Harvard Catalyst Profiles

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Charles A. Nelson III, Ph.D.

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Mentoring
Infant Screening Project[login at prompt]
Available: 07/15/11, Expires: 12/31/22

The goal of this project is to use a variety of neuroimaging, behavioral and genetic assays to identify infants at high risk for developing autism - ideally within the first 6 months of life. Several populations of infants are targeted, including those with a family history of the disorder as well as those with known single gene variants. Following training in our neuroimaging methods, the student will assist lab staff and students in scheduling and testing study participants; will be involved in data processing and data analysis; depending on how much time the student has, may be involved in manuscript preparation.

Available: 05/03/17, Expires: 04/30/22

An important function of the brain is to scan incoming sensory information for the presence of biologically relevant features and process and act on this information. For humans, the most salient signals of emotion are often social in nature, such as expressions of fear or anger. The goal of the current competing renewal is to study the nature and neural architecture of emotion processing across the first three years of life. Five-, seven-, and twelve-month-old infants, as well as three-year-old typically developing children will serve as participants across 5 specific aims. Aim 1 seeks to examine the neural correlates of the infant's ability to process emotion in both faces and non-face stimuli. Aim 2 examines a similar question, except that autonomic activity (skin conductance and pupil diameter) will be recorded in conjunction with functional Near Infrared Spectroscopy (fNIRS). Aim 3 seeks to elucidate the neural networks involved in emotion processing, and will do so by using state-of-the-art signal processing software to extract theta activity from the ongoing EEG. Aim 4 will focus on individual differences in emotion processing viewed through the lens of genetics; specifically, all infants serving as participants in Aims 1 and 2 will be genotyped, with most attention focused on 5 single-nucleotide polymorphisms (SNPs), with an additional 5 SNPs serving as a secondary aim. All SNPs have been shown to be relevant to emotion processing in both humans and non-human species. Finally, in Aim 5 we examine whether early biases in emotion processing (i.e., whether infants show greater visual or neural activity to one emotion vs. another; e.g., fear) predict (or are associated with) behavioral inhibition and anxiety. Although the current project focuses on typically developing children, this work has enormous implications for children and adults who suffer from deficits in social-emotional communication. First, this work seeks to explicate the ontogeny of facial emotion processing, an ability that likely provides a foundation upon which higher-level social communication builds. As a result, it may well be the case that errors in this ability that occur early in development can develop into more insidious deficits that occur later in development. Second, the approach adopted in this project is highly innovative, and can easily be extended to various clinical populations, such as toddlers with autism or children diagnosed with depression or bipolar illness. Areas of potential involvement for medical students: • They could participate in data collection or other existing part of the study • They could use the data to address a new research question

Available: 07/01/17, Expires: 03/31/22

The proposed project will rigorously test an evidence-based intervention that is developmentally-informed, child centered, and focused on early social-communication deficits of joint attention and joint engagement. Given the paucity of data on the effectiveness of behavioral intervention for infants with TSC and the lack of biomarkers of treatment response for ASD more generally, our primary goal is to determine if behavioral indices of social communication function can be improved with a targeted, short terms intervention, if these improvements endure 12 months after intervention, and whether this change is reflected in, and can be predicted by, electrophysiological indices of neural processing. We will accomplish this goal by comparing behavioral and EEG outcomes in the treatment group with the outcomes of those on the wait list, while they receive “care as usual” in the community, which can include behavioral intervention. Then after the randomized controlled trial, in a cross sectional analysis, we will compare social communication skills in the entire group of children who received intervention (60 children, 30 at UCLA, 30 at BCH) (twelve months after the end of intervention) with an age matched cohort of children with TSC who have never received treatment (42 children, 21 at UCLA, 21 at BCH) either due to age, distance from testing sites, or other factors that may have precluded their enrollment in the treatment trial. There will be variability in epilepsy and tuber burden, and we will try to understand their effect on treatment response. The only epilepsy-based exclusionary criterion is epilepsy surgery during the study period as surgery may undermine the family’s ability to participate in the treatment process. Areas of potential involvement for medical students: • They could participate in data collection or other existing part of the study • They could use the data to address a new research question

Available: 11/26/18, Expires: 12/31/19

To shed light on the brain mechanisms that influence the course of development, particularly for children from low-resource environments, and in so doing, identify the new treatment strategies for intervening in the lives of such children. Areas of potential involvement for medical students: • They could use the data to address a new research question

Available: 11/26/19, Expires: 08/31/21

The goal of this pilot project is to identify whether neurotypical individuals display a form of plasticity/learning that has been robustly documented in the mouse and may have potential as a biomarker of neurogenetic and neurodevelopmental disorders. Of highly penetrant genetic contributors to autism spectrum disorders (ASD), intellectual disability (ID) and language delay, copy number variations of the human 16p11.2 region are leading causes (1, 2). The 16p11.2 deletion has been reported to occur in up to 1% of patients with ASD (3-5). Much work is still required to identify biomarkers for patient stratification and therapeutic assessment. Studies in Charles Nelson's lab using human subjects with the chr16p11.2 deletion have revealed increased visual evoked potential (VEP) amplitude over occipital cortex compared to neurotypical, age-matched individuals. Mark Bear's lab at MIT has also identified alterations in visual cortical physiology in the mouse model of human chr16p11.2 micro-deletion (6) that lead to augmented VEP amplitude. Not only did Mark Bear's lab observe elevated VEP amplitude in the mouse model of human chr16p11.2 micro-deletion but they also noted that plasticity and learning, in the form of stimulus-selective response potentiation (SRP) of the VEP and orientation selective behavioral habituation (OSH), respectively, are impaired in the mice. Both SRP (7) and OSH (8) are relatively easy to assay non-invasively, so there exists an intriguing opportunity to determine whether humans also display these forms of plasticity/learning. If so, this work will lay the foundation for future projects examining VEP as a potential biomarker for stratification and treatment response. In this pilot project we aim to determine in the Nelson laboratory whether the electrophysiological and behavioral phenomena of SRP and OSH, which have previously been characterized in mice, are conserved in human subjects. We will test this by using electroencephalography (EEG) to non-invasively measure VEPs over visual cortex in human participants to sine-wave gratings over consecutive days of testing. We will use a paradigm that closely parallels that of the mouse work in Mark Bear's laboratory in order to determine if there are measurable changes in VEP amplitude to familiar versus novel stimuli that bear the features of SRP. Areas of potential involvement for medical students: • They could add on a small sub-study • They could participate in data collection or other existing part of the study • They could use the data to address a new research question

Available: 11/26/18, Expires: 11/26/19

We have published numerous articles using the Mullen Scales of Early Learning (MSEL) as our primary measure of cognitive and motor ability; however, as we begin studying cohorts of children with diseases that present with language and motor limitations we find a dearth of standardized testing tools that will accommodate these deficits. As we operate within a hospital infrastructure we understand that clinicians find the same paucity of appropriate tools when preforming clinical evaluations. Our urgent need for these tools for research and clinical purposes lead us to pilot a non-standard administration of the MSEL with a small cohort of children with Rett Syndrome. These children have no expressive language skills and have lost the ability to use their hands purposefully. For these reasons they rely on eye gaze, or 'eye pointing' as their primary form of communication. Understanding the physical constraints of this cohort our team of child psychologists, neurologists, and child development specialists chose a subset of the MSEL Visual Reception and Receptive Language tasks and agreed upon modified administration and score parameters. An example of this modification was enlarging the Receptive Language stimuli and accepting eye gaze, instead of proximal pointing, as the mode of communication. After seeing promise in the preliminary work we have done, we are excited to develop an adapted version of the MSEL Visual Reception and Receptive Language domains for children with language and motor limitations that encorportates the use of eye-tracking technology. Areas of potential involvement for medical students: • They could use the data to address a new research question

Available: 11/26/18, Expires: 12/31/19

The Bucharest Early Intervention Project (BEIP) is the first randomized controlled trial (RCT) comparing foster care to institutional care in young children with histories of profoundly adverse early experiences. Major findings demonstrate brain and behavioral abnormalities associated with institutional rearing (compared to no institutional rearing), advantages of foster care over institutional care for most developmental domains, and evidence of sensitive periods in many but not all developmental domains, suggesting that during the first 24 months of life, early adversity can profoundly influence brain development, executive functioning, mental health, and physiological stress responses; however, these effects can be reversed if placement into a family occurs within this time period. The proposed study will assess the original BEIP sample when they are 15-16 years of age in order to test the long-term effects of our intervention during the adolescent period, and to examine how our sample will make the transition to adolescence generally. We hypothesize that children originally assigned to care as usual (institutional care) will be poorly prepared to face the challenges of adolescence and thus, will evince higher rates of psychopathology, risk taking, and substance use compared to never institutionalized children; by contrast, children receiving our intervention will evince lower rates of psychopathology, risk taking, and substance use than institutionalized children. Our specific aims are: Specific Aim 1: To examine the long-term effects of early institutionalization on neural, psychiatric, cognitive, and socio-emotional outcomes at age 15-16. We will compare children with any history of institutionalization to a comparison group of typically developing, never institutionalized children. Children at age 15-16 who have experienced psychosocial deprivation associated with early institutionalization will display elevated symptoms of psychiatric problems, impaired cognitive and executive functioning, less white matter volume and a less mature pattern of EEG power, and maladaptive socio-emotional outcomes, including heightened reward sensitivity and risk taking, greater stress-emotional reactivity, and social relationships difficulties. Given that our previous work has demonstrated genetic modifications of these effects we will further assess whether genetic and epigenetic factors moderate long-term outcomes in this sample. Specific Aim 2: To examine the long-term effects of a family/foster care intervention and establish whether sensitive periods with regard to the efficacy of the intervention continue to impact brain and behavioral development at age 15-16. We will compare those children randomized to foster care at the start of our study to those randomized to care as usual. We predict that: a) Children randomized to foster care will display fewer symptoms of psychiatric problems, improvements in cognitive and executive functioning, a more mature pattern of EEG power and greater white matter volume, and better socio-emotional outcomes, including for example, improvements in stress-emotion regulation, less reward sensitivity and risk taking behavior, and positive social relationships. b) Children's earlier placement in foster care (e.g., <24 months), thus decreasing their percent time in an institution, will lead to better outcomes across all domains. Specific Aim 3: To examine the mediating effects of stress-emotion regulation, reward sensitivity and executive functioning on the relations between early adversity and both internalizing and externalizing symptoms and risk for substance use at age 15-16 among children with histories of institutionalization. We will use longitudinal data collected on our entire sample of children with a history of institutionalization to model the meditational effects of these constructs on the relations between early experience and age 15-16 psychiatric outcomes and heightened risk of substance use. We predict that: a) Percent time of a child's life in an institution will be related to symptoms of internalizing disorders at age 15-16 years. Specifically, children with a smaller percent time will display fewer internalizing symptoms. We will test attachment security (42 months), reward sensitivity (12 years), and stress-emotion regulation (12 years) as mediators of these relations. b) Percent time of a child's life in an institution will be related to fewer externalizing symptoms. Specifically children with a smaller percent time will have fewer symptoms of externalizing disorders and less risk of substance use at age 16 years. We will test EEG power (12 years), white matter volume (8 years), executive functioning (12 years), stress-emotion regulation (12 years), and risk taking (12 years) as mediators of these relations. Areas of potential involvement for medical students: • They could use the data to address a new research question

Available: 03/01/15, Expires: 02/28/21

The goal of this research network is to reduce the prevalence of lifelong health impairments that are caused by toxic stress in the early years of life. The network is focused on identifying biomarkers for behavioral, autonomic, neuroendocrine, immune, and metabolic resilience to early life adversity in very young children. Areas of potential involvement for medical students: • They could add on a small sub-study • They could participate in data collection or other existing part of the study • They could use the data to address a new research question

Exploring Policy Implications of the Bucharest Early Intervention Project
Summer, 06/12/13 - 08/16/13
Effects of Institutionalized Care on Social and Academic Acclimation
Summer, 06/14/13 - 08/09/13
Perinatal Factors in Long Term Developmental Outcomes
International, 08/05/13 - 09/29/13
Aggressive Behavior in Romanian Children
Summer, 06/25/13 - 08/05/13
Effects of perinatal factors on long term developmental outcomes in children the Bucharest Early Interventional Project, Romania
International/Summer, 08/01/13 - 09/28/13
Evaluating Foster Parents' Experiences in the Bucharest Early Intervention Project (BEIP)
Summer, 06/20/14 - 08/29/14
Investigation of the Reasons for Child Abandonment in Romania within the context of the Bucharest Early Intervention Project
International, 06/15/08 - 08/10/08
The use of event related potentials as a possible marker for the development of autism spectrum disorders.
Summer, 06/18/06 - 08/11/06
Memory and executive function in children with a history of early institutionalization
Full Time, 07/01/08 - 06/30/09

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32MH112510 (NELSON, CHARLES ALEXANDER) Jul 1, 2017 - Jun 30, 2022
    NIH/NIMH
    Translational Post-doctoral Training in Neurodevelopment
    Role: Principal Investigator
  2. U19MH108206 (MCPARTLAND, JAMES CHARLES) Jul 1, 2015 - Jun 30, 2019
    NIH/NIMH
    The Autism Biomarkers Consortium for Clinical Trials
    Role: Co-Principal Investigator
  3. R01MH091363 (NELSON, CHARLES ALEXANDER) Aug 1, 2010 - May 31, 2019
    NIH/NIMH
    Effects of Early Psychosocial Deprivation on Mental Health in Adolescence
    Role: Co-Principal Investigator
  4. R01DC010290 (TAGER-FLUSBERG, HELEN) Jul 1, 2009 - Nov 30, 2020
    NIH/NIDCD
    Neurobehavioral Research on Infants at Risk for Language Delay and ASD
    Role: Principal Investigator
  5. T32MH073129 (GEORGIEFF, MICHAEL K.) Sep 29, 2004 - Jul 31, 2009
    NIH/NIMH
    Postdoctoral Training in Neurobehavioral Development(RMI)
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Slopen N, Tang A, Nelson CA, Zeanah CH, McDade TW, McLaughlin KA, Fox NA. The Consequences of Foster Care Versus Institutional Care in Early Childhood on Adolescent Cardiometabolic and Immune Markers: Results From a Randomized Controlled Trial. Psychosom Med. 2019 Jun; 81(5):449-457. PMID: 31008902.
    Citations:    
  2. Sabatos-DeVito M, Murias M, Dawson G, Howell T, Yuan A, Marsan S, Bernier RA, Brandt CA, Chawarska K, Dzuira JD, Faja S, Jeste SS, Naples A, Nelson CA, Shic F, Sugar CA, Webb SJ, McPartland JC. Methodological considerations in the use of Noldus EthoVision XT video tracking of children with autism in multi-site studies. Biol Psychol. 2019 Jun 01. PMID: 31163191.
    Citations:    
  3. Debnath R, Tang A, Zeanah CH, Nelson CA, Fox NA. The Long-term effects of institutional rearing, foster care intervention and disruptions in care on brain electrical activity in adolescence. Dev Sci. 2019 May 30; e12872. PMID: 31148302.
    Citations:    
  4. Wilkinson CL, Levin AR, Gabard-Durnam LJ, Tager-Flusberg H, Nelson CA. Reduced frontal gamma power at 24 months is associated with better expressive language in toddlers at risk for autism. Autism Res. 2019 May 22. PMID: 31119899.
    Citations:    
  5. Guyon-Harris KL, Humphreys KL, Miron D, Gleason MM, Nelson CA, Fox NA, Zeanah CH. Disinhibited Social Engagement Disorder in Early Childhood Predicts Reduced Competence in Early Adolescence. J Abnorm Child Psychol. 2019 May 22. PMID: 31119469.
    Citations:    
  6. Berens AE, Kumar S, Tofail F, Jensen SKG, Alam M, Haque R, Kakon SH, Petri WA, Nelson CA. Cumulative psychosocial risk and early child development: validation and use of the Childhood Psychosocial Adversity Scale in global health research. Pediatr Res. 2019 May 18. PMID: 31103019.
    Citations:    
  7. Jensen SKG, Tofail F, Haque R, Petri WA, Nelson CA. Child development in the context of biological and psychosocial hazards among poor families in Bangladesh. PLoS One. 2019; 14(5):e0215304. PMID: 31059509.
    Citations:    
  8. Perdue KL, Jensen SKG, Kumar S, Richards JE, Kakon SH, Haque R, Petri WA, Lloyd-Fox S, Elwell C, Nelson CA. Using functional near-infrared spectroscopy to assess social information processing in poor urban Bangladeshi infants and toddlers. Dev Sci. 2019 Apr 24; e12839. PMID: 31017372.
    Citations:    
  9. Kadlaskar G, Seidl A, Tager-Flusberg H, Nelson CA, Keehn B. Atypical Response to Caregiver Touch in Infants at High Risk for Autism Spectrum Disorder. J Autism Dev Disord. 2019 Apr 23. PMID: 31016672.
    Citations:    
  10. Turesky TK, Jensen SKG, Yu X, Kumar S, Wang Y, Sliva DD, Gagoski B, Sanfilippo J, Zöllei L, Boyd E, Haque R, Hafiz Kakon S, Islam N, Petri WA, Nelson CA, Gaab N. The relationship between biological and psychosocial risk factors and resting-state functional connectivity in 2-month-old Bangladeshi infants: A feasibility and pilot study. Dev Sci. 2019 Apr 23; e12841. PMID: 31016808.
    Citations:    
  11. Pierce LJ, Thompson BL, Gharib A, Schlueter L, Reilly E, Valdes V, Roberts S, Conroy K, Levitt P, Nelson CA. Association of Perceived Maternal Stress During the Perinatal Period With Electroencephalography Patterns in 2-Month-Old Infants. JAMA Pediatr. 2019 Apr 08. PMID: 30958515.
    Citations:    
  12. Choi B, Shah P, Rowe ML, Nelson CA, Tager-Flusberg H. Gesture Development, Caregiver Responsiveness, and Language and Diagnostic Outcomes in Infants at High and Low Risk for Autism. J Autism Dev Disord. 2019 Mar 14. PMID: 30877417.
    Citations:    
  13. Jensen SKG, Kumar S, Xie W, Tofail F, Haque R, Petri WA, Nelson CA. Neural correlates of early adversity among Bangladeshi infants. Sci Rep. 2019 Mar 05; 9(1):3507. PMID: 30837491.
    Citations:    
  14. Wade M, Fox NA, Zeanah CH, Nelson CA, Drury SS. Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project. J Am Acad Child Adolesc Psychiatry. 2019 Mar 04. PMID: 30844465.
    Citations:    
  15. Nelson CA, Zeanah CH, Fox NA. How Early Experience Shapes Human Development: The Case of Psychosocial Deprivation. Neural Plast. 2019 01 14; 2019:1676285. PMID: 30774652.
    Citations:    
  16. Wade M, Fox NA, Zeanah CH, Nelson CA. Long-term effects of institutional rearing, foster care, and brain activity on memory and executive functioning. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1808-1813. PMID: 30642973.
    Citations:    Fields:    
  17. Iverson JM, Shic F, Wall CA, Chawarska K, Curtin S, Estes A, Gardner JM, Hutman T, Landa RJ, Levin AR, Libertus K, Messinger DS, Nelson CA, Ozonoff S, Sacrey LR, Sheperd K, Stone WL, Tager-Flusberg HB, Wolff JJ, Yirmiya N, Young GS. Early motor abilities in infants at heightened versus low risk for ASD: A Baby Siblings Research Consortium (BSRC) study. J Abnorm Psychol. 2019 Jan; 128(1):69-80. PMID: 30628809.
    Citations:    Fields:    
  18. Jeste SS, Nelson CA. Inaugural annual special section of the intellectual and developmental disabilities research centers: developmental cognitive neuroscience and neurodevelopmental disorders. J Neurodev Disord. 2018 Dec 13; 10(1):36. PMID: 30541435.
    Citations:    Fields:    
  19. Guyon-Harris KL, Humphreys KL, Fox NA, Nelson CA, Zeanah CH. Signs of attachment disorders and social functioning among early adolescents with a history of institutional care. Child Abuse Negl. 2019 Feb; 88:96-106. PMID: 30468966.
    Citations:    Fields:    
  20. Wade M, Fox NA, Zeanah CH, Nelson CA. Effect of Foster Care Intervention on Trajectories of General and Specific Psychopathology Among Children With Histories of Institutional Rearing: A Randomized Clinical Trial. JAMA Psychiatry. 2018 Nov 01; 75(11):1137-1145. PMID: 30810714.
    Citations:    
  21. Wade M, Fox NA, Zeanah CH, Nelson CA. Effect of Foster Care Intervention on Trajectories of General and Specific Psychopathology Among Children With Histories of Institutional Rearing: A Randomized Clinical Trial. JAMA Psychiatry. 2018 Nov 01; 75(11):1137-1145. PMID: 30267045.
    Citations:    
  22. Bayet L, Behrendt HF, Cataldo JK, Westerlund A, Nelson CA. Recognition of facial emotions of varying intensities by three-year-olds. Dev Psychol. 2018 Dec; 54(12):2240-2247. PMID: 30335429.
    Citations:    Fields:    
  23. Xie W, McCormick SA, Westerlund A, Bowman LC, Nelson CA. Neural correlates of facial emotion processing in infancy. Dev Sci. 2019 May; 22(3):e12758. PMID: 30276933.
    Citations:    Fields:    
  24. Almas AN, Papp LJ, Woodbury MR, Nelson CA, Zeanah CH, Fox NA. The Impact of Caregiving Disruptions of Previously Institutionalized Children on Multiple Outcomes in Late Childhood. Child Dev. 2018 Oct 08. PMID: 30295918.
    Citations: 1     Fields:    
  25. Tang A, Slopen N, Nelson CA, Zeanah CH, Georgieff MK, Fox NA. Catch-up growth, metabolic, and cardiovascular risk in post-institutionalized Romanian adolescents. Pediatr Res. 2018 12; 84(6):842-848. PMID: 30323348.
    Citations:    Fields:    
  26. Alamiri B, Nelson C, Fitzmaurice GM, Murphy JM, Gilman SE. Neurological soft signs and cognitive performance in early childhood. Dev Psychol. 2018 Nov; 54(11):2043-2052. PMID: 30265034.
    Citations:    Fields:    Translation:Humans
  27. Kopetz C, Woerner JI, MacPherson L, Lejuez CW, Nelson CA, Zeanah CH, Fox NA. Early psychosocial deprivation and adolescent risk-taking: The role of motivation and executive control. J Exp Psychol Gen. 2019 Feb; 148(2):388-399. PMID: 30221961.
    Citations:    Fields:    
  28. Johnson DE, Tang A, Almas AN, Degnan KA, McLaughlin KA, Nelson CA, Fox NA, Zeanah CH, Drury SS. Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial. J Pediatr. 2018 12; 203:345-353.e3. PMID: 30172435.
    Citations:    Fields:    
  29. Nelson CA. The hazards of out-of-home care for children experiencing adverse home environments. Lancet Child Adolesc Health. 2018 09; 2(9):623-624. PMID: 30119752.
    Citations:    
  30. Guyon-Harris KL, Humphreys KL, Degnan K, Fox NA, Nelson CA, Zeanah CH. A prospective longitudinal study of Reactive Attachment Disorder following early institutional care: considering variable- and person-centered approaches. Attach Hum Dev. 2019 Apr; 21(2):95-110. PMID: 30037301.
    Citations:    Fields:    
  31. Lamm C, Troller-Renfree SV, Zeanah CH, Nelson CA, Fox NA. Impact of early institutionalization on attention mechanisms underlying the inhibition of a planned action. Neuropsychologia. 2018 08; 117:339-346. PMID: 29908954.
    Citations:    Fields:    
  32. Sheridan MA, McLaughlin KA, Winter W, Fox N, Zeanah C, Nelson CA. Early deprivation disruption of associative learning is a developmental pathway to depression and social problems. Nat Commun. 2018 06 07; 9(1):2216. PMID: 29880851.
    Citations: 1     Fields:    Translation:Humans
  33. Donowitz JR, Cook H, Alam M, Tofail F, Kabir M, Colgate ER, Carmolli MP, Kirkpatrick BD, Nelson CA, Ma JZ, Haque R, Petri WA. Role of maternal health and infant inflammation in nutritional and neurodevelopmental outcomes of two-year-old Bangladeshi children. PLoS Negl Trop Dis. 2018 05; 12(5):e0006363. PMID: 29813057.
    Citations: 1     Fields:    Translation:Humans
  34. Leppänen JM, Cataldo JK, Bosquet Enlow M, Nelson CA. Early development of attention to threat-related facial expressions. PLoS One. 2018; 13(5):e0197424. PMID: 29768468.
    Citations:    Fields:    Translation:Humans
  35. Bosl WJ, Tager-Flusberg H, Nelson CA. EEG Analytics for Early Detection of Autism Spectrum Disorder: A data-driven approach. Sci Rep. 2018 May 01; 8(1):6828. PMID: 29717196.
    Citations: 1     Fields:    
  36. Choi B, Leech KA, Tager-Flusberg H, Nelson CA. Development of fine motor skills is associated with expressive language outcomes in infants at high and low risk for autism spectrum disorder. J Neurodev Disord. 2018 Apr 12; 10(1):14. PMID: 29649977.
    Citations:    Fields:    
  37. Guyon-Harris KL, Humphreys KL, Fox NA, Nelson CA, Zeanah CH. Course of Disinhibited Social Engagement Disorder From Early Childhood to Early Adolescence. J Am Acad Child Adolesc Psychiatry. 2018 May; 57(5):329-335.e2. PMID: 29706162.
    Citations:    Fields:    
  38. Behrendt HF, Firk C, Nelson CA, Perdue KL. Motion correction for infant functional near-infrared spectroscopy with an application to live interaction data. Neurophotonics. 2018 Jan; 5(1):015004. PMID: 29487875.
    Citations:    
  39. Humphreys KL, Miron D, McLaughlin KA, Sheridan MA, Nelson CA, Fox NA, Zeanah CH. Foster care promotes adaptive functioning in early adolescence among children who experienced severe, early deprivation. J Child Psychol Psychiatry. 2018 Jul; 59(7):811-821. PMID: 29389015.
    Citations: 2     Fields:    
  40. O'Leary HM, Kaufmann WE, Barnes KV, Rakesh K, Kapur K, Tarquinio DC, Cantwell NG, Roche KJ, Rose SA, Walco AC, Bruck NM, Bazin GA, Holm IA, Alexander ME, Swanson LC, Baczewski LM, Mayor Torres JM, Nelson CA, Sahin M. Placebo-controlled crossover assessment of mecasermin for the treatment of Rett syndrome. Ann Clin Transl Neurol. 2018 03; 5(3):323-332. PMID: 29560377.
    Citations: 3     
  41. Naheed A, Koly KN, Uddin Ahmed H, Akhter S, Uddin MMJ, Smith Fawzi MC, Chandir S, Mannan M, Hossain S, Nelson C, Munir K. Implementing a Mental Health Care Program and Home-Based Training for Mothers of Children With Autism Spectrum Disorder in an Urban Population in Bangladesh: Protocol for a Feasibility Assessment Study. JMIR Res Protoc. 2017 Dec 14; 6(12):e251. PMID: 29242177.
    Citations:    
  42. Bick J, Luyster R, Fox NA, Zeanah CH, Nelson CA. Effects of early institutionalization on emotion processing in 12-year-old youth. Dev Psychopathol. 2017 12; 29(5):1749-1761. PMID: 29162181.
    Citations: 2     Fields:    Translation:Humans
  43. Clarkson T, LeBlanc J, DeGregorio G, Vogel-Farley V, Barnes K, Kaufmann WE, Nelson CA. Adapting the Mullen Scales of Early Learning for a Standardized Measure of Development in Children With Rett Syndrome. Intellect Dev Disabil. 2017 12; 55(6):419-431. PMID: 29194024.
    Citations:    Fields:    Translation:Humans
  44. Finch KH, Tager-Flusberg H, Nelson CA. Neural responses to linguistic stimuli in children with and without autism spectrum disorder. Eur J Neurosci. 2018 Mar; 47(6):709-719. PMID: 28922545.
    Citations:    Fields:    
  45. Nelson CA. Hazards to Early Development: The Biological Embedding of Early Life Adversity. Neuron. 2017 Oct 11; 96(2):262-266. PMID: 29024653.
    Citations: 1     Fields:    Translation:Humans
  46. Edwards LA, Wagner JB, Tager-Flusberg H, Nelson CA. Differences in Neural Correlates of Speech Perception in 3 Month Olds at High and Low Risk for Autism Spectrum Disorder. J Autism Dev Disord. 2017 Oct; 47(10):3125-3138. PMID: 28688078.
    Citations: 1     Fields:    Translation:Humans
  47. Levin AR, Varcin KJ, O'Leary HM, Tager-Flusberg H, Nelson CA. EEG power at 3 months in infants at high familial risk for autism. J Neurodev Disord. 2017 Sep 13; 9(1):34. PMID: 28903722.
    Citations: 3     Fields:    
  48. Bick J, Zeanah CH, Fox NA, Nelson CA. Memory and Executive Functioning in 12-Year-Old Children With a History of Institutional Rearing. Child Dev. 2018 03; 89(2):495-508. PMID: 28898388.
    Citations: 1     Fields:    
  49. Troller-Renfree S, Zeanah CH, Nelson CA, Fox NA. Neural and Cognitive Factors Influencing the Emergence of Psychopathology: Insights From the Bucharest Early Intervention Project. Child Dev Perspect. 2018 Mar; 12(1):28-33. PMID: 29531577.
    Citations:    
  50. McDonald NM, Varcin KJ, Bhatt R, Wu JY, Sahin M, Nelson CA, Jeste SS. Early autism symptoms in infants with tuberous sclerosis complex. Autism Res. 2017 Dec; 10(12):1981-1990. PMID: 28801991.
    Citations: 2     Fields:    Translation:Humans
  51. Perdue KL, Edwards LA, Tager-Flusberg H, Nelson CA. Differing Developmental Trajectories in Heart Rate Responses to Speech Stimuli in Infants at High and Low Risk for Autism Spectrum Disorder. J Autism Dev Disord. 2017 08; 47(8):2434-2442. PMID: 28516424.
    Citations: 1     Fields:    Translation:Humans
  52. Jensen SKG, Berens AE, Nelson CA. Effects of poverty on interacting biological systems underlying child development. Lancet Child Adolesc Health. 2017 Nov; 1(3):225-239. PMID: 30169171.
    Citations:    
  53. Berens AE, Jensen SKG, Nelson CA. Biological embedding of childhood adversity: from physiological mechanisms to clinical implications. BMC Med. 2017 07 20; 15(1):135. PMID: 28724431.
    Citations: 4     Fields:    Translation:HumansAnimals
  54. Jiang NM, Tofail F, Ma JZ, Haque R, Kirkpatrick B, Nelson CA, Petri WA. Early Life Inflammation and Neurodevelopmental Outcome in Bangladeshi Infants Growing Up in Adversity. Am J Trop Med Hyg. 2017 Sep; 97(3):974-979. PMID: 28722635.
    Citations: 5     Fields:    Translation:Humans
  55. Stamoulis C, Vanderwert RE, Zeanah CH, Fox NA, Nelson CA. Neuronal networks in the developing brain are adversely modulated by early psychosocial neglect. J Neurophysiol. 2017 10 01; 118(4):2275-2288. PMID: 28679837.
    Citations:    Fields:    Translation:Humans
  56. Luyster RJ, Bick J, Westerlund A, Nelson CA. Testing the effects of expression, intensity and age on emotional face processing in ASD. Neuropsychologia. 2019 Mar 18; 126:128-137. PMID: 28647439.
    Citations:    Fields: