dudley SC, Shalaby AA, Weiss R, McNamara DM, London B, Ellinor PT. Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy. Heart Rhythm. 2012 Mar; 9(3):390-6. PMID: 22004663; PMCID: PMC3516872.
  75. Jeffs L, Rose D, Macrae C, Maione M, Macmillan KM. What near misses tell us about risk and safety in mental health care. J Psychiatr Ment Health Nurs. 2012 Jun; 19(5):430-7. PMID: 22070194.
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  76. MacRae CA, Vasan RS. Next-generation genome-wide association studies: time to focus on phenotype? Circ Cardiovasc Genet. 2011 Aug 1; 4(4):334-6. PMID: 21846867; PMCID: PMC3187849.
  77. Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, Macrae CA, Poss KD. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development. 2011 Aug; 138(16):3421-30. PMID: 21752928; PMCID: PMC3143562.
  78. Wythe JD, Jurynec MJ, Urness LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yost HJ, Grunwald DJ, Macrae CA, Li DY. Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Dis Model Mech. 2011 Sep; 4(5):607-21. PMID: 21628396; PMCID: PMC3180224.
  79. Naunheim MR, Walcott BP, Nahed BV, MacRae CA, Levinson JR, Ogilvy CS. Arterial tortuosity syndrome with multiple intracranial aneurysms: a case report. Arch Neurol. 2011 Mar; 68(3):369-71. PMID: 21403023.
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  80. Becker JR, Deo RC, Werdich AA, Panàkovà D, Coy S, MacRae CA. Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish. Dis Model Mech. 2011 May; 4(3):400-10. PMID: 21245263; PMCID: PMC3097461.
  81. Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/EBPß controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010 Dec 23; 143(7):1072-83. PMID: 21183071; PMCID: PMC3035164.
  82. Deo RC, MacRae CA. Clinical screening and genetic testing. Clin Lab Med. 2010 Dec; 30(4):775-84. PMID: 20832651; PMCID: PMC4308415.
  83. Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, Knowles JW, Thompson JR, Absher D, Iribarren C, Go A, Fortmann SP, Sidney S, Risch N, Tang H, Myers RM, Berger K, Stoll M, Shah SH, Thorgeirsson G, Andersen K, Havulinna AS, Herrera JE, Faraday N, Kim Y, Kral BG, Mathias RA, Ruczinski I, Suktitipat B, Wilson AF, Yanek LR, Becker LC, Linsel-Nitschke P, Lieb W, König IR, Hengstenberg C, Fischer M, Stark K, Reinhard W, Winogradow J, Grassl M, Grosshennig A, Preuss M, Schreiber S, Wichmann HE, Meisinger C, Yee J, Friedlander Y, Do R, Meigs JB, Williams G, Nathan DM, MacRae CA, Qu L, Wilensky RL, Matthai WH, Qasim AN, Hakonarson H, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser VE, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Martinelli N, Olivieri O, Trabetti E, Malerba G, Pignatti PF, Guiducci C, Mirel D, Parkin M, Hirschhorn JN, Asselta R, Duga S, Musunuru K, Daly MJ, Purcell S, Eifert S, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Ouwehand WH, Deloukas P, Scholz M, Cambien F, Huge A, Scheffold T, Salomaa V, Girelli D, Granger CB, Peltonen L, McKeown PP, Altshuler D, Melander O, Devaney JM, Epstein SE, Rader DJ, Elosua R, Engert JC, Anand SS, Hall AS, Ziegler A, O'Donnell CJ, Spertus JA, Siscovick D, Schwartz SM, Becker D, Thorsteinsdottir U, Stefansson K, Schunkert H, Samani NJ, Quertermous T. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010 Nov 2; 56(19):1552-63. PMID: 20933357; PMCID: PMC3084526.
  84. Sogah VM, Serluca FC, Fishman MC, Yelon DL, Macrae CA, Mably JD. Distinct troponin C isoform requirements in cardiac and skeletal muscle. Dev Dyn. 2010 Nov; 239(11):3115-23. PMID: 20925115; PMCID: PMC2965274.
  85. Deo RC, MacRae CA. The zebrafish: scalable in vivo modeling for systems biology. Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun; 3(3):335-46. PMID: 20882534; PMCID: PMC3251331.
  86. Panáková D, Werdich AA, Macrae CA. Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 2010 Aug 12; 466(7308):874-8. PMID: 20657579; PMCID: PMC2921013.
  87. Sabeh MK, MacRae CA. The genetics of atrial fibrillation. Curr Opin Cardiol. 2010 May; 25(3):186-91. PMID: 20224389.
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  88. Albert CM, MacRae CA, Chasman DI, VanDenburgh M, Buring JE, Manson JE, Cook NR, Newton-Cheh C. Common variants in cardiac ion channel genes are associated with sudden cardiac death. Circ Arrhythm Electrophysiol. 2010 Jun; 3(3):222-9. PMID: 20400777; PMCID: PMC2891421.
  89. Shin JT, Pomerantsev EV, Mably JD, MacRae CA. High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish. Physiol Genomics. 2010 Jul 7; 42(2):300-9. PMID: 20388839; PMCID: PMC3032279.
  90. MacRae CA. The genetics of congestive heart failure. Heart Fail Clin. 2010 Apr; 6(2):223-30. PMID: 20347790; PMCID: PMC2847583.
  91. Deo RC, MacRae CA. Clinical screening and genetic testing. Heart Fail Clin. 2010 Apr; 6(2):231-8. PMID: 20347791; PMCID: PMC2874821.
  92. Ellinor PT, MacRae CA, Thierfelder L. Arrhythmogenic right ventricular cardiomyopathy. Heart Fail Clin. 2010 Apr; 6(2):161-77. PMID: 20347785.
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  93. MacRae CA. Preface. Genetic studies of primary forms of heart failure. Heart Fail Clin. 2010 Apr; 6(2):xv-xvi. PMID: 20347782.
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  94. Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, Evans T, Macrae CA, Stainier DY, Poss KD. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 2010 Mar 25; 464(7288):601-5. PMID: 20336144; PMCID: PMC3040215.
  95. Gritli S, Ben Salah M, Shili A, Robson CD, Ferjaoui M, Hendaoui L, Belhani A, Jilani SB, Gusella JF, Macrae CA. Association of the long QT syndrome With goiter and deafness. Am J Cardiol. 2010 Mar 1; 105(5):681-6. PMID: 20185017.
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  96. Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, Soliman EZ, Rice KM, Van Wagoner DR, Beckmann BM, van Noord C, Wang K, Ehret GB, Rotter JI, Hazen SL, Steinbeck G, Smith AV, Launer LJ, Harris TB, Makino S, Nelis M, Milan DJ, Perz S, Esko T, Köttgen A, Moebus S, Newton-Cheh C, Li M, Möhlenkamp S, Wang TJ, Kao WH, Vasan RS, Nöthen MM, MacRae CA, Stricker BH, Hofman A, Uitterlinden AG, Levy D, Boerwinkle E, Metspalu A, Topol EJ, Chakravarti A, Gudnason V, Psaty BM, Roden DM, Meitinger T, Wichmann HE, Witteman JC, Barnard J, Arking DE, Benjamin EJ, Heckbert SR, Kääb S. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet. 2010 Mar; 42(3):240-4. PMID: 20173747; PMCID: PMC2871387.
  97. Lamont RE, Vu W, Carter AD, Serluca FC, MacRae CA, Childs SJ. Hedgehog signaling via angiopoietin1 is required for developmental vascular stability. Mech Dev. 2010 Apr; 127(3-4):159-68. PMID: 20156556.
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  98. Peal DS, Burns CG, Macrae CA, Milan D. Chondroitin sulfate expression is required for cardiac atrioventricular canal formation. Dev Dyn. 2009 Dec; 238(12):3103-10. PMID: 19890913; PMCID: PMC2852642.
  99. Saffitz JE, Macrae CA. Mutations in desmosomal protein genes and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2010 Jan; 7(1):30-2. PMID: 20129282.
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  100. MacRae CA. Closer look at genetic testing in long-QT syndrome: will DNA diagnostics ever be enough? Circulation. 2009 Nov 3; 120(18):1745-8. PMID: 19841296.
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  101. Macrae CA, McKenna WJ. Splicing and dilated cardiomyopathy one gene to rule them all? J Am Coll Cardiol. 2009 Sep 1; 54(10):942-3. PMID: 19712805.
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  103. MacRae CA. Symptoms in atrial fibrillation: why keep score? Circ Arrhythm Electrophysiol. 2009 Jun; 2(3):215-7. PMID: 19808470; PMCID: PMC3068191.
  104. Watanabe H, Kaiser DW, Makino S, MacRae CA, Ellinor PT, Wasserman BS, Kannankeril PJ, Donahue BS, Roden DM, Darbar D. ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling. Heart Rhythm. 2009 Sep; 6(9):1327-32. PMID: 19648063; PMCID: PMC2740737.
  105. Das S, Makino S, Melman YF, Shea MA, Goyal SB, Rosenzweig A, Macrae CA, Ellinor PT. Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation. Heart Rhythm. 2009 Aug; 6(8):1146-53. PMID: 19632626; PMCID: PMC3038671.
  106. Ho CY, MacRae CA. Defining the pathogenicity of DNA sequence variation. Circ Cardiovasc Genet. 2009 Apr; 2(2):95-7. PMID: 20031572; PMCID: PMC3068192.
  107. Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, Siscovick DS, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Ardissino D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Mannucci PM, Schwartz SM, Siscovick DS, Yee J, Friedlander Y, Elosua R, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Kathiresan S, Meigs JB, Williams G, Nathan DM, MacRae CA, O'Donnell CJ, Salomaa V, Havulinna AS, Peltonen L, Melander O, Berglund G, Voight BF, Kathiresan S, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Musunuru K, Daly MJ, Purcell S, Voight BF, Purcell S, Nemesh J, Korn JM, McCarroll SA, Schwartz SM, Yee J, Kathiresan S, Lucas G, Subirana I, Elosua R, Surti A, Guiducci C, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Samani NJ, Thompson JR, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall A, Schunkert H, Erdmann J, Linsel-Nitschke P, Lieb W, Ziegler A, König I, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Schunkert H, Samani NJ, Erdmann J, Ouwehand W, Hengstenberg C, Deloukas P, Scholz M, Cambien F, Reilly MP, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser V, Epstein SE, Rader DJ, Scheffold T, Berger K, Stoll M, Huge A, Girelli D, Martinelli N, Olivieri O, Corrocher R, Morgan T, Spertus JA, McKeown P, Patterson CC, Schunkert H, Erdmann E, Linsel-Nitschke P, Lieb W, Ziegler A, König IR, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Hólm H, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Engert JC, Do R, Xie C, Anand S, Kathiresan S, Ardissino D, Mannucci PM, Siscovick D, O'Donnell CJ, Samani NJ, Melander O, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Altshuler D. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009 Mar; 41(3):334-41. PMID: 19198609; PMCID: PMC2681011.
  108. Milan DJ, Macrae CA. Zebrafish genetic models for arrhythmia. Prog Biophys Mol Biol. 2008 Oct-Nov; 98(2-3):301-8. PMID: 19351520; PMCID: PMC2836909.
  109. Kääb S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, Lunetta KL, Larson MG, Levy D, MacRae CA, Ruskin JN, Wacker A, Schömig A, Wichmann HE, Steinbeck G, Meitinger T, Uitterlinden AG, Witteman JC, Roden DM, Benjamin EJ, Ellinor PT. Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Eur Heart J. 2009 Apr; 30(7):813-9. PMID: 19141561; PMCID: PMC2663727.
  110. Vasan RS, MacRae CA. A dream, a journey, and a promise: the inauguration of Circulation: Cardiovascular Genetics. Circ Cardiovasc Genet. 2008 Oct; 1(1):1-2. PMID: 20031535.
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  111. Wang L, Sewell WF, Kim SD, Shin JT, MacRae CA, Zon LI, Seidman JG, Seidman CE. Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish. Development. 2008 Oct; 135(20):3425-34. PMID: 18799547.
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  112. Jaggard MK, MacRae C, Ifeacho S, Robinson S, Tolley NS. New presentation of familial medullary thyroid carcinoma in 87-year-old patient with high-risk RET proto-oncogene codon 620 mutation. J Laryngol Otol. 2009 Jul; 123(7):796-800. PMID: 18771606.
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  114. Ellinor PT, Yi BA, MacRae CA. Genetics of atrial fibrillation. Med Clin North Am. 2008 Jan; 92(1):41-51, x. PMID: 18060996; PMCID: PMC2905167.
  115. Yeh JR, Munson KM, Chao YL, Peterson QP, Macrae CA, Peterson RT. AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development. 2008 Jan; 135(2):401-10. PMID: 18156164.
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  116. Albert CM, Nam EG, Rimm EB, Jin HW, Hajjar RJ, Hunter DJ, MacRae CA, Ellinor PT. Cardiac sodium channel gene variants and sudden cardiac death in women. Circulation. 2008 Jan 1; 117(1):16-23. PMID: 18071069.
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  117. Deo R, MacRae CA. The genetics of cardiomyopathies: what clinicians should know. Curr Heart Fail Rep. 2007 Dec; 4(4):229-35. PMID: 18221620.
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  119. Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, Sigurdsson A, Jonasdottir A, Baker A, Thorleifsson G, Kristjansson K, Palsson A, Blondal T, Sulem P, Backman VM, Hardarson GA, Palsdottir E, Helgason A, Sigurjonsdottir R, Sverrisson JT, Kostulas K, Ng MC, Baum L, So WY, Wong KS, Chan JC, Furie KL, Greenberg SM, Sale M, Kelly P, MacRae CA, Smith EE, Rosand J, Hillert J, Ma RC, Ellinor PT, Thorgeirsson G, Gulcher JR, Kong A, Thorsteinsdottir U, Stefansson K. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature. 2007 Jul 19; 448(7151):353-7. PMID: 17603472.
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  120. Gregory SA, MacRae CA, Aziz K, Sims KB, Schmahmann JD, Kardan A, Morss AM, Ellinor PT, Tawakol A, Fischman AJ, Gewirtz H. Myocardial blood flow and oxygen consumption in patients with Friedreich's ataxia prior to the onset of cardiomyopathy. Coron Artery Dis. 2007 Feb; 18(1):15-22. PMID: 17172925.
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  121. Maree AO, Jneid H, Palacios IF, Rosenfield K, MacRae CA, Fitzgerald DJ. Growth arrest specific gene (GAS) 6 modulates platelet thrombus formation and vascular wall homeostasis and represents an attractive drug target. Curr Pharm Des. 2007; 13(26):2656-61. PMID: 17897008.
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  122. Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML. Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006 Dec; 11(6):845-57. PMID: 17141159.
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  125. van Kimmenade RR, Januzzi JL, Ellinor PT, Sharma UC, Bakker JA, Low AF, Martinez A, Crijns HJ, MacRae CA, Menheere PP, Pinto YM. Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol. 2006 Sep 19; 48(6):1217-24. PMID: 16979009.
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  130. Burns CG, MacRae CA. Purification of hearts from zebrafish embryos. Biotechniques. 2006 Mar; 40(3):274, 276, 278 passim. PMID: 16568816.
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  133. Ellinor PT, Yoerger DM, Ruskin JN, MacRae CA. Familial aggregation in lone atrial fibrillation. Hum Genet. 2005 Nov; 118(2):179-84. PMID: 16133178.
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  135. Low AF, O'Donnell CJ, Kathiresan S, Everett B, Chae CU, Shaw SY, Ellinor PT, MacRae CA. Aging syndrome genes and premature coronary artery disease. BMC Med Genet. 2005 Oct 31; 6:38. PMID: 16262891; PMCID: PMC1289285.
  136. Shin JT, Priest JR, Ovcharenko I, Ronco A, Moore RK, Burns CG, MacRae CA. Human-zebrafish non-coding conserved elements act in vivo to regulate transcription. Nucleic Acids Res. 2005; 33(17):5437-45. PMID: 16179648; PMCID: PMC1236720.
  137. Burns CG, Milan DJ, Grande EJ, Rottbauer W, MacRae CA, Fishman MC. High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nat Chem Biol. 2005 Oct; 1(5):263-4. PMID: 16408054.
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  139. Mahon NG, Murphy RT, MacRae CA, Caforio AL, Elliott PM, McKenna WJ. Echocardiographic evaluation in asymptomatic relatives of patients with dilated cardiomyopathy reveals preclinical disease. Ann Intern Med. 2005 Jul 19; 143(2):108-15. PMID: 16027452.
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  141. Murphy RT, Mogensen J, McGarry K, Bahl A, Evans A, Osman E, Syrris P, Gorman G, Farrell M, Holton JL, Hanna MG, Hughes S, Elliott PM, Macrae CA, McKenna WJ. Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome: natural history. J Am Coll Cardiol. 2005 Mar 15; 45(6):922-30. PMID: 15766830.
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  142. Schönberger J, Wang L, Shin JT, Kim SD, Depreux FF, Zhu H, Zon L, Pizard A, Kim JB, Macrae CA, Mungall AJ, Seidman JG, Seidman CE. Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Nat Genet. 2005 Apr; 37(4):418-22. PMID: 15735644.
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  144. MacRae CA, Ellinor PT. Genetic screening and risk assessment in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2004 Dec 21; 44(12):2326-8. PMID: 15607393.
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  146. Gerull B, Heuser A, Wichter T, Paul M, Basson CT, McDermott DA, Lerman BB, Markowitz SM, Ellinor PT, MacRae CA, Peters S, Grossmann KS, Drenckhahn J, Michely B, Sasse-Klaassen S, Birchmeier W, Dietz R, Breithardt G, Schulze-Bahr E, Thierfelder L. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet. 2004 Nov; 36(11):1162-4. PMID: 15489853.
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  147. Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol. 2004 Sep; 24(18):8134-44. PMID: 15340074; PMCID: PMC515035.
  148. Peterson RT, Shaw SY, Peterson TA, Milan DJ, Zhong TP, Schreiber SL, MacRae CA, Fishman MC. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol. 2004 May; 22(5):595-9. PMID: 15097998.
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  150. MacRae CA, Peterson RT. Zebrafish-based small molecule discovery. Chem Biol. 2003 Oct; 10(10):901-8. PMID: 14583256.
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  153. Wang TJ, Nam BH, D'Agostino RB, Wolf PA, Lloyd-Jones DM, MacRae CA, Wilson PW, Polak JF, O'Donnell CJ. Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study. Circulation. 2003 Aug 5; 108(5):572-6. PMID: 12874190.
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  155. Tawakol A, Sims K, MacRae C, Friedman JR, Alpert NM, Fischman AJ, Gewirtz H. Myocardial flow regulation in people with mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes/myoclonic epilepsy and ragged red fibers and other mitochondrial syndromes. Coron Artery Dis. 2003 May; 14(3):197-205. PMID: 12702922.
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  157. CA MacRae and MC Fishman. Zebrafish-The Complete Cardiovascular Compendium. Symposium 67: The Cardiovascular System. 2003.
  158. CA MacRae and MC Fishman. Model Organisms for Cardiovascular Disease Gene Discovery. In KR Chien and CE Seidman, editors. The Molecular Basis of Cardiovascular Disease. 2003; 39-47.
  159. Hajjar RJ, MacRae CA. Adrenergic-receptor polymorphisms and heart failure. N Engl J Med. 2002 Oct 10; 347(15):1196-9. PMID: 12374881.
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  160. PT Ellinor, DM Yoerger, BM McGovern, JN Ruskin, CA MacRae . Familial aggregation of atrial fibrillation. Finalist, American Heart Association, Council on Clinical Cardiology, Samuel A. Levine Young Clinical Investigator Award. Circulation. 2002; 106:I-12.
  161. RJ Hajjar and CA MacRae. a/b Adrenoreceptor Polymorphisms in Heart Failure. New England Journal of Medicine. 2002; 347:1196-1199.
  162. MacRae CA, Fishman MC. Zebrafish: the complete cardiovascular compendium. Cold Spring Harb Symp Quant Biol. 2002; 67:301-7. PMID: 12858553.
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  163. MacRae CA. Genetics and dilated cardiomyopathy: limitations of candidate gene strategies. Eur Heart J. 2000 Nov; 21(22):1817-9. PMID: 11052851.
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  164. Schönberger J, Levy H, Grünig E, Sangwatanaroj S, Fatkin D, MacRae C, Stäcker H, Halpin C, Eavey R, Philbin EF, Katus H, Seidman JG, Seidman CE. Dilated cardiomyopathy and sensorineural hearing loss: a heritable syndrome that maps to 6q23-24. Circulation. 2000 Apr 18; 101(15):1812-8. PMID: 10769282.
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  165. Fatkin D, MacRae C, Sasaki T, Wolff MR, Porcu M, Frenneaux M, Atherton J, Vidaillet HJ, Spudich S, De Girolami U, Seidman JG, Seidman C, Muntoni F, Müehle G, Johnson W, McDonough B. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N Engl J Med. 1999 Dec 2; 341(23):1715-24. PMID: 10580070.
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  166. Mehdirad AA, Fatkin D, DiMarco JP, MacRae CA, Wase A, Seidman JG, Seidman CE, Benson DW. Electrophysiologic characteristics of accessory atrioventricular connections in an inherited form of Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol. 1999 May; 10(5):629-35. PMID: 10355918.
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  167. Siu BL, Niimura H, Osborne JA, Fatkin D, MacRae C, Solomon S, Benson DW, Seidman JG, Seidman CE. Familial dilated cardiomyopathy locus maps to chromosome 2q31. Circulation. 1999 Mar 2; 99(8):1022-6. PMID: 10051295.
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  168. CE Seidman, CA MacRae, JG Seidman. Inherited cardiomyopathies. Principles of Molecular Medicine. 1998; 225-248.
  169. MacRae CA. Familial atrial fibrillation. N Engl J Med. 1997 Jul 31; 337(5):350. PMID: 9235505.
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  170. Basson CT, MacRae CA, Korf B, Merliss A. Genetic heterogeneity of familial atrial myxoma syndromes (Carney complex). Am J Cardiol. 1997 Apr 1; 79(7):994-5. PMID: 9104925.
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  171. Benson DW, Basson CT, MacRae CA. New understandings in the genetics of congenital heart disease. Curr Opin Pediatr. 1996 Oct; 8(5):505-11. PMID: 8946132.
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  172. Basson CT, MacRae CA, Schoenberg-Fejzo M, Morton CC, Spinner NB, Genin A, Krug E, Seidman JG, Seidman CE. Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130. Genomics. 1996 Aug 1; 35(3):628-31. PMID: 8812507.
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  173. Manolis EN, Yandavi N, Nadol JB, Eavey RD, McKenna M, Rosenbaum S, Khetarpal U, Halpin C, Merchant SN, Duyk GM, MacRae C, Seidman CE, Seidman JG. A gene for non-syndromic autosomal dominant progressive postlingual sensorineural hearing loss maps to chromosome 14q12-13. Hum Mol Genet. 1996 Jul; 5(7):1047-50. PMID: 8817345.
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  174. Benson DW, MacRae CA, Vesely MR, Walsh EP, Seidman JG, Seidman CE, Satler CA. Missense mutation in the pore region of HERG causes familial long QT syndrome. Circulation. 1996 May 15; 93(10):1791-5. PMID: 8635257.
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  175. CA MacRae . The genetics of hypertrophic cardiomyopathy. Advances in Cardiology. In R. Gorlin and P.K. Toutouzas, editors. 1996; 1-16.
  176. JA Osborne, CA MacRae, DW Benson, S Solomon, JG Seidman, CE Seidman . Multiple genetic loci contribute to familial dilated cardiomyopathy. Circulation. 1996; 94:I-262.
  177. Watkins H, Conner D, Thierfelder L, Jarcho JA, MacRae C, McKenna WJ, Maron BJ, Seidman JG, Seidman CE. Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy. Nat Genet. 1995 Dec; 11(4):434-7. PMID: 7493025.
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  178. MacRae CA, Ghaisas N, Kass S, Donnelly S, Basson CT, Watkins HC, Anan R, Thierfelder LH, McGarry K, Rowland E, et al. Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3. J Clin Invest. 1995 Sep; 96(3):1216-20. PMID: 7657794; PMCID: PMC185741.
  179. Basson CT, Solomon SD, Weissman B, MacRae CA, Poznanski AK, Prieto F, Ruiz de la Fuente S, Pease WE, Levin SE, Holmes LB, et al. Genetic heterogeneity of heart-hand syndromes. Circulation. 1995 Mar 1; 91(5):1326-9. PMID: 7867169.
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  180. Wilton SD, Eyre H, Akkari PA, Watkins HC, MacRae C, Laing NG, Callen DC. Assignment of the human a-tropomyosin gene TPM3 to 1q22-->q23 by fluorescence in situ hybridisation. Cytogenet Cell Genet. 1995; 68(1-2):122-4. PMID: 7956350.
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  181. CA MacRae, R Anan, D Harris, P Keeling, H Vidaillet, S Kubo, H Skirton, M James, J Burgess, WJ McKenna, S Mohiudin, JG Seidman, CE Seidman . Familial dilated cardiomyopathy with conduction disease exhibits both genetic and phenotypic heterogeneity. Circulation. 1995; 92:I-83.
  182. Watkins H, MacRae CA, Fischman DA, Seidman JG, Seidman CE. A dinucleotide repeat polymorphism in the MYBPH gene. Hum Mol Genet. 1994 Dec; 3(12):2267. PMID: 7881442.
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  183. Kass S, MacRae C, Graber HL, Sparks EA, McNamara D, Boudoulas H, Basson CT, Baker PB, Cody RJ, Fishman MC, et al. A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1-1q1. Nat Genet. 1994 Aug; 7(4):546-51. PMID: 7951328.
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  184. Thierfelder L, Watkins H, MacRae C, Lamas R, McKenna W, Vosberg HP, Seidman JG, Seidman CE. Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell. 1994 Jun 3; 77(5):701-12. PMID: 8205619.
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  185. CA MacRae, HC Watkins, WJ McKenna Proc. . The genetics of hypertrophic cardiomyopathy. Royal Coll Phys Edin. 1994; 24:305-310.
  186. H Watkins, CA MacRae, LH Thierfelder, WJ McKenna, JG Seidman , CE Seidman . Clinical implications of cardiac troponin T mutations that cause familial hypertrophic cardiomyopathy. Circulation. 1994; 90:I-442.
  187. H Watkins, CA MacRae, LH Thierfelder, WJ McKenna, JG Seidman, CE Seidman . Mode of action of cardiac troponin T mutations in familial hypertrophic cardiomyopathy. Circulation. 1994; 90:I-520.
  188. MacRae CA, Watkins HC, Jarcho JA, Thierfelder L, McKenna WJ, Seidman JG, Seidman CE. An evaluation of ribonuclease protection assays for the detection of beta-cardiac myosin heavy chain gene mutations. Circulation. 1994 Jan; 89(1):33-5. PMID: 8281665.
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  189. Thierfelder L, MacRae C, Watkins H, Tomfohrde J, Williams M, McKenna W, Bohm K, Noeske G, Schlepper M, Bowcock A, et al. A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2. Proc Natl Acad Sci U S A. 1993 Jul 1; 90(13):6270-4. PMID: 8327508; PMCID: PMC46910.
  190. Watkins HC, MacRae CA, Thierfelder L, McKenna WJ, Seidman CE, Seidman JG. A dinucleotide repeat polymorphism in the human LAMB2 gene on chromosome 1q. Hum Mol Genet. 1993 Jul; 2(7):1084. PMID: 8364561.
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  191. Watkins H, MacRae C, Thierfelder L, Chou YH, Frenneaux M, McKenna W, Seidman JG, Seidman CE. A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3. Nat Genet. 1993 Apr; 3(4):333-7. PMID: 7981753.
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  192. H Watkins, L Thierfelder, R Anan, CA MacRae, WJ McKenna, JG Seidman and CE Seidman . Independent origin of myosin mutations in hypertrophic cardiomyopathy. Eur Heart J. 1993; 14:(abstract suppl):1..
  193. MacRae CA, Marber MS, Keywood C, Joy M. Need for invasive cardiological assessment and intervention: a ten year review. Br Heart J. 1992 Feb; 67(2):200-3. PMID: 1540444; PMCID: PMC1024755.
  194. Watkins H, Seidman CE, MacRae C, Seidman JG, McKenna W. Progress in familial hypertrophic cardiomyopathy: molecular genetic analyses in the original family studied by Teare. Br Heart J. 1992 Jan; 67(1):34-8. PMID: 1739523; PMCID: PMC1024696.
  195. M Hossein-Nia, P Brown, CF Shakespeare, CA MacRae, A O'Donoghue, DW Holt . Subclinical myocardial damage revealed by CK-MB2 isoform release in hypertrophic cardiomyopathy. Circulation. 1992; 86:I-592.
  196. CA MacRae, IA Simpson, JF Sneddon, S Gibson, AJ Camm . Dobutamine is the most physiological stress for echocardiographic regional wall motion studies in multivessel coronary artery disease. Br Heart J. 1992; 67:120.
  197. CA MacRae, C Lijia, MA DeBelder, DE Ward, CW Pumphrey, JC Kaski . Highly localised nitrate resistant coronary constriction occurs in humans immediately after percutaneous transluminal angioplasty. Circulation. 1992; 86:I-846.
  198. Marber M, MacRae C, Joy M. Delay to invasive investigation and revascularisation for coronary heart disease in south west Thames region: a two tier system? BMJ. 1991 May 18; 302(6786):1189-91. PMID: 2043817; PMCID: PMC1669849.
  199. D Bell, M Jackson, CA MacRae, J Dawes, AL Muir . Neutrophil elastase: a marker of neutrophil activation in acute myocardial infarction?. Clinical Science. 1988; 72(S16):87.
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