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profileSharon G. Kujawa, Ph.D.

TitleAssociate Professor of Otolaryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtolaryngology
AddressMassachusetts Eye & Ear Infrm
Audiology
243 Charles St
Boston MA 02114
Phone617/573-3266
Fax617/573-3023
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P50DC015857     (KUJAWA, SHARON G)Aug 2, 2017 - Jul 31, 2022
NIH/NIDCD
Cochlear Synaptopathy: Prevalence, Diagnosis and Functional Consequences
Role: Principal Investigator

R01DC008577     (KUJAWA, SHARON G)Mar 5, 2008 - Feb 28, 2014
NIH/NIDCD
Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
Role: Principal Investigator

R21DC004983     (KUJAWA, SHARON)Aug 1, 2001 - Jul 31, 2004
NIH/NIDCD
Genetics of Noise Resistance in the Aging Ear
Role: Principal Investigator

F32DC000180     (KUJAWA, SHARON)Jul 1, 1995
NIH/NIDCD
PROTECTIVE EFFECTS OF EFFERENT FEEDBACK TO THE COCHLEA
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Liberman MC, Kujawa SG. Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms. Hear Res. 2017 Jun; 349:138-147. PMID: 28087419.
    View in: PubMed
  2. Ryan AF, Kujawa SG, Hammill T, Le Prell C, Kil J. Temporary and Permanent Noise-induced Threshold Shifts: A Review of Basic and Clinical Observations. Otol Neurotol. 2016 09; 37(8):e271-5. PMID: 27518135; PMCID: PMC4988324 [Available on 09/01/17].
  3. Voss SE, Herrmann BS, Horton NJ, Amadei EA, Kujawa SG. Reflectance Measures from Infant Ears With Normal Hearing and Transient Conductive Hearing Loss. Ear Hear. 2016 Sep-Oct; 37(5):560-71. PMID: 27050773.
    View in: PubMed
  4. Macias AA, Eappen S, Malikin I, Goldfarb J, Kujawa S, Konowitz PM, Kamani D, Randolph GW. Successful intraoperative electrophysiologic monitoring of the recurrent laryngeal nerve, a multidisciplinary approach: The Massachusetts Eye and Ear Infirmary monitoring collaborative protocol with experience in over 3000 cases. Head Neck. 2016 Oct; 38(10):1487-94. PMID: 27062311.
    View in: PubMed
  5. Tandon V, Kang WS, Robbins TA, Spencer AJ, Kim ES, McKenna MJ, Kujawa SG, Fiering J, Pararas EE, Mescher MJ, Sewell WF, Borenstein JT. Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing. Lab Chip. 2016 Mar 07; 16(5):829-46. PMID: 26778829; PMCID: PMC4766044 [Available on 02/23/17].
  6. Fernandez KA, Jeffers PW, Lall K, Liberman MC, Kujawa SG. Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears. J Neurosci. 2015 May 13; 35(19):7509-20. PMID: 25972177; PMCID: PMC4429155.
  7. Tandon V, Kang WS, Spencer AJ, Kim ES, Pararas EE, McKenna MJ, Kujawa SG, Mescher MJ, Fiering J, Sewell WF, Borenstein JT. Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform. Biomed Microdevices. 2015 Apr; 17(2):37. PMID: 25686902.
    View in: PubMed
  8. Kujawa SG, Liberman MC. Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss. Hear Res. 2015 Dec; 330(Pt B):191-9. PMID: 25769437; PMCID: PMC4567542 [Available on 12/01/16].
  9. Remenschneider AK, Lookabaugh S, Aliphas A, Brodsky JR, Devaiah AK, Dagher W, Grundfast KM, Heman-Ackah SE, Rubin S, Sillman J, Tsai AC, Vecchiotti M, Kujawa SG, Lee DJ, Quesnel AM. Otologic outcomes after blast injury: the Boston Marathon experience. Otol Neurotol. 2014 Dec; 35(10):1825-34. PMID: 25393974.
    View in: PubMed
  10. Street VA, Kujawa SG, Manichaikul A, Broman KW, Kallman JC, Shilling DJ, Iwata AJ, Robinson LC, Robbins CA, Li J, Liberman MC, Tempel BL. Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. J Assoc Res Otolaryngol. 2014 Oct; 15(5):721-38. PMID: 24952082; PMCID: PMC4164691.
  11. Liberman MC, Kujawa SG. Hot Topics-Hidden hearing loss: Permanent cochlear-nerve degeneration after temporary noise-induced threshold shift. J Acoust Soc Am. 2014 Apr; 135(4):2311. PMID: 25235676.
    View in: PubMed
  12. Sergeyenko Y, Lall K, Liberman MC, Kujawa SG. Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline. J Neurosci. 2013 Aug 21; 33(34):13686-94. PMID: 23966690; PMCID: PMC3755715.
  13. Furman AC, Kujawa SG, Liberman MC. Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates. J Neurophysiol. 2013 Aug; 110(3):577-86. PMID: 23596328; PMCID: PMC3742994.
  14. Seixas NS, Neitzel R, Stover B, Sheppard L, Feeney P, Mills D, Kujawa S. 10-Year prospective study of noise exposure and hearing damage among construction workers. Occup Environ Med. 2012 Sep; 69(9):643-50. PMID: 22693267; PMCID: PMC4570847.
  15. Makary CA, Shin J, Kujawa SG, Liberman MC, Merchant SN. Age-related primary cochlear neuronal degeneration in human temporal bones. J Assoc Res Otolaryngol. 2011 Dec; 12(6):711-7. PMID: 21748533; PMCID: PMC3214241.
  16. Lin HW, Furman AC, Kujawa SG, Liberman MC. Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift. J Assoc Res Otolaryngol. 2011 Oct; 12(5):605-16. PMID: 21688060; PMCID: PMC3173555.
  17. Pararas EE, Chen Z, Fiering J, Mescher MJ, Kim ES, McKenna MJ, Kujawa SG, Borenstein JT, Sewell WF. Kinetics of reciprocating drug delivery to the inner ear. J Control Release. 2011 Jun 10; 152(2):270-7. PMID: 21385596; PMCID: PMC3114251.
  18. Peppi M, Kujawa SG, Sewell WF. A corticosteroid-responsive transcription factor, promyelocytic leukemia zinc finger protein, mediates protection of the cochlea from acoustic trauma. J Neurosci. 2011 Jan 12; 31(2):735-41. PMID: 21228182; PMCID: PMC3274172.
  19. McCall AA, Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug delivery for treatment of inner ear disease: current state of knowledge. Ear Hear. 2010 Apr; 31(2):156-65. PMID: 19952751; PMCID: PMC2836414.
  20. Chen Z, Kujawa SG, Sewell WF. Functional roles of high-affinity glutamate transporters in cochlear afferent synaptic transmission in the mouse. J Neurophysiol. 2010 May; 103(5):2581-6. PMID: 20220082; PMCID: PMC2867573.
  21. Sewell WF, Borenstein JT, Chen Z, Fiering J, Handzel O, Holmboe M, Kim ES, Kujawa SG, McKenna MJ, Mescher MM, Murphy B, Swan EE, Peppi M, Tao S. Development of a microfluidics-based intracochlear drug delivery device. Audiol Neurootol. 2009; 14(6):411-22. PMID: 19923811; PMCID: PMC2820330.
  22. Kujawa SG, Liberman MC. Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss. J Neurosci. 2009 Nov 11; 29(45):14077-85. PMID: 19906956; PMCID: PMC2812055.
  23. Chen Z, Peppi M, Kujawa SG, Sewell WF. Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons. J Neurophysiol. 2009 Aug; 102(2):1152-9. PMID: 19515954; PMCID: PMC2724347.
  24. Mescher MJ, Swan EE, Fiering J, Holmboe ME, Sewell WF, Kujawa SG, McKenna MJ, Borenstein JT. Fabrication Methods and Performance of Low-Permeability Microfluidic Components for a Miniaturized Wearable Drug Delivery System. J Microelectromech Syst. 2009 Jun 01; 18(3):501-510. PMID: 20852729.
    View in: PubMed
  25. Fiering J, Mescher MJ, Leary Swan EE, Holmboe ME, Murphy BA, Chen Z, Peppi M, Sewell WF, McKenna MJ, Kujawa SG, Borenstein JT. Local drug delivery with a self-contained, programmable, microfluidic system. Biomed Microdevices. 2009 Jun; 11(3):571-8. PMID: 19089621; PMCID: PMC2935585.
  26. Swan EE, Peppi M, Chen Z, Green KM, Evans JE, McKenna MJ, Mescher MJ, Kujawa SG, Sewell WF. Proteomics analysis of perilymph and cerebrospinal fluid in mouse. Laryngoscope. 2009 May; 119(5):953-8. PMID: 19358201; PMCID: PMC2940114.
  27. Handzel O, Wang H, Fiering J, Borenstein JT, Mescher MJ, Swan EE, Murphy BA, Chen Z, Peppi M, Sewell WF, Kujawa SG, McKenna MJ. Mastoid cavity dimensions and shape: method of measurement and virtual fitting of implantable devices. Audiol Neurootol. 2009; 14(5):308-14. PMID: 19372649; PMCID: PMC2712579.
  28. Chen Z, Kujawa SG, Sewell WF. Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors. Nat Neurosci. 2007 Oct; 10(10):1238-40. PMID: 17828255.
    View in: PubMed
  29. Goldman B, Sheppard L, Kujawa SG, Seixas NS. Modeling distortion product otoacoustic emission input/output functions using segmented regression. J Acoust Soc Am. 2006 Nov; 120(5 Pt 1):2764-76. PMID: 17139737.
    View in: PubMed
  30. Lin MY, Timmer FC, Oriel BS, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Merchant SN, Rauch SD. Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops. Laryngoscope. 2006 Jun; 116(6):987-92. PMID: 16735912; PMCID: PMC2758415.
  31. Timmer FC, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Rauch SD. Vestibular evoked myogenic potential (VEMP) in patients with Ménière's disease with drop attacks. Laryngoscope. 2006 May; 116(5):776-9. PMID: 16652086.
    View in: PubMed
  32. Kujawa SG, Liberman MC. Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci. 2006 Feb 15; 26(7):2115-23. PMID: 16481444; PMCID: PMC1855187.
  33. Zehnder AF, Kristiansen AG, Adams JC, Kujawa SG, Merchant SN, McKenna MJ. Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss. Laryngoscope. 2006 Feb; 116(2):201-6. PMID: 16467704; PMCID: PMC2563156.
  34. Chen Z, Kujawa SG, McKenna MJ, Fiering JO, Mescher MJ, Borenstein JT, Swan EE, Sewell WF. Inner ear drug delivery via a reciprocating perfusion system in the guinea pig. J Control Release. 2005 Dec 10; 110(1):1-19. PMID: 16274830; PMCID: PMC2030590.
  35. Chen Z, Mikulec AA, McKenna MJ, Sewell WF, Kujawa SG. A method for intracochlear drug delivery in the mouse. J Neurosci Methods. 2006 Jan 15; 150(1):67-73. PMID: 16043228.
    View in: PubMed
  36. Seixas NS, Goldman B, Sheppard L, Neitzel R, Norton S, Kujawa SG. Prospective noise induced changes to hearing among construction industry apprentices. Occup Environ Med. 2005 May; 62(5):309-17. PMID: 15837852; PMCID: PMC1741009.
  37. Seixas NS, Kujawa SG, Norton S, Sheppard L, Neitzel R, Slee A. Predictors of hearing threshold levels and distortion product otoacoustic emissions among noise exposed young adults. Occup Environ Med. 2004 Nov; 61(11):899-907. PMID: 15477283; PMCID: PMC1757883.
  38. Rauch SD, Silveira MB, Zhou G, Kujawa SG, Wall C, Guinan JJ, Herrmann BS. Vestibular evoked myogenic potentials versus vestibular test battery in patients with Meniere's disease. Otol Neurotol. 2004 Nov; 25(6):981-6. PMID: 15547430.
    View in: PubMed
  39. Rauch SD, Zhou G, Kujawa SG, Guinan JJ, Herrmann BS. Vestibular evoked myogenic potentials show altered tuning in patients with Ménière's disease. Otol Neurotol. 2004 May; 25(3):333-8. PMID: 15129114.
    View in: PubMed
  40. Rosowski JJ, Brinsko KM, Tempel BI, Kujawa SG. The aging of the middle ear in 129S6/SvEvTac and CBA/CaJ mice: measurements of umbo velocity, hearing function, and the incidence of pathology. J Assoc Res Otolaryngol. 2003 Sep; 4(3):371-83. PMID: 14690055; PMCID: PMC3202735.
  41. Kujawa SG, Liberman MC. Effects of olivocochlear feedback on distortion product otoacoustic emissions in guinea pig. J Assoc Res Otolaryngol. 2001 Sep; 2(3):268-78. PMID: 11669399; PMCID: PMC3201675.
  42. Parkinson NJ, Olsson CL, Hallows JL, McKee-Johnson J, Keogh BP, Noben-Trauth K, Kujawa SG, Tempel BL. Mutant beta-spectrin 4 causes auditory and motor neuropathies in quivering mice. Nat Genet. 2001 Sep; 29(1):61-5. PMID: 11528393.
    View in: PubMed
  43. Gates GA, Schmid P, Kujawa SG, Nam B, D'Agostino R. Longitudinal threshold changes in older men with audiometric notches. Hear Res. 2000 Mar; 141(1-2):220-8. PMID: 10713509.
    View in: PubMed
  44. Kujawa SG, Liberman MC. Long-term sound conditioning enhances cochlear sensitivity. J Neurophysiol. 1999 Aug; 82(2):863-73. PMID: 10444683.
    View in: PubMed
  45. Brown MC, Kujawa SG, Duca ML. Single olivocochlear neurons in the guinea pig. I. Binaural facilitation of responses to high-level noise. J Neurophysiol. 1998 Jun; 79(6):3077-87. PMID: 9636109.
    View in: PubMed
  46. Brown MC, Kujawa SG, Liberman MC. Single olivocochlear neurons in the guinea pig. II. Response plasticity due to noise conditioning. J Neurophysiol. 1998 Jun; 79(6):3088-97. PMID: 9636110.
    View in: PubMed
  47. Kujawa SG, Liberman MC. Conditioning-related protection from acoustic injury: effects of chronic deefferentation and sham surgery. J Neurophysiol. 1997 Dec; 78(6):3095-106. PMID: 9405529.
    View in: PubMed
  48. Kujawa SG, Fallon M, Skellett RA, Bobbin RP. Time-varying alterations in the f2-f1 DPOAE response to continuous primary stimulation. II. Influence of local calcium-dependent mechanisms. Hear Res. 1996 Aug; 97(1-2):153-64. PMID: 8844195.
    View in: PubMed
  49. Kujawa SG, Fallon M, Bobbin RP. Time-varying alterations in the f2-f1 DPOAE response to continuous primary stimulation. I: Response characterization and contribution of the olivocochlear efferents. Hear Res. 1995 May; 85(1-2):142-54. PMID: 7559170.
    View in: PubMed
  50. Goldsmith JD, Kujawa SG, McLaren JD, Bledsoe SC. In vivo release of neuroactive amino acids from the inferior colliculus of the guinea pig using brain microdialysis. Hear Res. 1995 Mar; 83(1-2):80-8. PMID: 7607993.
    View in: PubMed
  51. Kujawa SG, Fallon M, Bobbin RP. ATP antagonists cibacron blue, basilen blue and suramin alter sound-evoked responses of the cochlea and auditory nerve. Hear Res. 1994 Aug; 78(2):181-8. PMID: 7982811.
    View in: PubMed
  52. Kujawa SG, Erostegui C, Fallon M, Crist J, Bobbin RP. Effects of adenosine 5'-triphosphate and related agonists on cochlear function. Hear Res. 1994 Jun 01; 76(1-2):87-100. PMID: 7928720.
    View in: PubMed
  53. Kujawa SG, Glattke TJ, Fallon M, Bobbin RP. A nicotinic-like receptor mediates suppression of distortion product otoacoustic emissions by contralateral sound. Hear Res. 1994 Apr; 74(1-2):122-34. PMID: 8040083.
    View in: PubMed
  54. Kujawa SG, Glattke TJ, Fallon M, Bobbin RP. Contralateral sound suppresses distortion product otoacoustic emissions through cholinergic mechanisms. Hear Res. 1993 Jun; 68(1):97-106. PMID: 8376219.
    View in: PubMed
  55. Kujawa SG, Fallon M, Bobbin RP. Intracochlear salicylate reduces low-intensity acoustic and cochlear microphonic distortion products. Hear Res. 1992 Dec; 64(1):73-80. PMID: 1490903.
    View in: PubMed
  56. Kujawa SG, Glattke TJ, Fallon M, Bobbin RP. Intracochlear application of acetylcholine alters sound-induced mechanical events within the cochlear partition. Hear Res. 1992 Aug; 61(1-2):106-16. PMID: 1326504.
    View in: PubMed
  57. Bobbin RP, Fallon M, Kujawa SG. Magnitude of the negative summating potential varies with perilymph calcium levels. Hear Res. 1991 Nov; 56(1-2):101-10. PMID: 1663103.
    View in: PubMed
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