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Albert Edge, PH.D.

TitleProfessor of Otology and Laryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtology and Laryngology
AddressMassachusetts Eye & Ear Infrm
Eaton Peabody Lab
243 Charles St
Boston MA 02114
Phone617/573-4452
Fax617/720-4408
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 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Diensthuber M, Zecha V, Wagenblast J, Arnhold S, Edge AS, Stöver T. Spiral ganglion stem cells can be propagated and differentiated into neurons and glia. Biores Open Access. 2014 Jun 1; 3(3):88-97.
    View in: PubMed
  2. Shi F, Hu L, Jacques BE, Mulvaney JF, Dabdoub A, Edge AS. ß-Catenin Is Required for Hair-Cell Differentiation in the Cochlea. J Neurosci. 2014 May 7; 34(19):6470-9.
    View in: PubMed
  3. Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F, Forrest AR, Carninci P, Rehli M, Sandelin A, Kawaji H, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmid C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple CA, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furuno M, Furusawa J, Geijtenbeek TB, Gibson AP, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Kondo N, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JF, Lee W, Lennartsson A, Li K, Lilje B, Lipovich L, Mackay-sim A, Manabe R, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, de Lima Morais DA, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Nozaki T, Ogishima S, Ohkura N, Ohmiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JG, Rackham OJ, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Satoh H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Suzuki N, Swoboda RK, 't Hoen PA, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyoda H, Toyoda T, Valen E, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zhao X, Zucchelli S, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Hume DA, Hayashizaki Y. An atlas of active enhancers across human cell types and tissues. Nature. 2014 Mar 27; 507(7493):455-61.
    View in: PubMed
  4. Bramhall NF, Shi F, Arnold K, Hochedlinger K, Edge AS. Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Stem Cell Reports. 2014 Mar 11; 2(3):311-22.
    View in: PubMed
  5. Brugeaud A, Tong M, Luo L, Edge AS. Inhibition of repulsive guidance molecule, RGMa, increases afferent synapse formation with auditory hair cells. Dev Neurobiol. 2014 Apr; 74(4):457-66.
    View in: PubMed
  6. Parker MA, Cheng YF, Kinouchi H, Bieber R, Edge AS. An independent construct for conditional expression of atonal homolog-1. Hum Gene Ther Methods. 2014 Feb; 25(1):1-13.
    View in: PubMed
  7. Yuan Y, Shi F, Yin Y, Tong M, Lang H, Polley DB, Liberman MC, Edge AS. Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy. J Assoc Res Otolaryngol. 2014 Feb; 15(1):31-43.
    View in: PubMed
  8. Shi F, Hu L, Edge AS. Generation of hair cells in neonatal mice by ß-catenin overexpression in Lgr5-positive cochlear progenitors. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13851-6.
    View in: PubMed
  9. Kao SY, Kempfle JS, Jensen JB, Perez-Fernandez D, Lysaght AC, Edge AS, Stankovic KM. Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss. Neurobiol Dis. 2013 Aug; 56:25-33.
    View in: PubMed
  10. Tong M, Brugeaud A, Edge AS. Regenerated synapses between postnatal hair cells and auditory neurons. J Assoc Res Otolaryngol. 2013 Jun; 14(3):321-9.
    View in: PubMed
  11. Shi F, Edge AS. Prospects for replacement of auditory neurons by stem cells. Hear Res. 2013 Mar; 297:106-12.
    View in: PubMed
  12. Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge AS. Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Neuron. 2013 Jan 9; 77(1):58-69.
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  13. Nayagam BA, Edge AS, Needham K, Hyakumura T, Leung J, Nayagam DA, Dottori M. An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants. Stem Cells Dev. 2013 Mar 15; 22(6):901-12.
    View in: PubMed
  14. Shi F, Kempfle JS, Edge AS. Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. J Neurosci. 2012 Jul 11; 32(28):9639-48.
    View in: PubMed
  15. Jeon SJ, Fujioka M, Kim SC, Edge AS. Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells. J Neurosci. 2011 Jun 8; 31(23):8351-8.
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  16. Fujioka M, Tokano H, Fujioka KS, Okano H, Edge AS. Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation. J Clin Invest. 2011 Jun; 121(6):2462-9.
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  17. Parker MA, Jiang K, Kempfle JS, Mizutari K, Simmons CL, Bieber R, Adams J, Edge AS. TAK1 expression in the cochlea: a specific marker for adult supporting cells. J Assoc Res Otolaryngol. 2011 Aug; 12(4):471-83.
    View in: PubMed
  18. Parker M, Brugeaud A, Edge AS. Primary culture and plasmid electroporation of the murine organ of Corti. J Vis Exp. 2010; (36).
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  19. Shi F, Cheng YF, Wang XL, Edge AS. Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhancer. J Biol Chem. 2010 Jan 1; 285(1):392-400.
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  20. Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. BMC Neurosci. 2009; 10:122.
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  21. Edge AS, Chen ZY. Hair cell regeneration. Curr Opin Neurobiol. 2008 Aug; 18(4):377-82.
    View in: PubMed
  22. Martinez-Monedero R, Yi E, Oshima K, Glowatzki E, Edge AS. Differentiation of inner ear stem cells to functional sensory neurons. Dev Neurobiol. 2008 Apr; 68(5):669-84.
    View in: PubMed
  23. Shi F, Corrales CE, Liberman MC, Edge AS. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. Eur J Neurosci. 2007 Dec; 26(11):3016-23.
    View in: PubMed
  24. Martinez-Monedero R, Oshima K, Heller S, Edge AS. The potential role of endogenous stem cells in regeneration of the inner ear. Hear Res. 2007 May; 227(1-2):48-52.
    View in: PubMed
  25. Martinez-Monedero R, Edge AS. Stem cells for the replacement of inner ear neurons and hair cells. Int J Dev Biol. 2007; 51(6-7):655-61.
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  26. Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. J Assoc Res Otolaryngol. 2007 Mar; 8(1):18-31.
    View in: PubMed
  27. Jeon SJ, Oshima K, Heller S, Edge AS. Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Mol Cell Neurosci. 2007 Jan; 34(1):59-68.
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  28. Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS. Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. J Neurobiol. 2006 Nov; 66(13):1489-500.
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  29. Huang L, Shimaoka M, Rondon IJ, Roy I, Chang Q, Po M, Dransfield DT, Ladner RC, Edge AS, Salas A, Wood CR, Springer TA, Cohen EH. Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1. J Leukoc Biol. 2006 Oct; 80(4):905-14.
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  30. Martinez-Monedero R, Corrales CE, Cuajungco MP, Heller S, Edge AS. Reinnervation of hair cells by auditory neurons after selective removal of spiral ganglion neurons. J Neurobiol. 2006 Mar; 66(4):319-31.
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  31. Li H, Corrales CE, Edge A, Heller S. Stem cells as therapy for hearing loss. Trends Mol Med. 2004 Jul; 10(7):309-15.
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  32. Crosby K, Yatko C, Dersimonian H, Pan L, Edge AS. A novel monoclonal antibody inhibits the immune response of human cells against porcine cells: identification of a porcine antigen homologous to CD58. Transplantation. 2004 Apr 27; 77(8):1288-94.
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  33. Edge AS. Deglycosylation of glycoproteins with trifluoromethanesulphonic acid: elucidation of molecular structure and function. Biochem J. 2003 Dec 1; 376(Pt 2):339-50.
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  34. Nagata H, Ito M, Shirota C, Edge A, McCowan TC, Fox IJ. Route of hepatocyte delivery affects hepatocyte engraftment in the spleen. Transplantation. 2003 Aug 27; 76(4):732-4.
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  35. Pagani FD, DerSimonian H, Zawadzka A, Wetzel K, Edge AS, Jacoby DB, Dinsmore JH, Wright S, Aretz TH, Eisen HJ, Aaronson KD. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol. 2003 Mar 5; 41(5):879-88.
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  36. Del Priore LV, Sheng Y, Johnson E, Jacoby D, Edge A, Suzuki T, Geng L, Tezel TH, Kaplan HJ. Identification of transplanted retinal pigment epithelium with a novel chromosomal marker. Curr Eye Res. 2003 Feb; 26(2):125-31.
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  37. Nagata H, Ito M, Cai J, Edge AS, Platt JL, Fox IJ. Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation. Gastroenterology. 2003 Feb; 124(2):422-31.
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  38. Nagata H, Ito M, Shirota C, Edge ASB, McCowan TC, Fox IJ. Transplantation. Route of hepatocyte delivery affects hepatocyte engraftment in the spleen. 2003; 76:732-734.
  39. Jain M, DerSimonian H, Brenner DA, Ngoy S, Teller P, Edge AS, Zawadzka A, Wetzel K, Sawyer DB, Colucci WS, Apstein CS, Liao R. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation. 2001 Apr 10; 103(14):1920-7.
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  40. Edge ASB. Graft. Xenotransplantation of neural cells. 2001; 4:118-119.
  41. Edge AS, Spiro RG. A specific structural alteration in the heparan sulphate of human glomerular basement membrane in diabetes. Diabetologia. 2000 Aug; 43(8):1056-9.
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  42. Edge AS. Current applications of cellular xenografts. Transplant Proc. 2000 Aug; 32(5):1169-71.
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  43. Stefan AM, Coulter S, Gray B, LaMorte W, Nikelaeson S, Edge AS, Afdhal NH. Xenogeneic transplantation of porcine hepatocytes into the CCl4 cirrhotic rat model. Cell Transplant. 1999 Nov-Dec; 8(6):649-59.
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  44. DerSimonian H, Pan L, Yatko C, Rodrigue-Way A, Johnson E, Edge AS. Human anti-porcine T cell response: blocking with anti-class I antibody leads to hyporesponsiveness and a switch in cytokine production. J Immunol. 1999 Jun 15; 162(12):6993-7001.
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  45. Edge AS, Gosse ME, Dinsmore J. Xenogeneic cell therapy: current progress and future developments in porcine cell transplantation. Cell Transplant. 1998 Nov-Dec; 7(6):525-39.
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  46. Sullivan JA, Oettinger HF, Sachs DH, Edge AS. Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes. J Immunol. 1997 Sep 1; 159(5):2318-26.
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  47. Edge AS, Spiro RG. Structure of the O-linked oligosaccharides from a major thyroid cell surface glycoprotein. Arch Biochem Biophys. 1997 Jul 1; 343(1):73-80.
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  48. Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med. 1997 Mar; 3(3):350-3.
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  49. Gunsalus JR, Coulter SM, Gray BM, Edge AS. Xenotransplantation for the treatment of hypercholesterolemia. Transplant Proc. 1997 Feb-Mar; 29(1-2):905-6.
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  50. Donnelly CE, Yatko C, Johnson EW, Edge AS. Human natural killer cells account for non-MHC class I-restricted cytolysis of porcine cells. Cell Immunol. 1997 Feb 1; 175(2):171-8.
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  51. Oettinger HF, Sullivan JA, Horvath KE, Kelley JA, Jacoby DB, Dinsmore J, Zawadska A, Edge ASB. Xenotransplantation. Species-specific detection of porcine xenografts with an antibody against a novel epitope of the lymphocyte homing receptor CD44. 1997; 4:252-261.
  52. Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge AS. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med. 1997 Jan; 3(1):48-53.
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  53. Edge ASB, DInsmore J. Xeno. Xenotransplantation in the central nervous system. 1997; 5:23-25.
  54. LaVecchio JA, Dunne AD, Edge AS. Enzymatic removal of alpha-galactosyl epitopes from porcine endothelial cells diminishes the cytotoxic effect of natural antibodies. Transplantation. 1995 Oct 27; 60(8):841-7.
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  55. Oettinger HF, Rodrigue-Way A, Bousquet JJ, Edge AS. Porcine repeat element DNA: in situ detection of xenotransplanted cells. Cell Transplant. 1995 Mar-Apr; 4(2):253-6.
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  56. Edge AS, Karasik A, Yamada K, Kahn CR. Effect of dexamethasone on the carbohydrate chains of the insulin receptor. Biochem Biophys Res Commun. 1994 Apr 29; 200(2):852-9.
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  57. Edge AS, Kahn CR, Spiro RG. Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains. Endocrinology. 1990 Oct; 127(4):1887-95.
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  58. Edge AS, Spiro RG. Characterization of novel sequences containing 3-O-sulfated glucosamine in glomerular basement membrane heparan sulfate and localization of sulfated disaccharides to a peripheral domain. J Biol Chem. 1990 Sep 15; 265(26):15874-81.
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  59. Edge AS, Spiro RG. Presence of an O-glycosidically linked hexasaccharide in fetuin. J Biol Chem. 1987 Nov 25; 262(33):16135-41.
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  60. Edge AS, Spiro RG. Selective deglycosylation of the heparan sulfate proteoglycan of bovine glomerular basement membrane and identification of the core protein. J Biol Chem. 1987 May 15; 262(14):6893-8.
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  61. Edge AS, Van Langenhove A, Reinhold V, Weber P. Characterization of O-glycosidically linked oligosaccharides of rat erythrocyte membrane sialoglycoproteins. Biochemistry. 1986 Dec 2; 25(24):8017-24.
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  62. Edge AS, Spiro RG. Thyroid cell surface glycoproteins. Nature and disposition of carbohydrate units and evaluation of their blood group I activity. J Biol Chem. 1985 Dec 5; 260(28):15332-8.
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  63. Edge AS, Spiro RG. Structural elucidation of glycosaminoglycans through characterization of disaccharides obtained after fragmentation by hydrazine-nitrous acid treatment. Arch Biochem Biophys. 1985 Aug 1; 240(2):560-72.
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  64. Herzberg VL, Grigorescu F, Edge AS, Spiro RG, Kahn CR. Characterization of insulin receptor carbohydrate by comparison of chemical and enzymatic deglycosylation. Biochem Biophys Res Commun. 1985 Jun 28; 129(3):789-96.
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  65. Edge AS, Spiro RG. Presence of sulfate in N-glycosidically linked carbohydrate units of calf thyroid plasma membrane glycoproteins. J Biol Chem. 1984 Apr 25; 259(8):4710-3.
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  66. Edge AS, Weber P. Isolation of sulfited oligosaccharides from glycoproteins treated with alkaline sulfite. Carbohydr Res. 1984 Mar 15; 126(2):279-85.
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  67. Edge AS, Faltynek CR, Hof L, Reichert LE, Weber P. Deglycosylation of glycoproteins by trifluoromethanesulfonic acid. Anal Biochem. 1981 Nov 15; 118(1):131-7.
    View in: PubMed
  68. Edge AS, Weber P. Purification and characterization of the major sialoglycoproteins of the rat erythrocyte membrane. Arch Biochem Biophys. 1981 Jul; 209(2):697-705.
    View in: PubMed
  69. Edge AS, Weber P. Cleavage of dehydroalanine-containing peptides with mercuric acetate. Int J Pept Protein Res. 1981 Jul; 18(1):1-5.
    View in: PubMed
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