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Farouc Amin Jaffer, Ph.D., M.D.

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Overview
Our laboratory employes optical and MRI molecular imaging methods to investigate vascular biology. We utilize small and large animal models of atherosclerosis and have developed new clinical-type coronary catheters for intravascular molecular imaging.

Mentoring
Local inflammation imaging to predict plaque rupture
Summer, 06/20/11 - 08/12/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R41HL140671 (JAFFER, FAROUC) May 15, 2018 - Apr 30, 2019
    NIH/NHLBI
    Intravascular molecular-structural NIRF-IVUS imaging of coronary artery disease
    Role: Principal Investigator
  2. R01HL137913 (JAFFER, FAROUC) Jul 15, 2017 - May 31, 2021
    NIH/NHLBI
    Novel PET/CT and Treatment Strategies to reduce PTS following DVT
    Role: Principal Investigator
  3. R01HL122388 (JAFFER, FAROUC) Nov 14, 2014 - Nov 30, 2018
    NIH/NHLBI
    NIRF-OFDI of Inflammation in Atheroma Progression and Stent Complications
    Role: Principal Investigator
  4. R01HL108229 (JAFFER, FAROUC) Jul 15, 2010 - Apr 30, 2015
    NIH/NHLBI
    Intravascular Fluorescence Molecular Imaging of Inflammation in Atherosclerosis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Xenogiannis I, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Choi JW, Burke MN, Doing AH, Dattilo P, Toma C, Smith AJC, Uretsky B, Krestyaninov O, Khelimskii D, Holper E, Potluri S, Wyman RM, Kandzari DE, Garcia S, Koutouzis M, Tsiafoutis I, Jaber W, Samady H, Moses JW, Lembo NJ, Parikh M, Kirtane AJ, Ali ZA, Doshi D, Tajti P, Rangan BV, Abdullah S, Banerjee S, Brilakis ES. Comparison Between Traditional and Guide-Catheter Extension Reverse Controlled Antegrade Dissection and Retrograde Tracking: Insights From the PROGRESS-CTO Registry. J Invasive Cardiol. 2018 Nov 11. PMID: 30418166.
    View in: PubMed
  2. Tajti P, Xenogiannis I, Karmpaliotis D, Alaswad K, Jaffer FA, Nicholas Burke M, Ungi I, Brilakis ES. Chronic Total Occlusion Interventions: Update on Current Tips and Tricks. Curr Cardiol Rep. 2018 Oct 22; 20(12):141. PMID: 30350111.
    View in: PubMed
  3. Jaffer FA, Hara T. PET/MR Illumination of Atherosclerosis Pathobiology: How a Nanobody Becomes Somebody. JACC Cardiovasc Imaging. 2018 Oct 12. PMID: 30343084.
    View in: PubMed
  4. Tajti P, Karatasakis A, Danek BA, Alaswad K, Karmpaliotis D, Jaffer FA, Choi JW, Yeh RW, Patel M, Mahmud E, Burke MN, Krestyaninov O, Khelimskii D, Toma C, Doing AH, Uretsky B, Koutouzis M, Tsiafoutis I, Wyman RM, Garcia S, Holper E, Xenogiannis I, Rangan BV, Banerjee S, Ungi I, Brilakis ES. In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. J Invasive Cardiol. 2018 Nov; 30(11):E113-E121. PMID: 30218557.
    View in: PubMed
  5. Min JK, Jaffer FA. A New Decade of Old Questions: Steps Toward Demonstrating the Efficacy of Physiologic CAD Evaluation by CT. JACC Cardiovasc Imaging. 2018 Sep 06. PMID: 30219399.
    View in: PubMed
  6. Tajti P, Burke MN, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Choi JW, Doing AH, Datilo P, Toma C, Smith AJC, Uretsky B, Holper E, Garcia S, Krestyaninov O, Khelimskii D, Koutouzis M, Tsiafoutis I, Moses JW, Lembo NJ, Parikh M, Kirtane AJ, Ali ZA, Doshi D, Jaber W, Samady H, Rangan BV, Xenogiannis I, Ungi I, Banerjee S, Brilakis ES. Prevalence and Outcomes of Percutaneous Coronary Interventions for Ostial Chronic Total Occlusions: Insights From a Multicenter Chronic Total Occlusion Registry. Can J Cardiol. 2018 Oct; 34(10):1264-1274. PMID: 30269827.
    View in: PubMed
  7. Jaffer FA, Chandrashekhar Y. Ruptures and Thickening: Optical Coherence Tomography as the Arbiter of the Fibrous Cap. JACC Cardiovasc Imaging. 2018 Jun; 11(6):933-934. PMID: 29880116.
    View in: PubMed
  8. Tajti P, Alaswad K, Karmpaliotis D, Jaffer FA, Yeh RW, Patel M, Mahmud E, Choi JW, Burke MN, Doing AH, Toma C, Uretsky B, Holper E, Wyman RM, Kandzari DE, Garcia S, Krestyaninov O, Khelimskii D, Koutouzis M, Tsiafoutis I, Jaber W, Samady H, Moses JW, Lembo NJ, Parikh M, Kirtane AJ, Ali ZA, Doshi D, Xenogiannis I, Rangan BV, Ungi I, Banerjee S, Brilakis ES. In-hospital Outcomes of Attempting More Than One Chronic Total Coronary Occlusion Through Percutaneous Intervention During the Same Procedure. Am J Cardiol. 2018 Aug 01; 122(3):381-387. PMID: 30201106.
    View in: PubMed
  9. Tajti P, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Choi JW, Burke MN, Doing AH, Dattilo P, Toma C, Smith AJC, Uretsky B, Holper E, Wyman RM, Kandzari DE, Garcia S, Krestyaninov O, Khelimskii D, Koutouzis M, Tsiafoutis I, Moses JW, Lembo NJ, Parikh M, Kirtane AJ, Ali ZA, Doshi D, Rangan BV, Ungi I, Banerjee S, Brilakis ES. The Hybrid Approach to Chronic Total Occlusion Percutaneous Coronary Intervention: Update From the PROGRESS CTO Registry. JACC Cardiovasc Interv. 2018 Jul 23; 11(14):1325-1335. PMID: 29706508.
    View in: PubMed
  10. Lino Cardenas CL, Kessinger CW, MacDonald C, Jassar AS, Isselbacher EM, Jaffer FA, Lindsay ME. Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm. JCI Insight. 2018 Mar 08; 3(5). PMID: 29515022.
    View in: PubMed
  11. Lino Cardenas CL, Kessinger CW, Cheng Y, MacDonald C, MacGillivray T, Ghoshhajra B, Huleihel L, Nuri S, Yeri AS, Jaffer FA, Kaminski N, Ellinor P, Weintraub NL, Malhotra R, Isselbacher EM, Lindsay ME. An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nat Commun. 2018 03 08; 9(1):1009. PMID: 29520069.
    View in: PubMed
  12. Albaghdadi M, Jaffer FA. Wire-Free and Adenosine-Free Fractional Flow Reserve Derived From the Angiogram: A Promising Future Awaiting Outcomes Data. Circ Cardiovasc Imaging. 2018 Mar; 11(3):e007594. PMID: 29555837.
    View in: PubMed
  13. Danek BA, Basir MB, O'Neill WW, Alqarqaz M, Karatasakis A, Karmpaliotis D, Jaffer FA, Yeh RW, Wyman M, Lombardi WL, Kandzari D, Lembo N, Doing A, Patel M, Mahmud E, Choi JW, Toma C, Moses JW, Kirtane A, Parikh M, Ali ZA, Garcia S, Karacsonyi J, Rangan BV, Thompson CA, Banerjee S, Brilakis ES, Alaswad K. Mechanical Circulatory Support in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Multicenter U.S. Registry. J Invasive Cardiol. 2018 03; 30(3):81-87. PMID: 29493509.
    View in: PubMed
  14. Karacsonyi J, Tajti P, Rangan BV, Halligan SC, Allen RH, Nicholson WJ, Harvey JE, Spaedy AJ, Jaffer FA, Grantham JA, Salisbury A, Hart AJ, Safley DM, Lombardi WL, Hira R, Don C, McCabe JM, Burke MN, Alaswad K, Koenig GC, Sanghvi KA, Ice D, Kovach RC, Varghese V, Murad B, Baran KW, Resendes E, Martinez-Parachini JR, Karatasakis A, Danek BA, Iwnetu R, Roesle M, Khalili H, Banerjee S, Brilakis ES. Randomized Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusions: The CrossBoss First Trial. JACC Cardiovasc Interv. 2018 Feb 12; 11(3):225-233. PMID: 29413236.
    View in: PubMed
  15. Tajti P, Karmpaliotis D, Alaswad K, Toma C, Choi JW, Jaffer FA, Doing AH, Patel M, Mahmud E, Uretsky B, Karatasakis A, Karacsonyi J, Danek BA, Rangan BV, Banerjee S, Ungi I, Brilakis ES. Prevalence, Presentation and Treatment of 'Balloon Undilatable' Chronic Total Occlusions: Insights from a Multicenter US Registry. Catheter Cardiovasc Interv. 2018 Mar 01; 91(4):657-666. PMID: 29359452.
    View in: PubMed
  16. Tawakol A, Jaffer F. Imaging the Intersection of Oxidative Stress, Lipids, and Inflammation: Progress Toward Personalized Care of Atherosclerosis. J Am Coll Cardiol. 2018 Jan 23; 71(3):336-338. PMID: 29348026.
    View in: PubMed
  17. Tajti P, Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Choi JW, Doing AH, Toma C, Uretsky B, Garcia S, Moses JW, Parikh M, Kirtane A, Ali ZA, Hatem R, Karacsonyi J, Danek BA, Rangan BV, Banerjee S, Ungi I, Brilakis ES. Retrograde CTO-PCI of Native Coronary Arteries Via Left Internal Mammary Artery Grafts: Insights From a Multicenter U.S. Registry. J Invasive Cardiol. 2018 03; 30(3):89-96. PMID: 29138364.
    View in: PubMed
  18. Bozhko D, Osborn EA, Rosenthal A, Verjans JW, Hara T, Kellnberger S, Wissmeyer G, Ovsepian SV, McCarthy JR, Mauskapf A, Stein AF, Jaffer FA, Ntziachristos V. Quantitative intravascular biological fluorescence-ultrasound imaging of coronary and peripheral arteries in vivo. Eur Heart J Cardiovasc Imaging. 2017 Nov 01; 18(11):1253-1261. PMID: 28031233.
    View in: PubMed
  19. Patel SM, Menon RV, Burke MN, Jaffer FA, Yeh RW, Vo M, Karmpaliotis D, Azzalini L, Carlino M, Mashayekhi K, Galassi AR, Rinfret S, Ellis SG, Patel M, Rangan BV, Karatasakis A, Danek BA, Karacsonyi J, Resendes E, Banerjee S, Brilakis ES. Current Perspectives and Practices on Chronic Total Occlusion Percutaneous Coronary Interventions. J Invasive Cardiol. 2018 02; 30(2):43-50. PMID: 29035846.
    View in: PubMed
  20. Secemsky EA, Gallagher R, Harkness J, Pomerantsev E, Gewirtz H, Jaffer FA, Yeh RW. Target Vessel Revascularization and Territory of Myocardial Ischemia in Patients With Chronic Total Occlusions. J Am Coll Cardiol. 2017 Aug 29; 70(9):1196-1197. PMID: 28838371.
    View in: PubMed
  21. Danek BA, Karatasakis A, Tajti P, Sandoval Y, Karmpaliotis D, Alaswad K, Jaffer F, Yeh RW, Kandzari DE, Lembo NJ, Patel MP, Mahmud E, Choi JW, Doing AH, Lombardi WL, Wyman RM, Toma C, Garcia S, Moses JW, Kirtane AJ, Hatem R, Ali ZA, Parikh M, Karacsonyi J, Rangan BV, Khalili H, Burke MN, Banerjee S, Brilakis ES. Incidence, Treatment, and Outcomes of Coronary Perforation During Chronic Total Occlusion Percutaneous Coronary Intervention. Am J Cardiol. 2017 Oct 15; 120(8):1285-1292. PMID: 28826896.
    View in: PubMed
  22. Wang Y, Gao H, Kessinger CW, Schmaier A, Jaffer FA, Simon DI. Myeloid-related protein-14 regulates deep vein thrombosis. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570273.
    View in: PubMed
  23. Karacsonyi J, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Doing A, Toma C, Uretsky B, Choi J, Moses JW, Kirtane A, Parikh M, Ali Z, Lombardi WL, Kandzari DE, Lembo N, Garcia S, Wyman MR, Martinez-Parachini JR, Karatasakis A, Danek BA, Alame AJ, Resendes E, Rangan BV, Ungi I, Thompson CA, Banerjee S, Brilakis ES. The Impact of Proximal Vessel Tortuosity on the Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Contemporary Multicenter Registry. J Invasive Cardiol. 2017 Aug; 29(8):264-270. PMID: 28570257.
    View in: PubMed
  24. Stein-Merlob AF, Hara T, McCarthy JR, Mauskapf A, Hamilton JA, Ntziachristos V, Libby P, Jaffer FA. Atheroma Susceptible to Thrombosis Exhibit Impaired Endothelial Permeability In Vivo as Assessed by Nanoparticle-Based Fluorescence Molecular Imaging. Circ Cardiovasc Imaging. 2017 May; 10(5). PMID: 28487316.
    View in: PubMed
  25. Calfon Press MA, Mallas G, Rosenthal A, Hara T, Mauskapf A, Nudelman RN, Sheehy A, Polyakov IV, Kolodgie F, Virmani R, Guerrero JL, Ntziachristos V, Jaffer FA. Everolimus-eluting stents stabilize plaque inflammation in vivo: assessment by intravascular fluorescence molecular imaging. Eur Heart J Cardiovasc Imaging. 2017 May 01; 18(5):510-518. PMID: 28039209.
    View in: PubMed
  26. Osborn EA, Kessinger CW, Tawakol A, Jaffer FA. Metabolic and Molecular Imaging of Atherosclerosis and Venous Thromboembolism. J Nucl Med. 2017 Jun; 58(6):871-877. PMID: 28450558.
    View in: PubMed
  27. Karacsonyi J, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Lombardi W, Wyman MR, Doing A, Moses JW, Kirtane A, Parikh M, Ali Z, Kandzari D, Lembo N, Garcia S, Danek BA, Karatasakis A, Resendes E, Kalsaria P, Rangan BV, Ungi I, Thompson CA, Banerjee S, Brilakis ES. Impact of Calcium on Chronic Total Occlusion Percutaneous Coronary Interventions. Am J Cardiol. 2017 07 01; 120(1):40-46. PMID: 28499595.
    View in: PubMed
  28. Lu MT, Ferencik M, Roberts RS, Lee KL, Ivanov A, Adami E, Mark DB, Jaffer FA, Leipsic JA, Douglas PS, Hoffmann U. Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial. JACC Cardiovasc Imaging. 2017 Nov; 10(11):1350-1358. PMID: 28412436.
    View in: PubMed
  29. Okai I, Iwata H, Osborn EA, Fukuda K, Shiozaki M, Kimura Y, Chikata Y, Inoue K, Fujiwara Y, Jaffer FA, Daida H, Sumiyoshi M. Sequential Acute Coronary Syndrome 4 Days Apart: A Missed Opportunity? Circ J. 2017 Jul 25; 81(8):1231-1233. PMID: 28190858.
    View in: PubMed
  30. Bourantas CV, Jaffer FA, Gijsen FJ, van Soest G, Madden SP, Courtney BK, Fard AM, Tenekecioglu E, Zeng Y, van der Steen AFW, Emelianov S, Muller J, Stone PH, Marcu L, Tearney GJ, Serruys PW. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology. Eur Heart J. 2017 02 07; 38(6):400-412. PMID: 27118197.
    View in: PubMed
  31. Chowdhury MM, Tawakol A, Jaffer FA. Molecular Imaging of Atherosclerosis: A Clinical Focus. Curr Cardiovasc Imaging Rep. 2017 Jan; 10(1). PMID: 29861824.
    View in: PubMed
  32. Karatasakis A, Iwnetu R, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Kandzari DE, Lembo NJ, Patel M, Mahmud E, Lombardi WL, Wyman RM, Grantham JA, Doing AH, Toma C, Choi JW, Uretsky BF, Moses JW, Kirtane AJ, Ali ZA, Parikh M, Karacsonyi J, Rangan BV, Thompson CA, Banerjee S, Brilakis ES. The Impact of Age and Sex on In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention. J Invasive Cardiol. 2017 Apr; 29(4):116-122. PMID: 28089997.
    View in: PubMed
  33. Obi AT, Andraska E, Kanthi Y, Kessinger CW, Elfline M, Luke C, Siahaan TJ, Jaffer FA, Wakefield TW, Henke PK. Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb Haemost. 2017 01 26; 117(2):339-348. PMID: 27975098.
    View in: PubMed
  34. Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel MP, Bahadorani JN, Lombardi WL, Wyman RM, Grantham JA, Kandzari DE, Lembo NJ, Doing AH, Toma C, Moses JW, Kirtane AJ, Ali Z, Parikh M, Garcia S, Danek BA, Karacsonyi J, Alame A, Kalsaria P, Thompson C, Banerjee S, Brilakis ES. Approaches to percutaneous coronary intervention of right coronary artery chronic total occlusions: insights from a multicentre US registry. EuroIntervention. 2016 Dec 10; 12(11):e1326-e1335. PMID: 27934609.
    View in: PubMed
  35. Christakopoulos GE, Christopoulos G, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman MR, Lombardi WL, Tarar MN, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh M, Green P, Finn M, Garcia S, Doing AH, Hatem R, Thompson CA, Banerjee S, Brilakis ES. Predictors of Excess Patient Radiation Exposure During Chronic Total Occlusion Coronary Intervention: Insights From a Contemporary Multicentre Registry. Can J Cardiol. 2017 04; 33(4):478-484. PMID: 28169091.
    View in: PubMed
  36. Garcia S, Alraies MC, Karatasakis A, Yannopoulos D, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel MP, Bahadorani J, Karacsonyi J, Kalsaria P, Danek B, Banerjee S, Brilakis ES. Coronary artery spatial distribution of chronic total occlusions: Insights from a large US registry. Catheter Cardiovasc Interv. 2017 Jul; 90(1):23-30. PMID: 27860111.
    View in: PubMed
  37. Martinez-Parachini JR, Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Bahadorani J, Doing A, Nguyen-Trong PK, Danek BA, Karacsonyi J, Alame A, Rangan BV, Thompson CA, Banerjee S, Brilakis ES. Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions: insights from a US multicentre registry. Diabet Med. 2017 04; 34(4):558-562. PMID: 27743404.
    View in: PubMed
  38. Patel S, Menon R, Burke MN, Jaffer FA, Yeh R, Vo M, Karmpaliotis D, Azzalini L, Carlino M, Mashayekhi K, Galassi A, Rinfret S, Ellis S, Patel M, Rangan B, Karatasakis A, Danek BA, Karacsonyi J, Resendes E, Banerjee S, Brilakis E. TCT-287 Current Perspectives and Practices on Chronic Total Occlusion Percutaneous Coronary Interventions. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B118. PMID: 27969630.
    View in: PubMed
  39. Jaffer F, Grantham JA, Sapontis J, Spertus J, Gosch K, Jones P, Bruckel J, Lombardi W, Yeh R. TCT-284 Interrelationship between depression, angina, and dyspnea before and after CTO PCI in the OPEN CTO Registry. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B116-B117. PMID: 27969626.
    View in: PubMed
  40. Karatasakis A, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh R, Kandzari D, Lembo N, Patel M, Bahadorani J, Lombardi W, Wyman RM, Grantham JA, Doing A, Toma C, Choi J, Uretsky B, Garcia S, Moses J, Kirtane A, Ali Z, Parikh M, Karacsonyi J, Rangan B, Thompson C, Banerjee S, Brilakis E. TCT-278 Application and Outcomes of the Hybrid Approach to Chronic Total Occlusion Percutaneous Coronary Intervention: an Update from a Contemporary Multicenter US Registry. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B113-B114. PMID: 27969620.
    View in: PubMed
  41. Toma C, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh R, Jaffer F, Kandzari D, Lembo N, Lombardi W, Grantham JA, Wyman RM, Doing A, Patel M, Bahadorani J, Moses J, Kirtane A, Ali Z, Danek BA, Karacsonyi J, Rangan B, Banerjee S, Brilakis E. TCT-273 Predictors of successful Stingray-assisted antegrade dissection reentry: data from the Progress CTO registry. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B111-B112. PMID: 27969614.
    View in: PubMed
  42. Gallagher R, Harkness J, Pomerantsev E, Jaffer F, Yeh R. TCT-294 Discordance Between Territory of Ischemia and Target Vessel in Patients with Chronic Total Occlusions. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B121. PMID: 27969639.
    View in: PubMed
  43. Alame A, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Wyman RM, Patel M, Bahadorani J, Lombardi W, Grantham JA, Kandzari D, Lembo N, Moses J, Kirtane A, Toma C, Doing A, Choi J, Uretsky B, Karacsonyi J, Resendes E, Nguyen-Trong PK, Martinez-Parachini JR, Karatasakis A, Danek BA, Rangan B, Thompson C, Banerjee S, Brilakis E. TCT-301 Outcomes of Percutaneous Coronary Intervention in Chronic Total Occlusions Caused by In-Stent Restenosis: Insights from a U.S. Multicenter Registry. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B123-B124. PMID: 27969644.
    View in: PubMed
  44. Alraies MC, Yannopoulos D, Karatasakis A, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh R, Patel M, Bahadorani J, Karacsonyi J, Alame A, Banerjee S, Brilakis E, Garcia S. TCT-286 Coronary Artery Spatial Distribution of Chronic Total Occlusions: Insights from a large US Registry. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B117-B118. PMID: 27969627.
    View in: PubMed
  45. Resendes E, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Wyman RM, Patel M, Bahadorani J, Lombardi W, Grantham JA, Kandzari D, Lembo N, Moses J, Kirtane A, Toma C, Doing A, Choi J, Uretsky B, Alame A, Karacsonyi J, Danek BA, Smith M, Karatasakis A, Rangan B, Banerjee S, Brilakis E. TCT-308 Impact of Race and Ethnicity on Technical and In-Hospital Outcomes Following Chronic Total Occlusions Percutaneous Coronary Intervention. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B126-B127. PMID: 27969651.
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  46. Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh R, Jaffer F, Patel M, Bahadorani J, Lombardi W, Wyman RM, Grantham JA, Doing A, Kandzari D, Lembo N, Garcia S, Toma C, Moses J, Kirtane A, Parikh M, Ali Z, Karacsonyi J, Alame A, Nguyen-Trong PK, Martinez-Parachini JR, Kalsaria P, Rangan B, Thompson C, Banerjee S, Brilakis E. TCT-281 Development and Validation of a Scoring System for Predicting Major Adverse Cardiovascular Events during Percutaneous Coronary Interventions of Chronic Total Occlusions: The PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) MACE Score. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B115-B116. PMID: 27969623.
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  47. Karatasakis A, Danek BA, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Patel M, Bahadorani J, Lombardi W, Wyman RM, Grantham JA, Kandzari D, Lembo N, Doing A, Toma C, Moses J, Kirtane A, Parikh M, Ali Z, Garcia S, Kalsaria P, Karacsonyi J, Alame A, Thompson C, Banerjee S, Brilakis E. TCT-289 Comparison of Various Scores for Predicting Success and Efficiency of Chronic Total Occlusion Percutaneous Coronary Intervention. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B119. PMID: 27969631.
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  48. Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh R, Jaffer F, Patel M, Bahadorani J, Lombardi W, Wyman RM, Grantham JA, Doing A, Kandzari D, Lembo N, Garcia S, Toma C, Moses J, Kirtane A, Parikh M, Ali Z, Karacsonyi J, Alame A, Nguyen-Trong PK, Martinez-Parachini JR, Kalsaria P, Rangan B, Thompson C, Banerjee S, Brilakis E. TCT-15 Use of Antegrade Dissection Re-entry in Coronary Chronic Total Occlusion Percutaneous Coronary Intervention in a Contemporary Multicenter Registry. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B6-B7. PMID: 27970311.
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  49. Karacsonyi J, Alaswad K, Jaffer F, Yeh R, Patel M, Bahadorani J, Danek BA, Karatasakis A, Doing A, Grantham JA, Karmpaliotis D, Moses J, Kirtane A, Parikh M, Ali Z, Lombardi W, Kandzari D, Lembo N, Garcia S, Wyman RM, Alame A, Martinez-Parachini JR, Nguyen-Trong PK, Resendes E, Kalsaria P, Rangan B, Ungi I, Thompson C, Banerjee S, Brilakis E. TCT-572 Use of Intravascular Imaging During Chronic Total Occlusion Percutaneous Coronary Intervention: Insights from a Contemporary Multicenter Registry. J Am Coll Cardiol. 2016 Nov 01; 68(18S):B231. PMID: 27969943.
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  50. Obi AT, Andraska E, Kanthi Y, Luke CE, Elfline M, Madathilparambil S, Siahaan TJ, Jaffer FA, Wakefield TW, Raghavendran K, Henke PK. Gram-Negative Pneumonia Alters Large-Vein Cell-Adhesion Molecule Profile and Potentiates Experimental Stasis Venous Thrombosis. J Vasc Res. 2016; 53(3-4):186-195. PMID: 27771726.
    View in: PubMed
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  125. Sabatine MS, Jaffer FA, Staats PN, Stone JR. Case records of the Massachusetts General Hospital. Case 28-2010. A 32-year-old woman, 3 weeks post partum, with substernal chest pain. N Engl J Med. 2010 Sep 16; 363(12):1164-73. PMID: 20843252.
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  126. Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA. Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1933-9. PMID: 20689078; PMCID: PMC3030475.
  127. Razansky RN, Rosenthal A, Mallas G, Razansky D, Jaffer FA, Ntziachristos V. Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo. Opt Express. 2010 May 24; 18(11):11372-81. PMID: 20588998.
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  128. Subramanian S, Jaffer FA, Tawakol A. Optical molecular imaging in atherosclerosis. J Nucl Cardiol. 2010 Jan-Feb; 17(1):135-44. PMID: 20039152.
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  129. Calfon MA, Vinegoni C, Ntziachristos V, Jaffer FA. Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques. J Biomed Opt. 2010 Jan-Feb; 15(1):011107. PMID: 20210433; PMCID: PMC3188610.
  130. Ladapo JA, Jaffer FA, Hoffmann U, Thomson CC, Bamberg F, Dec W, Cutler DM, Weinstein MC, Gazelle GS. Clinical outcomes and cost-effectiveness of coronary computed tomography angiography in the evaluation of patients with chest pain. J Am Coll Cardiol. 2009 Dec 15; 54(25):2409-22. PMID: 20082932.
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  131. Jaffer FA. Assessing niacin as an atherosclerosis therapeutic agent valuable insights provided by high-resolution vascular magnetic resonance imaging. J Am Coll Cardiol. 2009 Nov 03; 54(19):1795-6. PMID: 19874993.
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  132. McCarthy JR, Patel P, Botnaru I, Haghayeghi P, Weissleder R, Jaffer FA. Multimodal nanoagents for the detection of intravascular thrombi. Bioconjug Chem. 2009 Jun; 20(6):1251-5. PMID: 19456115; PMCID: PMC2733224.
  133. Jaffer FA, Libby P, Weissleder R. Optical and multimodality molecular imaging: insights into atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1017-24. PMID: 19359659; PMCID: PMC2733228.
  134. Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009 Apr 07; 119(13):1785-94. PMID: 19307473; PMCID: PMC2717745.
  135. Osborn EA, Jaffer FA. The year in molecular imaging. JACC Cardiovasc Imaging. 2009 Jan; 2(1):97-113. PMID: 19356541; PMCID: PMC4802868.
  136. Osborn EA, Jaffer FA. Advances in molecular imaging of atherosclerotic vascular disease. Curr Opin Cardiol. 2008 Nov; 23(6):620-8. PMID: 18830079; PMCID: PMC3984946.
  137. Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R. Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation. 2008 Oct 28; 118(18):1802-9. PMID: 18852366; PMCID: PMC2729441.
  138. Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE. Noninvasive imaging of apoptosis in cardiovascular disease. Heart Fail Rev. 2008 Jun; 13(2):163-73. PMID: 18074226; PMCID: PMC2597223.
  139. Chang K, Jaffer F. Advances in fluorescence imaging of the cardiovascular system. J Nucl Cardiol. 2008 May-Jun; 15(3):417-28. PMID: 18513648.
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  140. Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne SW, Blankesteijn WM, Sosnovik DE, Jaffer FA, Tung CH, Weissleder R. Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction. Eur Heart J. 2008 Feb; 29(4):445-54. PMID: 18276618.
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  141. Hahn JO, Asada HH, Reisner AT, Jaffer FA. A new approach to reconstruction of central aortic blood pressure using 'adaptive' transfer function. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:813-6. PMID: 19162781.
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  142. Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation. 2007 Dec 11; 116(24):2841-50. PMID: 18040026.
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  143. Jaffer FA, Libby P, Weissleder R. Molecular imaging of cardiovascular disease. Circulation. 2007 Aug 28; 116(9):1052-61. PMID: 17724271.
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  144. Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R. Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation. 2007 May 01; 115(17):2292-8. PMID: 17420353.
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  145. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007 Jan 23; 115(3):377-86. PMID: 17224478.
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  146. Kathiresan S, Larson MG, Keyes MJ, Polak JF, Wolf PA, D'Agostino RB, Jaffer FA, Clouse ME, Levy D, Manning WJ, O'Donnell CJ. Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata. Am J Cardiol. 2007 Feb 01; 99(3):310-4. PMID: 17261388.
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  147. Johnson PA, Jaffer FA, Neilan TG, Shepard JA, Stone JR. Case records of the Massachusetts General Hospital. Case 34-2006. A 72-year-old woman with nausea followed by hypotension and respiratory failure. N Engl J Med. 2006 Nov 09; 355(19):2022-31. PMID: 17093254.
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  148. Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R. Molecular imaging of myocardial infarction. J Mol Cell Cardiol. 2006 Dec; 41(6):921-33. PMID: 17067633.
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  149. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 2006 Oct 03; 114(14):1504-11. PMID: 17000904.
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  150. McCarthy JR, Jaffer FA, Weissleder R. A macrophage-targeted theranostic nanoparticle for biomedical applications. Small. 2006 Aug; 2(8-9):983-7. PMID: 17193154.
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  151. Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10340-10345. PMID: 16801531.
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  152. Jaffer FA, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R. Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials. Mol Imaging. 2006 Apr-Jun; 5(2):85-92. PMID: 16954022.
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  153. Jaffer FA, Libby P, Weissleder R. Molecular and cellular imaging of atherosclerosis: emerging applications. J Am Coll Cardiol. 2006 Apr 04; 47(7):1328-38. PMID: 16580517.
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  154. Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA. Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy. J Biomed Opt. 2006 Mar-Apr; 11(2):021009. PMID: 16674184.
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  155. Nahrendorf M, Hu K, Frantz S, Jaffer FA, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlöhner S, Novikov M, Dickneite G, Reed GL, Jakob P, Rosenzweig A, Bauer WR, Weissleder R, Ertl G. Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction. Circulation. 2006 Mar 07; 113(9):1196-202. PMID: 16505171; PMCID: PMC4066325.
  156. Carrillo-Jimenez R, Houser SL, Jaffer FA. Images in cardiovascular medicine. Culprit lesion atherothrombectomy during acute myocardial infarction: extraction of an acute coronary plaque rupture. Circulation. 2005 Oct 18; 112(16):e267. PMID: 16230488.
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  157. Jaffer FA, Weissleder R. Molecular imaging in the clinical arena. JAMA. 2005 Feb 16; 293(7):855-62. PMID: 15713776.
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  158. Kim DE, Schellingerhout D, Jaffer FA, Weissleder R, Tung CH. Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis. J Cereb Blood Flow Metab. 2005 Feb; 25(2):226-33. PMID: 15678125.
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  159. Tung CH, Quinti L, Jaffer FA, Weissleder R. A branched fluorescent peptide probe for imaging of activated platelets. Mol Pharm. 2005 Jan-Feb; 2(1):92-5. PMID: 15804182.
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  160. Jaffer FA, Tung CH, Wykrzykowska JJ, Ho NH, Houng AK, Reed GL, Weissleder R. Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi. Circulation. 2004 Jul 13; 110(2):170-6. PMID: 15210587.
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  161. Jaffer FA, Weissleder R. Seeing within: molecular imaging of the cardiovascular system. Circ Res. 2004 Mar 05; 94(4):433-45. PMID: 15001542.
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  162. Tung CH, Ho NH, Zeng Q, Tang Y, Jaffer FA, Reed GL, Weissleder R. Novel factor XIII probes for blood coagulation imaging. Chembiochem. 2003 Sep 05; 4(9):897-9. PMID: 12964167.
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  163. Becker R, Butenas S, Carr M, Jaffer F, Kleiman NS, Marmur JD, Schneider DJ, Spiess BD, Steinhubl SR, Weitz JI. Bivalirudin, thrombin and platelets: clinical implications and future directions. J Invasive Cardiol. 2003 Aug; Suppl:2-15. PMID: 23570139.
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  164. Jaffer FA, Tung CH, Gerszten RE, Weissleder R. In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol. 2002 Nov 01; 22(11):1929-35. PMID: 12426227.
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  165. Jaffer FA, O'Donnell CJ, Larson MG, Chan SK, Kissinger KV, Kupka MJ, Salton C, Botnar RM, Levy D, Manning WJ. Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2002 May 01; 22(5):849-54. PMID: 12006401.
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  166. Tung CH, Gerszten RE, Jaffer FA, Weissleder R. A novel near-infrared fluorescence sensor for detection of thrombin activation in blood. Chembiochem. 2002 Mar 01; 3(2-3):207-11. PMID: 11921399.
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  167. Ong KC, Wen H, Chesnick AS, Duewell S, Jaffer FA, Balaban RS. . Radiofrequency Shielding of Surface Coils at 4 T. Journal of Magnetic Resonance Imaging 1995; 5:773-778. . 2002.
  168. Chan SK, Jaffer FA, Botnar RM, Kissinger KV, Goepfert L, Chuang ML, O'Donnell CJ, Levy D, Manning WJ. Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden. J Cardiovasc Magn Reson. 2001; 3(4):331-8. PMID: 11777225.
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  169. Jaffer FA, Wen H, Jezzard P, Balaban RS, Wolff SD. Centric ordering is superior to gradient moment nulling for motion artifact reduction in EPI. J Magn Reson Imaging. 1997 Nov-Dec; 7(6):1122-31. PMID: 9400858.
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  170. Jaffer FA, Wen H, Balaban RS, Wolff SD. A method to improve the B0 homogeneity of the heart in vivo. Magn Reson Med. 1996 Sep; 36(3):375-83. PMID: 8875407.
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  171. Wen H, Jaffer FA, Denison TJ, Duewell S, Chesnick AS, Balaban RS. The evaluation of dielectric resonators containing H2O or D2O as RF coils for high-field MR imaging and spectroscopy. J Magn Reson B. 1996 Feb; 110(2):117-23. PMID: 8819760.
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  172. Wen H, Jaffer FA. An in vivo automated shimming method taking into account shim current constraints. Magn Reson Med. 1995 Dec; 34(6):898-904. PMID: 8598818.
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  173. Ong KC, Wen H, Chesnick AS, Duewell S, Jaffer FA, Balaban RS. Radiofrequency shielding of surface coils at 4.0 T. J Magn Reson Imaging. 1995 Nov-Dec; 5(6):773-7. PMID: 8748501.
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  174. Duewell SH, Ceckler TL, Ong K, Wen H, Jaffer FA, Chesnick SA, Balaban RS. Musculoskeletal MR imaging at 4 T and at 1.5 T: comparison of relaxation times and image contrast. Radiology. 1995 Aug; 196(2):551-5. PMID: 7617876.
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  175. Jaffer F, Saunders C, Shultz P, Throckmorton D, Weinshell E, Abboud HE. Regulation of mesangial cell growth by polypeptide mitogens. Inhibitory role of transforming growth factor beta. Am J Pathol. 1989 Aug; 135(2):261-9. PMID: 2782372; PMCID: PMC1879918.
  176. Mankin HJ, Fogelson FS, Thrasher AZ, Jaffer F. Massive resection and allograft transplantation in the treatment of malignant bone tumors. N Engl J Med. 1976 Jun 03; 294(23):1247-55. PMID: 772430.
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  177. Andrus WS, Dreyfuss JR, Jaffer F, Bird KT. Interpretation of roentgenograms via interactive television. Radiology. 1975 Jul; 116(1):25-31. PMID: 1138279.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.