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Last Name

profileRalph Scully, PH.D., M.B.,B.S.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
AddressBeth Israel Deaconess Med Ctr
Cls 438
330 Brookline Ave
Boston MA 02215
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AG042848     (SCULLY, RALPH)Jan 1, 2015 - Dec 31, 2016
A mouse model for studying homologous recombination fidelity during aging
Role: Principal Investigator

R21CA144022     (SCULLY, RALPH)Jul 1, 2010 - Jun 30, 2013
Analysis of recombination in vivo
Role: Principal Investigator

R21CA144017     (SCULLY, RALPH)Dec 1, 2009 - Nov 30, 2012
Mammalian Replication fork stalling
Role: Principal Investigator

RC1CA145867     (SCULLY, RALPH)Sep 30, 2009 - Aug 31, 2011
Targeting non-homologous end joining in cancer therapy
Role: Principal Investigator

R01GM073894     (SCULLY, RALPH)Sep 15, 2005 - Jun 30, 2015
The chromatin response in mammalian double strand break repair
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Willis NA, Scully R. DNA Polymerase ?: Duct Tape and Zip Ties for a Fragile Genome. Mol Cell. 2016 Aug 18; 63(4):542-4. PMID: 27540853.
    View in: PubMed
  2. Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, Wulf GM. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A. 2016 Jul 26; 113(30):E4338-47. PMID: 27402769.
    View in: PubMed
  3. Willis NA, Scully R. Spatial separation of replisome arrest sites influences homologous recombination quality at a Tus/Ter-mediated replication fork barrier. Cell Cycle. 2016 Jul 17; 15(14):1812-20. PMID: 27136113.
    View in: PubMed
  4. Elia AE, Wang DC, Willis NA, Boardman AP, Hajdu I, Adeyemi RO, Lowry E, Gygi SP, Scully R, Elledge SJ. RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks. Mol Cell. 2015 Oct 15; 60(2):280-93. PMID: 26474068; PMCID: PMC4609029 [Available on 10/15/16].
  5. Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015; 6:8325. PMID: 26446488; PMCID: PMC4633636.
  6. Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W. Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair. Mol Cell. 2015 Feb 19; 57(4):648-61. PMID: 25661488; PMCID: PMC4336609 [Available on 02/19/16].
  7. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov. 2014 Dec; 4(12):1430-47. PMID: 25252691; PMCID: PMC4258125.
  8. Willis NA, Chandramouly G, Huang B, Kwok A, Follonier C, Deng C, Scully R. BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks. Nature. 2014 Jun 26; 510(7506):556-9. PMID: 24776801; PMCID: PMC4118467.
  9. Beck C, Boehler C, Guirouilh Barbat J, Bonnet ME, Illuzzi G, Ronde P, Gauthier LR, Magroun N, Rajendran A, Lopez BS, Scully R, Boussin FD, Schreiber V, Dantzer F. PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways. Nucleic Acids Res. 2014 May; 42(9):5616-32. PMID: 24598253; PMCID: PMC4027158.
  10. Scully R, Xie A. Double strand break repair functions of histone H2AX. Mutat Res. 2013 Oct; 750(1-2):5-14. PMID: 23916969; PMCID: PMC3818383.
  11. Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov. 2013 Aug; 3(8):870-9. PMID: 23715154; PMCID: PMC3753578.
  12. Somyajit K, Basavaraju S, Scully R, Nagaraju G. ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. Mol Cell Biol. 2013 May; 33(9):1830-44. PMID: 23438602; PMCID: PMC3624173.
  13. Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R. BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids. Nat Commun. 2013; 4:2404. PMID: 23994874; PMCID: PMC3838905.
  14. Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One. 2012; 7(11):e49211. PMID: 23209566; PMCID: PMC3509127.
  15. Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, Cantley LC, Wulf GM. Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discov. 2012 Nov; 2(11):1048-63. PMID: 22915751; PMCID: PMC3733368.
  16. Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Mol Cell Biol. 2012 Oct; 32(19):3963-77. PMID: 22851694; PMCID: PMC3457524.
  17. Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM. BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell. 2011 Oct 21; 44(2):235-51. PMID: 21963239; PMCID: PMC3200447.
  18. Chandramouly G, Willis NA, Scully R. A protective role for BRCA2 at stalled replication forks. Breast Cancer Res. 2011; 13(5):314. PMID: 21996371; PMCID: PMC3262192.
  19. Scully R. Epistatic relationships in the BRCA1-BRCA2 pathway. PLoS Genet. 2011 Jul; 7(7):e1002183. PMID: 21779182; PMCID: PMC3136443.
  20. Dumitrache LC, Hu L, Son MY, Li H, Wesevich A, Scully R, Stark J, Hasty P. Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair. Genetics. 2011 Aug; 188(4):787-97. PMID: 21546543; PMCID: PMC3176084.
  21. Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev. 2011 Apr 1; 25(7):685-700. PMID: 21406551; PMCID: PMC3070932.
  22. Hartlerode A, Odate S, Shim I, Brown J, Scully R. Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein. PLoS One. 2011; 6(3):e16501. PMID: 21408059; PMCID: PMC3052302.
  23. Scully R. The spindle-assembly checkpoint, aneuploidy, and gastrointestinal cancer. N Engl J Med. 2010 Dec 30; 363(27):2665-6. PMID: 21190461; PMCID: PMC3731131.
  24. Xie A, Odate S, Chandramouly G, Scully R. H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle. 2010 Sep 1; 9(17):3602-10. PMID: 20703100; PMCID: PMC2980696.
  25. Scully R. A histone code for DNA repair. Nat Rev Mol Cell Biol. 2010 Mar; 11(3):164. PMID: 20213875.
    View in: PubMed
  26. Hartlerode AJ, Scully R. Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J. 2009 Oct 15; 423(2):157-68. PMID: 19772495; PMCID: PMC2983087.
  27. Xie A, Kwok A, Scully R. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol. 2009 Aug; 16(8):814-8. PMID: 19633669; PMCID: PMC2730592.
  28. Nagaraju G, Hartlerode A, Kwok A, Chandramouly G, Scully R. XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. Mol Cell Biol. 2009 Aug; 29(15):4283-94. PMID: 19470754; PMCID: PMC2715807.
  29. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18. PMID: 19041753; PMCID: PMC2853975.
  30. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell. 2007 Dec 28; 28(6):1045-57. PMID: 18158901; PMCID: PMC2275782.
  31. Xie A, Scully R. Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX. Mol Cell. 2007 Jul 20; 27(2):178-9. PMID: 17643367; PMCID: PMC2977995.
  32. Nagaraju G, Scully R. Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks. DNA Repair (Amst). 2007 Jul 1; 6(7):1018-31. PMID: 17379580; PMCID: PMC2989184.
  33. Nagaraju G, Odate S, Xie A, Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol Cell Biol. 2006 Nov; 26(21):8075-86. PMID: 16954385; PMCID: PMC1636746.
  34. Scully R, Xie A. In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases. Oncogene. 2005 Apr 18; 24(17):2871-6. PMID: 15838521; PMCID: PMC2977996.
  35. Puget N, Knowlton M, Scully R. Molecular analysis of sister chromatid recombination in mammalian cells. DNA Repair (Amst). 2005 Feb 3; 4(2):149-61. PMID: 15590323; PMCID: PMC2967438.
  36. Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R. Control of sister chromatid recombination by histone H2AX. Mol Cell. 2004 Dec 22; 16(6):1017-25. PMID: 15610743; PMCID: PMC2991138.
  37. Scully R, Xie A. BRCA1 and BRCA2 in breast cancer predisposition and recombination control. J Mammary Gland Biol Neoplasia. 2004 Jul; 9(3):237-46. PMID: 15557797.
    View in: PubMed
  38. Scully R, Xie A, Nagaraju G. Molecular functions of BRCA1 in the DNA damage response. Cancer Biol Ther. 2004 Jun; 3(6):521-7. PMID: 15280660.
    View in: PubMed
  39. Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA. Novel consensus DNA-binding sequence for BRCA1 protein complexes. Mol Carcinog. 2003 Oct; 38(2):85-96. PMID: 14502648.
    View in: PubMed
  40. Avni D, Yang H, Martelli F, Hofmann F, ElShamy WM, Ganesan S, Scully R, Livingston DM. Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Mol Cell. 2003 Sep; 12(3):735-46. PMID: 14527418.
    View in: PubMed
  41. Scully R, Puget N. Hereditary breast and ovarian cancer genes. Methods Mol Biol. 2003; 222:41-57. PMID: 12710679.
    View in: PubMed
  42. Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8173-8. PMID: 12034884; PMCID: PMC123040.
  43. Scully R, Puget N. BRCA1 and BRCA2 in hereditary breast cancer. Biochimie. 2002 Jan; 84(1):95-102. PMID: 11900881.
    View in: PubMed
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