There are several general areas of study within my laboratory that provide potential projects for students: 1.We recently showed that variants in the APOL1 gene account for the large disparity in the rates of kidney disease between people of recent African ancestry and other groups. There are potential projects to help better understand this at many levels: genetic testing in humans; social and ethical implications; cell biologic studies to understand disease mechanism; development of animal models. 2. We do family based genetic studies to look for new genes involved in the etiology of kidney disease. These include studies of diseases of the glomerulus and disorders of kidney development. 3. We are using mouse models to explore the role of several human disease genes, including APOL1, INF2, ACTN4, and CASR. Students could play a role in any of these studies.