Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
HarvardTrials will no longer be available as of June 7. You can search ClinicalTrials.gov directly for Harvard-sponsored studies. If you have questions, please email us.
Check out the new look and feel of Harvard Catalyst Profiles! Learn more on our About and Help pages.

Joseph E. Italiano, PH.D.

Title
Institution
Department
Address
Phone
Fax
Other Positions
Title
Institution
Department

Mentoring
A platelet-mediated approach to reducing amyloid deposits in the CNS
Summer, 06/18/07 - 08/10/07

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL136394 (FURIE, BRUCE) Apr 1, 2017 - Mar 31, 2021
    NIH/NHLBI
    Vascular Thiol Isomerases in Thrombosis
    Role: Co-Principal Investigator
  2. R01CA200748 (ITALIANO, JOSEPH E) Dec 16, 2016 - Nov 30, 2021
    NIH/NCI
    How does malignancy subvert platelet and megakaryocytic biology?
    Role: Co-Principal Investigator
  3. R13HL127767 (ITALIANO, JOSEPH E) Apr 15, 2015 - Mar 31, 2016
    NIH/NHLBI
    Cell Biology of Megakaryocytes &Platelets GRC &GRS /Bridging the Divide Between Megakaryocytes and Platelets-
    Role: Principal Investigator
  4. R01HL068130 (ITALIANO, JOSEPH E) Jul 1, 2001 - Mar 31, 2021
    NIH/NHLBI
    Cytoskeletal Mechanisms of Platelet Formation
    Role: Principal Investigator
  5. F32HL010192 (ITALIANO, JOSEPH E) Mar 15, 1999
    NIH/NHLBI
    MECHANISM OF PLATELET PRODUCTION
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. Proc Natl Acad Sci U S A. 2018 Feb 13; 115(7):E1550-E1559. PMID: 29386381.
    View in: PubMed
  2. Lorenz V, Ramsey H, Liu ZJ, Italiano J, Hoffmeister K, Bihorel S, Mager D, Hu Z, Slayton WB, Kile BT, Sola-Visner M, Ferrer-Marin F. Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. Thromb Haemost. 2017 12; 117(12):2322-2333. PMID: 29212120.
    View in: PubMed
  3. Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE, Semple JW. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. Blood Adv. 2017 Sep 12; 1(20):1773-1785. PMID: 29296823.
    View in: PubMed
  4. Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE, Weyrich AS, Bear JE, Bergmeier W. Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Adv. 2017 Aug 08; 1(18):1398-1408. PMID: 29104956.
    View in: PubMed
  5. Machlus KR, Wu SK, Vijey P, Soussou TS, Liu ZJ, Shacham E, Unger TJ, Kashyap T, Klebanov B, Sola-Visner M, Crochiere M, Italiano JE, Landesman Y. Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis. Blood. 2017 08 31; 130(9):1132-1143. PMID: 28630120.
    View in: PubMed
  6. Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, Ware J, Gurish MF, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest. 2017 May 01; 127(5):1714-1724. PMID: 28375155.
    View in: PubMed
  7. Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE, Battinelli EM. Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis. Arterioscler Thromb Vasc Biol. 2017 Apr; 37(4):664-674. PMID: 28153880.
    View in: PubMed
  8. Kim K, Tseng A, Barazia A, Italiano JE, Cho J. DREAM plays an important role in platelet activation and thrombogenesis. Blood. 2017 01 12; 129(2):209-225. PMID: 27903531.
    View in: PubMed
  9. Carubbi C, Masselli E, Martini S, Galli D, Aversa F, Mirandola P, Italiano JE, Gobbi G, Vitale M. Human thrombopoiesis depends on Protein kinase Cd/protein kinase Ce functional couple. Haematologica. 2016 07; 101(7):812-20. PMID: 27081176; PMCID: PMC5004460.
  10. Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501. PMID: 26755713; PMCID: PMC4797025 [Available on 03/17/17].
  11. Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE. Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood. 2016 Mar 17; 127(11):1468-80. PMID: 26744461; PMCID: PMC4797023 [Available on 03/17/17].
  12. Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE, Battinelli EM. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. 2016 Feb 18; 127(7):921-6. PMID: 26647394; PMCID: PMC4760093 [Available on 02/18/17].
  13. Bury L, Falcinelli E, Chiasserini D, Springer TA, Italiano JE, Gresele P. Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia. Haematologica. 2016 Jan; 101(1):46-56. PMID: 26452979; PMCID: PMC4697891.
  14. Barbieri SS, Petrucci G, Tarantino E, Amadio P, Rocca B, Pesce M, Machlus KR, Ranelletti FO, Gianellini S, Weksler B, Italiano JE, Tremoli E. Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice. Thromb Haemost. 2015 Nov 25; 114(6):1218-29. PMID: 26272103.
    View in: PubMed
  15. Thon JN, Medvetz DA, Karlsson SM, Italiano JE. Road blocks in making platelets for transfusion. J Thromb Haemost. 2015 Jun; 13 Suppl 1:S55-62. PMID: 26149051.
    View in: PubMed
  16. Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. J Clin Invest. 2015 Jun; 125(6):2369-74. PMID: 25961454; PMCID: PMC4497743.
  17. Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, Italiano JE, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R. IL-1a induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol. 2015 May 11; 209(3):453-66. PMID: 25963822; PMCID: PMC4427781.
  18. Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE, Hartwig JH. Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein. Blood. 2015 Jan 29; 125(5):860-8. PMID: 25411426; PMCID: PMC4311231.
  19. Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R. Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports. 2014 Nov 11; 3(5):817-31. PMID: 25418726; PMCID: PMC4235139.
  20. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Sep 18; 124(12):1857-67. PMID: 25606631; PMCID: PMC4168343.
  21. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-1044. PMID: 25171405; PMCID: PMC4149754.
  22. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE, Christensen H, Kahr WH, Li DY, Weyrich AS. Proteasome function is required for platelet production. J Clin Invest. 2014 Sep; 124(9):3757-66. PMID: 25061876; PMCID: PMC4151230.
  23. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Jul 21. PMID: 25049277.
    View in: PubMed
  24. Liu ZJ, Hoffmeister KM, Hu Z, Mager DE, Ait-Oudhia S, Debrincat MA, Pleines I, Josefsson EC, Kile BT, Italiano J, Ramsey H, Grozovsky R, Veng-Pedersen P, Chavda C, Sola-Visner M. Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood. 2014 May 29; 123(22):3381-9. PMID: 24599546; PMCID: PMC4041172.
  25. Machlus KR, Thon JN, Italiano JE. Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation. Br J Haematol. 2014 Apr; 165(2):227-36. PMID: 24499183.
    View in: PubMed
  26. Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, DiMauro S, Paw BH. Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet. 2013 Nov 07; 93(5):906-14. PMID: 24119684; PMCID: PMC3824126.
  27. Battinelli EM, Markens BA, Kulenthirarajan RA, Machlus KR, Flaumenhaft R, Italiano JE. Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood. 2014 Jan 02; 123(1):101-12. PMID: 24065244; PMCID: PMC3879901.
  28. Thon JN, Kitterman AC, Italiano JE. Animating platelet production adds physiological context. Trends Mol Med. 2013 Oct; 19(10):583-5. PMID: 23953478; PMCID: PMC4418476.
  29. Gobbi G, Mirandola P, Carubbi C, Masselli E, Sykes SM, Ferraro F, Nouvenne A, Thon JN, Italiano JE, Vitale M. Proplatelet generation in the mouse requires PKCe-dependent RhoA inhibition. Blood. 2013 Aug 15; 122(7):1305-11. PMID: 23838351; PMCID: PMC3952532.
  30. Machlus KR, Italiano JE. The incredible journey: From megakaryocyte development to platelet formation. J Cell Biol. 2013 Jun 10; 201(6):785-96. PMID: 23751492; PMCID: PMC3678154.
  31. Koseoglu S, Dilks JR, Peters CG, Fitch-Tewfik JL, Fadel NA, Jasuja R, Italiano JE, Haynes CL, Flaumenhaft R. Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):481-8. PMID: 23288151; PMCID: PMC3573216.
  32. Italiano JE. Unraveling mechanisms that control platelet production. Semin Thromb Hemost. 2013 Feb; 39(1):15-24. PMID: 23266965.
    View in: PubMed
  33. Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE, Mammoto A, Bielenberg DR, Klagsbrun M. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem. 2013 Jan 25; 288(4):2210-22. PMID: 23195957; PMCID: PMC3554894.
  34. Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE, Maguire PB. Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood. 2013 Jan 03; 121(1):188-96. PMID: 23160460; PMCID: PMC3538329.
  35. Drabek K, Gutiérrez L, Vermeij M, Clapes T, Patel SR, Boisset JC, van Haren J, Pereira AL, Liu Z, Akinci U, Nikolic T, van Ijcken W, van den Hout M, Meinders M, Melo C, Sambade C, Drabek D, Hendriks RW, Philipsen S, Mommaas M, Grosveld F, Maiato H, Italiano JE, Robin C, Galjart N. The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance. Cell Rep. 2012 Oct 25; 2(4):781-8. PMID: 23084744.
    View in: PubMed
  36. Nürnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K, Thon JN, Lloyd-Jones H, Sambrook JG, Tijssen MR, Italiano JE, Deloukas P, Gottgens B, Soranzo N, Ouwehand WH. A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood. 2012 Dec 06; 120(24):4859-68. PMID: 22972982; PMCID: PMC3520622.
  37. Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE, Hartwig JH, Walter U. Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis. Exp Hematol. 2013 Jan; 41(1):91-101.e4. PMID: 22981933; PMCID: PMC3638753.
  38. Meyer I, Kunert S, Schwiebert S, Hagedorn I, Italiano JE, Dütting S, Nieswandt B, Bachmann S, Schulze H. Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. Blood. 2012 Oct 25; 120(17):3594-602. PMID: 22936655.
    View in: PubMed
  39. Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE. T granules in human platelets function in TLR9 organization and signaling. J Cell Biol. 2012 Aug 20; 198(4):561-74. PMID: 22908309; PMCID: PMC3514030.
  40. Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE, Krause DS. MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation. Blood. 2012 Sep 13; 120(11):2317-29. PMID: 22806889; PMCID: PMC3447785.
  41. Thon JN, Italiano JE. Does size matter in platelet production? Blood. 2012 Aug 23; 120(8):1552-61. PMID: 22665937; PMCID: PMC3429301.
  42. Thon JN, Devine MT, Jurak Begonja A, Tibbitts J, Italiano JE. High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production. Blood. 2012 Sep 06; 120(10):1975-84. PMID: 22665936; PMCID: PMC3437592.
  43. Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE. Microtubule and cortical forces determine platelet size during vascular platelet production. Nat Commun. 2012 May 22; 3:852. PMID: 22617292.
    View in: PubMed
  44. Wandall HH, Rumjantseva V, Sørensen AL, Patel-Hett S, Josefsson EC, Bennett EP, Italiano JE, Clausen H, Hartwig JH, Hoffmeister KM. The origin and function of platelet glycosyltransferases. Blood. 2012 Jul 19; 120(3):626-35. PMID: 22613794; PMCID: PMC3401214.
  45. Peterson JE, Zurakowski D, Italiano JE, Michel LV, Connors S, Oenick M, D'Amato RJ, Klement GL, Folkman J. VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients. Angiogenesis. 2012 Jun; 15(2):265-73. PMID: 22402885.
    View in: PubMed
  46. Thon JN, Italiano JE. Visualization and manipulation of the platelet and megakaryocyte cytoskeleton. Methods Mol Biol. 2012; 788:109-25. PMID: 22130704.
    View in: PubMed
  47. Thon JN, Italiano JE. Platelets: production, morphology and ultrastructure. Handb Exp Pharmacol. 2012; (210):3-22. PMID: 22918725.
    View in: PubMed
  48. Battinelli EM, Markens BA, Italiano JE. Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. Blood. 2011 Aug 04; 118(5):1359-69. PMID: 21680800; PMCID: PMC3152500.
  49. Ma D, Zhang J, Lin HF, Italiano J, Handin RI. The identification and characterization of zebrafish hematopoietic stem cells. Blood. 2011 Jul 14; 118(2):289-97. PMID: 21586750; PMCID: PMC3138684.
  50. Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011 Aug 11; 118(6):1641-52. PMID: 21566095; PMCID: PMC3156050.
  51. Semple JW, Italiano JE, Freedman J. Platelets and the immune continuum. Nat Rev Immunol. 2011 Apr; 11(4):264-74. PMID: 21436837.
    View in: PubMed
  52. Liu ZJ, Italiano J, Ferrer-Marin F, Gutti R, Bailey M, Poterjoy B, Rimsza L, Sola-Visner M. Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood. 2011 Apr 14; 117(15):4106-17. PMID: 21304100; PMCID: PMC3087534.
  53. Lu SJ, Li F, Yin H, Feng Q, Kimbrel EA, Hahm E, Thon JN, Wang W, Italiano JE, Cho J, Lanza R. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res. 2011 Mar; 21(3):530-45. PMID: 21221130; PMCID: PMC3193430.
  54. Thon JN, Montalvo A, Patel-Hett S, Devine MT, Richardson JL, Ehrlicher A, Larson MK, Hoffmeister K, Hartwig JH, Italiano JE. Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol. 2010 Nov 15; 191(4):861-74. PMID: 21079248; PMCID: PMC2983072.
  55. Flaumenhaft R, Mairuhu AT, Italiano JE. Platelet- and megakaryocyte-derived microparticles. Semin Thromb Hemost. 2010 Nov; 36(8):881-7. PMID: 21049389.
    View in: PubMed
  56. Italiano JE, Mairuhu AT, Flaumenhaft R. Clinical relevance of microparticles from platelets and megakaryocytes. Curr Opin Hematol. 2010 Nov; 17(6):578-84. PMID: 20739880; PMCID: PMC3082287.
  57. Thon JN, Italiano JE. Platelet formation. Semin Hematol. 2010 Jul; 47(3):220-6. PMID: 20620432; PMCID: PMC2904625.
  58. Peterson JE, Zurakowski D, Italiano JE, Michel LV, Fox L, Klement GL, Folkman J. Normal ranges of angiogenesis regulatory proteins in human platelets. Am J Hematol. 2010 Jul; 85(7):487-93. PMID: 20575035.
    View in: PubMed
  59. Halene S, Gao Y, Hahn K, Massaro S, Italiano JE, Schulz V, Lin S, Kupfer GM, Krause DS. Serum response factor is an essential transcription factor in megakaryocytic maturation. Blood. 2010 Sep 16; 116(11):1942-50. PMID: 20525922; PMCID: PMC3173990.
  60. Pozner RG, Ure AE, Jaquenod de Giusti C, D'Atri LP, Italiano JE, Torres O, Romanowski V, Schattner M, Gómez RM. Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling. PLoS Pathog. 2010 Apr 15; 6(4):e1000847. PMID: 20419155; PMCID: PMC2855331.
  61. Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, Folkman J, Italiano JE, Ryeom S. Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis. Blood. 2010 Jun 03; 115(22):4605-13. PMID: 20086246; PMCID: PMC2881490.
  62. Chase TH, Lyons BL, Bronson RT, Foreman O, Donahue LR, Burzenski LM, Gott B, Lane P, Harris B, Ceglarek U, Thiery J, Wittenburg H, Thon JN, Italiano JE, Johnson KR, Shultz LD. The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood. 2010 Feb 11; 115(6):1267-76. PMID: 19846887; PMCID: PMC2826237.
  63. Italiano JE, Battinelli EM. Selective sorting of alpha-granule proteins. J Thromb Haemost. 2009 Jul; 7 Suppl 1:173-6. PMID: 19630794; PMCID: PMC3004150.
  64. Reems JA, Wang W, Tsubata K, Abdurrahman N, Sundell B, Tijssen MR, van der Schoot E, Di Summa F, Patel-Hett S, Italiano J, Gilligan DM. Dynamin 3 participates in the growth and development of megakaryocytes. Exp Hematol. 2008 Dec; 36(12):1714-27. PMID: 19007685; PMCID: PMC2728587.
  65. Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, Italiano JE, Wheatley E, Abou-Slaybi A, Bender E, Almog N, Kieran MW, Folkman J. Platelets actively sequester angiogenesis regulators. Blood. 2009 Mar 19; 113(12):2835-42. PMID: 19036702; PMCID: PMC2661866.
  66. Flaumenhaft R, Dilks JR, Richardson J, Alden E, Patel-Hett SR, Battinelli E, Klement GL, Sola-Visner M, Italiano JE. Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles. Blood. 2009 Jan 29; 113(5):1112-21. PMID: 18802008; PMCID: PMC2635076.
  67. Shimizu A, Mammoto A, Italiano JE, Pravda E, Dudley AC, Ingber DE, Klagsbrun M. ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem. 2008 Oct 03; 283(40):27230-8. PMID: 18660502; PMCID: PMC2555994.
  68. Papadantonakis N, Makitalo M, McCrann DJ, Liu K, Nguyen HG, Martin G, Patel-Hett S, Italiano JE, Ravid K. Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells. Cell Cycle. 2008 Aug; 7(15):2352-6. PMID: 18677109; PMCID: PMC2861775.
  69. Schulze H, Dose M, Korpal M, Meyer I, Italiano JE, Shivdasani RA. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem. 2008 May 16; 283(20):14109-19. PMID: 18347012; PMCID: PMC2376235.
  70. Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE. Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 01; 111(9):4605-16. PMID: 18230754; PMCID: PMC2343595.
  71. Sehrawat S, Cullere X, Patel S, Italiano J, Mayadas TN. Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell. 2008 Mar; 19(3):1261-70. PMID: 18172027; PMCID: PMC2262967.
  72. Italiano JE, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood. 2008 Feb 01; 111(3):1227-33. PMID: 17962514; PMCID: PMC2214735.
  73. Cervi D, Yip TT, Bhattacharya N, Podust VN, Peterson J, Abou-Slaybi A, Naumov GN, Bender E, Almog N, Italiano JE, Folkman J, Klement GL. Platelet-associated PF-4 as a biomarker of early tumor growth. Blood. 2008 Feb 01; 111(3):1201-7. PMID: 17914028.
    View in: PubMed
  74. Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Shivdasani RA, von Andrian UH. Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007 Sep 21; 317(5845):1767-70. PMID: 17885137.
    View in: PubMed
  75. Battinelli EM, Hartwig JH, Italiano JE. Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis. Curr Opin Hematol. 2007 Sep; 14(5):419-26. PMID: 17934346.
    View in: PubMed
  76. Italiano JE, Patel-Hett S, Hartwig JH. Mechanics of proplatelet elaboration. J Thromb Haemost. 2007 Jul; 5 Suppl 1:18-23. PMID: 17635704.
    View in: PubMed
  77. Hartwig JH, Italiano JE. Cytoskeletal mechanisms for platelet production. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):99-103. PMID: 16464622.
    View in: PubMed
  78. Patel SR, Hartwig JH, Italiano JE. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest. 2005 Dec; 115(12):3348-54. PMID: 16322779; PMCID: PMC1297261.
  79. Patel SR, Richardson JL, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005 Dec 15; 106(13):4076-85. PMID: 16118321; PMCID: PMC1895246.
  80. Richardson JL, Shivdasani RA, Boers C, Hartwig JH, Italiano JE. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15; 106(13):4066-75. PMID: 16118320; PMCID: PMC1895242.
  81. Varo N, Libby P, Nuzzo R, Italiano J, Doria A, Schönbeck U. Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and advanced glycation end products. Diab Vasc Dis Res. 2005 May; 2(2):81-7. PMID: 16308911.
    View in: PubMed
  82. Schulze H, Korpal M, Bergmeier W, Italiano JE, Wahl SM, Shivdasani RA. Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood. 2004 Dec 15; 104(13):3949-57. PMID: 15315966.
    View in: PubMed
  83. Tiwari S, Italiano JE, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC, Shivdasani RA. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 2003 Dec 01; 102(12):3970-9. PMID: 12907454.
    View in: PubMed
  84. Hartwig J, Italiano J. The birth of the platelet. J Thromb Haemost. 2003 Jul; 1(7):1580-6. PMID: 12871294.
    View in: PubMed
  85. Barkalow KL, Falet H, Italiano JE, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH. Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C797-805. PMID: 12788695.
    View in: PubMed
  86. Italiano JE, Shivdasani RA. Megakaryocytes and beyond: the birth of platelets. J Thromb Haemost. 2003 Jun; 1(6):1174-82. PMID: 12871316.
    View in: PubMed
  87. Barkalow KL, Italiano JE, Chou DE, Matsuoka Y, Bennett V, Hartwig JH. Alpha-adducin dissociates from F-actin and spectrin during platelet activation. J Cell Biol. 2003 May 12; 161(3):557-70. PMID: 12743105; PMCID: PMC2172952.
  88. Italiano JE, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15; 101(12):4789-96. PMID: 12586623.
    View in: PubMed
  89. Falet H, Hoffmeister KM, Neujahr R, Italiano JE, Stossel TP, Southwick FS, Hartwig JH. Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16782-7. PMID: 12464680; PMCID: PMC139221.
  90. Schwer HD, Lecine P, Tiwari S, Italiano JE, Hartwig JH, Shivdasani RA. A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17; 11(8):579-86. PMID: 11369202.
    View in: PubMed
  91. Italiano JE, Stewart M, Roberts TM. How the assembly dynamics of the nematode major sperm protein generate amoeboid cell motility. Int Rev Cytol. 2001; 202:1-34. PMID: 11061562.
    View in: PubMed
  92. Lecine P, Italiano JE, Kim SW, Villeval JL, Shivdasani RA. Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood. 2000 Aug 15; 96(4):1366-73. PMID: 10942379.
    View in: PubMed
  93. Italiano JE, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312. PMID: 10601342; PMCID: PMC2168104.
  94. Italiano JE, Stewart M, Roberts TM. Localized depolymerization of the major sperm protein cytoskeleton correlates with the forward movement of the cell body in the amoeboid movement of nematode sperm. J Cell Biol. 1999 Sep 06; 146(5):1087-96. PMID: 10477761; PMCID: PMC2169480.
  95. Hartwig JH, Barkalow K, Azim A, Italiano J. The elegant platelet: signals controlling actin assembly. Thromb Haemost. 1999 Aug; 82(2):392-8. PMID: 10605729.
    View in: PubMed
  96. Stewart M, Roberts TM, Italiano JE, King KL, Hammel R, Parathasathy G, Bullock TL, McCoy AJ, Kent H, Haaf A, Neuhaus D. Amoeboid motility without actin: insights into the molecular mechanism of locomotion using the major sperm protein (MSP) of nematodes. Biol Bull. 1998 Jun; 194(3):342-3; discussion 343-4. PMID: 9664658.
    View in: PubMed
  97. Italiano JE, Roberts TM, Stewart M, Fontana CA. Reconstitution in vitro of the motile apparatus from the amoeboid sperm of Ascaris shows that filament assembly and bundling move membranes. Cell. 1996 Jan 12; 84(1):105-14. PMID: 8548814.
    View in: PubMed
  98. Royal D, Royal M, Italiano J, Roberts T, Soll DR. In Ascaris sperm pseudopods, MSP fibers move proximally at a constant rate regardless of the forward rate of cellular translocation. Cell Motil Cytoskeleton. 1995; 31(3):241-53. PMID: 7585993.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Italiano's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (464)
Explore
_
Co-Authors (47)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_