Tracey Lynn Petryshen, Ph.D.
|Title||Assistant Professor of Psychiatry|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Center for Human Genetic Research
185 Cambridge St
Boston MA 02114
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Available: 01/06/14, Expires: 08/28/15
The ankyrin 3 gene (ANK3) has been identified by large-scale patient genome-wide association studies as one of the strongest genetic risk factors for bipolar disorder. We and others have obtained evidence that the ankyrin G protein encoded by ANK3 localizes to the synapse of neurons in the brain where it may scaffold cell membrane proteins such as ion channels and neurotransmitter receptors. This project will investigate whether ankyrin G forms complexes with known synaptic membrane components (e.g., NMDA receptors). The student will utilize techniques including Western blot analysis and co-immunoprecipitation to identify synaptic proteins bound to ankyrin G. The results may provide insight into the role of ANK3 in synaptic function in the brain and risk of bipolar disorder.
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