Rakesh K. Jain, PH.D.
|Title||A. Werk Cook Professor of Radiation Oncology (Tumor Biology)|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Dept of Radiation Oncology, Cox 7
100 Blossom Street
Boston MA 02114
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|Title||Member of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology|
|Institution||Massachusetts Institute of Technology|
|Department||Health Sciences and Technology|
|1983 - 1984||Guggenheim Fellow|
|2003||Elected to the Institute of Medicine (IOM)|
|2004||Elected to the National Academy of Engineering (NAE)|
|2008||Elected to the American Academy of Arts and Sciences|
|2009||Elected to the National Academy of Sciences (NAS)|
My research goals are (i) to further mechanistic understanding of the vascular, interstitial and cellular barriers to the delivery and efficacy of molecular medicine in tumors, (ii) to develop and test new strategies to overcome these barriers for improving detection and treatment of tumors, and (iii) to translate these strategies from bench to bedside and in the process discover new biomarkers and new strategies to improve the outcome further. This tight integration between bench and bedside is a hallmark of my research.
My educational goals are to train basic scientists, bioengineers and physicians in the systems biology of cancer. I have had the good fortune of mentoring more than 150 doctoral and postdoctoral fellows from diverse backgrounds including engineering, mathematics, physics, chemistry, molecular and cellular biology, immunology, pathology, radiology, radiation, medical and surgical oncology – listed in the Table in the next section. I have also had productive collaborations with a similar number of basic scientists and clinicians from Harvard, MIT and elsewhere. Findings from these collaborative efforts are summarized in more than 525 publications, seven monographs and six patents.
For highlights of our key research findings, please visit: http://steele.mgh.harvard.edu
Available: 06/13/14, Expires: 07/10/18
The overall goal of our research is to understand the role of the tumor microenvironment, including the tumor vasculature, in tumor growth and response to therapy, to develop novel strategies to manipulate the tumor microenvironment, and to translate these strategies into improved cancer detection, prevention and treatment in humans.
To unravel the complex biology of tumors, we have developed an array of imaging technologies, mathematical models, and animal preparations. These include multiphoton microscopy and genetically engineered mice with surgically implanted transparent windows, which permit in vivo visualization of gene expression and function in tumors and their surrounding host stroma. This undertaking has provided powerful molecular, cellular, anatomical and functional insights into the barriers to cancer treatment.
Our work has revealed that the abnormal vasculature in solid tumors often thwarts the effectiveness of both conventional and novel therapies. Our laboratory is known for a new hypothesis that antiangiogenic therapy can "normalize" the abnormal tumor vasculature and improve both the delivery and efficacy of therapeutics. We have validated this concept in mice and patients receiving antiangiogenic therapy and in the process, discovered potential biomarkers for tailoring individual therapies.
We have translated this insight into the vascular biology of tumors to engineer long-lasting blood vessels used for regenerative medicine. Now we are exploring the use of adult stem cells in engineering blood vessels. Other projects in the lab include manipulation of the extracellular matrix of tumors to improve the delivery of conventional and nano-medicine; lymphatic function and lymphangiogenesis; dissection of steps in hematologic and lymphatic metastasis; drug screening for treatment of metastasis; and translation of these findings to the clinic.
Our laboratory is truly multidisciplinary spanning expertise in molecular and cellular biology, physiology, bioengineering, optics, mathematics to radiation, medical and surgical oncology. A tight integration between bench and bedside guides our research.
Simultaneous Measurements of pO2 and pH in Living Tumors with Three-Dimensional Resolution by Multiphoton Laser-scanning Microscopy
Summer, 06/16/02 - 08/10/02
In vitro Quantification of Metastic Tumor Cell Migration
Summer, 06/23/99 - 08/31/99
Tumor vessel normalization effects of MMP-14 inhibition
Summer, 05/20/10 - 08/31/10
Search for the Mechanism of Resistance of HER2-positive Breast Cancer Brain Metastases to Targeted Therapies
Summer, 06/11/12 - 07/31/12
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