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profileLisa D Nickerson, Ph.D.

TitleAssistant Professor of Psychiatry
InstitutionMcLean Hospital
DepartmentPsychiatry
AddressMclean Hospital
Brain Imaging Center
115 Mill St
Belmont MA 02478
Phone617/855-3548
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Collapse Biography 
Collapse awards and honors
2003 - 2005NRSA Fellowship
2003 - 2008Student Loan Repayment Award
2005 - 2010K25 Career Development Award
2009 - 2010Visiting Scientist, FMRIB, Oxford Univ.
2010Tutor FSL Course
2012O'Keefe Family Junior Investigator Award for Excellence in Imaging
2013Chair, Morning Workshop, OHBM
2014Organizer, Education Course, OHBM
2015Director, Applied Neuroimaging Statistics Lab
2016Member, Communications Committee, OHBM

Collapse Overview 
Collapse overview
My research interests focus on the application of multivariate statistical methods and machine learning techniques to neuroimaging data to investigate the neurobiology of addiction and psychiatric illness. My current efforts are focused on: investigating the structure and functional connectivity of brain circuits in chronic heavy marijuana smokers by applying multi-modal data fusion and machine learning techniques to existing FMRI, structural MRI and DTI data from multiple imaging studies, investigating the acute effects of alcohol and nicotine co-use on brain circuitry in individuals who smoke and drink alcohol using quantitative FMRI (BOLD, perfusion and CMRO2), and utilizing data from the Human Connectome Project to investigate the impact of addiction on brain circuitry.

I am seeking a post-doctoral research fellow with experience in FMRI statistics (must be a US citizen or hold a green card) and I also occasionally have openings for post-docs who do not need to be US citizens/green card holders. I am also accepting Harvard students who wish to learn about MRI data analysis and addiction. Please contact me if interested.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AA024565     (NICKERSON, LISA D)Aug 1, 2016 - Jul 31, 2018
NIH/NIAAA
Sex Differences in the Effects of Alcohol Use Disorder on Brain Circuitry using Existing Data
Role: Principal Investigator

R01DA037265     (NICKERSON, LISA D)Jul 15, 2014 - Jun 30, 2017
NIH/NIDA
Multi-modal MRI data fusion to assess neurobiological effects of marijuana use
Role: Principal Investigator

R21DA032257     (NICKERSON, LISA D)Feb 15, 2012 - Oct 31, 2014
NIH/NIDA
Neural Mechanisms Underlying Nicotine and Alcohol Combinations: Quantitative fMRI
Role: Principal Investigator

K25DA017712     (NICKERSON, LISA D)Apr 1, 2005 - Sep 30, 2010
NIH/NIDA
Novel Use of fMRI to Study Substance Abuse Problems
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Killgore WDS, Smith R, Olson EA, Weber M, Rauch SL, Nickerson LD. Emotional intelligence is associated with connectivity within and between resting state networks. Soc Cogn Affect Neurosci. 2017 Oct 01; 12(10):1624-1636. PMID: 28981827.
    View in: PubMed
  2. Cohen-Gilbert JE, Nickerson LD, Sneider JT, Oot EN, Seraikas AM, Rohan ML, Silveri MM. College Binge Drinking Associated with Decreased Frontal Activation to Negative Emotional Distractors during Inhibitory Control. Front Psychol. 2017; 8:1650. PMID: 29018380.
    View in: PubMed
  3. Olson EA, Cui J, Fukunaga R, Nickerson LD, Rauch SL, Rosso IM. Disruption of white matter structural integrity and connectivity in posttraumatic stress disorder: A TBSS and tractography study. Depress Anxiety. 2017 May; 34(5):437-445. PMID: 28294462.
    View in: PubMed
  4. Nickerson LD, Smith SM, Öngür D, Beckmann CF. Using Dual Regression to Investigate Network Shape and Amplitude in Functional Connectivity Analyses. Front Neurosci. 2017; 11:115. PMID: 28348512.
    View in: PubMed
  5. Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM. Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry. Hum Brain Mapp. 2017 Apr; 38(4):2276-2325. PMID: 28145075.
    View in: PubMed
  6. Li H, Nickerson LD, Nichols TE, Gao JH. Comparison of a non-stationary voxelation-corrected cluster-size test with TFCE for group-Level MRI inference. Hum Brain Mapp. 2017 Mar; 38(3):1269-1280. PMID: 27785843.
    View in: PubMed
  7. Maher S, Ekstrom T, Tong Y, Nickerson LD, Frederick B, Chen Y. Greater sensitivity of the cortical face processing system to perceptually-equated face detection. Brain Res. 2016 Jan 15; 1631:13-21. PMID: 26592952; PMCID: PMC4733446 [Available on 01/15/17].
  8. Fan Y, Nickerson LD, Li H, Ma Y, Lyu B, Miao X, Zhuo Y, Ge J, Zou Q, Gao JH. Functional Connectivity-Based Parcellation of the Thalamus: An Unsupervised Clustering Method and Its Validity Investigation. Brain Connect. 2015 Dec; 5(10):620-30. PMID: 26106821.
    View in: PubMed
  9. Bolo NR, Musen G, Simonson DC, Nickerson LD, Flores VL, Siracusa T, Hager B, Lyoo IK, Renshaw PF, Jacobson AM. Functional Connectivity of Insula, Basal Ganglia, and Prefrontal Executive Control Networks during Hypoglycemia in Type 1 Diabetes. J Neurosci. 2015 Aug 05; 35(31):11012-23. PMID: 26245963; PMCID: PMC4524972.
  10. Mashhoon Y, Sava S, Sneider JT, Nickerson LD, Silveri MM. Cortical thinness and volume differences associated with marijuana abuse in emerging adults. Drug Alcohol Depend. 2015 Oct 01; 155:275-83. PMID: 26249265; PMCID: PMC4581973 [Available on 10/01/16].
  11. Li H, Nickerson LD, Zhao X, Nichols TE, Gao JH. A voxelation-corrected non-stationary 3D cluster-size test based on random field theory. Neuroimage. 2015 Sep; 118:676-82. PMID: 26067343.
    View in: PubMed
  12. Li H and Nickerson LD (co-firsts), Xiong J, Zou Q, Fan Y, Ma Y, Shi T, Ge J, Gao JH. A high performance 3D cluster-based test of unsmoothed fMRI data. Neuroimage. 2014; (98):537-46.
  13. Admon R, Nickerson LD, Dillon DG, Holmes AJ, Bogdan R, Kumar P, Dougherty DD, Iosifescu DV, Mischoulon D, Fava M, Pizzagalli DA. Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties. Psychol Med. 2015 Jan; 45(1):121-31. PMID: 25055809; PMCID: PMC4233014.
  14. Kumar P, Berghorst LH, Nickerson LD, Dutra SJ, Goer FK, Greve DN, Pizzagalli DA. Differential effects of acute stress on anticipatory and consummatory phases of reward processing. Neuroscience. 2014 Apr 25; 266:1-12. PMID: 24508744; PMCID: PMC4026279.
  15. Janes AC, Farmer S, Frederick Bd, Nickerson LD, Lukas SE. An increase in tobacco craving is associated with enhanced medial prefrontal cortex network coupling. PLoS One. 2014; 9(2):e88228. PMID: 24505440; PMCID: PMC3914963.
  16. Janes AC, Ross RS, Farmer S, Frederick BB, Nickerson LD, Lukas SE, Stern CE. Memory retrieval of smoking-related images induce greater insula activation as revealed by an fMRI-based delayed matching to sample task. Addict Biol. 2015 Mar; 20(2):349-56. PMID: 24261848; PMCID: PMC4031308.
  17. Tong Y, Hocke LM, Nickerson LD, Licata SC, Lindsey KP, Frederick Bd. Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks. Neuroimage. 2013 Aug 01; 76:202-15. PMID: 23523805; PMCID: PMC3652630.
  18. Licata SC, Nickerson LD, Lowen SB, Trksak GH, Maclean RR, Lukas SE. The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm. Neuroimage. 2013 Apr 15; 70:211-22. PMID: 23296183; PMCID: PMC3580018.
  19. Frederick Bd, Nickerson LD, Tong Y. Physiological denoising of BOLD fMRI data using Regressor Interpolation at Progressive Time Delays (RIPTiDe) processing of concurrent fMRI and near-infrared spectroscopy (NIRS). Neuroimage. 2012 Apr 15; 60(3):1913-23. PMID: 22342801; PMCID: PMC3593078.
  20. Janes AC and Nickerson LD (co-firsts), Frederick Bde B, Kaufman MJ. Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls. Drug Alcohol Depend. 2012; 3(125):252-9.
  21. Filippini N, Nickerson LD, Beckmann CF, Ebmeier KP, Frisoni GB, Matthews PM, Smith SM, Mackay CE. Age-related adaptations of brain function during a memory task are also present at rest. Neuroimage. 2012 Feb 15; 59(4):3821-8. PMID: 22155375.
    View in: PubMed
  22. Nickerson LD, Ravichandran C, Lundahl LH, Rodolico J, Dunlap S, Trksak GH, Lukas SE. Cue reactivity in cannabis-dependent adolescents. Psychol Addict Behav. 2011 Mar; 25(1):168-73. PMID: 21142334; PMCID: PMC3066287.
  23. Lowen SB, Nickerson LD, Levin JM. Differential effects of acute cocaine and placebo administration on visual cortical activation in healthy subjects measured using BOLD fMRI. Pharmacol Biochem Behav. 2009 Apr; 92(2):277-82. PMID: 19138702; PMCID: PMC2701656.
  24. Frederick Bd, Lindsey KP, Nickerson LD, Ryan ET, Lukas SE. An MR-compatible device for delivering smoked marijuana during functional imaging. Pharmacol Biochem Behav. 2007 May; 87(1):81-9. PMID: 17521714; PMCID: PMC2570055.
  25. Nickerson LD, Narayana S, Lancaster JL, Fox PT, Gao JH. Estimation of the local statistical noise in positron emission tomography revisited: practical implementation. Neuroimage. 2003 Jun; 19(2 Pt 1):442-56. PMID: 12814593.
    View in: PubMed
  26. Nunneley SA, Martin CC, Slauson JW, Hearon CM, Nickerson LD, Mason PA. Changes in regional cerebral metabolism during systemic hyperthermia in humans. J Appl Physiol (1985). 2002 Feb; 92(2):846-51. PMID: 11796700.
    View in: PubMed
  27. Nickerson LD, Martin CC, Lancaster JL, Gao JH, Fox PT. A tool for comparison of PET and fMRI methods: calculation of the uncertainty in the location of an activation site in a PET image. Neuroimage. 2001 Jul; 14(1 Pt 1):194-201. PMID: 11525328.
    View in: PubMed
  28. Liu HL, Pu Y, Nickerson LD, Liu Y, Fox PT, Gao JH. Comparison of the temporal response in perfusion and BOLD-based event-related functional MRI. Magn Reson Med. 2000 May; 43(5):768-72. PMID: 10800045.
    View in: PubMed
  29. Liu HL, Pu Y, Liu Y, Nickerson L, Andrews T, Fox PT, Gao JH. Cerebral blood flow measurement by dynamic contrast MRI using singular value decomposition with an adaptive threshold. Magn Reson Med. 1999 Jul; 42(1):167-72. PMID: 10398963.
    View in: PubMed
  30. Martin CC, Jerabek PA, Nickerson LD, Fox PT. Effect of partition coefficient, permeability surface product, and radioisotope on the signal-to-noise ratio in PET functional brain mapping: a computer simulation. Hum Brain Mapp. 1999; 7(3):151-60. PMID: 10194616.
    View in: PubMed
  31. Martin CC, Williams RF, Gao JH, Nickerson LD, Xiong J, Fox PT. The pharmacokinetics of hyperpolarized xenon: implications for cerebral MRI. J Magn Reson Imaging. 1997 Sep-Oct; 7(5):848-54. PMID: 9307910.
    View in: PubMed
  32. Xiong J, Nickerson LD, Downs JH, Fox PT. Basic principles and neurosurgical applications of positron emission tomography. Neurosurg Clin N Am. 1997 Jul; 8(3):293-306. PMID: 9188539.
    View in: PubMed
  33. Martin CC, Christian BT, Satter MR, Nickerson LH, Nickles RJ. Quantitative PET with positron emitters that emit prompt gamma rays. IEEE Trans Med Imaging. 1995; 14(4):681-7. PMID: 18215872.
    View in: PubMed
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