Harvard Catalyst Profiles

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Daniel Geoffrey Tenen, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA197697 (TENEN, DANIEL G) Aug 1, 2015 - Jul 31, 2022
    NIH/NCI
    Mechanisms of regulation by RNA in acute myeloid leukemia
    Role: Principal Investigator
  2. R01DK103858 (TENEN, DANIEL G) Jun 15, 2015 - May 31, 2018
    NIH/NIDDK
    Noncoding RNA-DNMT1 interactions in hematopoiesis
    Role: Principal Investigator
  3. R01CA138211 (TENEN, DANIEL G) Sep 25, 2008 - Jul 31, 2014
    NIH/NCI
    Targeting Leukemic Stem Cells
    Role: Principal Investigator
  4. P01DK080665 (TENEN, DANIEL G) Sep 1, 2008 - Jul 31, 2014
    NIH/NIDDK
    Hematopoietic stem cell commitment
    Role: Principal Investigator
  5. R01CA118316 (TENEN, DANIEL G) Apr 12, 2007 - Jan 31, 2014
    NIH/NCI
    Distinct acute myeloid leukemia subclasses with CEBPA mutations
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Numata A, Kwok HS, Zhou QL, Li J, Tirado-Magallanes R, Espinosa Angarcia V, Hannah RL, Park J, Wang CQ, Krishnan V, Rajagopalan D, Zhang Y, Zhou S, Welner R, Osato M, Jha S, Bohlander SK, Gƶttgens B, Yang H, Benoukraf T, Lough JW, Bararia D, Tenen DG. Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. Blood. 2020 Jun 15. PMID: 32542325.
    Citations:    
  2. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, Zhang Z, You H, Wu M, Zheng Q, Xiong Y, Xiong H, Wang C, Chen C, Xiong F, Zhang Y, Peng Y, Ge S, Zhen B, Yu T, Wang L, Wang H, Liu Y, Chen Y, Mei J, Gao X, Li Z, Gan L, He C, Li Z, Shi Y, Qi Y, Yang J, Tenen DG, Chai L, Mucci LA, Santillana M, Cai H. Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak. Cancer Discov. 2020 06; 10(6):783-791. PMID: 32345594.
    Citations:    
  3. Tham CY, Tirado-Magallanes R, Goh Y, Fullwood MJ, Koh BTH, Wang W, Ng CH, Chng WJ, Thiery A, Tenen DG, Benoukraf T. NanoVar: accurate characterization of patients' genomic structural variants using low-depth nanopore sequencing. Genome Biol. 2020 03 03; 21(1):56. PMID: 32127024.
    Citations:    
  4. Qi Y, Fang Y, Sinclair DR, Guo S, Alberich-Jorda M, Lu J, Tenen DG, Kharas MG, Pyne S. High-speed automatic characterization of rare events in flow cytometric data. PLoS One. 2020; 15(2):e0228651. PMID: 32045462.
    Citations:    
  5. Chin TM, Boopathy GTK, Man EPS, Clohessy JG, Csizmadia E, Quinlan MP, Putti T, Wan SC, Xie C, Ali A, Wai FC, Ong YS, Goh BC, Settleman J, Hong W, Levantini E, Tenen DG. Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors. Theranostics. 2020; 10(6):2727-2743. PMID: 32194831.
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  6. Jadhav SP, Kumari N, Ng L, Tan PF, Yeo-Teh NSL, Goh Y, Fam WN, Tng JQ, Tian JS, Koh BTH, Chun CM, Wang W, Chng WJ, Fullwood MJ, Guccione E, Karnani N, Tenen DG, Jha S. circASXL1-1 regulates BAP1 deubiquitinase activity in leukemia. Haematologica. 2020 Jul; 105(7):e343-e348. PMID: 31780633.
    Citations:    
  7. Tan HK, Wu CS, Li J, Tan ZH, Hoffman JR, Fry CJ, Yang H, Di Ruscio A, Tenen DG. DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells. Nucleic Acids Res. 2019 08 22; 47(14):7460-7475. PMID: 31219573.
    Citations:    
  8. Tan JL, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu GD, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG, Chai L. New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. Gastroenterology. 2019 12; 157(6):1615-1629.e17. PMID: 31446059.
    Citations:    
  9. Ali A, Levantini E, Fhu CW, Teo JT, Clohessy JG, Goggi JL, Wu CS, Chen L, Chin TM, Tenen DG. CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer. Theranostics. 2019; 9(21):6157-6174. PMID: 31534543.
    Citations:    
  10. Wolock SL, Krishnan I, Tenen DE, Matkins V, Camacho V, Patel S, Agarwal P, Bhatia R, Tenen DG, Klein AM, Welner RS. Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths. Cell Rep. 2019 07 09; 28(2):302-311.e5. PMID: 31291568.
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  11. Tatetsu H, Armant M, Wang F, Gao C, Ueno S, Tian X, Federation A, Qi J, Bradner J, Tenen DG, Chai L. Maintenance and enhancement of human peripheral blood mobilized stem/progenitor cell engraftment after ex vivo culture via an HDACi/SALL4 axis (3465). Exp Hematol. 2019 07; 75:53-63.e11. PMID: 31260717.
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  12. Radhakrishnan S, Syed R, Takei H, Kobayashi IS, Nakamura E, Sultana F, Kamal A, Tenen DG, Kobayashi SS. Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation. Bioorg Med Chem Lett. 2019 08 15; 29(16):2286-2289. PMID: 31278031.
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  13. Yokomizo T, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T, Komatsu N. Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors. J Exp Med. 2019 07 01; 216(7):1599-1614. PMID: 31076455.
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  14. Tan SH, Leong WZ, Ngoc PCT, Tan TK, Bertulfo FC, Lim MC, An O, Li Z, Yeoh AEJ, Fullwood MJ, Tenen DG, Sanda T. The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia. Blood. 2019 07 18; 134(3):239-251. PMID: 31076442.
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  15. Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM. Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. Immunity. 2019 05 21; 50(5):1317-1334.e10. PMID: 30979687.
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  16. Sun W, Dai L, Yu H, Puspita B, Zhao T, Li F, Tan JL, Lim YT, Chen MW, Sobota RM, Tenen DG, Prabhu N, Nordlund P. Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA. Redox Biol. 2019 06; 24:101168. PMID: 30925293.
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  17. Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM. Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nat Metab. 2019; 1(3):360-370. PMID: 31161155.
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