Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profilePablo Argueso, Ph.D.

TitleAssociate Professor of Ophthalmology
InstitutionSchepens Eye Research Institute
DepartmentOphthalmology
AddressSchepens Eye Research Inst.
20 Staniford St.
Boston MA 02114
Phone617/912-0249
Fax617/912-0101
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01EY026147     (ARGUESO, PABLO)Aug 1, 2016 - Jul 31, 2020
NIH/NEI
N-glycosylation and ocular surface homeostasis
Role: Principal Investigator

R01EY024031     (ARGUESO, PABLO)Jan 1, 2015 - Dec 31, 2019
NIH/NEI
CD147 and Corneal Wound Repair
Role: Principal Investigator

R01EY014847     (ARGUESO, PABLO)Sep 1, 2003 - Nov 30, 2015
NIH/NEI
O-Glycans on Mucins at the Ocular Surface
Role: Principal Investigator

P30EY003790     (ARGUESO, PABLO)Aug 1, 1981 - Jun 30, 2022
NIH/NEI
Core Grant for Vision Research
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Uchino Y, Mauris J, Woodward AM, Dieckow J, Amparo F, Dana R, Mantelli F, Argüeso P. Alteration of galectin-3 in tears of patients with dry eye disease. Am J Ophthalmol. 2015 Jun; 159(6):1027-1035.e3. PMID: 25703476; PMCID: PMC4426220.
  2. Bron AJ, Argüeso P, Irkec M, Bright FV. Clinical staining of the ocular surface: mechanisms and interpretations. Prog Retin Eye Res. 2015 Jan; 44:36-61. PMID: 25461622.
    View in: PubMed
  3. Woodward AM, Argüeso P. Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia. Invest Ophthalmol Vis Sci. 2014 Aug 28; 55(10):6132-8. PMID: 25168902; PMCID: PMC4184386.
  4. Uchino Y, Uchino M, Yokoi N, Dogru M, Kawashima M, Okada N, Inaba T, Tamaki S, Komuro A, Sonomura Y, Kato H, Argüeso P, Kinoshita S, Tsubota K. Alteration of tear mucin 5AC in office workers using visual display terminals: The Osaka Study. JAMA Ophthalmol. 2014 Aug; 132(8):985-92. PMID: 24903353.
    View in: PubMed
  5. Mauris J, Woodward AM, Cao Z, Panjwani N, Argüeso P. Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3. J Cell Sci. 2014 Jul 15; 127(Pt 14):3141-8. PMID: 24829150; PMCID: PMC4095856.
  6. Craig JP, Willcox MD, Argüeso P, Maissa C, Stahl U, Tomlinson A, Wang J, Yokoi N, Stapleton F. The TFOS International Workshop on Contact Lens Discomfort: report of the contact lens interactions with the tear film subcommittee. Invest Ophthalmol Vis Sci. 2013 Oct 18; 54(11):TFOS123-56. PMID: 24058139.
    View in: PubMed
  7. Mantelli F, Mauris J, Argüeso P. The ocular surface epithelial barrier and other mechanisms of mucosal protection: from allergy to infectious diseases. Curr Opin Allergy Clin Immunol. 2013 Oct; 13(5):563-8. PMID: 23974687; PMCID: PMC3858173.
  8. Mauris J, Mantelli F, Woodward AM, Cao Z, Bertozzi CR, Panjwani N, Godula K, Argüeso P. Modulation of ocular surface glycocalyx barrier function by a galectin-3 N-terminal deletion mutant and membrane-anchored synthetic glycopolymers. PLoS One. 2013; 8(8):e72304. PMID: 23977277; PMCID: PMC3747151.
  9. Woodward AM, Mauris J, Argüeso P. Binding of transmembrane mucins to galectin-3 limits herpesvirus 1 infection of human corneal keratinocytes. J Virol. 2013 May; 87(10):5841-7. PMID: 23487460; PMCID: PMC3648170.
  10. Argüeso P. Glycobiology of the ocular surface: mucins and lectins. Jpn J Ophthalmol. 2013 Mar; 57(2):150-5. PMID: 23325272; PMCID: PMC3889467.
  11. Shovlin JP, Argüeso P, Carnt N, Chalmers RL, Efron N, Fleiszig SM, Nichols JJ, Polse KA, Stapleton F, Wiley L, Willcox M, Bright FV, Efron N, Jones LW, Keir N, Peterson RC, Stapleton F. 3. Ocular surface health with contact lens wear. Cont Lens Anterior Eye. 2013 Jan 15; 36 Suppl 1:S14-21. PMID: 23347571.
    View in: PubMed
  12. Kelleher Davis R, Doane MG, Knop E, Knop N, Dubielzig RR, Colitz CM, Argüeso P, Sullivan DA. Characterization of ocular gland morphology and tear composition of pinnipeds. Vet Ophthalmol. 2013 Jul; 16(4):269-75. PMID: 23067374; PMCID: PMC3594129.
  13. Woodward AM, Senchyna M, Williams R, Argüeso P. Characterization of the interaction between hydroxypropyl guar galactomannan and galectin-3. Biochem Biophys Res Commun. 2012 Jul 20; 424(1):12-7. PMID: 22683626.
    View in: PubMed
  14. Bravo-Osuna I, Noiray M, Briand E, Woodward AM, Argüeso P, Molina Martínez IT, Herrero-Vanrell R, Ponchel G. Interfacial interaction between transmembrane ocular mucins and adhesive polymers and dendrimers analyzed by surface plasmon resonance. Pharm Res. 2012 Aug; 29(8):2329-40. PMID: 22565639; PMCID: PMC3867740.
  15. Guzman-Aranguez A, Woodward AM, Pintor J, Argüeso P. Targeted disruption of core 1 ß1,3-galactosyltransferase (C1galt1) induces apical endocytic trafficking in human corneal keratinocytes. PLoS One. 2012; 7(5):e36628. PMID: 22574202; PMCID: PMC3344913.
  16. Woodward AM, Senchyna M, Argüeso P. Differential contribution of hypertonic electrolytes to corneal epithelial dysfunction. Exp Eye Res. 2012 Jul; 100:98-100. PMID: 22564970; PMCID: PMC3889657.
  17. Govindarajan B, Menon BB, Spurr-Michaud S, Rastogi K, Gilmore MS, Argüeso P, Gipson IK. A metalloproteinase secreted by Streptococcus pneumoniae removes membrane mucin MUC16 from the epithelial glycocalyx barrier. PLoS One. 2012; 7(3):e32418. PMID: 22412870; PMCID: PMC3296694.
  18. Argüeso P, Gipson IK. Assessing mucin expression and function in human ocular surface epithelia in vivo and in vitro. Methods Mol Biol. 2012; 842:313-25. PMID: 22259145; PMCID: PMC3480083.
  19. Xiong L, Woodward AM, Argüeso P. Notch signaling modulates MUC16 biosynthesis in an in vitro model of human corneal and conjunctival epithelial cell differentiation. Invest Ophthalmol Vis Sci. 2011 Jul 29; 52(8):5641-6. PMID: 21508102; PMCID: PMC3176047.
  20. Argüeso P, Panjwani N. Focus on molecules: galectin-3. Exp Eye Res. 2011 Jan; 92(1):2-3. PMID: 21111733; PMCID: PMC3034303.
  21. Mantelli F, Argüeso P. MUC1 biosynthesis in human corneal and conjunctival epithelia. Br J Ophthalmol. 2010 Jul; 94(7):956-7; author reply 957-8. PMID: 20606033.
    View in: PubMed
  22. Guzman-Aranguez A, Argüeso P. Structure and biological roles of mucin-type O-glycans at the ocular surface. Ocul Surf. 2010 Jan; 8(1):8-17. PMID: 20105403; PMCID: PMC2847370.
  23. Argüeso P, Guzman-Aranguez A, Mantelli F, Cao Z, Ricciuto J, Panjwani N. Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier. J Biol Chem. 2009 Aug 21; 284(34):23037-45. PMID: 19556244; PMCID: PMC2755710.
  24. Guzman-Aranguez A, Mantelli F, Argüeso P. Mucin-type O-glycans in tears of normal subjects and patients with non-Sjögren's dry eye. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4581-7. PMID: 19407012; PMCID: PMC2751810.
  25. Mantelli F, Schaffer L, Dana R, Head SR, Argüeso P. Glycogene expression in conjunctiva of patients with dry eye: downregulation of Notch signaling. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2666-72. PMID: 19011014; PMCID: PMC2693254.
  26. Mantelli F, Argüeso P. Functions of ocular surface mucins in health and disease. Curr Opin Allergy Clin Immunol. 2008 Oct; 8(5):477-83. PMID: 18769205; PMCID: PMC2666617.
  27. Ricciuto J, Heimer SR, Gilmore MS, Argüeso P. Cell surface O-glycans limit Staphylococcus aureus adherence to corneal epithelial cells. Infect Immun. 2008 Nov; 76(11):5215-20. PMID: 18794288; PMCID: PMC2573382.
  28. Argüeso P. Sugars: an exceptional protective coat for the ocular surface. Arch Soc Esp Oftalmol. 2008 May; 83(5):287-90. PMID: 18464176.
    View in: PubMed
  29. Sumiyoshi M, Ricciuto J, Tisdale A, Gipson IK, Mantelli F, Argüeso P. Antiadhesive character of mucin O-glycans at the apical surface of corneal epithelial cells. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):197-203. PMID: 18172093; PMCID: PMC2247472.
  30. Spurr-Michaud S, Argüeso P, Gipson I. Assay of mucins in human tear fluid. Exp Eye Res. 2007 May; 84(5):939-50. PMID: 17399701; PMCID: PMC1950265.
  31. Argüeso P, Sumiyoshi M. Characterization of a carbohydrate epitope defined by the monoclonal antibody H185: sialic acid O-acetylation on epithelial cell-surface mucins. Glycobiology. 2006 Dec; 16(12):1219-28. PMID: 16940404; PMCID: PMC1976397.
  32. Hori Y, Argüeso P, Spurr-Michaud S, Gipson IK. Mucins and contact lens wear. Cornea. 2006 Feb; 25(2):176-81. PMID: 16371777.
    View in: PubMed
  33. Argüeso P, Gipson IK. Quantitative analysis of mucins in mucosal secretions using indirect enzyme-linked immunosorbent assay. Methods Mol Biol. 2006; 347:277-88. PMID: 17072017.
    View in: PubMed
  34. Argüeso P, Tisdale A, Spurr-Michaud S, Sumiyoshi M, Gipson IK. Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):113-9. PMID: 16384952; PMCID: PMC1351157.
  35. Hori Y, Spurr-Michaud SJ, Russo CL, Argüeso P, Gipson IK. Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4050-61. PMID: 16249480; PMCID: PMC1473963.
  36. Gipson IK, Hori Y, Argüeso P. Character of ocular surface mucins and their alteration in dry eye disease. Ocul Surf. 2004 Apr; 2(2):131-48. PMID: 17216084.
    View in: PubMed
  37. Hori Y, Spurr-Michaud S, Russo CL, Argüeso P, Gipson IK. Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Invest Ophthalmol Vis Sci. 2004 Jan; 45(1):114-22. PMID: 14691162.
    View in: PubMed
  38. Paz HB, Tisdale AS, Danjo Y, Spurr-Michaud SJ, Argüeso P, Gipson IK. The role of calcium in mucin packaging within goblet cells. Exp Eye Res. 2003 Jul; 77(1):69-75. PMID: 12823989.
    View in: PubMed
  39. Gipson IK, Spurr-Michaud S, Argüeso P, Tisdale A, Ng TF, Russo CL. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2496-506. PMID: 12766048.
    View in: PubMed
  40. Argüeso P, Spurr-Michaud S, Russo CL, Tisdale A, Gipson IK. MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2487-95. PMID: 12766047.
    View in: PubMed
  41. Argüeso P, Tisdale A, Mandel U, Letko E, Foster CS, Gipson IK. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):86-92. PMID: 12506059.
    View in: PubMed
  42. Gipson IK, Argüeso P. Role of mucins in the function of the corneal and conjunctival epithelia. Int Rev Cytol. 2003; 231:1-49. PMID: 14713002.
    View in: PubMed
  43. Argüeso P, Spurr-Michaud S, Tisdale A, Gipson IK. Variation in the amount of T antigen and N-acetyllactosamine oligosaccharides in human cervical mucus secretions with the menstrual cycle. J Clin Endocrinol Metab. 2002 Dec; 87(12):5641-8. PMID: 12466366.
    View in: PubMed
  44. Argüeso P, Balaram M, Spurr-Michaud S, Keutmann HT, Dana MR, Gipson IK. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjögren syndrome. Invest Ophthalmol Vis Sci. 2002 Apr; 43(4):1004-11. PMID: 11923240.
    View in: PubMed
  45. Garcia ML, Herreras JM, Dios E, Argueso P, Almaraz A. Evaluation of lectin staining in the diagnosis of fungal keratitis in an experimental rabbit model. Mol Vis. 2002 Jan 25; 8:10-6. PMID: 11815751.
    View in: PubMed
  46. Gómez S, Herreras JM, Merayo J, García M, Argüeso P, Cuevas J. Effect of hyaluronic acid on corneal haze in a photorefractive keratectomy experimental model. J Refract Surg. 2001 Sep-Oct; 17(5):549-54. PMID: 11583225.
    View in: PubMed
  47. Argüeso P, Gipson IK. Epithelial mucins of the ocular surface: structure, biosynthesis and function. Exp Eye Res. 2001 Sep; 73(3):281-9. PMID: 11520103.
    View in: PubMed
  48. Gipson IK, Moccia R, Spurr-Michaud S, Argüeso P, Gargiulo AR, Hill JA, Offner GD, Keutmann HT. The Amount of MUC5B mucin in cervical mucus peaks at midcycle. J Clin Endocrinol Metab. 2001 Feb; 86(2):594-600. PMID: 11158014.
    View in: PubMed
  49. Diebold Y, Herreras JM, Callejo S, Argüeso P, Calonge M. Carbomer- versus cellulose-based artificial-tear formulations: morphologic and toxicologic effects on a corneal cell line. Cornea. 1998 Jul; 17(4):433-40. PMID: 9676917.
    View in: PubMed
  50. Citores L, de Benito FM, Iglesias R, Miguel Ferreras J, Argüéso P, Jiménez P, Méndez E, Girbés T. Presence of polymerized and free forms of the non-toxic type 2 ribosome-inactivating protein ebulin and a structurally related new homodimeric lectin in fruits of Sambucus ebulus L. Planta. 1998 Mar; 204(3):310-9. PMID: 9530875.
    View in: PubMed
  51. Argüeso P, Herreras JM, Calonge M, Citores L, Pastor JC, Girbés T. Analysis of human ocular mucus: effects of neuraminidase and chitinase enzymes. Cornea. 1998 Mar; 17(2):200-7. PMID: 9520199.
    View in: PubMed
  52. Citores L, De Benito FM, Iglesias R, Ferreras JM, Argüeso P, Jiménez P, Testera A, Camafeita E, Méndez E, Girbés T. Characterization of a new non-toxic two-chain ribosome-inactivating protein and a structurally-related lectin from rhizomes of dwarf elder (Sambucus ebulus L.). Cell Mol Biol (Noisy-le-grand). 1997 Jun; 43(4):485-99. PMID: 9220142.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Argueso's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_