Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Phillip L. Kraft, Ph.D.

Profile Picture
Other Positions

My research concentrates on the design and analysis of genetic association studies, with particular emphasis on studies linking variation in germline DNA to cancer risk. I have played a key role in multiple international consortia studying genetics and other exposures in relation to cancer risk over the last ten years: I have been a member of the statistical working group of the Breast and Prostate Cancer Cohort Consortium since its inception, and currently chair the BPC3 steering committee; I played a leading role in the design and analysis of GWAS of breast, prostate and pancreatic cancers as part of the NCI's Cancer Genetic Markers of Susceptibility and PanScan projects; and I chair the Analytic Working Group for the NCI's "post-GWAS" GAME-ON consortium, which aims to better understand the biological mechanisms underlying GWAS-identified cancer risk markers at five cancer sites (including breast and lung) and their public health implications.

I am also the contact PI for the epidemiology project of the breast cancer arm of GAME-ON, which focuses on gene-environment interactions and risk prediction. I have been the primary statistical geneticist for the Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS) for over ten years, and oversee the genotype databases for both studies, including genome-wide association data on over 20,000 subjects. I have collaborated on numerous analyses in the NHS and HPFS examining associations between genetic markers, behaviors (including diet and smoking), and risk of complex diseases. I have also collaborated with NHS investigators on the analyses of metabolite profiles in a case-control study of pancreatic cancer.

My current methodological research focuses on 1) efficient and interpretable "gene x environment interaction" analyses, 2) genetic risk prediction using common and rare genetic variation, biomarkers (including metabolites), and clinical and environmental risk factors, and 3) methods linking low-frequency variation, emerging functional annotation, and risk of complex disease.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kraft P, Aschard H. Finding the missing gene-environment interactions. Eur J Epidemiol. 2015 May; 30(5):353-5. PMID: 26026724.
    Citations: 12     Fields:    Translation:Humans
  2. Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. Int J Cancer. 2012 May 01; 130(9):2129-37. PMID: 21633955.
    Citations: 31     Fields:    Translation:Humans
  3. Lindström S, Schumacher FR, Campa D, Albanes D, Andriole G, Berndt SI, Bueno-de-Mesquita HB, Chanock SJ, Diver WR, Ganziano JM, Gapstur SM, Giovannucci E, Haiman CA, Henderson B, Hunter DJ, Johansson M, Kolonel LN, Le Marchand L, Ma J, Stampfer M, Stevens VL, Trichopoulos D, Virtamo J, Willett WC, Yeager M, Hsing AW, Kraft P. Replication of five prostate cancer loci identified in an Asian population--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). Cancer Epidemiol Biomarkers Prev. 2012 Jan; 21(1):212-6. PMID: 22056501.
    Citations: 15     Fields:    Translation:Humans
  4. Lindström S, Kraft P. Averaged or stratified measures of risk profile discrimination: horses for courses. Epidemiology. 2011 Nov; 22(6):813-4. PMID: 21968771.
    Citations:    Fields:    Translation:Humans
  5. Zhang M, Liang L, Morar N, Dixon AL, Lathrop GM, Ding J, Moffatt MF, Cookson WO, Kraft P, Qureshi AA, Han J. Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma. Hum Genet. 2012 Apr; 131(4):615-23. PMID: 22006220.
    Citations: 18     Fields:    Translation:HumansCells
  6. Gu F, Kraft P, Rice M, Michels KB. Leptin and leptin receptor genes in relation to premenopausal breast cancer incidence and grade in Caucasian women. Breast Cancer Res Treat. 2012 Jan; 131(1):17-25. PMID: 21947707.
    Citations: 6     Fields:    Translation:Humans
  7. Kasperzyk JL, Chang ET, Birmann BM, Kraft P, Zheng T, Mueller NE. Nutrients and genetic variation involved in one-carbon metabolism and Hodgkin lymphoma risk: a population-based case-control study. Am J Epidemiol. 2011 Oct 01; 174(7):816-27. PMID: 21810727.
    Citations: 5     Fields:    Translation:HumansCells
  8. Sinnott JA, Kraft P. Artifact due to differential error when cases and controls are imputed from different platforms. Hum Genet. 2012 Jan; 131(1):111-9. PMID: 21735171.
    Citations: 19     Fields:    Translation:Humans
  9. Nan H, Xu M, Kraft P, Qureshi AA, Chen C, Guo Q, Hu FB, Curhan G, Amos CI, Wang LE, Lee JE, Wei Q, Hunter DJ, Han J. Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma. Hum Mol Genet. 2011 Sep 15; 20(18):3718-24. PMID: 21700618.
    Citations: 33     Fields:    Translation:Humans
  10. Lin JH, Manson JE, Kraft P, Cochrane BB, Gunter MJ, Chlebowski RT, Zhang SM. Estrogen and progesterone-related gene variants and colorectal cancer risk in women. BMC Med Genet. 2011 May 31; 12:78. PMID: 21627810.
    Citations: 7     Fields:    Translation:Humans
  11. Machiela MJ, Chen CY, Chen C, Chanock SJ, Hunter DJ, Kraft P. Evaluation of polygenic risk scores for predicting breast and prostate cancer risk. Genet Epidemiol. 2011 Sep; 35(6):506-514. PMID: 21618606.
    Citations: 35     Fields:    Translation:Humans
  12. Shui IM, Stark JR, Penney KL, Schumacher FR, Epstein MM, Pitt MJ, Stampfer MJ, Tamimi RM, Lindstrom S, Sesso HD, Fall K, Ma J, Kraft P, Giovannucci E, Mucci LA. Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality. Prostate. 2012 Feb 01; 72(2):209-16. PMID: 21563195.
    Citations: 7     Fields:    Translation:Humans
  13. Prescott J, Kraft P, Chasman DI, Savage SA, Mirabello L, Berndt SI, Weissfeld JL, Han J, Hayes RB, Chanock SJ, Hunter DJ, De Vivo I. Genome-wide association study of relative telomere length. PLoS One. 2011 May 10; 6(5):e19635. PMID: 21573004.
    Citations: 41     Fields:    Translation:HumansCells
  14. Penney KL, Sinnott JA, Fall K, Pawitan Y, Hoshida Y, Kraft P, Stark JR, Fiorentino M, Perner S, Finn S, Calza S, Flavin R, Freedman ML, Setlur S, Sesso HD, Andersson SO, Martin N, Kantoff PW, Johansson JE, Adami HO, Rubin MA, Loda M, Golub TR, Andrén O, Stampfer MJ, Mucci LA. mRNA expression signature of Gleason grade predicts lethal prostate cancer. J Clin Oncol. 2011 Jun 10; 29(17):2391-6. PMID: 21537050.
    Citations: 53     Fields:    Translation:Humans
  15. Nan H, Xu M, Zhang J, Zhang M, Kraft P, Qureshi AA, Chen C, Guo Q, Hu FB, Rimm EB, Curhan G, Song Y, Amos CI, Wang LE, Lee JE, Wei Q, Hunter DJ, Han J. Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk. Hum Mol Genet. 2011 Jul 01; 20(13):2673-9. PMID: 21478494.
    Citations: 24     Fields:    Translation:Humans
  16. Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi MT, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet. 2011 Apr; 7(4):e1002033. PMID: 21490707.
    Citations: 79     Fields:    Translation:HumansCells
  17. Penney KL, Schumacher FR, Kraft P, Mucci LA, Sesso HD, Ma J, Niu Y, Cheong JK, Hunter DJ, Stampfer MJ, Hsu SI. Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels. Carcinogenesis. 2011 Jun; 32(6):853-9. PMID: 21421545.
    Citations: 17     Fields:    Translation:Humans
  18. Tchetgen Tchetgen EJ, Kraft P. On the robustness of tests of genetic associations incorporating gene-environment interaction when the environmental exposure is misspecified. Epidemiology. 2011 Mar; 22(2):257-61. PMID: 21228699.
    Citations: 32     Fields:    Translation:HumansPHPublic Health
  19. Lindstrom S, Schumacher F, Siddiq A, Travis RC, Campa D, Berndt SI, Diver WR, Severi G, Allen N, Andriole G, Bueno-de-Mesquita B, Chanock SJ, Crawford D, Gaziano JM, Giles GG, Giovannucci E, Guo C, Haiman CA, Hayes RB, Halkjaer J, Hunter DJ, Johansson M, Kaaks R, Kolonel LN, Navarro C, Riboli E, Sacerdote C, Stampfer M, Stram DO, Thun MJ, Trichopoulos D, Virtamo J, Weinstein SJ, Yeager M, Henderson B, Ma J, Le Marchand L, Albanes D, Kraft P. Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3. PLoS One. 2011 Feb 24; 6(2):e17142. PMID: 21390317.
    Citations: 35     Fields:    Translation:Humans
  20. Aschard H, Hancock DB, London SJ, Kraft P. Genome-wide meta-analysis of joint tests for genetic and gene-environment interaction effects. Hum Hered. 2010; 70(4):292-300. PMID: 21293137.
    Citations: 32     Fields:    Translation:Humans
  21. Lindström S, Vachon CM, Li J, Varghese J, Thompson D, Warren R, Brown J, Leyland J, Audley T, Wareham NJ, Loos RJ, Paterson AD, Rommens J, Waggott D, Martin LJ, Scott CG, Pankratz VS, Hankinson SE, Hazra A, Hunter DJ, Hopper JL, Southey MC, Chanock SJ, Silva Idos S, Liu J, Eriksson L, Couch FJ, Stone J, Apicella C, Czene K, Kraft P, Hall P, Easton DF, Boyd NF, Tamimi RM. Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nat Genet. 2011 Mar; 43(3):185-7. PMID: 21278746.
    Citations: 62     Fields:    Translation:Humans
  22. Lin W, Qureshi AA, Kraft P, Nan H, Guo Q, Hu FB, Jensen MK, Han J. ASIP genetic variants and the number of non-melanoma skin cancers. Cancer Causes Control. 2011 Mar; 22(3):495-501. PMID: 21221757.
    Citations: 2     Fields:    Translation:Humans
  23. Karageorgi S, McGrath M, Lee IM, Buring J, Kraft P, De Vivo I. Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk. Gynecol Oncol. 2011 Apr; 121(1):54-8. PMID: 21129770.
    Citations: 4     Fields:    Translation:Humans
  24. Penney KL, Pyne S, Schumacher FR, Sinnott JA, Mucci LA, Kraft PL, Ma J, Oh WK, Kurth T, Kantoff PW, Giovannucci EL, Stampfer MJ, Hunter DJ, Freedman ML. Genome-wide association study of prostate cancer mortality. Cancer Epidemiol Biomarkers Prev. 2010 Nov; 19(11):2869-76. PMID: 20978177.
    Citations: 28     Fields:    Translation:Humans
  25. Gu F, Schumacher FR, Canzian F, Allen NE, Albanes D, Berg CD, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Buring JE, Chabbert-Buffet N, Chanock SJ, Clavel-Chapelon F, Dumeaux V, Gaziano JM, Giovannucci EL, Haiman CA, Hankinson SE, Hayes RB, Henderson BE, Hunter DJ, Hoover RN, Johansson M, Key TJ, Khaw KT, Kolonel LN, Lagiou P, Lee IM, LeMarchand L, Lund E, Ma J, Onland-Moret NC, Overvad K, Rodriguez L, Sacerdote C, Sánchez MJ, Stampfer MJ, Stattin P, Stram DO, Thomas G, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Virtamo J, Weinstein SJ, Willett WC, Yeager M, Zhang SM, Kaaks R, Riboli E, Ziegler RG, Kraft P. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. Cancer Epidemiol Biomarkers Prev. 2010 Nov; 19(11):2877-87. PMID: 20810604.
    Citations: 33     Fields:    Translation:HumansCells
  26. Paulus JK, Zhou W, Kraft P, Johnson BE, Lin X, Christiani DC. Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women. Lung Cancer. 2011 Mar; 71(3):258-63. PMID: 20655613.
    Citations: 2     Fields:    Translation:Humans
  27. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010 Jul; 42(7):579-89. PMID: 20581827.
    Citations: 806     Fields:    Translation:Humans
  28. Lindström S, Ma J, Altshuler D, Giovannucci E, Riboli E, Albanes D, Allen NE, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Chanock SJ, Dunning AM, Feigelson HS, Gaziano JM, Haiman CA, Hayes RB, Henderson BE, Hunter DJ, Kaaks R, Kolonel LN, Le Marchand L, Martínez C, Overvad K, Siddiq A, Stampfer M, Stattin P, Stram DO, Thun MJ, Trichopoulos D, Tumino R, Virtamo J, Weinstein SJ, Yeager M, Kraft P, Freedman ML. A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. J Clin Endocrinol Metab. 2010 Sep; 95(9):E121-7. PMID: 20534771.
    Citations: 25     Fields:    Translation:HumansCells
  29. Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Breast Cancer Res Treat. 2011 Jan; 125(1):207-14. PMID: 20496165.
    Citations: 11     Fields:    Translation:HumansCells
  30. Derti A, Cenik C, Kraft P, Roth FP. Absence of evidence for MHC-dependent mate selection within HapMap populations. PLoS Genet. 2010 Apr 29; 6(4):e1000925. PMID: 20442868.
    Citations: 13     Fields:    Translation:Humans
  31. Penney KL, Schumacher FR, Li H, Kraft P, Morris JS, Kurth T, Mucci LA, Hunter DJ, Kantoff PW, Stampfer MJ, Ma J. A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival. Cancer Prev Res (Phila). 2010 May; 3(5):604-10. PMID: 20424130.
    Citations: 30     Fields:    Translation:Humans
  32. Qi L, Cornelis MC, Kraft P, Stanya KJ, Linda Kao WH, Pankow JS, Dupuis J, Florez JC, Fox CS, Paré G, Sun Q, Girman CJ, Laurie CC, Mirel DB, Manolio TA, Chasman DI, Boerwinkle E, Ridker PM, Hunter DJ, Meigs JB, Lee CH, Hu FB, van Dam RM. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet. 2010 Jul 01; 19(13):2706-15. PMID: 20418489.
    Citations: 107     Fields:    Translation:HumansCells
  33. Lindström S, Hunter DJ, Grönberg H, Stattin P, Wiklund F, Xu J, Chanock SJ, Hayes R, Kraft P. Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies. Cancer Epidemiol Biomarkers Prev. 2010 Mar; 19(3):873-6. PMID: 20200442.
    Citations: 17     Fields:    Translation:Humans
  34. Sun Q, Cornelis MC, Kraft P, Qi L, van Dam RM, Girman CJ, Laurie CC, Mirel DB, Gong H, Sheu CC, Christiani DC, Hunter DJ, Mantzoros CS, Hu FB. Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels. Hum Mol Genet. 2010 May 01; 19(9):1846-55. PMID: 20167575.
    Citations: 18     Fields:    Translation:Humans
  35. He M, Cornelis MC, Kraft P, van Dam RM, Sun Q, Laurie CC, Mirel DB, Chasman DI, Ridker PM, Hunter DJ, Hu FB, Qi L. Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels. Arterioscler Thromb Vasc Biol. 2010 Apr; 30(4):885-90. PMID: 20150558.
    Citations: 34     Fields:    Translation:Humans
  36. Qi L, Cornelis MC, Kraft P, Jensen M, van Dam RM, Sun Q, Girman CJ, Laurie CC, Mirel DB, Hunter DJ, Rimm E, Hu FB. Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet. 2010 May 01; 19(9):1856-62. PMID: 20147318.
    Citations: 63     Fields:    Translation:Humans
  37. Paulus JK, Asomaning K, Kraft P, Johnson BE, Lin X, Christiani DC. Parity and risk of lung cancer in women. Am J Epidemiol. 2010 Mar 01; 171(5):557-63. PMID: 20123687.
    Citations: 16     Fields:    Translation:Humans
  38. Karageorgi S, Hankinson SE, Kraft P, De Vivo I. Reproductive factors and postmenopausal hormone use in relation to endometrial cancer risk in the Nurses' Health Study cohort 1976-2004. Int J Cancer. 2010 Jan 01; 126(1):208-16. PMID: 19551854.
    Citations: 45     Fields:    Translation:Humans
  39. Monsees GM, Tamimi RM, Kraft P. Genome-wide association scans for secondary traits using case-control samples. Genet Epidemiol. 2009 Dec; 33(8):717-28. PMID: 19365863.
    Citations: 52     Fields:    Translation:Humans
  40. Kraft P, Zeggini E, Ioannidis JP. Replication in genome-wide association studies. Stat Sci. 2009 Nov 01; 24(4):561-573. PMID: 20454541.
    Citations: 80     
  41. Hazra A, Kraft P, Lazarus R, Chen C, Chanock SJ, Jacques P, Selhub J, Hunter DJ. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet. 2009 Dec 01; 18(23):4677-87. PMID: 19744961.
    Citations: 53     Fields:    Translation:HumansCells
  42. Nan H, Kraft P, Hunter DJ, Han J. Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. Int J Cancer. 2009 Aug 15; 125(4):909-17. PMID: 19384953.
    Citations: 64     Fields:    Translation:Humans
  43. Kraft P, Raychaudhuri S. Complex diseases, complex genes: keeping pathways on the right track. Epidemiology. 2009 Jul; 20(4):508-11. PMID: 19525687.
    Citations: 19     Fields:    Translation:Humans
  44. Lindström S, Yen YC, Spiegelman D, Kraft P. The impact of gene-environment dependence and misclassification in genetic association studies incorporating gene-environment interactions. Hum Hered. 2009; 68(3):171-81. PMID: 19521099.
    Citations: 22     Fields:    Translation:Humans
  45. Stark JR, Li H, Kraft P, Kurth T, Giovannucci EL, Stampfer MJ, Ma J, Mucci LA. Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality. Int J Cancer. 2009 Jun 01; 124(11):2683-9. PMID: 19189403.
    Citations: 36     Fields:    Translation:Humans
  46. Stark JR, Wiklund F, Grönberg H, Schumacher F, Sinnott JA, Stampfer MJ, Mucci LA, Kraft P. Toll-like receptor signaling pathway variants and prostate cancer mortality. Cancer Epidemiol Biomarkers Prev. 2009 Jun; 18(6):1859-63. PMID: 19505919.
    Citations: 14     Fields:    Translation:HumansCells
  47. He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. Nat Genet. 2009 Jun; 41(6):724-8. PMID: 19448621.
    Citations: 143     Fields:    Translation:HumansCells
  48. Pezzotti A, Kraft P, Hankinson SE, Hunter DJ, Buring J, Cox DG. The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk. PLoS One. 2009; 4(4):e5356. PMID: 19390621.
    Citations: 21     Fields:    Translation:Humans
  49. Cornelis MC, Qi L, Zhang C, Kraft P, Manson J, Cai T, Hunter DJ, Hu FB. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med. 2009 Apr 21; 150(8):541-50. PMID: 19380854.
    Citations: 107     Fields:    Translation:Humans
  50. Kraft P, Hunter DJ. Genetic risk prediction--are we there yet? N Engl J Med. 2009 Apr 23; 360(17):1701-3. PMID: 19369656.
    Citations: 173     Fields:    Translation:Humans
  51. Nan H, Kraft P, Qureshi AA, Guo Q, Chen C, Hankinson SE, Hu FB, Thomas G, Hoover RN, Chanock S, Hunter DJ, Han J. Genome-wide association study of tanning phenotype in a population of European ancestry. J Invest Dermatol. 2009 Sep; 129(9):2250-7. PMID: 19340012.
    Citations: 59     Fields:    Translation:Humans
  52. Kraft P, Wacholder S, Cornelis MC, Hu FB, Hayes RB, Thomas G, Hoover R, Hunter DJ, Chanock S. Beyond odds ratios--communicating disease risk based on genetic profiles. Nat Rev Genet. 2009 04; 10(4):264-9. PMID: 19238176.
    Citations: 66     Fields:    Translation:Humans
  53. De Vivo I, Prescott J, Wong JY, Kraft P, Hankinson SE, Hunter DJ. A prospective study of relative telomere length and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2009 Apr; 18(4):1152-6. PMID: 19293310.
    Citations: 74     Fields:    Translation:HumansCells
  54. Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol. 2009 Mar 20; 27(9):1477-84. PMID: 19237633.
    Citations: 136     Fields:    Translation:Humans
  55. Cornelis MC, Qi L, Kraft P, Hu FB. TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women. Am J Clin Nutr. 2009 Apr; 89(4):1256-62. PMID: 19211816.
    Citations: 32     Fields:    Translation:HumansPHPublic Health
  56. Birmann BM, Tamimi RM, Giovannucci E, Rosner B, Hunter DJ, Kraft P, Mitsiades C, Anderson KC, Colditz GA. Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):282-8. PMID: 19124510.
    Citations: 18     Fields:    Translation:Humans
  57. Gu F, Qureshi AA, Niu T, Kraft P, Guo Q, Hunter DJ, Han J. Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Melanoma Res. 2008 Oct; 18(5):330-5. PMID: 18781131.
    Citations: 14     Fields:    Translation:HumansCells
  58. Hazra A, Kraft P, Selhub J, Giovannucci EL, Thomas G, Hoover RN, Chanock SJ, Hunter DJ. Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat Genet. 2008 Oct; 40(10):1160-2. PMID: 18776911.
    Citations: 56     Fields:    Translation:Humans
  59. Kraft P. Curses--winner's and otherwise--in genetic epidemiology. Epidemiology. 2008 Sep; 19(5):649-51; discussion 657-8. PMID: 18703928.
    Citations: 88     Fields:    Translation:Humans
  60. Qi L, Kraft P, Hunter DJ, Hu FB. The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet. 2008 Nov 15; 17(22):3502-8. PMID: 18697794.
    Citations: 78     Fields:    Translation:Humans
  61. Tamimi RM, Cox D, Kraft P, Colditz GA, Hankinson SE, Hunter DJ. Breast cancer susceptibility loci and mammographic density. Breast Cancer Res. 2008; 10(4):R66. PMID: 18681954.
    Citations: 10     Fields:    Translation:Humans
  62. Qi L, Kang K, Zhang C, van Dam RM, Kraft P, Hunter D, Lee CH, Hu FB. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes. 2008 Nov; 57(11):3145-51. PMID: 18647953.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  63. Han J, Kraft P, Nan H, Guo Q, Chen C, Qureshi A, Hankinson SE, Hu FB, Duffy DL, Zhao ZZ, Martin NG, Montgomery GW, Hayward NK, Thomas G, Hoover RN, Chanock S, Hunter DJ. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet. 2008 May 16; 4(5):e1000074. PMID: 18483556.
    Citations: 174     Fields:    Translation:Humans
  64. Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI, Sanna S, Eyheramendy S, Voight BF, Butler JL, Guiducci C, Illig T, Hackett R, Heid IM, Jacobs KB, Lyssenko V, Uda M, Boehnke M, Chanock SJ, Groop LC, Hu FB, Isomaa B, Kraft P, Peltonen L, Salomaa V, Schlessinger D, Hunter DJ, Hayes RB, Abecasis GR, Wichmann HE, Mohlke KL, Hirschhorn JN. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 2008 May; 40(5):584-91. PMID: 18391950.
    Citations: 276     Fields:    Translation:Humans
  65. Chen YC, Giovannucci E, Kraft P, Hunter DJ. Association between genetic polymorphisms of macrophage scavenger receptor 1 gene and risk of prostate cancer in the health professionals follow-up study. Cancer Epidemiol Biomarkers Prev. 2008 Apr; 17(4):1001-3. PMID: 18398045.
    Citations: 2     Fields:    Translation:Humans
  66. Chen YC, Giovannucci E, Kraft P, J Hunter D. Sequence variants of elaC homolog 2 (Escherichia coli) (ELAC2) gene and susceptibility to prostate cancer in the Health Professionals Follow-Up Study. Carcinogenesis. 2008 May; 29(5):999-1004. PMID: 18375959.
    Citations: 4     Fields:    Translation:Humans
  67. Cox DG, Bretsky P, Kraft P, Pharoah P, Albanes D, Altshuler D, Amiano P, Berglund G, Boeing H, Buring J, Burtt N, Calle EE, Canzian F, Chanock S, Clavel-Chapelon F, Colditz GA, Feigelson HS, Haiman CA, Hankinson SE, Hirschhorn J, Henderson BE, Hoover R, Hunter DJ, Kaaks R, Kolonel L, LeMarchand L, Lund E, Palli D, Peeters PH, Pike MC, Riboli E, Stram DO, Thun M, Tjonneland A, Travis RC, Trichopoulos D, Yeager M. Haplotypes of the estrogen receptor beta gene and breast cancer risk. Int J Cancer. 2008 Jan 15; 122(2):387-92. PMID: 17935138.
    Citations: 16     Fields:    Translation:Humans
  68. Kraft P, Cox DG. Study designs for genome-wide association studies. Adv Genet. 2008; 60:465-504. PMID: 18358330.
    Citations: 21     Fields:    Translation:Humans
  69. Gu F, Monsees G, Kraft P. Exhaustive screens for disease susceptibility loci incorporating statistical interaction of genotypes: a comparison of likelihood-ratio-based and Akaike and Bayesian information criteria-based methods. BMC Proc. 2007; 1 Suppl 1:S25. PMID: 18466522.
    Citations: 1     
  70. Schumacher FR, Kraft P. A Bayesian latent class analysis for whole-genome association analyses: an illustration using the GAW15 simulated rheumatoid arthritis dense scan data. BMC Proc. 2007; 1 Suppl 1:S112. PMID: 18466453.
    Citations: 6     
  71. Yang Y, Ruiz-Narvaez E, Kraft P, Campos H. Effect of apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica. Hum Biol. 2007 Dec; 79(6):637-47. PMID: 18494374.
    Citations: 4     Fields:    Translation:Humans
  72. Ruiz-Narváez EA, Kraft P, Campos H. Ala12 variant of the peroxisome proliferator-activated receptor-gamma gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction. Am J Clin Nutr. 2007 Oct; 86(4):1238-42. PMID: 17921408.
    Citations: 11     Fields:    Translation:HumansCells
  73. Chen YC, Giovannucci E, Kraft P, Lazarus R, Hunter DJ. Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007 Oct; 16(10):1982-9. PMID: 17932345.
    Citations: 16     Fields:    Translation:Humans
  74. Chen YC, Kraft P, Bretsky P, Ketkar S, Hunter DJ, Albanes D, Altshuler D, Andriole G, Berg CD, Boeing H, Burtt N, Bueno-de-Mesquita B, Cann H, Canzian F, Chanock S, Dunning A, Feigelson HS, Freedman M, Gaziano JM, Giovannucci E, Sánchez MJ, Haiman CA, Hallmans G, Hayes RB, Henderson BE, Hirschhorn J, Kaaks R, Key TJ, Kolonel LN, LeMarchand L, Ma J, Overvad K, Palli D, Pharaoh P, Pike M, Riboli E, Rodriguez C, Setiawan VW, Stampfer M, Stram DO, Thomas G, Thun MJ, Travis RC, Virtamo J, Trichopoulou A, Wacholder S, Weinstein SJ. Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2007 Oct; 16(10):1973-81. PMID: 17932344.
    Citations: 16     Fields:    Translation:Humans
  75. Hunter DJ, Kraft P. Drinking from the fire hose--statistical issues in genomewide association studies. N Engl J Med. 2007 Aug 02; 357(5):436-9. PMID: 17634446.
    Citations: 60     Fields:    Translation:Humans
  76. Ogino S, Kawasaki T, Kirkner GJ, Kraft P, Loda M, Fuchs CS. Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. J Mol Diagn. 2007 Jul; 9(3):305-14. PMID: 17591929.
    Citations: 159     Fields:    Translation:HumansCells
  77. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Hoover RN, Thomas G, Chanock SJ. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet. 2007 Jul; 39(7):870-4. PMID: 17529973.
    Citations: 737     Fields:    Translation:Humans
  78. Schumacher FR, Feigelson HS, Cox DG, Haiman CA, Albanes D, Buring J, Calle EE, Chanock SJ, Colditz GA, Diver WR, Dunning AM, Freedman ML, Gaziano JM, Giovannucci E, Hankinson SE, Hayes RB, Henderson BE, Hoover RN, Kaaks R, Key T, Kolonel LN, Kraft P, Le Marchand L, Ma J, Pike MC, Riboli E, Stampfer MJ, Stram DO, Thomas G, Thun MJ, Travis R, Virtamo J, Andriole G, Gelmann E, Willett WC, Hunter DJ. A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res. 2007 Apr 01; 67(7):2951-6. PMID: 17409400.
    Citations: 67     Fields:    Translation:HumansCells
  79. Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ. Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study. Carcinogenesis. 2007 Jul; 28(7):1510-9. PMID: 17389618.
    Citations: 24     Fields:    Translation:Humans
  80. Zhai R, Zhou W, Gong MN, Thompson BT, Su L, Yu C, Kraft P, Christiani DC. Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians. Crit Care Med. 2007 Mar; 35(3):893-8. PMID: 17235259.
    Citations: 22     Fields:    Translation:HumansCells
  81. Kraft P, Yen YC, Stram DO, Morrison J, Gauderman WJ. Exploiting gene-environment interaction to detect genetic associations. Hum Hered. 2007; 63(2):111-9. PMID: 17283440.
    Citations: 194     Fields:    Translation:Humans
  82. Tamimi RM, Cox DG, Kraft P, Pollak MN, Haiman CA, Cheng I, Freedman ML, Hankinson SE, Hunter DJ, Colditz GA. Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study. Breast Cancer Res. 2007; 9(1):R18. PMID: 17300730.
    Citations: 31     Fields:    Translation:Humans
  83. Koushik A, Kraft P, Fuchs CS, Hankinson SE, Willett WC, Giovannucci EL, Hunter DJ. Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2408-17. PMID: 17164363.
    Citations: 41     Fields:    Translation:HumansCells
  84. Govindarajulu US, Spiegelman D, Miller KL, Kraft P. Quantifying bias due to allele misclassification in case-control studies of haplotypes. Genet Epidemiol. 2006 Nov; 30(7):590-601. PMID: 16830341.
    Citations: 4     Fields:    Translation:Humans
  85. Han J, Kraft P, Colditz GA, Wong J, Hunter DJ. Melanocortin 1 receptor variants and skin cancer risk. Int J Cancer. 2006 Oct 15; 119(8):1976-84. PMID: 16721784.
    Citations: 39     Fields:    Translation:Humans
  86. Miller KL, Karagas MR, Kraft P, Hunter DJ, Catalano PJ, Byler SH, Nelson HH. XPA, haplotypes, and risk of basal and squamous cell carcinoma. Carcinogenesis. 2006 Aug; 27(8):1670-5. PMID: 16513681.
    Citations: 22     Fields:    Translation:Humans
  87. Cox DG, Kraft P. Quantification of the power of Hardy-Weinberg equilibrium testing to detect genotyping error. Hum Hered. 2006; 61(1):10-4. PMID: 16514241.
    Citations: 25     Fields:    Translation:Humans
  88. McGrath M, Lee IM, Hankinson SE, Kraft P, Hunter DJ, Buring J, De Vivo I. Androgen receptor polymorphisms and endometrial cancer risk. Int J Cancer. 2006 Mar 01; 118(5):1261-8. PMID: 16161040.
    Citations: 13     Fields:    Translation:HumansCells
  89. Kraft P. Efficient two-stage genome-wide association designs based on false positive report probabilities. Pac Symp Biocomput. 2006; 523-34. PMID: 17094266.
    Citations: 4     Fields:    Translation:Humans
  90. Cox DG, Blanché H, Pearce CL, Calle EE, Colditz GA, Pike MC, Albanes D, Allen NE, Amiano P, Berglund G, Boeing H, Buring J, Burtt N, Canzian F, Chanock S, Clavel-Chapelon F, Feigelson HS, Freedman M, Haiman CA, Hankinson SE, Henderson BE, Hoover R, Hunter DJ, Kaaks R, Kolonel L, Kraft P, LeMarchand L, Lund E, Palli D, Peeters PH, Riboli E, Stram DO, Thun M, Tjonneland A, Trichopoulos D, Yeager M. A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Breast Cancer Res. 2006; 8(5):R54. PMID: 16987421.
    Citations: 13     Fields:    Translation:Humans
  91. McQueen MB, Murphy A, Kraft P, Su J, Lazarus R, Laird NM, Lange C, Van Steen K. Comparison of linkage and association strategies for quantitative traits using the COGA dataset. BMC Genet. 2005 Dec 30; 6 Suppl 1:S96. PMID: 16451712.
    Citations:    Fields:    Translation:HumansCells
  92. Murphy A, McQueen MB, Su J, Kraft P, Lazarus R, Laird NM, Lange C, Van Steen K. Genomic screening in family-based association testing. BMC Genet. 2005 Dec 30; 6 Suppl 1:S115. PMID: 16451572.
    Citations: 2     Fields:    Translation:Humans
  93. Chen YC, Giovannucci E, Lazarus R, Kraft P, Ketkar S, Hunter DJ. Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer. Cancer Res. 2005 Dec 15; 65(24):11771-8. PMID: 16357190.
    Citations: 63     Fields:    Translation:Humans
  94. Kraft P, Pharoah P, Chanock SJ, Albanes D, Kolonel LN, Hayes RB, Altshuler D, Andriole G, Berg C, Boeing H, Burtt NP, Bueno-de-Mesquita B, Calle EE, Cann H, Canzian F, Chen YC, Crawford DE, Dunning AM, Feigelson HS, Freedman ML, Gaziano JM, Giovannucci E, Gonzalez CA, Haiman CA, Hallmans G, Henderson BE, Hirschhorn JN, Hunter DJ, Kaaks R, Key T, Le Marchand L, Ma J, Overvad K, Palli D, Pike MC, Riboli E, Rodriguez C, Setiawan WV, Stampfer MJ, Stram DO, Thomas G, Thun MJ, Travis R, Trichopoulou A, Virtamo J, Wacholder S. Genetic variation in the HSD17B1 gene and risk of prostate cancer. PLoS Genet. 2005 Nov; 1(5):e68. PMID: 16311626.
    Citations: 24     Fields:    Translation:Humans
  95. Kraft P, Hunter D. Integrating epidemiology and genetic association: the challenge of gene-environment interaction. Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29; 360(1460):1609-16. PMID: 16096111.
    Citations: 19     Fields:    Translation:HumansPHPublic Health
  96. Paynter RA, Hankinson SE, Colditz GA, Kraft P, Hunter DJ, De Vivo I. CYP19 (aromatase) haplotypes and endometrial cancer risk. Int J Cancer. 2005 Aug 20; 116(2):267-74. PMID: 15800924.
    Citations: 21     Fields:    Translation:Humans
  97. Pai JK, Kraft P, Cannuscio CC, Manson JE, Rexrode KM, Albert CM, Hunter D, Rimm EB. Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women. Atherosclerosis. 2006 May; 186(1):132-9. PMID: 16055130.
    Citations: 16     Fields:    Translation:Humans
  98. Litonjua AA, Belanger K, Celedón JC, Milton DK, Bracken MB, Kraft P, Triche EW, Sredl DL, Weiss ST, Leaderer BP, Gold DR. Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children. J Allergy Clin Immunol. 2005 May; 115(5):1056-62. PMID: 15867866.
    Citations: 11     Fields:    Translation:Humans
  99. Kraft P, Cox DG, Paynter RA, Hunter D, De Vivo I. Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques. Genet Epidemiol. 2005 Apr; 28(3):261-72. PMID: 15637718.
    Citations: 62     Fields:    Translation:Humans
  100. Cox DG, Kraft P, Hankinson SE, Hunter DJ. Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer. Breast Cancer Res. 2005; 7(2):R171-5. PMID: 15743496.
    Citations: 22     Fields:    Translation:Humans
  101. Kraft P, Thomas DC. Case-sibling gene-association studies for diseases with variable age at onset. Stat Med. 2004 Dec 15; 23(23):3697-712. PMID: 15534888.
    Citations: 5     Fields:    Translation:Humans
  102. Kraft P, Palmer CG, Woodward AJ, Turunen JA, Minassian S, Paunio T, Lönnqvist J, Peltonen L, Sinsheimer JS. RHD maternal-fetal genotype incompatibility and schizophrenia: extending the MFG test to include multiple siblings and birth order. Eur J Hum Genet. 2004 Mar; 12(3):192-8. PMID: 14735156.
    Citations: 9     Fields:    Translation:Humans
  103. Kraft P, Bauman L, Yuan JY, Horvath S. Multivariate variance-components analysis of longitudinal blood pressure measurements from the Framingham Heart Study. BMC Genet. 2003 Dec 31; 4 Suppl 1:S55. PMID: 14975123.
    Citations: 9     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: SPH faculty should contact Faculty Affairs at facultyaffairshsph.harvard.edu).
Kraft's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (378)
Co-Authors (75)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.