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Suryasarathi Dasgupta, Ph.D.

TitleInstructor in Microbiology and Immunobiology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Medical School
Micriobiology and Immunob NRB 1058
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-8301
Fax617/432-4787
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 Biography 
 awards and honors
2005 - Young Investigator travel award at the 14th European Macrophage and Dendritic Cell Conference
2006 - Travel award for attending the International Dendritic Cell Conference, Edinburgh
2007 - Young scientist travel grant

 Overview 
 overview
I am a researcher in Biomedicine with an experience of around 10 years in immunology related work. My broad interest is in how cellular immunology and biochemistry can be integrated to understand diagnostic and therapeutic approaches in a better way. I graduated from the Indian Institute of Technology-Bombay, Mumbai, India with a PhD in Biosciences and Bioengineering. I did postdoctoral research in UMRS 872 Equipe 16, INSERM, PARIS, France, wherein I focused to understand the genesis of immune response against therapeutic factor VIII in hemophilia A patients utilizing various model systems. In 2008, I shifted to Boston and worked as an Instructor in Medicine at Channing Laboratory, Brigham and Women's Hospital (2009-2012). From 2012 August onwards, I am working as an Instructor at the Department of Microbiology and Immunobiology, Harvard Medical School. My current work is to understand how components of commensal microflora induce immunomodulation.

I co-authored several peer-reviewed research articles and review articles (35+, 14 as first, co-first or corresponding author) in reputed international journals and presented my work in several international conferences on Immunology, Hematology, Glycobiology and Colitis. My work formed the basis of various projects in our laboratory and resulted in two patents.

I was a member of the European Macrophage and Dendritic cell Society (EMDS, 2005-2007) and currently regular member of AAI (2010 - ) and have been invited to deliver lecture at international conferences and review research and review articles from several journals including Arteriosclerosis, Thrombosis and Vascular Biology & Scientific Reports, Nature Publishing Group.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Dasgupta S, Erturk-Hasdemir D, Ochoa-Reparaz J, Reinecker HC, Kasper DL. Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms. Cell Host Microbe. 2014 Apr 9; 15(4):413-23.
    View in: PubMed
  2. Dasgupta S, Kasper DL. Relevance of commensal microbiota in the treatment and prevention of inflammatory bowel disease. Inflamm Bowel Dis. 2013 Oct; 19(11):2478-89.
    View in: PubMed
  3. Repessé Y, Peyron I, Dimitrov JD, Dasgupta S, Moshai EF, Costa C, Borel-Derlon A, Guillet B, D'Oiron R, Aouba A, Rothschild C, Oldenburg J, Pavlova A, Kaveri SV, Lacroix-Desmazes S. Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter. Haematologica. 2013 Oct; 98(10):1650-5.
    View in: PubMed
  4. Dasgupta S, Kasper DL. Traffic control at the "Gut-GALT crossroads". Cell Res. 2013 May; 23(5):590-1.
    View in: PubMed
  5. Teyssandier M, André S, Gupta N, Dasgupta S, Bayry J, Kaveri SV, Lacroix-Desmazes S. Therapeutic factor VIII does not trigger TLR1.2 and TLR2.6 signalling in vitro. Haemophilia. 2013 May; 19(3):399-402.
    View in: PubMed
  6. Repessé Y, Dimitrov JD, Peyron I, Farrokhi Moshai E, Kiger L, Dasgupta S, Delignat S, Marden MC, Kaveri SV, Lacroix-Desmazes S. Heme binds to factor VIII and inhibits its interaction with activated factor IX. J Thromb Haemost. 2012 Jun; 10(6):1062-71.
    View in: PubMed
  7. Repessé Y, Dasgupta S, Navarrete AM, Delignat S, Kaveri SV, Lacroix-Desmazes S. Mannose-sensitive receptors mediate the uptake of factor VIII therapeutics by human dendritic cells. J Allergy Clin Immunol. 2012 Apr; 129(4):1172-3; author reply 1174-5.
    View in: PubMed
  8. Dasgupta S. Mediation of immunoregulation by dendritic cells. ScientificWorldJournal. 2011; 11:118-20.
    View in: PubMed
  9. Navarrete AM, Dasgupta S, Teyssandier M, Repesse Y, Delignat S, André S, Bayry J, Kaveri SV, Lacroix-Desmazes S. Endocytic receptor for pro-coagulant factor VIII: relevance to inhibitor formation. Thromb Haemost. 2010 Dec; 104(6):1093-8.
    View in: PubMed
  10. Ochoa-Repáraz J, Mielcarz DW, Ditrio LE, Burroughs AR, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH. Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression. J Immunol. 2010 Oct 1; 185(7):4101-8.
    View in: PubMed
  11. Ochoa-Repáraz J, Mielcarz DW, Wang Y, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH. A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol. 2010 Sep; 3(5):487-95.
    View in: PubMed
  12. Dasgupta S, Kasper DL. Novel tools for modulating immune responses in the host-polysaccharides from the capsule of commensal bacteria. Adv Immunol. 2010; 106:61-91.
    View in: PubMed
  13. Dimitrov JD, Dasgupta S, Navarrete AM, Delignat S, Repesse Y, Meslier Y, Planchais C, Teyssandier M, Motterlini R, Bayry J, Kaveri SV, Lacroix-Desmazes S. Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII. Blood. 2010 Apr 1; 115(13):2682-5.
    View in: PubMed
  14. André S, Meslier Y, Dimitrov JD, Repessé Y, Kaveri SV, Lacroix-Desmazes S, Dasgupta S. A cellular viewpoint of anti-FVIII immune response in hemophilia A. Clin Rev Allergy Immunol. 2009 Oct; 37(2):105-13.
    View in: PubMed
  15. Navarrete A, Dasgupta S, Delignat S, Caligiuri G, Christophe OD, Bayry J, Nicoletti A, Kaveri SV, Lacroix-Desmazes S. Splenic marginal zone antigen-presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A. J Thromb Haemost. 2009 Nov; 7(11):1816-23.
    View in: PubMed
  16. Dasgupta S, Bayry J, André S, Dimitrov JD, Kaveri SV, Lacroix-Desmazes S. Auditing protein therapeutics management by professional APCs: toward prevention of immune responses against therapeutic proteins. J Immunol. 2008 Aug 1; 181(3):1609-15.
    View in: PubMed
  17. Wootla B, Dasgupta S, Dimitrov JD, Bayry J, Lévesque H, Borg JY, Borel-Derlon A, Rao DN, Friboulet A, Kaveri SV, Lacroix-Desmazes S. Factor VIII hydrolysis mediated by anti-factor VIII autoantibodies in acquired hemophilia. J Immunol. 2008 Jun 1; 180(11):7714-20.
    View in: PubMed
  18. Lacroix-Desmazes S, Navarrete AM, André S, Bayry J, Kaveri SV, Dasgupta S. Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A. Blood. 2008 Jul 15; 112(2):240-9.
    View in: PubMed
  19. Lacroix-Desmazes S, Repessé Y, Kaveri SV, Dasgupta S. The role of VWF in the immunogenicity of FVIII. Thromb Res. 2008; 122 Suppl 2:S3-6.
    View in: PubMed
  20. Dasgupta S, Navarrete AM, André S, Wootla B, Delignat S, Repessé Y, Bayry J, Nicoletti A, Saenko EL, d'Oiron R, Jacquemin M, Saint-Remy JM, Kaveri SV, Lacroix-Desmazes S. Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica. 2008 Jan; 93(1):83-9.
    View in: PubMed
  21. Bayry J, Lacroix-Desmazes S, Dasgupta S, Kazatchkine MD, Kaveri SV. Efficacy of regulatory T-cell immunotherapy: are inflammatory cytokines key determinants? Nat Rev Immunol. 2008 Jan; 8(1):1p following 86; author reply 1p following 86.
    View in: PubMed
  22. Kaveri SV, Dasgupta S, Andre S, Navarrete AM, Repessé Y, Wootla B, Lacroix-Desmazes S. Factor VIII inhibitors: role of von Willebrand factor on the uptake of factor VIII by dendritic cells. Haemophilia. 2007 Dec; 13 Suppl 5:61-4.
    View in: PubMed
  23. Delignat S, Dasgupta S, André S, Navarrete AM, Kaveri SV, Bayry J, André MH, Chtourou S, Tellier Z, Lacroix-Desmazes S. Comparison of the immunogenicity of different therapeutic preparations of human factor VIII in the murine model of hemophilia A. Haematologica. 2007 Oct; 92(10):1423-6.
    View in: PubMed
  24. Dasgupta S, Bayry J, Lacroix-Desmazes S, Kaveri SV. Human mannose receptor (CD206) in immune response: novel insights into vaccination strategies using a humanized mouse model. Expert Rev Clin Immunol. 2007 Sep; 3(5):677-81.
    View in: PubMed
  25. Dasgupta S, Navarrete AM, Bayry J, Delignat S, Wootla B, André S, Christophe O, Nascimbeni M, Jacquemin M, Martinez-Pomares L, Geijtenbeek TB, Moris A, Saint-Remy JM, Kazatchkine MD, Kaveri SV, Lacroix-Desmazes S. A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8965-70.
    View in: PubMed
  26. Dasgupta S, Navarrete AM, Delignat S, Wootla B, Andre S, Nagaraja V, Lacroix-Desmazes S, Kaveri SV. Immune response against therapeutic factor VIII in hemophilia A patients--a survey of probable risk factors. Immunol Lett. 2007 May 15; 110(1):23-8.
    View in: PubMed
  27. Dasgupta S, Bayry J, Lacroix-Desmazes S, Kaveri SV. Expert Rev Clin Immunol. Human mannose receptor (CD206) in immune response: novel insights into vaccination strategies using a humanized mouse model. 2007; 3(5):677-681.
  28. Dasgupta S, Repessé Y, Bayry J, Navarrete AM, Wootla B, Delignat S, Irinopoulou T, Kamaté C, Saint-Remy JM, Jacquemin M, Lenting PJ, Borel-Derlon A, Kaveri SV, Lacroix-Desmazes S. VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors. Blood. 2007 Jan 15; 109(2):610-2.
    View in: PubMed
  29. Lacroix-Desmazes S, Wootla B, Dasgupta S, Delignat S, Bayry J, Reinbolt J, Hoebeke J, Saenko E, Kazatchkine MD, Friboulet A, Christophe O, Nagaraja V, Kaveri SV. Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII. J Immunol. 2006 Jul 15; 177(2):1355-63.
    View in: PubMed
  30. Wootla B, Dasgupta S, Mallet V, Kazatchkine MD, Nagaraja V, Friboulet A, Kaveri SV, Lacroix-Desmazes S. Physiopathology of catalytic antibodies: the case for factor VIII-hydrolyzing immunoglobulin G. Blood Coagul Fibrinolysis. 2006 Jun; 17(4):229-34.
    View in: PubMed
  31. Bayry J, Bayary J, Dasgupta S, Misra N, Ephrem A, Duong Van Huyen JP, Delignat S, Hassan G, Caligiuri G, Nicoletti A, Lacroix-Desmazes S, Kazatchkine MD, Kaveri S. Intravenous immunoglobulin in autoimmune disorders: an insight into the immunoregulatory mechanisms. Int Immunopharmacol. 2006 Apr; 6(4):528-34.
    View in: PubMed
  32. Misra N, Bayary J, Dasgupta S, Ephrem A, Huyen JP, Delignat S, Hassan G, Caligiuri G, Nicoletti A, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV. Intravenous immunoglobulin and dendritic cells. Clin Rev Allergy Immunol. 2005 Dec; 29(3):201-5.
    View in: PubMed
  33. Ephrem A, Misra N, Hassan G, Dasgupta S, Delignat S, Duong Van Huyen JP, Chamat S, Prost F, Lacroix-Desmazes S, Kavery SV, Kazatchkine MD. Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulin. Clin Exp Med. 2005 Dec; 5(4):135-40.
    View in: PubMed
  34. Lacroix-Desmazes S, Wootla B, Delignat S, Dasgupta S, Nagaraja V, Kazatchkine MD, Kaveri SV. Pathophysiology of catalytic antibodies. Immunol Lett. 2006 Feb 28; 103(1):3-7.
    View in: PubMed
  35. Bayry J, Misra N, Dasgupta S, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV. Natural autoantibodies: immune homeostasis and therapeutic intervention. Expert Rev Clin Immunol. 2005 Jul; 1(2):213-22.
    View in: PubMed
  36. Misra N, Bayry J, Ephrem A, Dasgupta S, Delignat S, Duong Van Huyen JP, Prost F, Lacroix-Desmazes S, Nicoletti A, Kazatchkine MD, Kaveri SV. Intravenous immunoglobulin in neurological disorders: a mechanistic perspective. J Neurol. 2005 May; 252 Suppl 1:I1-6.
    View in: PubMed
  37. Dasgupta S, Chandran V, Bhinge A, Sewlikar S, Nimbkar A, Datta D. Role of L-lysine HCl in adoptive immune therapy towards development of suitable tuberculosis vaccination. Indian J Exp Biol. 2004 Aug; 42(8):758-65.
    View in: PubMed
  38. Dasgupta S, Bhinge A, Chandran V, Sewlikar S, Nimbkar A, Datta D. Role of L-lysine HCl in immunopotentiation towards development of suitable tuberculosis vaccination. Vaccine. 2003 Dec 1; 21(32):4722-7.
    View in: PubMed
  39. Giri J, Ray A, Dasgupta S, Datta D, Bahadur D. Investigation on Tc tuned nano particles of magnetic oxides for hyperthermia applications. Biomed Mater Eng. 2003; 13(4):387-99.
    View in: PubMed
  40. Datta D, Kundu PK, Dasgupta S, Fulzele K, Sewlikar S. Effect of addition of proton carriers in culture medium on growth and secretion of hybridoma cell line OKT3. Indian J Physiol Pharmacol. 2001 Jul; 45(3):367-72.
    View in: PubMed
  41. Datta D, Kundu PK, Biswas S, Dasgupta S, Bhinge A, Chandran V. Effect of cationic amino acid, L-lysine and its polymers on the growth and secretion of hybridoma cell line OKT-3. Hybridoma. 2000 Aug; 19(4):339-46.
    View in: PubMed
  42. Amar S. Kumbhar, Shirish G. Damle, Suryasarathi T. Dasgupta, Sandhya Y. Rane and Avinash S. Kumbhar. Journal of Chemical Research (S). Nuclease Activity of Oxo-bridged Diiron Complexes. 1999; 98-99.
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