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profileDeborah Jean Culley, M.D.

TitleAssociate Professor of Anaesthesia
InstitutionBrigham and Women's Hospital
DepartmentAnaesthesia
AddressBrigham and Women's Hospital
Anesthesiology, Perioperative & Pain Mgt
75 Francis St
Boston MA 02115
Phone617/732-7330
Fax617/730-2813
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AG048522     (CULLEY, DEBORAH J)Aug 1, 2015 - Apr 30, 2017
NIH/NIA
Preoperative Cognitive Screening in Elderly Surgical Patients: Feasibility and Utility for Predicting Morbidity
Role: Principal Investigator

K08GM077057     (CULLEY, DEBORAH J)Apr 1, 2006 - Mar 31, 2011
NIH/NIGMS
Cellular Mechanisms of General Anesthetic Mediated Neurotoxicity
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Palanisamy A, Crosby G, Culley DJ. EARLY gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats. Behav Brain Funct. 2017 Dec 26; 13(1):14. PMID: 29279051.
    View in: PubMed
  2. Culley DJ, Flaherty D, Fahey MC, Rudolph JL, Javedan H, Huang CC, Wright J, Bader AM, Hyman BT, Blacker D, Crosby G. Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients. Anesthesiology. 2017 11; 127(5):765-774. PMID: 28891828.
    View in: PubMed
  3. Miao H, Dong Y, Zhang Y, Zheng H, Shen Y, Crosby G, Culley DJ, Marcantonio ER, Xie Z. Anesthetic Isoflurane or Desflurane Plus Surgery Differently Affects Cognitive Function in Alzheimer's Disease Transgenic Mice. Mol Neurobiol. 2017 Oct 06. PMID: 28986748.
    View in: PubMed
  4. Zhou Y, Sun H, Culley DJ, Young A, Harman AE, Warner DO. Effectiveness of Written and Oral Specialty Certification Examinations to Predict Actions against the Medical Licenses of Anesthesiologists. Anesthesiology. 2017 06; 126(6):1171-1179. PMID: 28383325.
    View in: PubMed
  5. Fahy BG, Vasilopoulos T, White P, Culley DJ. Academic Productivity of Accreditation Council for Graduate Medical Education-Accredited Critical Care Fellowship Program Directors. Crit Care Med. 2016 Dec; 44(12):e1194-e1201. PMID: 27495817.
    View in: PubMed
  6. Sun H, Zhou Y, Culley DJ, Lien CA, Harman AE, Warner DO. Association between Participation in an Intensive Longitudinal Assessment Program and Performance on a Cognitive Examination in the Maintenance of Certification in Anesthesiology Program®. Anesthesiology. 2016 11; 125(5):1046-1055. PMID: 27560464.
    View in: PubMed
  7. Palanisamy A, Friese MB, Cotran E, Moller L, Boyd JD, Crosby G, Culley DJ. Prolonged Treatment with Propofol Transiently Impairs Proliferation but Not Survival of Rat Neural Progenitor Cells In Vitro. PLoS One. 2016; 11(7):e0158058. PMID: 27379684; PMCID: PMC4933334.
  8. Culley DJ, Flaherty D, Reddy S, Fahey MC, Rudolph J, Huang CC, Liu X, Xie Z, Bader AM, Hyman BT, Blacker D, Crosby G. Preoperative Cognitive Stratification of Older Elective Surgical Patients: A Cross-Sectional Study. Anesth Analg. 2016 07; 123(1):186-92. PMID: 27028776; PMCID: PMC4912429 [Available on 07/01/17].
  9. Culley DJ, Crosby G. Dementia after Cardiac Surgery: Is It the Procedure or the Patient? Anesthesiology. 2016 07; 125(1):14-6. PMID: 27127918.
    View in: PubMed
  10. Englert JA, Macias AA, Amador-Munoz D, Pinilla Vera M, Isabelle C, Guan J, Magaoay B, Suarez Velandia M, Coronata A, Lee A, Fredenburgh LE, Culley DJ, Crosby G, Baron RM. Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity. Anesthesiology. 2015 Aug; 123(2):377-88. PMID: 26068207; PMCID: PMC4510009 [Available on 08/01/16].
  11. Culley DJ, Crosby G. Prehabilitation for Prevention of Postoperative Cognitive Dysfunction? Anesthesiology. 2015 Jul; 123(1):7-9. PMID: 26001030; PMCID: PMC4626317 [Available on 07/01/16].
  12. Warner DO, Sun H, Harman AE, Culley DJ. Feasibility of patient and peer surveys for Maintenance of Certification among diplomates of the American Board of Anesthesiology. J Clin Anesth. 2015 Jun; 27(4):290-5. PMID: 25792177.
    View in: PubMed
  13. Sun H, Culley DJ, Lien CA, Kitchener DL, Harman AE, Warner DO. Predictors of performance on the Maintenance of Certification in Anesthesiology Program® (MOCA®) examination. J Clin Anesth. 2015 Feb; 27(1):1-6. PMID: 25468588.
    View in: PubMed
  14. Tao G, Zhang J, Zhang L, Dong Y, Yu B, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3ß activation in young mice. Anesthesiology. 2014 Sep; 121(3):510-27. PMID: 24787352; PMCID: PMC4165789.
  15. Culley DJ, Snayd M, Baxter MG, Xie Z, Lee IH, Rudolph J, Inouye SK, Marcantonio ER, Crosby G. Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. Front Aging Neurosci. 2014; 6:107. PMID: 24959140; PMCID: PMC4050637.
  16. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Peripheral surgical wounding and age-dependent neuroinflammation in mice. PLoS One. 2014; 9(5):e96752. PMID: 24796537; PMCID: PMC4010504.
  17. Crosby G, Culley DJ, Dexter F. Cognitive outcome of surgery: is there no place like home? Anesth Analg. 2014 May; 118(5):898-900. PMID: 24781557.
    View in: PubMed
  18. Schartel SA, Kuhn C, Culley DJ, Wood M, Cohen N. Development of the anesthesiology educational milestones. J Grad Med Educ. 2014 Mar; 6(1 Suppl 1):12-4. PMID: 24701261; PMCID: PMC3966605.
  19. Zhang Y, Pan C, Wu X, Dong Y, Culley DJ, Crosby G, Li T, Xie Z. Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons. Front Cell Neurosci. 2014; 8:14. PMID: 24523673; PMCID: PMC3906516.
  20. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep. 2014 Jan 20; 4:3766. PMID: 24441878; PMCID: PMC3895908.
  21. Culley DJ, Fahy BG, Xie Z, Lekowski R, Buetler S, Liu X, Cohen NH, Crosby G. Academic productivity of directors of ACGME-accredited residency programs in surgery and anesthesiology. Anesth Analg. 2014 Jan; 118(1):200-5. PMID: 24247229.
    View in: PubMed
  22. Culley DJ, Cotran EK, Karlsson E, Palanisamy A, Boyd JD, Xie Z, Crosby G. Isoflurane affects the cytoskeleton but not survival, proliferation, or synaptogenic properties of rat astrocytes in vitro. Br J Anaesth. 2013 Jun; 110 Suppl 1:i19-28. PMID: 23722058; PMCID: PMC3667346.
  23. Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC. Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth. 2013 Aug; 111(2):143-51. PMID: 23722106; PMCID: PMC3711392.
  24. Culley DJ. Report on SNACC's 40th anniversary meeting. J Neurosurg Anesthesiol. 2013 Apr; 25(2):221-2. PMID: 23456035.
    View in: PubMed
  25. Zheng H, Dong Y, Xu Z, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice. Anesthesiology. 2013 Mar; 118(3):516-26. PMID: 23314109; PMCID: PMC3580035.
  26. Culley DJ, Sun H, Harman AE, Warner DO. Perceived value of Board certification and the Maintenance of Certification in Anesthesiology Program (MOCA®). J Clin Anesth. 2013 Feb; 25(1):12-9. PMID: 23391341.
    View in: PubMed
  27. Crosby G, Culley DJ. Anesthesia & analgesia by the numbers: then & now. Anesth Analg. 2012 Dec; 115(6):1265-7. PMID: 23175575.
    View in: PubMed
  28. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 May; 71(5):687-98. PMID: 22368036; PMCID: PMC3942786.
  29. Crosby G, Culley DJ. Processed electroencephalogram and depth of anesthesia: window to nowhere or into the brain? Anesthesiology. 2012 Feb; 116(2):235-7. PMID: 22222481.
    View in: PubMed
  30. Culley DJ, Maze M, Crosby G. Reprogramming of the infant brain by surgery with general anesthesia. Mayo Clin Proc. 2012 Feb; 87(2):110-3. PMID: 22305023; PMCID: PMC3497865.
  31. Palanisamy A, Crosby G, Culley DJ. In reply. Anesthesiology. 2011 Oct; 115(4):904-5. PMID: 21934420.
    View in: PubMed
  32. Culley DJ, Boyd JD, Palanisamy A, Xie Z, Kojima K, Vacanti CA, Tanzi RE, Crosby G. Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology. 2011 Oct; 115(4):754-63. PMID: 21666433; PMCID: PMC3432861.
  33. Crosby G, Culley DJ, Hyman BT. Preoperative cognitive assessment of the elderly surgical patient: a call for action. Anesthesiology. 2011 Jun; 114(6):1265-8. PMID: 21490501; PMCID: PMC3123886.
  34. Crosby G, Culley DJ. Surgery and anesthesia: healing the body but harming the brain? Anesth Analg. 2011 May; 112(5):999-1001. PMID: 21515644; PMCID: PMC3092153.
  35. Palanisamy A, Baxter MG, Keel PK, Xie Z, Crosby G, Culley DJ. Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. Anesthesiology. 2011 Mar; 114(3):521-8. PMID: 21307768; PMCID: PMC3071297.
  36. Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-a, IL-6, and IL-1ß. Neurobiol Aging. 2012 Jul; 33(7):1364-78. PMID: 21190757; PMCID: PMC3117127.
  37. Rudolph JL, Schreiber KA, Culley DJ, McGlinchey RE, Crosby G, Levitsky S, Marcantonio ER. Measurement of post-operative cognitive dysfunction after cardiac surgery: a systematic review. Acta Anaesthesiol Scand. 2010 Jul; 54(6):663-77. PMID: 20397979; PMCID: PMC2919360.
  38. Crosby G, Culley DJ, Patel PM. At the sharp end of spines: anesthetic effects on synaptic remodeling in the developing brain. Anesthesiology. 2010 Mar; 112(3):521-3. PMID: 20124984; PMCID: PMC2828506.
  39. Crosby G, Culley DJ, Marcantonio ER. Delirium: a cognitive cost of the comfort of procedural sedation in elderly patients? Mayo Clin Proc. 2010 Jan; 85(1):12-4. PMID: 20042555; PMCID: PMC2800293.
  40. Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol. 2009 May; 66(5):620-31. PMID: 19433662; PMCID: PMC2748878.
  41. Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, Zuo Z. Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Anesth Analg. 2009 May; 108(5):1627-30. PMID: 19372347; PMCID: PMC2769511.
  42. Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol. 2008 Dec; 64(6):618-27. PMID: 19006075; PMCID: PMC2612087.
  43. Lee IH, Culley DJ, Baxter MG, Xie Z, Tanzi RE, Crosby G. Spatial memory is intact in aged rats after propofol anesthesia. Anesth Analg. 2008 Oct; 107(4):1211-5. PMID: 18806029.
    View in: PubMed
  44. Marcantonio ER, Aneja J, Jones RN, Alsop DC, Fong TG, Crosby GJ, Culley DJ, Cupples LA, Inouye SK. Maximizing clinical research participation in vulnerable older persons: identification of barriers and motivators. J Am Geriatr Soc. 2008 Aug; 56(8):1522-7. PMID: 18662204; PMCID: PMC2562594.
  45. Rudolph JL, Marcantonio ER, Culley DJ, Silverstein JH, Rasmussen LS, Crosby GJ, Inouye SK. Delirium is associated with early postoperative cognitive dysfunction. Anaesthesia. 2008 Sep; 63(9):941-7. PMID: 18547292; PMCID: PMC2562627.
  46. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci. 2008 Apr 23; 28(17):4551-60. PMID: 18434534; PMCID: PMC3844798.
  47. Culley DJ, Crosby G. Nitrous oxide in neuroanesthesia: tried and true or toxin? Anesthesiology. 2008 Apr; 108(4):553-4. PMID: 18362583.
    View in: PubMed
  48. Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 2008 May 02; 283(18):11866-75. PMID: 18326038; PMCID: PMC2335348.
  49. Baxter MG, Murphy KL, Crosby G, Culley DJ. Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia. Hippocampus. 2008; 18(3):245-50. PMID: 18058823; PMCID: PMC2386959.
  50. Culley DJ, Xie Z, Crosby G. General anesthetic-induced neurotoxicity: an emerging problem for the young and old? Curr Opin Anaesthesiol. 2007 Oct; 20(5):408-13. PMID: 17873593.
    View in: PubMed
  51. Culley DJ, Raghavan SV, Waly M, Baxter MG, Yukhananov R, Deth RC, Crosby G. Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats. Anesth Analg. 2007 Jul; 105(1):83-8. PMID: 17578961.
    View in: PubMed
  52. Culley DJ, Crosby G, Xie Z, Vacanti CA, Kitz RJ, Zapol WM. Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery. Anesthesiology. 2007 Apr; 106(4):836-42. PMID: 17413922.
    View in: PubMed
  53. Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci. 2007 Feb 07; 27(6):1247-54. PMID: 17287498.
    View in: PubMed
  54. Marcantonio ER, Rudolph JL, Culley D, Crosby G, Alsop D, Inouye SK. Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1281-6. PMID: 17234821.
    View in: PubMed
  55. Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1300-6. PMID: 17234824.
    View in: PubMed
  56. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol. 2006 Nov 07; 549(1-3):71-8. PMID: 16979155.
    View in: PubMed
  57. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 2006 May; 104(5):988-94. PMID: 16645451.
    View in: PubMed
  58. Culley DJ, Loguinov A, Yukhananov R, Crosby G. General anesthesia does not reduce life expectancy in aged rats. Anesth Analg. 2006 Mar; 102(3):956-9. PMID: 16492858.
    View in: PubMed
  59. Crosby C, Culley DJ, Baxter MG, Yukhananov R, Crosby G. Spatial memory performance 2 weeks after general anesthesia in adult rats. Anesth Analg. 2005 Nov; 101(5):1389-92. PMID: 16243999.
    View in: PubMed
  60. Culley DJ, Baxter MG, Crosby CA, Yukhananov R, Crosby G. Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats. Anesth Analg. 2004 Nov; 99(5):1393-7; table of contents. PMID: 15502036.
    View in: PubMed
  61. Tran T, Culley DJ, Crosby G. Hemorrhagic stroke after spinal anesthesia and minor surgery. J Clin Anesth. 2004 Jun; 16(4):293-5. PMID: 15261323.
    View in: PubMed
  62. Culley DJ, Baxter MG, Yukhananov R, Crosby G. Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology. 2004 Feb; 100(2):309-14. PMID: 14739805.
    View in: PubMed
  63. Culley DJ, Crosby G. Mechanisms of postoperative neurobehavioral deficits and stroke may differ. Anesth Analg. 2003 Aug; 97(2):601; author reply 601. PMID: 12873962.
    View in: PubMed
  64. Culley DJ, Baxter M, Yukhananov R, Crosby G. The memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg. 2003 Apr; 96(4):1004-9, table of contents. PMID: 12651650.
    View in: PubMed
  65. Walther MM, Johnson B, Culley D, Shah R, Weber J, Venzon D, Yang JC, Linehan WM, Rosenberg SA. Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival. J Urol. 1998 Mar; 159(3):718-22. PMID: 9474133.
    View in: PubMed
  66. Culley DJ, Berger MS, Shaw D, Geyer R. An analysis of factors determining the need for ventriculoperitoneal shunts after posterior fossa tumor surgery in children. Neurosurgery. 1994 Mar; 34(3):402-7; discussion 407-8. PMID: 8190214.
    View in: PubMed
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