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M. Amin Arnaout, M.D.

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Division of Nephrology
149 13th Street
Charlestown MA 02129
Phone617/726-5663
Fax617/726-5671
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 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Palmyre A, Lee J, Ryklin G, Camarata T, Selig MK, Duchemin AL, Nowak P, Arnaout MA, Drummond IA, Vasilyev A. Collective epithelial migration drives kidney repair after acute injury. PLoS One. 2014; 9(7):e101304.
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  2. Rui X, Mehrbod M, Van Agthoven JF, Anand S, Xiong JP, Mofrad MR, Arnaout MA. The a-Subunit Regulates Stability of the Metal Ion at the Ligand-associated Metal Ion-binding Site in ß3 Integrins. J Biol Chem. 2014 Aug 15; 289(33):23256-63.
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  3. Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA. Atomic Basis for the Species-specific Inhibition of aV Integrins by Monoclonal Antibody 17E6 Is Revealed by the Crystal Structure of aVß3 Ectodomain-17E6 Fab Complex. J Biol Chem. 2014 May 16; 289(20):13801-9.
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  4. Van Agthoven JF, Xiong JP, Alonso JL, Rui X, Adair BD, Goodman SL, Arnaout MA. Structural basis for pure antagonism of integrin aVß3 by a high-affinity form of fibronectin. Nat Struct Mol Biol. 2014 Apr; 21(4):383-8.
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  5. Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA. Stress Hematopoiesis Is Regulated by the Krüppel-Like Transcription Factor ZBP-89. Stem Cells. 2014 Mar; 32(3):791-801.
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  6. Adair BD, Altintas MM, Möller CC, Arnaout MA, Reiser J. Structure of the Kidney Slit Diaphragm Adapter Protein CD2-Associated Protein as Determined with Electron Microscopy. J Am Soc Nephrol. 2014 Jul; 25(7):1465-73.
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  7. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013 Dec 19; 369(25):2416-23.
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  8. Frohlich EM, Alonso JL, Borenstein JT, Zhang X, Arnaout MA, Charest JL. Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers. Lab Chip. 2013 Jun 21; 13(12):2311-9.
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  9. Adair BD, Xiong JP, Alonso JL, Hyman BT, Arnaout MA. EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane. PLoS One. 2013; 8(2):e57951.
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  10. Mahalingam B, Ajroud K, Alonso JL, Anand S, Adair BD, Horenstein AL, Malavasi F, Xiong JP, Arnaout MA. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol. 2011 Dec 15; 187(12):6393-401.
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  11. Levy BD, Zhang QY, Bonnans C, Primo V, Reilly JJ, Perkins DL, Liang Y, Amin Arnaout M, Nikolic B, Serhan CN. The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. Prostaglandins Leukot Essent Fatty Acids. 2011 Jan-Feb; 84(1-2):43-50.
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  12. Arnaout MA. Autosomal Dominant Polycystic Kidney Disease. eLS. 2010; DOI: 10.1002/9780470015902.a00.
  13. Primo VC, Marusic S, Franklin CC, Goldmann WH, Achaval CG, Smith RN, Arnaout MA, Nikolic B. Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis. Clin Exp Immunol. 2010 Mar; 159(3):327-37.
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  14. Xiong JP, Mahalingham B, Alonso JL, Borrelli LA, Rui X, Anand S, Hyman BT, Rysiok T, Müller-Pompalla D, Goodman SL, Arnaout MA. Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. J Cell Biol. 2009 Aug 24; 186(4):589-600.
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  15. Gupta V, Alonso JL, Sugimori T, Essafi M, Issafi M, Xiong JP, Arnaout MA. Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. J Immunol. 2008 Feb 1; 180(3):1713-8.
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  16. Arnaout MA, Goodman SL, Xiong JP. Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol. 2007 Oct; 19(5):495-507.
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  17. Park JY, Arnaout MA, Gupta V. A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen. 2007 Apr; 12(3):406-17.
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  18. Steele DJ, Hamilton E, Arnaout MA. A case management model to improve hemodialysis outpatient outcomes. Hemodial Int. 2007 Apr; 11(2):247-51.
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  19. Xiong JP, Goodman SL, Arnaout MA. Purification, analysis, and crystal structure of integrins. Methods Enzymol. 2007; 426:307-36.
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  20. Gupta V, Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, Arnaout MA. The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood. 2007 Apr 15; 109(8):3513-20.
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  21. Zerria K, Jerbi E, Hammami S, Maaroufi A, Boubaker S, Xiong JP, Arnaout MA, Fathallah DM. Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat. Immunology. 2006 Dec; 119(4):431-40.
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  22. Li X, Xiong JW, Shelley CS, Park H, Arnaout MA. The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development. 2006 Sep; 133(18):3641-50.
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  23. Ding Z, Bradley KA, Amin Arnaout M, Xiong JP. Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli. Protein Expr Purif. 2006 Sep; 49(1):121-8.
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  24. Adair BD, Xiong JP, Maddock C, Goodman SL, Arnaout MA, Yeager M. Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin. J Cell Biol. 2005 Mar 28; 168(7):1109-18.
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  25. Devchand PR, Schmidt BA, Primo VC, Zhang QY, Arnaout MA, Serhan CN, Nikolic B. A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. FASEB J. 2005 Feb; 19(2):203-10.
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  26. Arnaout MA, Mahalingam B, Xiong JP. Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol. 2005; 21:381-410.
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  27. Xiong JP, Stehle T, Goodman SL, Arnaout MA. A novel adaptation of the integrin PSI domain revealed from its crystal structure. J Biol Chem. 2004 Sep 24; 279(39):40252-4.
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  28. Arnaout MA. The structural basis of elasticity in fibrillin-based microfibrils. Structure. 2004 May; 12(5):734-6.
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  29. Ajroud K, Sugimori T, Goldmann WH, Fathallah DM, Xiong JP, Arnaout MA. Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands. J Biol Chem. 2004 Jun 11; 279(24):25483-8.
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  30. Xiong JP, Stehle T, Goodman SL, Arnaout MA. Integrins, cations and ligands: making the connection. J Thromb Haemost. 2003 Jul; 1(7):1642-54.
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  31. Xiong JP, Stehle T, Goodman SL, Arnaout MA. New insights into the structural basis of integrin activation. Blood. 2003 Aug 15; 102(4):1155-9.
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  32. Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD. Blood. 2003 May 15; 101(10):4033-41.
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  33. Xu GM, González-Perrett S, Essafi M, Timpanaro GA, Montalbetti N, Arnaout MA, Cantiello HF. Polycystin-1 activates and stabilizes the polycystin-2 channel. J Biol Chem. 2003 Jan 17; 278(3):1457-62.
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  34. Arnaout MA, Goodman SL, Xiong JP. Coming to grips with integrin binding to ligands. Curr Opin Cell Biol. 2002 Oct; 14(5):641-51.
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  35. Park H, Shelley CS, Arnaout MA. The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene. Blood. 2003 Feb 1; 101(3):894-902.
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  36. Seow KT, Xiong JP, Arnaout MA, Welge J, Rippmann F, Goodman SL. Divalent cations and the relationship between alphaA and betaA domains in integrins. Biochem Pharmacol. 2002 Sep; 64(5-6):805-12.
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  37. Arnaout MA. Integrin structure: new twists and turns in dynamic cell adhesion. Immunol Rev. 2002 Aug; 186:125-40.
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  38. Alonso JL, Essafi M, Xiong JP, Stehle T, Arnaout MA. Does the integrin alphaA domain act as a ligand for its betaA domain? Curr Biol. 2002 May 14; 12(10):R340-2.
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  39. Gonzalez-Perrett S, Batelli M, Kim K, Essafi M, Timpanaro G, Moltabetti N, Reisin IL, Arnaout MA, Cantiello HF. Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity. J Biol Chem. 2002 Jul 12; 277(28):24959-66.
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  40. Shelley CS, Teodoridis JM, Park H, Farokhzad OC, Böttinger EP, Arnaout MA. During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter. J Immunol. 2002 Apr 15; 168(8):3887-93.
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  41. Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science. 2002 Apr 5; 296(5565):151-5.
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  42. Rabb H, Chandran PK, Arnaout MA, Kehrli ME. Use of a bovine model to study the role of adhesion molecule CD11/CD18 in hemodialysis-induced neutropenia. Am J Kidney Dis. 2002 Mar; 39(3):587-93.
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  43. Li R, Haruta I, Rieu P, Sugimori T, Xiong JP, Arnaout MA. Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b. J Immunol. 2002 Feb 1; 168(3):1219-25.
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  44. Xu GM, Arnaout MA. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Genomics. 2002 Jan; 79(1):87-94.
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  45. Xu GM, Sikaneta T, Sullivan BM, Zhang Q, Andreucci M, Stehle T, Drummond I, Arnaout MA. Polycystin-1 interacts with intermediate filaments. J Biol Chem. 2001 Dec 7; 276(49):46544-52.
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  46. Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science. 2001 Oct 12; 294(5541):339-45.
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  47. González-Perrett S, Kim K, Ibarra C, Damiano AE, Zotta E, Batelli M, Harris PC, Reisin IL, Arnaout MA, Cantiello HF. Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1182-7.
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  48. Arnaout MA. Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease. Annu Rev Med. 2001; 52:93-123.
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  49. Xiong JP, Li R, Essafi M, Stehle T, Arnaout MA. An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J Biol Chem. 2000 Dec 8; 275(49):38762-7.
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  50. Arnaout MA. The vasculopathy of autosomal dominant polycystic kidney disease: insights from animal models. Kidney Int. 2000 Dec; 58(6):2599-610.
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  51. Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000 Oct 15; 165(8):4272-80.
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  52. Farokhzad OC, Teodoridis JM, Park H, Arnaout MA, Shelley CS. CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA. Nucleic Acids Res. 2000 Jun 1; 28(11):2256-67.
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  53. Kim K, Drummond I, Ibraghimov-Beskrovnaya O, Klinger K, Arnaout MA. Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1731-6.
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  54. Goldmann WH, Niles JL, Arnaout MA. Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers. Eur J Biochem. 1999 Apr; 261(1):155-62.
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  55. Li R, Arnaout MA. Functional analysis of the beta 2 integrins. Methods Mol Biol. 1999; 129:105-24.
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  56. Li R, Rieu P, Griffith DL, Scott D, Arnaout MA. Two functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures. J Cell Biol. 1998 Dec 14; 143(6):1523-34.
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  57. Shelley CS, Da Silva N, Georgakis A, Chomienne C, Arnaout MA. Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb. Genomics. 1998 Apr 15; 49(2):334-6.
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  58. Ingalls RR, Arnaout MA, Delude RL, Flaherty S, Savedra R, Golenbock DT. The CD11/CD18 integrins: characterization of three novel LPS signaling receptors. Prog Clin Biol Res. 1998; 397:107-17.
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  59. Ingalls RR, Arnaout MA, Golenbock DT. Outside-in signaling by lipopolysaccharide through a tailless integrin. J Immunol. 1997 Jul 1; 159(1):433-8.
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  60. Sugimori T, Griffith DL, Arnaout MA. Emerging paradigms of integrin ligand binding and activation. Kidney Int. 1997 May; 51(5):1454-62.
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  61. Kanazashi SI, Sharma CP, Arnaout MA. Integrin-ligand interactions: scratching the surface. Curr Opin Hematol. 1997 Jan; 4(1):67-74.
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  62. Farokhzad OC, Shelley CS, Arnaout MA. Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2. J Immunol. 1996 Dec 15; 157(12):5597-605.
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  63. Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, von Andrian UH, Arnaout MA, Mayadas TN. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec; 5(6):653-66.
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  64. Palsson R, Sharma CP, Kim K, McLaughlin M, Brown D, Arnaout MA. Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1. Mol Med. 1996 Nov; 2(6):702-11.
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  65. Rieu P, Sugimori T, Griffith DL, Arnaout MA. Solvent-accessible residues on the metal ion-dependent adhesion site face of integrin CR3 mediate its binding to the neutrophil inhibitory factor. J Biol Chem. 1996 Jul 5; 271(27):15858-61.
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  66. Lee JO, Bankston LA, Arnaout MA, Liddington RC. Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure. 1995 Dec 15; 3(12):1333-40.
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  67. Xie J, Li R, Kotovuori P, Vermot-Desroches C, Wijdenes J, Arnaout MA, Nortamo P, Gahmberg CG. Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain. J Immunol. 1995 Oct 1; 155(7):3619-28.
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  68. Choi M, Rabb H, Arnaout MA, Ehrlich HP. Preventing the infiltration of leukocytes by monoclonal antibody blocks the development of progressive ischemia in rat burns. Plast Reconstr Surg. 1995 Oct; 96(5):1177-85; discussion 1186-7.
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  69. Daouk GH, Palsson R, Arnaout MA. Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis. Kidney Int. 1995 Jun; 47(6):1528-36.
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  70. Sharma CP, Ezzell RM, Arnaout MA. Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18. J Immunol. 1995 Apr 1; 154(7):3461-70.
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  71. Lee JO, Rieu P, Arnaout MA, Liddington R. Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell. 1995 Feb 24; 80(4):631-8.
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  72. Preventing the infiltration of leukocytes by monoclonal antibody blocks the development of progressive ischemia in rat burns. Plast Reconstr Surg. 1995; 96(5):1177-1185.
  73. Rieu P, Ueda T, Haruta I, Sharma CP, Arnaout MA. The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF. J Cell Biol. 1994 Dec; 127(6 Pt 2):2081-91.
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  74. Ueda T, Rieu P, Brayer J, Arnaout MA. Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18). Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10680-4.
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  75. Böttinger EP, Shelley CS, Farokhzad OC, Arnaout MA. The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol. 1994 Apr; 14(4):2604-15.
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  76. Fathallah DM, Cherif D, Dellagi K, Arnaout MA. Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5. J Immunol. 1993 Jul 15; 151(2):810-3.
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  77. Rabb H, Michishita M, Sharma CP, Brown D, Arnaout MA. Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b/CD18) regulate ligand avidity and the internalization of occupied receptors. J Immunol. 1993 Jul 15; 151(2):990-1002.
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  78. Shelley CS, Farokhzad OC, Arnaout MA. Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene. Proc Natl Acad Sci U S A. 1993 Jun 1; 90(11):5364-8.
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  79. Maruiwa M, Mizoguchi A, Russell GJ, Narula N, Stronska M, Mizoguchi E, Rabb H, Arnaout MA, Bhan AK. Anti-KCA-3, a monoclonal antibody reactive with a rat complement C3 receptor, distinguishes Kupffer cells from other macrophages. J Immunol. 1993 May 1; 150(9):4019-30.
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  80. Michishita M, Videm V, Arnaout MA. A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell. 1993 Mar 26; 72(6):857-67.
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  81. Colgan SP, Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion. J Cell Biol. 1993 Feb; 120(3):785-98.
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  82. Arnaout MA. Cell adhesion molecules in inflammation and thrombosis: status and prospects. Am J Kidney Dis. 1993 Jan; 21(1):72-6.
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  83. Arnaout MA. The dynamics and regulation of leukocyte-endothelial cell interactions. Current Opinions in Hematology. 1993; 1:113-122.
  84. Li Z, Daniel EE, Lane CG, Arnaout MA, O'Byrne PM. Effect of an anti-Mo1 MAb on ozone-induced airway inflammation and airway hyperresponsiveness in dogs. Am J Physiol. 1992 Dec; 263(6 Pt 1):L723-6.
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  85. Böttinger EP, Niles JL, Collins AB, McCluskey RT, Arnaout MA. Antineutrophil cytoplasmic autoantibody-associated vasculitis presenting as Sjögren's syndrome. Arthritis Rheum. 1992 Nov; 35(11):1373-6.
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  86. Niles JL, McCluskey RT, Arnaout MA. Wegener granulomatosis. Ann Intern Med. 1992 Oct 1; 117(7):620; author reply 620-1.
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  87. Parkos CA, Colgan SP, Delp C, Arnaout MA, Madara JL. Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways. J Cell Biol. 1992 May; 117(4):757-64.
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  88. Nelson C, Rabb H, Arnaout MA. Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins. J Biol Chem. 1992 Feb 15; 267(5):3351-7.
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  89. Arnaout MA, Michishita M, Sharma CP. On the regulation of beta 2 integrins. Adv Exp Med Biol. 1992; 323:171-9.
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  90. Shelley CS, Arnaout MA. The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10525-9.
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  91. Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction. J Clin Invest. 1991 Nov; 88(5):1605-12.
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  92. Toothaker LE, Gonzalez DA, Tung N, Lemons RS, Le Beau MM, Arnaout MA, Clayton LK, Tenen DG. Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation. Blood. 1991 Oct 1; 78(7):1826-33.
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  93. Niles JL, Pan GL, Collins AB, Shannon T, Skates S, Fienberg R, Arnaout MA, McCluskey RT. Antigen-specific radioimmunoassays for anti-neutrophil cytoplasmic antibodies in the diagnosis of rapidly progressive glomerulonephritis. J Am Soc Nephrol. 1991 Jul; 2(1):27-36.
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  94. Dana N, Fathallah DM, Arnaout MA. Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3106-10.
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  95. Gupta SK, Niles JL, McCluskey RT, Arnaout MA. Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin. Blood. 1990 Nov 15; 76(10):2162.
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  96. Lencer WI, Verkman AS, Arnaout MA, Ausiello DA, Brown D. Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase. J Cell Biol. 1990 Aug; 111(2):379-89.
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  97. Arnaout MA. Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol Rev. 1990 Apr; 114:145-80.
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  98. Arnaout MA, Dana N, Gupta SK, Tenen DG, Fathallah DM. Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency. J Clin Invest. 1990 Mar; 85(3):977-81.
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  99. Arnaout MA. Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood. 1990 Mar 1; 75(5):1037-50.
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  100. Arnaout MA. Autoantigens in Wegener's Granulomatosis. Blood. 1990; 75:188-1589.
  101. Dana N Arnaout MA. Leukocyte adhesion molecule deficiency. Current Opinions in Pediatrics. 1990; 2:916-919.
  102. Chatila TA, Geha RS, Arnaout MA. Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules. J Cell Biol. 1989 Dec; 109(6 Pt 2):3435-44.
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  103. Niles JL, McCluskey RT, Ahmad MF, Arnaout MA. Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase. Blood. 1989 Nov 1; 74(6):1888-93.
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  104. Southwick FS, Howard TH, Holbrook T, Anderson DC, Stossel TP, Arnaout MA. The relationship between CR3 deficiency and neutrophil actin assembly. Blood. 1989 May 15; 73(7):1973-9.
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  105. Luscinskas FW, Brock AF, Arnaout MA, Gimbrone MA. Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol. 1989 Apr 1; 142(7):2257-63.
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  106. Schwartz D, Wong RC, Chatila T, Arnaout A, Miller R, Geha R. Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact. J Clin Immunol. 1989 Mar; 9(2):151-8.
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  107. Rosmarin AG, Weil SC, Rosner GL, Griffin JD, Arnaout MA, Tenen DG. Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes during myeloid differentiation. Blood. 1989 Jan; 73(1):131-6.
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  108. Arnaout MA, Lanier LL, Faller DV. Relative contribution of the leukocyte molecules Mo1, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific. J Cell Physiol. 1988 Nov; 137(2):305-9.
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  109. Arnaout MA, Gupta SK, Pierce MW, Tenen DG. Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3). J Cell Biol. 1988 Jun; 106(6):2153-8.
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  110. Arnaout MA, Remold-O'Donnell E, Pierce MW, Harris P, Tenen DG. Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2776-80.
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  111. Freyer DR, Morganroth ML, Rogers CE, Arnaout MA, Todd RF. Modulation of surface CD11/CD18 glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes. Clin Immunol Immunopathol. 1988 Feb; 46(2):272-83.
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  112. Dana N, Todd RF, Colten HR, Arnaout MA. A dysfunctional Mo1 glycoprotein is present on a subline of the KG1 acute myelogenous leukemia cell line. J Immunol. 1987 May 15; 138(10):3549-54.
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  113. Dana N, Clayton LK, Tennen DG, Pierce MW, Lachmann PJ, Law SA, Arnaout MA. Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta-subunit precursor and beta-subunit messenger RNA. J Clin Invest. 1987 Mar; 79(3):1010-5.
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  114. Dimanche MT, Le Deist F, Fischer A, Arnaout MA, Griscelli C, Lisowska-Grospierre B. LFA-1 beta-chain synthesis and degradation in patients with leukocyte-adhesive proteins deficiency. Eur J Immunol. 1987 Mar; 17(3):417-9.
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  115. Arnaout MA, Pierce MW, Dana N, Clayton LK. Human complement receptor type 3. Methods Enzymol. 1987; 150:602-15.
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  116. Pierce MW, Remold-O'Donnell E, Todd RF, Arnaout MA. N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa. Biochim Biophys Acta. 1986 Dec 12; 874(3):368-71.
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  117. Dana N, Styrt B, Griffin JD, Todd RF, Klempner MS, Arnaout MA. Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies. J Immunol. 1986 Nov 15; 137(10):3259-63.
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  118. Arnaout MA, Wang EA, Clark SC, Sieff CA. Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes. J Clin Invest. 1986 Aug; 78(2):597-601.
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  119. Dana N, Todd RF, Arnaout MA. Mo1 surface glycoprotein: structure, function and clinical importance. Pathol Immunopathol Res. 1986; 5(3-5):371-83.
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  120. Dana N, Todd RF 3rd, Arnaout MA. Mo1 surface glycoprotein: structure, function and clinical importance. Pathol Immunopathol Res. 1986; 5:371-383.
  121. Lanier LL, Arnaout MA, Schwarting R, Warner NL, Ross GD. p150/95, Third member of the LFA-1/CR3 polypeptide family identified by anti-Leu M5 monoclonal antibody. Eur J Immunol. 1985 Jul; 15(7):713-8.
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  122. Arnaout MA, Dana N, Pitt J, Todd RF. Deficiency of two human leukocyte surface membrane glycoproteins (Mo1 and LFA-1). Fed Proc. 1985 Jul; 44(10):2664-70.
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  123. Todd RF, Roach JA, Arnaout MA. The modulated expression of Mo5, a human myelomonocytic plasma membrane antigen. Blood. 1985 Apr; 65(4):964-73.
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  124. Arnaout MA, Hakim RM, Todd RF, Dana N, Colten HR. Increased expression of an adhesion-promoting surface glycoprotein in the granulocytopenia of hemodialysis. N Engl J Med. 1985 Feb 21; 312(8):457-62.
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  125. Arnaout MA Hakim RM Todd, RF Dana, N Colten HR. The Granulocytopenia of Hemodialysis. N Engl J Med. 1985; 312:1578-1579.
  126. Arnaout MA, Spits H, Terhorst C, Pitt J, Todd RF. Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest. 1984 Oct; 74(4):1291-300.
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  127. Todd RF, Arnaout MA, Rosin RE, Crowley CA, Peters WA, Babior BM. Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion. J Clin Invest. 1984 Oct; 74(4):1280-90.
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  128. Anderson DC, Schmalstieg FC, Arnaout MA, Kohl S, Tosi MF, Dana N, Buffone GJ, Hughes BJ, Brinkley BR, Dickey WD, et al. Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): common relationship to diminished cell adherence. J Clin Invest. 1984 Aug; 74(2):536-51.
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  129. Goldberger G, Arnaout MA Aden D Kay R Rits M Colten HR. Biosynthesis and postsynthetic processing of human C3b/C4b inactivator (factor I) in three hepatoma cell lines. J Biol Chem. 1984; 259(10):6492-6497.
  130. Arnaout MA Colten HR. Complement C3 receptors: structure and function. Mol Immunol. 1984; 21:1191-1199.
  131. Dana N, Todd RF, Pitt J, Springer TA, Arnaout MA. Deficiency of a surface membrane glycoprotein (Mo1) in man. J Clin Invest. 1984 Jan; 73(1):153-9.
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  132. Melamed J, Medicus RG, Arnaout MA, Colten HR. Induction of granulocyte histaminase release by particle-bound complement C3 cleavage products (C3b, C3bi) and IgG. J Immunol. 1983 Jul; 131(1):439-44.
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  133. Arnaout MA, Todd RF, Dana N, Melamed J, Schlossman SF, Colten HR. Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest. 1983 Jul; 72(1):171-9.
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  134. Medicus RG, Melamed J, Arnaout MA. Role of human factor I and C3b receptor in the cleavage of surface-bound C3bi molecules. Eur J Immunol. 1983 Jun; 13(6):465-70.
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  135. Arnaout MA, Dana N, Melamed J, Medicus R, Colten HR. Low ionic strength or chemical cross-linking of monomeric C3b increases its binding affinity to the human complement C3b receptor. Immunology. 1983 Feb; 48(2):229-37.
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  136. Melamed J, Arnaout MA, Colten HR. Complement (C3b) interaction with the human granulocyte receptor: correlation of binding of fluid-phase radiolabeled ligand with histaminase release. J Immunol. 1982 May; 128(5):2313-8.
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  137. Arnaout MA, Pitt J, Cohen HJ, Melamed J, Rosen FS, Colten HR. Deficiency of a granulocyte-membrane glycoprotein (gp150) in a boy with recurrent bacterial infections. N Engl J Med. 1982 Mar 25; 306(12):693-9.
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  138. Pennington JE, Hickey WF, Blackwood LL, Arnaut MA. Active immunization with lipopolysaccharide Pseudomonas antigen for chronic Pseudomonas bronchopneumonia in guinea pigs. J Clin Invest. 1981 Nov; 68(5):1140-8.
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  139. Arnaout MA, Melamed J, Tack BF, Colten HR. Characterization of the human complement (c3b) receptor with a fluid phase C3b dimer. J Immunol. 1981 Oct; 127(4):1348-54.
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  140. Arnaout MA, Luscinskas FW, Lionetti FJ, Alper CA, Valeri CR. Alternative complement pathway-dependent ingestion of fluolite particles by human granulocytes. J Immunol. 1981 Jul; 127(1):278-81.
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  141. Arnaout MA, Stossel TP, Rosen FS, Alper CA. Solubilization of C3 fragments deposited on cross-linked dextran gel beads. Clin Immunol Immunopathol. 1979 Nov; 14(3):384-94.
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  142. Herman JJ, Rosner IK, Davis AE, Zeiger RS, Arnaout MA, Colten HR. Complement-dependent histaminase release from human granulocytes. J Clin Invest. 1979 Jun; 63(6):1195-202.
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  143. Arnaout MA, Davis AE, Rosen RS, Alper CA. Complement activation in semisolid media: insolubilization of alternative pathway convertases in agar gels with C3 nephritic factor-containing sera. J Immunol. 1977 Oct; 119(4):1316-20.
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  144. Davis AE, Arnaout MA, Alper CA, Rosen FS. Transfer of C3 nephritic factor from mother to fetus. Is C3 nephritic factor IgG? N Engl J Med. 1977 Jul 21; 297(3):144-5.
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  145. Frayha RA, Salti IS, Arnaout A, Khatchadurian A, Uthman SM. Hereditary xanthinuria: report on three patients and short review of the literature. Nephron. 1977; 19(6):328-32.
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  146. Arnaout MA Salti I. Phenytoin in benign insulinoma. Lancet. 1976; 7964:861.
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