Dusica Bajic, PH.D., M.D.
|Title||Assistant Professor of Anaesthesia|
|Institution||Children's Hospital Boston|
Anesthesia, Pavilion 3
300 Longwood Ave
Boston MA 02115
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1994||Dean’s Award for Exceptional Accomplishments in Medical School|
1999||International Brain Research Organization (IBRO) Travel Grant|
1999||International Association for the Study of Pain (IASP) Travel Grant|
2001||U.S. Permanent Residency Petition approved in the category of the Outstanding Researcher|
1994||Fellowship from Ministry of Science and Education|
1997||Fellowship from Ministry of Science and Education|
1999||Panich Fund Fellowship in Pharmacology|
1999||Graduate College and Graduate Student Council Travel Awards|
2000||Graduate Student Symposium Award, Chicago Chapter of the Society for Neuroscience|
2000||Student Medical Research Forum Recognition|
2008||Farley Fund Fellowship in Pediatric Anesthesiology|
2009||International Narcotic Research Conference (INRC) Travel Award|
2010||Advanced Techniques in Molecular Neuroscience Attendee|
2011||Patient’s Choice Award |
2011||Compassionate Doctor Recognition|
2012||International Anesthesia Research Society (IARS) Best of Category Abstract|
2012||International Anesthesia Research Society (IARS) 2012 Best of Meeting Finalists|
2012||Top Ten Doctors - Anesthesiology |
2012||Association of American Medical Colleges (AAMC) Leadership Seminar Attendee|
2015||The Anesthesia Research Distinguished Trailblazer Award: Basic Science|
2013||Journal Cover; Journal of Chemical Neuroanatomy|
2013||Recipient of NIH Mentored Clinical Scientist Development Award (K08) with highest score: 10|
PAST Funding Information:
1. Foundation in Anesthesia Education and Research (FAER) Mentored Research Training Grant – Basic Research (MRTG-BR): MRTG-2/15/09-Bajic (Dusica)
Title: Age Differences of Brain Circuits Mediating Morphine Effect and Development of Morphine Tolerance
The specific goal of this project is to understand how chronic morphine exposure influences Fos and nNOS expression in the ventrolateral periaqueductal gray, an area that is strongly implicated in analgesic tolerance development. Age-dependent effects of morphine exposure are determined using neuroanatomical tools in a rodent model. The broad long-term objective of the proposed research is to understand mechanisms contributing to morphine tolerance during postnatal development.
2. NIH Support Opportunity for Addiction Research (SOAR) for New Investigators (R03)
Title: Age Differences of Brain Circuits Mediating Morphine Effect and Morphine Tolerance
Gene expression differences with age and chronic morphine exposure are determined using PCR Arrays (SABiosciences) in a rodent model. The broad long-term objective of the study was to understand mechanisms contributing to morphine tolerance that differ with age.
CURRENT Funding Information:
1. The Anesthesia Research Distinguished Trailblazer Award, Department of Anesthesiology, Perioperative and Pain Medicine Research Grant, Boston Children’s Hospital, Harvard Medical School
Title: Ontogeny of Supraspinal Mechanisms of Addiction
Study examines the ontogeny of supraspinal mechanisms of addiction, specifically the role of cholinergic system in adolescent rat brain following chronic morphine administration. Experiments involve systems approach using fMRI, as well as cellular approach (fluorescent immunohistochemistry).
2. NIH Mentored Clinical Scientist Development Award (K08): 1K08DA035972-01
Title: Immediate and Delayed Effects of Morphine on Brain Circuits: Animal – Human Correlation
This mentored clinical scientist research career award (K08) is unique in its translational effort to define the impact of prolonged morphine exposure in the rats of different ages using neuroimaging, behavioral, and immunohistochemical techniques (AIM 1), as well as in children of different ages using neuroimaging (AIM 2). Functional magnetic resonance imaging (fMRI) in both rats and children will allow a translational systems level investigation of prolonged morphine administration and its long-term effects.
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