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Gerburg Wulf, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA226776 (WULF, GERBURG M) Mar 1, 2018 - Feb 28, 2023
    NIH/NCI
    Novel Uses of PI3K-inhibitors for the Treatment of advanced PIK3CA-mutant Breast Cancer
    Role: Principal Investigator
  2. K08CA093655 (WULF, GERBURG M) Jul 17, 2002 - Jun 30, 2007
    NIH/NCI
    Role of the Prolylisomerase Pin1 in Oncogenesis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang L, Wulf GM. Not Black or White but Shades of Gray: Homologous Recombination Deficiency as a Continuous Variable Modulated by RNF168. Cancer Res. 2020 Jul 01; 80(13):2720-2721. PMID: 32616507.
    Citations:    
  2. Liu H, Paddock MN, Wang H, Murphy CJ, Geck RC, Navarro AJ, Wulf GM, Elemento O, Haucke V, Cantley LC, Toker A. The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer. Cancer Discov. 2020 Aug; 10(8):1226-1239. PMID: 32513774.
    Citations:    
  3. Luo ML, Zheng F, Chen W, Liang ZM, Chandramouly G, Tan J, Willis NA, Chen CH, Taveira MO, Zhou XZ, Lu KP, Scully R, Wulf GM, Hu H. Inactivation of the Prolyl Isomerase Pin1 Sensitizes BRCA1-Proficient Breast Cancer to PARP Inhibition. Cancer Res. 2020 Jul 15; 80(14):3033-3045. PMID: 32193285.
    Citations:    
  4. Eismann J, Heng YJ, Waldschmidt JM, Vlachos IS, Gray KP, Matulonis UA, Konstantinopoulos PA, Murphy CJ, Nabavi S, Wulf GM. Transcriptome analysis reveals overlap in fusion genes in a phase I clinical cohort of TNBC and HGSOC patients treated with buparlisib and olaparib. J Cancer Res Clin Oncol. 2020 Feb; 146(2):503-514. PMID: 31745703.
    Citations:    
  5. Baker GM, Pyle ME, Tobias AM, Bartlett RA, Phillips J, Fein-Zachary VJ, Wulf GM, Heng YJ. Establishing a Cohort of Transgender Men and Gender Nonconforming Individuals to Understand the Molecular Impact of Testosterone on Breast Physiology. Transgend Health. 2019; 4(1):326-330. PMID: 31750394.
    Citations:    
  6. Sonzogni O, Millard AL, Taveira A, Schneider MKJ, Duo L, Speck RF, Wulf GM, Mueller NJ. Efficient Human Cytomegalovirus Replication in Primary Endothelial Cells Is SOCS3 Dependent. Intervirology. 2019; 62(2):80-89. PMID: 31315128.
    Citations:    
  7. Sonzogni O, Wulf GM. How cancers usurp macrophages to keep growing. Cell Res. 2019 06; 29(6):423-424. PMID: 31061439.
    Citations:    
  8. Pantelidou C, Sonzogni O, De Oliveria Taveira M, Mehta AK, Kothari A, Wang D, Visal T, Li MK, Pinto J, Castrillon JA, Cheney EM, Bouwman P, Jonkers J, Rottenberg S, Guerriero JL, Wulf GM, Shapiro GI. PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer. Cancer Discov. 2019 06; 9(6):722-737. PMID: 31015319.
    Citations:    
  9. Eismann J, Heng YJ, Fleischmann-Rose K, Tobias AM, Phillips J, Wulf GM, Kansal KJ. Interdisciplinary Management of Transgender Individuals at Risk for Breast Cancer: Case Reports and Review of the Literature. Clin Breast Cancer. 2019 02; 19(1):e12-e19. PMID: 30527351.
    Citations:    Fields:    
  10. Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. Cancer Discov. 2018 03; 8(3):354-369. PMID: 29203461.
    Citations: 3     Fields:    
  11. Breitkopf SB, Taveira MO, Yuan M, Wulf GM, Asara JM. Serial-omics of P53-/-, Brca1-/- Mouse Breast Tumor and Normal Mammary Gland. Sci Rep. 2017 11 06; 7(1):14503. PMID: 29109428.
    Citations:    Fields:    
  12. de Oliveira Taveira M, Nabavi S, Wang Y, Tonellato P, Esteva FJ, Cantley LC, Wulf GM. Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer. J Cancer Res Clin Oncol. 2017 Jul; 143(7):1255-1262. PMID: 28247034.
    Citations: 1     Fields:    Translation:Humans
  13. Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, Wulf GM. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A. 2016 07 26; 113(30):E4338-47. PMID: 27402769.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7596-601. PMID: 27313209.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Hu H, Luo ML, Desmedt C, Nabavi S, Yadegarynia S, Hong A, Konstantinopoulos PA, Gabrielson E, Hines-Boykin R, Pihan G, Yuan X, Sotiriou C, Dittmer DP, Fingeroth JD, Wulf GM. Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation. EBioMedicine. 2016 Jul; 9:148-160. PMID: 27333046.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  16. Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, Asara JM, Cantley LC, Wulf GM. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 2016 Jan 28; 164(3):433-46. PMID: 26824656.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  17. Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep. 2015 Apr 07; 11(1):111-24. PMID: 25818297.
    Citations: 20     Fields:    Translation:HumansCells
  18. Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res. 2014 Jul 01; 74(13):3603-16. PMID: 24786790.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  19. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 07; 155(4):844-57. PMID: 24209622.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  20. Massa J, Hamdan A, Simon KC, Bertrand K, Wulf G, Tamimi RM, Ascherio A. Infectious mononucleosis and risk of breast cancer in a prospective study of women. Cancer Causes Control. 2012 Dec; 23(12):1893-8. PMID: 23053791.
    Citations: 1     Fields:    Translation:Humans
  21. Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, Cantley LC, Wulf GM. Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discov. 2012 Nov; 2(11):1048-63. PMID: 22915751.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  22. Hu H, Wulf GM. The amplifier effect: how Pin1 empowers mutant p53. Breast Cancer Res. 2011 Oct 13; 13(5):315. PMID: 22017796.
    Citations: 3     Fields:    Translation:HumansAnimals
  23. Burga LN, Hu H, Juvekar A, Tung NM, Troyan SL, Hofstatter EW, Wulf GM. Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice. Breast Cancer Res. 2011 Mar 11; 13(2):R30. PMID: 21396117.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  24. Yuan TL, Wulf G, Burga L, Cantley LC. Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr Biol. 2011 Feb 08; 21(3):173-83. PMID: 21256021.
    Citations: 31     Fields:    Translation:HumansCells
  25. Pories SE, Wulf GM. Evidence for the role of bevacizumab in the treatment of advanced metastatic breast cancer: a review. Breast Cancer (Dove Med Press). 2010 Jun 21; 2:37-44. PMID: 24367165.
    Citations: 3     
  26. Ryo A, Wulf G, Lee TH, Lu KP. Pinning down HER2-ER crosstalk in SMRT regulation. Trends Biochem Sci. 2009 Apr; 34(4):162-5. PMID: 19269830.
    Citations: 7     Fields:    Translation:HumansCells
  27. Burga LN, Tung NM, Troyan SL, Bostina M, Konstantinopoulos PA, Fountzilas H, Spentzos D, Miron A, Yassin YA, Lee BT, Wulf GM. Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers. Cancer Res. 2009 Feb 15; 69(4):1273-8. PMID: 19190334.
    Citations: 35     Fields:    Translation:HumansCells
  28. Lam PB, Burga LN, Wu BP, Hofstatter EW, Lu KP, Wulf GM. Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability. Mol Cancer. 2008 Dec 15; 7:91. PMID: 19077306.
    Citations: 28     Fields:    Translation:HumansCells
  29. Lee TH, Tun-Kyi A, Shi R, Lim J, Soohoo C, Finn G, Balastik M, Pastorino L, Wulf G, Zhou XZ, Lu KP. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nat Cell Biol. 2009 Jan; 11(1):97-105. PMID: 19060891.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  30. Lu KP, Suizu F, Zhou XZ, Finn G, Lam P, Wulf G. Targeting carcinogenesis: a role for the prolyl isomerase Pin1? Mol Carcinog. 2006 Jun; 45(6):397-402. PMID: 16652378.
    Citations: 20     Fields:    Translation:HumansCells
  31. Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. 2006 Mar 23; 440(7083):528-34. PMID: 16554819.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  32. Suizu F, Ryo A, Wulf G, Lim J, Lu KP. Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis. Mol Cell Biol. 2006 Feb; 26(4):1463-79. PMID: 16449657.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  33. Chen SY, Wulf G, Zhou XZ, Rubin MA, Lu KP, Balk SP. Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction. Mol Cell Biol. 2006 Feb; 26(3):929-39. PMID: 16428447.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  34. Wulf G, Finn G, Suizu F, Lu KP. Phosphorylation-specific prolyl isomerization: is there an underlying theme? Nat Cell Biol. 2005 May; 7(5):435-41. PMID: 15867923.
    Citations: 92     Fields:    Translation:HumansCells
  35. Wulf G, Garg P, Liou YC, Iglehart D, Lu KP. Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. EMBO J. 2004 Aug 18; 23(16):3397-407. PMID: 15257284.
    Citations: 55     Fields:    Translation:AnimalsCells
  36. Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 2003 Dec; 12(6):1413-26. PMID: 14690596.
    Citations: 197     Fields:    Translation:HumansAnimalsCells
  37. Ayala G, Wang D, Wulf G, Frolov A, Li R, Sowadski J, Wheeler TM, Lu KP, Bao L. The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer. Cancer Res. 2003 Oct 01; 63(19):6244-51. PMID: 14559810.
    Citations: 79     Fields:    Translation:Humans
  38. Ryo A, Liou YC, Lu KP, Wulf G. Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer. J Cell Sci. 2003 Mar 01; 116(Pt 5):773-83. PMID: 12571275.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  39. Wulf G, Ryo A, Liou YC, Lu KP. The prolyl isomerase Pin1 in breast development and cancer. Breast Cancer Res. 2003; 5(2):76-82. PMID: 12631385.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  40. Wulf GM, Liou YC, Ryo A, Lee SW, Lu KP. Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem. 2002 Dec 13; 277(50):47976-9. PMID: 12388558.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  41. Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G, Gu L, Tang X, Lu KP, Xiao ZX. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 2002 Oct 24; 419(6909):849-53. PMID: 12397361.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  42. Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP. PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol Cell Biol. 2002 Aug; 22(15):5281-95. PMID: 12101225.
    Citations: 77     Fields:    Translation:HumansCells
  43. Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol. 2001 Sep; 3(9):793-801. PMID: 11533658.
    Citations: 149     Fields:    Translation:HumansCells
  44. Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 2001 Jul 02; 20(13):3459-72. PMID: 11432833.
    Citations: 142     Fields:    Translation:HumansCells
  45. Kishi S, Wulf G, Nakamura M, Lu KP. Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors. Oncogene. 2001 Mar 22; 20(12):1497-508. PMID: 11313893.
    Citations: 18     Fields:    Translation:HumansCells
  46. Wulf G, Pool S. Images in clinical medicine. Waldenström's macroglobulinemia. N Engl J Med. 2001 Mar 15; 344(11):816. PMID: 11248158.
    Citations:    Fields:    Translation:HumansCells
  47. Zhou XZ, Lu PJ, Wulf G, Lu KP. Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism. Cell Mol Life Sci. 1999 Nov 30; 56(9-10):788-806. PMID: 11212339.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  48. Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature. 1999 Jun 24; 399(6738):784-8. PMID: 10391244.
    Citations: 182     Fields:    Translation:HumansAnimalsCells
  49. Wulf GM, Van Deerlin VM, Leonard DG, Bauer KA. Thrombosis in a patient with combined homozygosity for the factor V Leiden mutation and a mutation in the 3'-untranslated region of the prothrombin gene. Blood Coagul Fibrinolysis. 1999 Mar; 10(2):107-10. PMID: 10192660.
    Citations: 2     Fields:    Translation:Humans
  50. Voso MT, Burn TC, Wulf G, Lim B, Leone G, Tenen DG. Inhibition of hematopoiesis by competitive binding of transcription factor PU.1. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):7932-6. PMID: 7520173.
    Citations: 34     Fields:    Translation:HumansCells
  51. Wulf G, Kluding H, Ho AD, Doerner M, Doehner H, Manegold C, Hunstein W. Multidrug resistance phenotype in patients with chronic lymphocytic leukemia as detected by immunofluorescence (FACS) and northern blot analysis. Leuk Res. 1994 Jul; 18(7):475-84. PMID: 7912754.
    Citations:    
  52. Wulf GM, Adra CN, Lim B. Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA. EMBO J. 1993 Dec 15; 12(13):5065-74. PMID: 8262049.
    Citations: 12     Fields:    Translation:AnimalsCells
  53. Lelias JM, Adra CN, Wulf GM, Guillemot JC, Khagad M, Caput D, Lim B. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1479-83. PMID: 8434008.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.