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profileTao Lu, Ph.D.

TitleInstructor in Genetics
InstitutionHarvard Medical School
DepartmentGenetics
AddressHarvard Medical School
Pathology, NRB 858
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-6801
Fax617/432-6825
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lu T, Qian S, Meng F, Ning C, Liu X. Enhanced osteogenic activity of poly ether ether ketone using calcium plasma immersion ion implantation. Colloids Surf B Biointerfaces. 2016 Jun 1; 142:192-8. PMID: 26954085.
    View in: PubMed
  2. Cao H, Qin H, Zhao Y, Jin G, Lu T, Meng F, Zhang X, Liu X. Nano-thick calcium oxide armed titanium: boosts bone cells against methicillin-resistant Staphylococcus aureus. Sci Rep. 2016; 6:21761. PMID: 26899567.
    View in: PubMed
  3. Ouyang L, Zhao Y, Jin G, Lu T, Li J, Qiao Y, Ning C, Zhang X, Chu PK, Liu X. Influence of sulfur content on bone formation and antibacterial ability of sulfonated PEEK. Biomaterials. 2016 Mar; 83:115-26. PMID: 26773668.
    View in: PubMed
  4. Wang X, Lu T, Wen J, Xu L, Zeng D, Wu Q, Cao L, Lin S, Liu X, Jiang X. Selective responses of human gingival fibroblasts and bacteria on carbon fiber reinforced polyetheretherketone with multilevel nanostructured TiO2. Biomaterials. 2016 Mar; 83:207-18. PMID: 26774566.
    View in: PubMed
  5. Li C, Zhang YX, Yang C, Hao F, Chen SS, Hao Q, Lu T, Qu TY, Zhao LR, Duan WM. Intraventricular administration of endoneuraminidase-N facilitates ectopic migration of subventricular zone-derived neural progenitor cells into 6-OHDA lesioned striatum of mice. Exp Neurol. 2016 Mar; 277:139-49. PMID: 26724216.
    View in: PubMed
  6. Liu HC, Tang SZ, Lu S, Ran T, Wang J, Zhang YM, Xu AY, Lu T, Chen YD. Studies on [5,6]-Fused Bicyclic Scaffolds Derivatives as Potent Dual B-Raf(V600E)/KDR Inhibitors Using Docking and 3D-QSAR Approaches. Int J Mol Sci. 2015; 16(10):24451-74. PMID: 26501259; PMCID: PMC4632759.
  7. Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science. 2015 Sep 25; 349(6255):aaa5612. PMID: 26404840.
    View in: PubMed
  8. Lu T, Wen J, Qian S, Cao H, Ning C, Pan X, Jiang X, Liu X, Chu PK. Enhanced osteointegration on tantalum-implanted polyetheretherketone surface with bone-like elastic modulus. Biomaterials. 2015 May; 51:173-83. PMID: 25771008.
    View in: PubMed
  9. Chen SS, Yang C, Hao F, Li C, Lu T, Zhao LR, Duan WM. Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism. Exp Neurol. 2014 Nov; 261:87-96. PMID: 24997241.
    View in: PubMed
  10. Lu T, Liu X, Qian S, Cao H, Qiao Y, Mei Y, Chu PK, Ding C. Multilevel surface engineering of nanostructured TiO2 on carbon-fiber-reinforced polyetheretherketone. Biomaterials. 2014 Jul; 35(22):5731-40. PMID: 24767786.
    View in: PubMed
  11. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 Mar 27; 507(7493):448-54. PMID: 24670762; PMCID: PMC4110979.
  12. Wang H, Lu T, Meng F, Zhu H, Liu X. Enhanced osteoblast responses to poly ether ether ketone surface modified by water plasma immersion ion implantation. Colloids Surf B Biointerfaces. 2014 May 1; 117:89-97. PMID: 24632035.
    View in: PubMed
  13. Liu X, Lu T, Dou Y, Yu B, Zhang C. Identification of RNA silencing components in soybean and sorghum. BMC Bioinformatics. 2014; 15:4. PMID: 24387046; PMCID: PMC3882329.
  14. Wang ZQ, Yang Y, Lu T, Luo P, Li J, Wu JP, Tang ZZ, Lu QP, Duan QH. Protective effect of autophagy inhibition on ischemia-reperfusion-induced injury of N2a cells. J Huazhong Univ Sci Technolog Med Sci. 2013 Dec; 33(6):810-6. PMID: 24337840.
    View in: PubMed
  15. Zhou QF, Chu XP, Ge FF, Li C, Lu T. Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions. Mol Divers. 2013 Aug; 17(3):563-71. PMID: 23780558.
    View in: PubMed
  16. Li S, Xu Y, Shen Q, Liu X, Lu J, Chen Y, Lu T, Luo C, Luo X, Zheng M, Jiang H. Non-covalent interactions with aromatic rings: current understanding and implications for rational drug design. Curr Pharm Des. 2013; 19(36):6522-33. PMID: 23772607.
    View in: PubMed
  17. Cao H, Qiao Y, Liu X, Lu T, Cui T, Meng F, Chu PK. Electron storage mediated dark antibacterial action of bound silver nanoparticles: smaller is not always better. Acta Biomater. 2013 Feb; 9(2):5100-10. PMID: 23085265.
    View in: PubMed
  18. Lin Q, Wang L, Lin Y, Liu X, Ren X, Wen S, Du X, Lu T, Su SY, Yang X, Huang W, Zhou S, Wen F, Su SB. Toll-like receptor 3 ligand polyinosinic:polycytidylic acid promotes wound healing in human and murine skin. J Invest Dermatol. 2012 Aug; 132(8):2085-92. PMID: 22572822.
    View in: PubMed
  19. Lu T, Qiao Y, Liu X. Surface modification of biomaterials using plasma immersion ion implantation and deposition. Interface Focus. 2012 Jun 6; 2(3):325-36. PMID: 23741609; PMCID: PMC3363023.
  20. Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011 Dec 15; 480(7377):372-5. PMID: 22056987; PMCID: PMC3240702.
  21. Ran T, Lu T, Yuan H, Liu H, Wang J, Zhang W, Leng Y, Lin G, Zhuang S, Chen Y. A selectivity study on mTOR/PI3Ka inhibitors by homology modeling and 3D-QSAR. J Mol Model. 2012 Jan; 18(1):171-86. PMID: 21523553.
    View in: PubMed
  22. Yuan H, Lu T, Ran T, Liu H, Lu S, Tai W, Leng Y, Zhang W, Wang J, Chen Y. Novel strategy for three-dimensional fragment-based lead discovery. J Chem Inf Model. 2011 Apr 25; 51(4):959-74. PMID: 21438547.
    View in: PubMed
  23. Xia Y, Cheng S, He J, Liu X, Tang Y, Yuan H, He L, Lu T, Tu B, Wang Y. Effects of subchronic exposure to benzo[a]pyrene (B[a]P) on learning and memory, and neurotransmitters in male Sprague-Dawley rat. Neurotoxicology. 2011 Mar; 32(2):188-98. PMID: 21216261.
    View in: PubMed
  24. Lin G, Wang Y, Zhou Q, Tang W, Wang J, Lu T. A facile synthesis of 3-substituted 9H-pyrido[3,4-b]indol-1(2H)-one derivatives from 3-substituted beta-carbolines. Molecules. 2010 Aug; 15(8):5680-91. PMID: 20717074.
    View in: PubMed
  25. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14164-9. PMID: 20660724; PMCID: PMC2922576.
  26. Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell. 2010 May 28; 38(4):500-11. PMID: 20513426; PMCID: PMC2888511.
  27. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature. 2010 Mar 25; 464(7288):529-35. PMID: 20336135; PMCID: PMC2927852.
  28. Han X, Dorsey-Oresto A, Malik M, Wang JY, Drlica K, Zhao X, Lu T. Escherichia coli genes that reduce the lethal effects of stress. BMC Microbiol. 2010; 10:35. PMID: 20128927; PMCID: PMC2824699.
  29. Yankner BA, Lu T. Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem. 2009 Feb 20; 284(8):4755-9. PMID: 18957434; PMCID: PMC2643502.
  30. Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PLoS One. 2008; 3(10):e3329. PMID: 18830410; PMCID: PMC2553198.
  31. Yankner BA, Lu T, Loerch P. The aging brain. Annu Rev Pathol. 2008; 3:41-66. PMID: 18039130.
    View in: PubMed
  32. Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell. 2006 Aug 4; 23(3):331-41. PMID: 16885023.
    View in: PubMed
  33. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem. 2006 May 19; 281(20):14474-85. PMID: 16522639.
    View in: PubMed
  34. Chen G, Zhu Y, Wang Y, Xu X, Lu T. Determination of bioactive constituents in traditional Chinese medicines by CE with electrochemical detection. Curr Med Chem. 2006; 13(21):2467-85. PMID: 17017905.
    View in: PubMed
  35. Kandel ES, Lu T, Wan Y, Agarwal MK, Jackson MW, Stark GR. Mutagenesis by reversible promoter insertion to study the activation of NF-kappaB. Proc Natl Acad Sci U S A. 2005 May 3; 102(18):6425-30. PMID: 15851657; PMCID: PMC1088393.
  36. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the ageing human brain. Nature. 2004 Jun 24; 429(6994):883-91. PMID: 15190254.
    View in: PubMed
  37. Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem. 2003 Apr 25; 278(17):14971-7. PMID: 12578828.
    View in: PubMed
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