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Lisa D Nickerson, Ph.D.

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2003 - 2005
NRSA Fellowship
2003 - 2008
Student Loan Repayment Award
2005 - 2010
K25 Career Development Award
2009 - 2010
Visiting Scientist
Tutor FSL Course
O'Keefe Family Junior Investigator Award for Excellence in Imaging
Chair, Morning Workshop
Organizer, Education Course
Director, Applied Neuroimaging Statistics Lab
Member, Communications Committee
Team Leader, Communications Committee

I am the Director of the Applied Neuroimaging Statistics Lab at McLean Hospital, which focuses on developing new statistical methods for functional magnetic resonance imaging (fMRI) and on applying state-of-the-art analysis methods such as multi-modal data fusion and machine learning methods for basic neuroscience research and to investigate problems of addiction and psychiatric illness. Current projects involve developing a new method to combine multi-modal MRI data across multiple research studies, developing new brain network analysis techniques for task fMRI, and using data fusion (linked ICA) to investigate the links between brain structure and function in heavy chronic cannabis users. Other research utilizes the Human Connectome Project (HCP) data to investigate sex differences in the effects of alcohol use disorder (AUD) on brain circuitry implicated in social cognition. I also provide statistical support and training for numerous junior scientists and collaborators through mentoring and teaching seminars and courses on imaging statistics, resting state and task fMRI data processing, multivariate data-driven methods and other imaging analysis topics.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AA024565 (NICKERSON, LISA D) Aug 1, 2016 - Jul 31, 2018
    Sex Differences in the Effects of Alcohol Use Disorder on Brain Circuitry using Existing Data
    Role: Principal Investigator
  2. R01DA037265 (NICKERSON, LISA D) Jul 15, 2014 - Jun 30, 2017
    Multi-modal MRI data fusion to assess neurobiological effects of marijuana use
    Role: Principal Investigator
  3. R21DA032257 (NICKERSON, LISA D) Feb 15, 2012 - Oct 31, 2014
    Neural Mechanisms Underlying Nicotine and Alcohol Combinations: Quantitative fMRI
    Role: Principal Investigator
  4. K25DA017712 (NICKERSON, LISA D) Apr 1, 2005 - Sep 30, 2010
    Novel Use of fMRI to Study Substance Abuse Problems
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sneider JT, Cohen-Gilbert JE, Hamilton DA, Stein ER, Golan N, Oot EN, Seraikas AM, Rohan ML, Harris SK, Nickerson LD, Silveri MM. Adolescent Hippocampal and Prefrontal Brain Activation During Performance of the Virtual Morris Water Task. Front Hum Neurosci. 2018; 12:238. PMID: 29997486.
    View in: PubMed
  2. Dumais KM, Chernyak S, Nickerson LD, Janes AC. Sex differences in default mode and dorsal attention network engagement. PLoS One. 2018; 13(6):e0199049. PMID: 29902249.
    View in: PubMed
  3. Killgore WDS, Smith R, Olson EA, Weber M, Rauch SL, Nickerson LD. Emotional intelligence is associated with connectivity within and between resting state networks. Soc Cogn Affect Neurosci. 2017 10 01; 12(10):1624-1636. PMID: 28981827.
    View in: PubMed
  4. Cohen-Gilbert JE, Nickerson LD, Sneider JT, Oot EN, Seraikas AM, Rohan ML, Silveri MM. College Binge Drinking Associated with Decreased Frontal Activation to Negative Emotional Distractors during Inhibitory Control. Front Psychol. 2017; 8:1650. PMID: 29018380.
    View in: PubMed
  5. Olson EA, Cui J, Fukunaga R, Nickerson LD, Rauch SL, Rosso IM. Disruption of white matter structural integrity and connectivity in posttraumatic stress disorder: A TBSS and tractography study. Depress Anxiety. 2017 05; 34(5):437-445. PMID: 28294462.
    View in: PubMed
  6. Nickerson LD, Smith SM, Öngür D, Beckmann CF. Using Dual Regression to Investigate Network Shape and Amplitude in Functional Connectivity Analyses. Front Neurosci. 2017; 11:115. PMID: 28348512.
    View in: PubMed
  7. Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM. Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry. Hum Brain Mapp. 2017 04; 38(4):2276-2325. PMID: 28145075.
    View in: PubMed
  8. Li H, Nickerson LD, Nichols TE, Gao JH. Comparison of a non-stationary voxelation-corrected cluster-size test with TFCE for group-Level MRI inference. Hum Brain Mapp. 2017 03; 38(3):1269-1280. PMID: 27785843.
    View in: PubMed
  9. Maher S, Ekstrom T, Tong Y, Nickerson LD, Frederick B, Chen Y. Greater sensitivity of the cortical face processing system to perceptually-equated face detection. Brain Res. 2016 Jan 15; 1631:13-21. PMID: 26592952; PMCID: PMC4733446 [Available on 01/15/17].
  10. Fan Y, Nickerson LD, Li H, Ma Y, Lyu B, Miao X, Zhuo Y, Ge J, Zou Q, Gao JH. Functional Connectivity-Based Parcellation of the Thalamus: An Unsupervised Clustering Method and Its Validity Investigation. Brain Connect. 2015 Dec; 5(10):620-30. PMID: 26106821.
    View in: PubMed
  11. Bolo NR, Musen G, Simonson DC, Nickerson LD, Flores VL, Siracusa T, Hager B, Lyoo IK, Renshaw PF, Jacobson AM. Functional Connectivity of Insula, Basal Ganglia, and Prefrontal Executive Control Networks during Hypoglycemia in Type 1 Diabetes. J Neurosci. 2015 Aug 05; 35(31):11012-23. PMID: 26245963; PMCID: PMC4524972.
  12. Mashhoon Y, Sava S, Sneider JT, Nickerson LD, Silveri MM. Cortical thinness and volume differences associated with marijuana abuse in emerging adults. Drug Alcohol Depend. 2015 Oct 01; 155:275-83. PMID: 26249265; PMCID: PMC4581973 [Available on 10/01/16].
  13. Li H, Nickerson LD, Zhao X, Nichols TE, Gao JH. A voxelation-corrected non-stationary 3D cluster-size test based on random field theory. Neuroimage. 2015 Sep; 118:676-82. PMID: 26067343.
    View in: PubMed
  14. Li H and Nickerson LD (co-firsts), Xiong J, Zou Q, Fan Y, Ma Y, Shi T, Ge J, Gao JH. A high performance 3D cluster-based test of unsmoothed fMRI data. Neuroimage. 2014; (98):537-46.
  15. Admon R, Nickerson LD, Dillon DG, Holmes AJ, Bogdan R, Kumar P, Dougherty DD, Iosifescu DV, Mischoulon D, Fava M, Pizzagalli DA. Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties. Psychol Med. 2015 Jan; 45(1):121-31. PMID: 25055809; PMCID: PMC4233014.
  16. Kumar P, Berghorst LH, Nickerson LD, Dutra SJ, Goer FK, Greve DN, Pizzagalli DA. Differential effects of acute stress on anticipatory and consummatory phases of reward processing. Neuroscience. 2014 Apr 25; 266:1-12. PMID: 24508744; PMCID: PMC4026279.
  17. Janes AC, Farmer S, Frederick Bd, Nickerson LD, Lukas SE. An increase in tobacco craving is associated with enhanced medial prefrontal cortex network coupling. PLoS One. 2014; 9(2):e88228. PMID: 24505440; PMCID: PMC3914963.
  18. Janes AC, Ross RS, Farmer S, Frederick BB, Nickerson LD, Lukas SE, Stern CE. Memory retrieval of smoking-related images induce greater insula activation as revealed by an fMRI-based delayed matching to sample task. Addict Biol. 2015 Mar; 20(2):349-56. PMID: 24261848; PMCID: PMC4031308.
  19. Tong Y, Hocke LM, Nickerson LD, Licata SC, Lindsey KP, Frederick Bd. Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks. Neuroimage. 2013 Aug 01; 76:202-15. PMID: 23523805; PMCID: PMC3652630.
  20. Licata SC, Nickerson LD, Lowen SB, Trksak GH, Maclean RR, Lukas SE. The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm. Neuroimage. 2013 Apr 15; 70:211-22. PMID: 23296183; PMCID: PMC3580018.
  21. Frederick Bd, Nickerson LD, Tong Y. Physiological denoising of BOLD fMRI data using Regressor Interpolation at Progressive Time Delays (RIPTiDe) processing of concurrent fMRI and near-infrared spectroscopy (NIRS). Neuroimage. 2012 Apr 15; 60(3):1913-23. PMID: 22342801; PMCID: PMC3593078.
  22. Janes AC and Nickerson LD (co-firsts), Frederick Bde B, Kaufman MJ. Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls. Drug Alcohol Depend. 2012; 3(125):252-9.
  23. Filippini N, Nickerson LD, Beckmann CF, Ebmeier KP, Frisoni GB, Matthews PM, Smith SM, Mackay CE. Age-related adaptations of brain function during a memory task are also present at rest. Neuroimage. 2012 Feb 15; 59(4):3821-8. PMID: 22155375.
    View in: PubMed
  24. Nickerson LD, Ravichandran C, Lundahl LH, Rodolico J, Dunlap S, Trksak GH, Lukas SE. Cue reactivity in cannabis-dependent adolescents. Psychol Addict Behav. 2011 Mar; 25(1):168-73. PMID: 21142334; PMCID: PMC3066287.
  25. Lowen SB, Nickerson LD, Levin JM. Differential effects of acute cocaine and placebo administration on visual cortical activation in healthy subjects measured using BOLD fMRI. Pharmacol Biochem Behav. 2009 Apr; 92(2):277-82. PMID: 19138702; PMCID: PMC2701656.
  26. Frederick Bd, Lindsey KP, Nickerson LD, Ryan ET, Lukas SE. An MR-compatible device for delivering smoked marijuana during functional imaging. Pharmacol Biochem Behav. 2007 May; 87(1):81-9. PMID: 17521714; PMCID: PMC2570055.
  27. Nickerson LD, Narayana S, Lancaster JL, Fox PT, Gao JH. Estimation of the local statistical noise in positron emission tomography revisited: practical implementation. Neuroimage. 2003 Jun; 19(2 Pt 1):442-56. PMID: 12814593.
    View in: PubMed
  28. Nunneley SA, Martin CC, Slauson JW, Hearon CM, Nickerson LD, Mason PA. Changes in regional cerebral metabolism during systemic hyperthermia in humans. J Appl Physiol (1985). 2002 Feb; 92(2):846-51. PMID: 11796700.
    View in: PubMed
  29. Nickerson LD, Martin CC, Lancaster JL, Gao JH, Fox PT. A tool for comparison of PET and fMRI methods: calculation of the uncertainty in the location of an activation site in a PET image. Neuroimage. 2001 Jul; 14(1 Pt 1):194-201. PMID: 11525328.
    View in: PubMed
  30. Liu HL, Pu Y, Nickerson LD, Liu Y, Fox PT, Gao JH. Comparison of the temporal response in perfusion and BOLD-based event-related functional MRI. Magn Reson Med. 2000 May; 43(5):768-72. PMID: 10800045.
    View in: PubMed
  31. Liu HL, Pu Y, Liu Y, Nickerson L, Andrews T, Fox PT, Gao JH. Cerebral blood flow measurement by dynamic contrast MRI using singular value decomposition with an adaptive threshold. Magn Reson Med. 1999 Jul; 42(1):167-72. PMID: 10398963.
    View in: PubMed
  32. Martin CC, Jerabek PA, Nickerson LD, Fox PT. Effect of partition coefficient, permeability surface product, and radioisotope on the signal-to-noise ratio in PET functional brain mapping: a computer simulation. Hum Brain Mapp. 1999; 7(3):151-60. PMID: 10194616.
    View in: PubMed
  33. Martin CC, Williams RF, Gao JH, Nickerson LD, Xiong J, Fox PT. The pharmacokinetics of hyperpolarized xenon: implications for cerebral MRI. J Magn Reson Imaging. 1997 Sep-Oct; 7(5):848-54. PMID: 9307910.
    View in: PubMed
  34. Xiong J, Nickerson LD, Downs JH, Fox PT. Basic principles and neurosurgical applications of positron emission tomography. Neurosurg Clin N Am. 1997 Jul; 8(3):293-306. PMID: 9188539.
    View in: PubMed
  35. Martin CC, Christian BT, Satter MR, Nickerson LH, Nickles RJ. Quantitative PET with positron emitters that emit prompt gamma rays. IEEE Trans Med Imaging. 1995; 14(4):681-7. PMID: 18215872.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.