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James Arthur Lederer, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AI138318 (LEDERER, JAMES A.) Apr 1, 2018 - Mar 31, 2023
    NIH/NIAID
    Therapy of acute radiation syndrome and its complications by mesenchymal stromal cells conditioned with Toll-like receptor 9 agonists
    Role: Principal Investigator
  2. P30AR070253 (NIGROVIC, PETER A) Aug 11, 2016 - Jul 31, 2021
    NIH/NIAMS
    Joint Biology Consortium Resource-based Center
    Role: Co-Principal Investigator
  3. P30AR069625 (CLARK, RACHAEL ANN) Jul 19, 2016 - Jun 30, 2021
    NIH/NIAMS
    Human Skin Disease Resource-based Center
    Role: Co-Principal Investigator
  4. U01AI107360 (LEDERER, JAMES A.) May 9, 2013 - Apr 30, 2018
    NIH/NIAID
    Restoring Immune Function Following Radiation Injuries by TLR9 Agonist Treatment
    Role: Principal Investigator
  5. R01AI092905 (LEDERER, JAMES A.) Jun 15, 2011 - May 31, 2016
    NIH/NIAID
    Injury-Specific Activation of the Immune System
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Lederer Lab - Mouse strains (11) and Protocols (3)
CyTOF Antibody Resource and Core - Core services (2), Protocols (4) and Software (1)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ledderose C, Liu K, Kondo Y, Slubowski CJ, Dertnig T, Denicoló S, Arbab M, Hubner J, Konrad K, Fakhari M, Lederer JA, Robson SC, Visner GA, Junger WG. Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 Aug 01; 128(8):3583-3594. PMID: 29894310.
    View in: PubMed
  2. Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Res Ther. 2018 Jul 11; 20(1):139. PMID: 29996944.
    View in: PubMed
  3. Baron RM, Kwon MY, Castano AP, Ghanta S, Riascos-Bernal DF, Lopez-Guzman S, Macias AA, Ith B, Schissel SL, Lederer JA, Reeves R, Yet SF, Layne MD, Liu X, Perrella MA. Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis. J Leukoc Biol. 2018 Jul 05. PMID: 29975792.
    View in: PubMed
  4. Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB. Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nat Commun. 2018 02 23; 9(1):789. PMID: 29476097.
    View in: PubMed
  5. Seshadri A, Brat GA, Yorkgitis BK, Keegan J, Dolan J, Salim A, Askari R, Lederer JA. Phenotyping the Immune Response to Trauma: A Multiparametric Systems Immunology Approach. Crit Care Med. 2017 Sep; 45(9):1523-1530. PMID: 28671900.
    View in: PubMed
  6. Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017 02 01; 542(7639):110-114. PMID: 28150777.
    View in: PubMed
  7. Seshadri A, Brat G, Yorkgitis B, Keegan J, Dolan J, Salim A, Askari R, Lederer J. 630: THE HUMAN RESPONSE TO TRAUMA: A SYSTEMS IMMUNOLOGY APPROACH. Crit Care Med. 2016 Dec; 44(12 Suppl 1):234. PMID: 27850269.
    View in: PubMed
  8. Zhao G, Zaidi TS, Bozkurt-Guzel C, Zaidi TH, Lederer JA, Priebe GP, Pier GB. Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens. Invest Ophthalmol Vis Sci. 2016 12 01; 57(15):6797-6804. PMID: 28002842.
    View in: PubMed
  9. Gao P, Rong HH, Lu T, Tang G, Si LY, Lederer JA, Xiong W. The CD4/CD8 ratio is associated with coronary artery disease (CAD) in elderly Chinese patients. Int Immunopharmacol. 2017 Jan; 42:39-43. PMID: 27866071.
    View in: PubMed
  10. Foks AC, Engelbertsen D, Kuperwaser F, Alberts-Grill N, Gonen A, Witztum JL, Lederer J, Jarolim P, DeKruyff RH, Freeman GJ, Lichtman AH. Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):456-65. PMID: 26821944; PMCID: PMC4853762 [Available on 03/01/17].
  11. Wanke-Jellinek L, Keegan JW, Dolan JW, Guo F, Chen J, Lederer JA. Beneficial Effects of CpG-Oligodeoxynucleotide Treatment on Trauma and Secondary Lung Infection. J Immunol. 2016 Jan 15; 196(2):767-77. PMID: 26673136.
    View in: PubMed
  12. Engelbertsen D, Foks AC, Alberts-Grill N, Kuperwaser F, Chen T, Lederer JA, Jarolim P, Grabie N, Lichtman AH. Expansion of CD25+ Innate Lymphoid Cells Reduces Atherosclerosis. Arterioscler Thromb Vasc Biol. 2015 Dec; 35(12):2526-35. PMID: 26494229; PMCID: PMC4717486 [Available on 12/01/16].
  13. Wanke-Jellinek L, Keegan JW, Dolan JW, Lederer JA. Characterization of lung infection-induced TCR?d T cell phenotypes by CyTOF mass cytometry. J Leukoc Biol. 2016 Mar; 99(3):483-93. PMID: 26428679.
    View in: PubMed
  14. Lederer JA. Response to comment on "Radiation exposure induces inflammasome pathway activation in immune cells". J Immunol. 2015 Jun 01; 194(11):5039. PMID: 25980026.
    View in: PubMed
  15. Shay T, Lederer JA, Benoist C. Genomic responses to inflammation in mouse models mimic humans: we concur, apples to oranges comparisons won't do. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):E346. PMID: 25540423; PMCID: PMC4313855.
  16. Stoecklein VM, Osuka A, Ishikawa S, Lederer MR, Wanke-Jellinek L, Lederer JA. Radiation exposure induces inflammasome pathway activation in immune cells. J Immunol. 2015 Feb 01; 194(3):1178-89. PMID: 25539818; PMCID: PMC4326002.
  17. Fellner J, Lederer J, Purgar A, Winterstetter A, Rechberger H, Winter F, Laner D. Evaluation of resource recovery from waste incineration residues--the case of zinc. Waste Manag. 2015 Mar; 37:95-103. PMID: 25458759.
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  18. Yamaguchi T, Calvacanti BM, Cruzat A, Qazi Y, Ishikawa S, Osuka A, Lederer J, Hamrah P. Correlation between human tear cytokine levels and cellular corneal changes in patients with bacterial keratitis by in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2014 Oct 16; 55(11):7457-66. PMID: 25324281; PMCID: PMC4240721.
  19. Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM, Ifedigbo E, Lederer JA, Englert J, Pelton A, Coronata A, Fredenburgh LE, Choi AM. Circadian rhythm reprogramming during lung inflammation. Nat Commun. 2014 Sep 11; 5:4753. PMID: 25208554; PMCID: PMC4162491.
  20. Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH. Abandon the mouse research ship? Not just yet! Shock. 2014 Jun; 41(6):463-75. PMID: 24569509; PMCID: PMC4139038.
  21. Doyle TJ, Lee JS, Dellaripa PF, Lederer JA, Matteson EL, Fischer A, Ascherman DP, Glassberg MK, Ryu JH, Danoff SK, Brown KK, Collard HR, Rosas IO. A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. Chest. 2014 Mar 01; 145(3):454-463. PMID: 24590021; PMCID: PMC3941243.
  22. Osuka A, Ogura H, Ueyama M, Shimazu T, Lederer JA. Immune response to traumatic injury: harmony and discordance of immune system homeostasis. Acute Med Surg. 2014 Apr; 1(2):63-69. PMID: 29930824.
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  23. Hall SR, Tsoyi K, Ith B, Padera RF, Lederer JA, Wang Z, Liu X, Perrella MA. Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils. Stem Cells. 2013 Feb; 31(2):397-407. PMID: 23132816; PMCID: PMC3572335.
  24. Tajima G, Delisle AJ, Hoang K, O'Leary FM, Ikeda K, Hanschen M, Stoecklein VM, Lederer JA. Immune system phenotyping of radiation and radiation combined injury in outbred mice. Radiat Res. 2013 Jan; 179(1):101-12. PMID: 23216446; PMCID: PMC4287236.
  25. Lederer JA. What's new in shock, November 2012? Shock. 2012 Nov; 38(5):447-9. PMID: 23076440.
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  26. Osuka A, Hanschen M, Stoecklein V, Lederer J. Reply. Shock. 2012 Jun; 37(6):659-60. PMID: 22592637.
    View in: PubMed
  27. Stoecklein VM, Osuka A, Lederer JA. Trauma equals danger--damage control by the immune system. J Leukoc Biol. 2012 Sep; 92(3):539-51. PMID: 22654121; PMCID: PMC3427603.
  28. Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM. Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):209-17. PMID: 22517795; PMCID: PMC3423463.
  29. Osuka A, Hanschen M, Stoecklein V, Lederer JA. A protective role for inflammasome activation following injury. Shock. 2012 Jan; 37(1):47-55. PMID: 21921832; PMCID: PMC3241872.
  30. Byrne WL, Mills KH, Lederer JA, O'Sullivan GC. Targeting regulatory T cells in cancer. Cancer Res. 2011 Nov 15; 71(22):6915-20. PMID: 22068034; PMCID: PMC4287207.
  31. Hanschen M, Tajima G, O'Leary F, Hoang K, Ikeda K, Lederer JA. Phospho-flow cytometry based analysis of differences in T cell receptor signaling between regulatory T cells and CD4+ T cells. J Immunol Methods. 2012 Feb 28; 376(1-2):1-12. PMID: 21945004; PMCID: PMC4287240.
  32. O'Leary FM, Tajima G, Delisle AJ, Ikeda K, Dolan SM, Hanschen M, Mannick JA, Lederer JA. Injury-induced GR-1+ macrophage expansion and activation occurs independently of CD4 T-cell influence. Shock. 2011 Aug; 36(2):162-9. PMID: 21430603; PMCID: PMC3139815.
  33. Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1100-7. PMID: 21393583; PMCID: PMC3104026.
  34. Hanschen M, Tajima G, O'Leary F, Ikeda K, Lederer JA. Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T cells. Shock. 2011 Mar; 35(3):252-7. PMID: 20720513; PMCID: PMC3045756.
  35. MacConmara MP, Tajima G, O'Leary F, Delisle AJ, McKenna AM, Stallwood CG, Mannick JA, Lederer JA. Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. J Leukoc Biol. 2011 Jan; 89(1):137-47. PMID: 20884652; PMCID: PMC3004517.
  36. Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, West MA, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Cobb JP, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O'Keefe G. Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):9923-8. PMID: 20479259; PMCID: PMC2890487.
  37. Whelan MC, Casey G, MacConmara M, Lederer JA, Soden D, Collins JK, Tangney M, O'Sullivan GC. Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation. Cancer Gene Ther. 2010 Jul; 17(7):501-11. PMID: 20186173.
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  38. Fujimi S, Lapchak PH, Zang Y, MacConmara MP, Maung AA, Delisle AJ, Mannick JA, Lederer JA. Murine dendritic cell antigen-presenting cell function is not altered by burn injury. J Leukoc Biol. 2009 May; 85(5):862-70. PMID: 19228816; PMCID: PMC2669406.
  39. Maung AA, Fujimi S, MacConmara MP, Tajima G, McKenna AM, Delisle AJ, Stallwood C, Onderdonk AB, Mannick JA, Lederer JA. Injury enhances resistance to Escherichia coli infection by boosting innate immune system function. J Immunol. 2008 Feb 15; 180(4):2450-8. PMID: 18250454.
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  40. Kawasaki T, Choudhry MA, Schwacha MG, Fujimi S, Lederer JA, Bland KI, Chaudry IH. Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C754-64. PMID: 18199702.
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  41. Lederer JA, Brownstein BH, Lopez MC, Macmillan S, Delisle AJ, Macconmara MP, Choudhry MA, Xiao W, Lekousi S, Cobb JP, Baker HV, Mannick JA, Chaudry IH. Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiol Genomics. 2008 Feb 19; 32(3):299-310. PMID: 17986522.
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  42. Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 07; 114(19):2047-55. PMID: 17060381.
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  43. MacConmara MP, Maung AA, Fujimi S, McKenna AM, Delisle A, Lapchak PH, Rogers S, Lederer JA, Mannick JA. Increased CD4+ CD25+ T regulatory cell activity in trauma patients depresses protective Th1 immunity. Ann Surg. 2006 Oct; 244(4):514-23. PMID: 16998360; PMCID: PMC1856576.
  44. Kawasaki T, Fujimi S, Lederer JA, Hubbard WJ, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH. Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice. J Immunol. 2006 Oct 01; 177(7):4514-20. PMID: 16982888.
    View in: PubMed
  45. Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH. Platelet depletion in mice increases mortality after thermal injury. Blood. 2006 Jun 01; 107(11):4399-406. PMID: 16467203; PMCID: PMC1895793.
  46. Purcell EM, Dolan SM, Kriynovich S, Mannick JA, Lederer JA. Burn injury induces an early activation response by lymph node CD4+ T cells. Shock. 2006 Feb; 25(2):135-40. PMID: 16525351.
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  47. Ni Choileain N, MacConmara M, Zang Y, Murphy TJ, Mannick JA, Lederer JA. Enhanced regulatory T cell activity is an element of the host response to injury. J Immunol. 2006 Jan 01; 176(1):225-36. PMID: 16365414.
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  48. Brownstein BH, Logvinenko T, Lederer JA, Cobb JP, Hubbard WJ, Chaudry IH, Remick DG, Baker HV, Xiao W, Mannick JA. Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiol Genomics. 2006 Feb 14; 24(3):298-309. PMID: 16478828.
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  49. MacConmara M, Lederer JA. B cells. Crit Care Med. 2005 Dec; 33(12 Suppl):S514-6. PMID: 16340437.
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  50. Maung AA, Fujimi S, Miller ML, MacConmara MP, Mannick JA, Lederer JA. Enhanced TLR4 reactivity following injury is mediated by increased p38 activation. J Leukoc Biol. 2005 Aug; 78(2):565-73. PMID: 15857937.
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  51. Lederer JA. Does nitric oxide control the counter-inflammatory response in endotoxic shock? Crit Care Med. 2005 Apr; 33(4):896-8. PMID: 15818123.
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  52. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13):4801-6. PMID: 15781863; PMCID: PMC555033.
  53. Murphy TJ, Ni Choileain N, Zang Y, Mannick JA, Lederer JA. CD4+CD25+ regulatory T cells control innate immune reactivity after injury. J Immunol. 2005 Mar 01; 174(5):2957-63. PMID: 15728508.
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  54. Murphy TJ, Paterson HM, Kriynovich S, Zang Y, Kurt-Jones EA, Mannick JA, Lederer JA. Linking the "two-hit" response following injury to enhanced TLR4 reactivity. J Leukoc Biol. 2005 Jan; 77(1):16-23. PMID: 15496450.
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  55. Zang Y, Dolan SM, Ni Choileain N, Kriynovich SJ, Murphy TJ, Sayles P, Mannick JA, Lederer JA. Burn injury initiates a shift in superantigen-induced T cell responses and host survival. J Immunol. 2004 Apr 15; 172(8):4883-92. PMID: 15067067.
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  56. Guo Z, Kavanagh E, Zang Y, Dolan SM, Kriynovich SJ, Mannick JA, Lederer JA. Burn injury promotes antigen-driven Th2-type responses in vivo. J Immunol. 2003 Oct 15; 171(8):3983-90. PMID: 14530317.
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  57. Murphy TJ, Paterson HM, Mannick JA, Lederer JA. Injury, sepsis, and the regulation of Toll-like receptor responses. J Leukoc Biol. 2004 Mar; 75(3):400-7. PMID: 14557385.
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  58. Murphy T, Paterson H, Rogers S, Mannick JA, Lederer JA. Use of intracellular cytokine staining and bacterial superantigen to document suppression of the adaptive immune system in injured patients. Ann Surg. 2003 Sep; 238(3):401-10; discussion 410-1. PMID: 14501506; PMCID: PMC1422703.
  59. Shelley O, Murphy T, Paterson H, Mannick JA, Lederer JA. Interaction between the innate and adaptive immune systems is required to survive sepsis and control inflammation after injury. Shock. 2003 Aug; 20(2):123-9. PMID: 12865655.
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  60. Paterson HM, Murphy TJ, Purcell EJ, Shelley O, Kriynovich SJ, Lien E, Mannick JA, Lederer JA. Injury primes the innate immune system for enhanced Toll-like receptor reactivity. J Immunol. 2003 Aug 01; 171(3):1473-83. PMID: 12874240.
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  61. Shelley O, Murphy T, Lederer JA, Mannick JA, Rodrick ML. Mast cells and resistance to peritoneal sepsis after burn injury. Shock. 2003 Jun; 19(6):513-8. PMID: 12785005.
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  62. Mueller TF, Ma C, Lederer JA, Perkins DL. Differentiation of stress, metabolism, communication, and defense responses following transplantation. J Leukoc Biol. 2003 Mar; 73(3):379-90. PMID: 12629152.
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  63. Mannick JA, Rodrick ML, Lederer JA. The immunologic response to injury. J Am Coll Surg. 2001 Sep; 193(3):237-44. PMID: 11548792.
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  64. O'Suilleabhain CB, Kim S, Rodrick MR, Mannick JA, Lederer JA. Injury induces alterations in T-cell NFkappaB and AP-1 activation. Shock. 2001 Jun; 15(6):432-7. PMID: 11386614.
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  65. Kell MR, Shelley O, Mannick JA, Guo Z, Lederer JA. A central role for CD95 (Fas) in T-cell reactivity after injury. Surgery. 2000 Aug; 128(2):159-64. PMID: 10922986.
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  66. Göebel A, Kavanagh E, Lyons A, Saporoschetz IB, Soberg C, Lederer JA, Mannick JA, Rodrick ML. Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Ann Surg. 2000 Feb; 231(2):253-61. PMID: 10674618; PMCID: PMC1420994.
  67. Lyons A, Goebel A, Mannick JA, Lederer JA. Protective effects of early interleukin 10 antagonism on injury-induced immune dysfunction. Arch Surg. 1999 Dec; 134(12):1317-23; discussion 1324. PMID: 10593329.
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  68. Kell MR, Kavanaugh EG, Goebel A, Soberg CC, Lederer JA. Injury primes the immune system for an enhanced and lethal T-cell response against bacterial superantigen. Shock. 1999 Aug; 12(2):139-44. PMID: 10446895.
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  69. Kavanagh EK, Kell MR, Goebel A, Soberg CC, Mannick JA, Lederer JA. Interleukin 10 is not essential for survival or for modulating T-cell function after injury. Surgery. 1999 Aug; 126(2):456-62. PMID: 10455921.
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  70. Sadanaga N, Nagoshi M, Lederer JA, Joo HG, Eberlein TJ, Goedegebuure PS. Local secretion of IFN-gamma induces an antitumor response: comparison between T cells plus IL-2 and IFN-gamma transfected tumor cells. J Immunother. 1999 Jul; 22(4):315-23. PMID: 10404433.
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  71. Kelly JL, O'Suilleabhain CB, Soberg CC, Mannick JA, Lederer JA. Severe injury triggers antigen-specific T-helper cell dysfunction. Shock. 1999 Jul; 12(1):39-45. PMID: 10468050.
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  72. Lederer JA, Rodrick ML, Mannick JA. The effects of injury on the adaptive immune response. Shock. 1999 Mar; 11(3):153-9. PMID: 10188766.
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  73. Mark DA, Donovan CE, De Sanctis GT, Krinzman SJ, Kobzik L, Linsley PS, Sayegh MH, Lederer J, Perkins DL, Finn PW. Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation. Int Immunol. 1998 Nov; 10(11):1647-55. PMID: 9846693.
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  74. Kavanagh EG, Kelly JL, Lyons A, Soberg CC, Mannick JA, Lederer JA. Burn injury primes naive CD4+ T cells for an augmented T-helper 1 response. Surgery. 1998 Aug; 124(2):269-76; discussion 276-7. PMID: 9706148.
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  75. Behar SM, Roy C, Lederer J, Fraser P, Brenner MB. Clonally expanded Valpha12+ (AV12S1),CD8+ T cells from a patient with rheumatoid arthritis are autoreactive. Arthritis Rheum. 1998 Mar; 41(3):498-506. PMID: 9506578.
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  76. Lyons A, Kelly JL, Rodrick ML, Mannick JA, Lederer JA. Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection. Ann Surg. 1997 Oct; 226(4):450-8; discussion 458-60. PMID: 9351713; PMCID: PMC1191059.
  77. Kelly JL, Lyons A, Soberg CC, Mannick JA, Lederer JA. Anti-interleukin-10 antibody restores burn-induced defects in T-cell function. Surgery. 1997 Aug; 122(2):146-52. PMID: 9288117.
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  78. Borriello F, Lederer J, Scott S, Sharpe AH. MRC OX-2 defines a novel T cell costimulatory pathway. J Immunol. 1997 May 15; 158(10):4548-54. PMID: 9144466.
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  79. O'Suilleabhain C, O'Sullivan ST, Kelly JL, Lederer J, Mannick JA, Rodrick ML. Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury. Surgery. 1996 Aug; 120(2):290-6. PMID: 8751595.
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  80. Lederer JA, Perez VL, DesRoches L, Kim SM, Abbas AK, Lichtman AH. Cytokine transcriptional events during helper T cell subset differentiation. J Exp Med. 1996 Aug 01; 184(2):397-406. PMID: 8760793; PMCID: PMC2192740.
  81. Lederer JA, Liou JS, Kim S, Rice N, Lichtman AH. Regulation of NF-kappa B activation in T helper 1 and T helper 2 cells. J Immunol. 1996 Jan 01; 156(1):56-63. PMID: 8598494.
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  82. Borriello F, Lederer J. Construction of quantitative RT-PCR MIMICs. Biotechniques. 1995 Oct; 19(4):580-2, 584. PMID: 8777050.
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  83. O'Sullivan ST, Lederer JA, Horgan AF, Chin DH, Mannick JA, Rodrick ML. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg. 1995 Oct; 222(4):482-90; discussion 490-2. PMID: 7574928; PMCID: PMC1234878.
  84. Perez VL, Lederer JA, Carniel E, Lichtman A, Abbas AK. The role of IL12 in helper T-cell differentiation. Res Immunol. 1995 Sep-Oct; 146(7-8):477-80. PMID: 8839149.
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  85. Briscoe DM, DesRoches LE, Kiely JM, Lederer JA, Lichtman AH. Antigen-dependent activation of T helper cell subsets by endothelium. Transplantation. 1995 Jun 15; 59(11):1638-41. PMID: 7778184.
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  86. Perez VL, Lederer JA, Lichtman AH, Abbas AK. Stability of Th1 and Th2 populations. Int Immunol. 1995 May; 7(5):869-75. PMID: 7547713.
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  87. Young HA, Ghosh P, Ye J, Lederer J, Lichtman A, Gerard JR, Penix L, Wilson CB, Melvin AJ, McGurn ME, et al. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene. J Immunol. 1994 Oct 15; 153(8):3603-10. PMID: 7523497.
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  88. Lederer JA, Czuprynski CJ. Species-specific binding of IL-1, but not the IL-1 receptor antagonist, by fibroblasts. Cytokine. 1994 Mar; 6(2):154-61. PMID: 8031998.
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  89. Lederer JA, Liou JS, Todd MD, Glimcher LH, Lichtman AH. Regulation of cytokine gene expression in T helper cell subsets. J Immunol. 1994 Jan 01; 152(1):77-86. PMID: 8254209.
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  90. St Louis JD, Lederer JA, Lichtman AH. Costimulator deficient antigen presentation by an endothelial cell line induces a nonproliferative T cell activation response without anergy. J Exp Med. 1993 Nov 01; 178(5):1597-605. PMID: 7693852; PMCID: PMC2191235.
  91. Todd MD, Grusby MJ, Lederer JA, Lacy E, Lichtman AH, Glimcher LH. Transcription of the interleukin 4 gene is regulated by multiple promoter elements. J Exp Med. 1993 Jun 01; 177(6):1663-74. PMID: 8496684; PMCID: PMC2191048.
  92. Nishri Z, Zalewski SE, Glücks L, Avni R, Lederer J, Mates A. Prevalence of antibodies to Toxoplasma gondii in the Tel-Mond area. Isr J Med Sci. 1993 Jan; 29(1):30-2. PMID: 8454443.
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  93. Kenefick KB, Lederer JA, Schell RF, Czuprynski CJ. Borrelia burgdorferi stimulates release of interleukin-1 activity from bovine peripheral blood monocytes. Infect Immun. 1992 Sep; 60(9):3630-4. PMID: 1500171; PMCID: PMC257370.
  94. Lederer JA, Czuprynski CJ. Characterization and identification of interleukin 1 receptors on bovine neutrophils. J Leukoc Biol. 1992 Jun; 51(6):586-90. PMID: 1535356.
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  95. Lederer JA, Czuprynski CJ. Species preference of bovine thymocytes and fibroblasts for bovine interleukin 1. Vet Immunol Immunopathol. 1989 Dec; 23(3-4):213-22. PMID: 2629193.
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  96. Lederer JA, Czuprynski CJ. Production and purification of bovine monocyte-derived interleukin 1. Vet Immunol Immunopathol. 1989 Dec; 23(3-4):201-11. PMID: 2629192.
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  97. Lederer J. [The problem of the prevention of selenium deficiency in Belgium]. Arch Belg. 1989; 47(7-8):291-311. PMID: 2486231.
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  98. Lederer JA, Brown JF, Czuprynski CJ. "Haemophilus somnus," a facultative intracellular pathogen of bovine mononuclear phagocytes. Infect Immun. 1987 Feb; 55(2):381-7. PMID: 3026966; PMCID: PMC260338.
  99. Lederer J. [Incidence of diabetes in ethnic groups]. Probl Actuels Endocrinol Nutr. 1975; 19:301-10. PMID: 1233500.
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  100. LEDERER J. A new development in aids for sub-normal vision. Nature. 1954 Nov 20; 174(4438):977-8. PMID: 13214058.
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  101. LEDERER J, DAVIS R. [Pathology of the thyroid-adrenocortical system]. Schweiz Med Wochenschr. 1951 Oct 13; 81(41):1020-3. PMID: 14876420.
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