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Svetlana Egorova, M.D., Ph.D.

TitleInstructor in Neurology
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressPartners MS Clinical Research Center
MRI Analysis Unit
One Brookline Place, Suite 602
Brookline MA 02445
Phone617/732-5401
Fax617/732-6466
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 Overview 
 overview
My current research interest is connected with MRI and its quantitative imaging biomarkers to study MS, to predict disease course and treatment response of MS patients and facilitate therapy development and treatment monitoring and search for disease biomarkers

MRI Analysis Unit

My experience also include applications of MRI to study normal ageing, neurodegenerative diseases, AD and MCI
I co-authored a number of articles on the above projects as well as abstracts presented on the international and national scientific meetings


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kivisäkk P, Healy BC, Francois K, Gandhi R, Gholipour T, Egorova S, Sevdalinova V, Quintana F, Chitnis T, Weiner HL, Khoury SJ. Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development. Mult Scler. 2014 Apr; 20(4):438-44.
    View in: PubMed
  2. Gandhi R, Healy B, Gholipour T, Egorova S, Musallam A, Hussain MS, Nejad P, Patel B, Hei H, Khoury S, Quintana F, Kivisakk P, Chitnis T, Weiner HL. Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. Ann Neurol. 2013 Jun; 73(6):729-40.
    View in: PubMed
  3. Sorond FA, Kiely DK, Galica A, Moscufo N, Serrador JM, Iloputaife I, Egorova S, Dell'Oglio E, Meier DS, Newton E, Milberg WP, Guttmann CR, Lipsitz LA. Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study. Ann Neurol. 2011 Aug; 70(2):213-20.
    View in: PubMed
  4. Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S. A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Arch Neurol. 2010 Sep; 67(9):1055-61.
    View in: PubMed
  5. Gauthier SA, Berger AM, Liptak Z, Duan Y, Egorova S, Buckle GJ, Glanz BI, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR. Rate of brain atrophy in benign vs early multiple sclerosis. Arch Neurol. 2009 Feb; 66(2):234-7.
    View in: PubMed
  6. Gauthier SA, Glanz BI, Mandel M, Tsagaropoulos A, Neema M, Stankiewicz J, Arora A, Duan Y, Liptak Z, Egorova S, Buckle G, Bakshi R, Guttmann CRG, Khoury S, Weiner HL . The incidence and factors associated with treatment failure in the CLIMB multiple sclerosis cohort study. J Neurol Sci. 2009; 284:116- 9.
  7. Bakshi R, Neema M, Healy BC, Liptak Z, Betensky RA, Buckle GJ, Gauthier SA, Stankiewicz J, Meier D, Egorova S, Arora A, Guss ZD, Glanz B, Khoury SJ, Guttmann CR, Weiner HL. Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Arch Neurol. 2008 Nov; 65(11):1449-53.
    View in: PubMed
  8. Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ. CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology. 2008 Sep 16; 71(12):917-24.
    View in: PubMed
  9. Wisco JJ, Rosene DL, Killiany RJ, Moss MB, Warfield SK, Egorova S, Wu Y, Liptak Z, Warner J, Guttmann CR. A rhesus monkey reference label atlas for template driven segmentation. J Med Primatol. 2008 Oct; 37(5):250-60.
    View in: PubMed
  10. Egorova S, Sampat P, Sander RC, Blacker D, Albert MS, Killiany RJ, Guttmann CRG. Relation of Corpus Callosum Commissural System Volume and its Projection Regions to Volume of White Matter Lesion Load and Whole Brain Atrophy with Age in Healthy Adults. 2008.
  11. Bakshi R, Neema M, Healy B, Liptak Z, Betensky R, Buckle G, Gauthier S, Stankiewicz J, Meier D, Egorova S, Arora A, Guss ZD, Glanz B, Khoury S, Guttmann CRG, Weiner HL. Magnetic Resonance Disease Severity Scale (MRDSS) Predicts Clinical Progression in Multiple Sclerosis. 10th Annual Meeting of the American Society for Experimental NeuroTherapeutics, Arlington, VA, 2008. 2008.
  12. Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, Tanzi RE, Albert MS, Greenberg SM, Guttmann CR. Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Arch Neurol. 2008 Jan; 65(1):94-100.
    View in: PubMed
  13. Rohit Bakshi, Mohit Neema, Brian C. Healy, Zsuzsanna Liptak, Rebecca A. Betensky, Guy J Buckle, Susan A. Gauthier,James Stankiewicz, Dominik Meier, Svetlana Egorova, Ashish Arora, Zachary D. Guss, Bonnie Glanz, Samia J. Khoury, Charles R.G. Guttmann, Howard L. Weiner. Magnetic Resonance Disease Severity Scale (MRDSS) predicts clinical progression in multiple sclerosis. 2007.
  14. Garg R, Egorova S, Pendergrass M, Blacker D, Guttmann C. Brain Parenchyma Fraction and White Matter Signal Abnormalities in Patients with Diabetes Mellitus are Similar to Non-diabetic Subjects. ENDO-2006, Boston. 2006.
  15. Svetlana Egorova, Zsuzsanna Liptak, Lifeng Liu, Dominik Meier, Nan-Kuei Chen, Ron J. Killiany, Marilyn S. Albert, Charles R.G. Guttmann . Accelerated Brain Parenchymal Loss in Healthy People Above 60. 2005 Scientific Meeting Proceedings, MR Imaging of White Matter (other than MS). 2005; 761.
  16. Haissam Haidar, Svetlana Egorova, Janet Soul. New numerical solution of the Laplace equation for tissue thickness measurment in three dimensional MRI. Journal of Mathematical Modelling and Algorithms. 2005; 4(1):83-97.
  17. Waubant E, Buckle G, Sharma J, Kachuck N, Bourdette D, Weiner H, Guttmann C, Bakshi R, Gilman D, Villarete, Liu CP. A phase II study of oral ovine interferon tau in relapsing remitting (RR) MS. AAN 2005, Miami. 2005.
  18. Charles R.G.Guttmann, MD and Svetlana Egorova, MD, PhD. MRI Estimates of Volumetric Age-Related Changes in White Matter and Grey Matter. Workshop on Aging Connections: MRI of Age-Related White Matter Changes in the Brain. 2004; 13-16.
  19. Svetlana Egorova, Zsuzsanna Liptak, Lifeng Liu, Dominik Meier, Nan-Kuei Chen, Ron J Killiany, Marilyn S Albert, Charles RG Guttmann . Accelerated Brain Parenchymal Loss in Healthy People Above 60. . ISMRM Workshop on Aging Connections: Advanced MRI of Age-Related White Matter Changes in the Brain Syllabus. 2004; 109.
  20. Chen NK, Egorova S, Guttmann CR, Panych LP. Functional MRI with variable echo time acquisition. Neuroimage. 2003 Dec; 20(4):2062-70.
    View in: PubMed
  21. Haissam Haidar, Svetlana Egorova, Janet S. Soul. New Numerical Solution of the Laplace Equation for Three-Dimensional MRI. Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Scienes, METMBS '03, June 23 - 26, 2003, Las Vegas, Nevada, USA. 2003; 307-311.
  22. Haissam Haidar, Svetlana Egorova, Janet Soul. Measurement of cortical thickness of newborns at preterm and term age. Proceedings of the 9th Annual Meeting of The Organization of Human Brain Mapping. 2003.
  23. Alexandre Guimond, Svetlana Egorova, Ronald J. Killiany, Marilyn S. Albert, Charles R.G. Guttmann . Automatic Statistical Identification of Neuroanatomical Abnormalities between Different Populations in Medical Image Computing and Computer-Assisted Intervention - MICCAI 2002, 5th International Conference, Tokyo, Japan, September 25-28, 2002, Proceedings, Part I. Lecture Notes in Computer Science (LNCS). 2002; 785 – 792.
  24. Egorova, Svetlana. Pharmacological study of Magnetic-Resonance Contrast Agents. 1998.
  25. Panov VO, Egorova SV, Semenova IYu, Salnikova VM . Modeling system for estimation of influence of chelates complexes of gadolinium on proton relaxation. Book of Abstracts of International Conference «Magnetic Resonance in Medicine» (8-10 September 1997), Kazan, Russia. 1997; 120.
  26. Srgeev P, Shimanovsky N, Bolotova E, Panov V, Popov K, Kulakov V, Akhadov T, Mirzoyan R, Topchiyan A, Plyush G, Barskov I, Egorova S, Zalevskaya E, Salnikova V. Distribution of MRCA in normal and pathology animals organism. Book of Abstracts of International Conference «Magnetic Resonance in Medicine» (8-10 September 1997), Kazan, Russia. 1997; 47.
  27. Sergeev PV, Panov OV, Egorova SV, Bolotova EN, Shimanovskii NL, Akhadov TA, Sviridov NK. [Artificial contrasting during magnetic resonance tomography]. Vestn Rentgenol Radiol. 1997 Jan-Feb; (1):45-52.
    View in: PubMed
  28. Panov VO, Semenova IYu, Panov VO, Egorova SV, Bolotova EN, Zalevskaya EV, Salnikova VM, Shimanovsky NL. The mathematical modeling of the MRCA distribution kinetic. In Book of Abstracts IV Russian National Congress "Man and Medicament" (8-12 April 1997), Moscow. - M.: RC «Pharmedino». 1997; 282.
  29. Sergeev PV, Shimanovsky NL, Panov VO, Akhadov TA, Popov KI, Bolotova EN, Egorova SV, Zalevskaya EV, Semenova IYu, Salnikova VM. Investigation of diagnostical characteristic MRCA in normal and pathology rats. Book of Abstracts IV Russian National Congress "Man and Medicament" (8-12 April 1997), Moscow. - M: RC «Pharmedino». 1997; 291.
  30. Srgeev PV, Shimanovsky NL, Bolotova EN, Panov VO, Egorova SV, Zalevskaya EV, Paevsky AS, Salnikova VM, Kulakov VN, Goltyapin YuN. The comparison of the relaxational effectivity of different chelates complexes on base of Gd in solution and tissues of intact rats. Book of Abstracts of International Conference «Magnetic Resonance in Medicine» (8-10 September 1997), Kazan, Russia. 1997; 114.
  31. Mirzoyan RC, Topchiyan AV, Balasanyan MG, Akhadov TA, Panov VO, Sergeev PV, Shimanovsky NL, Bolotova EN, Egorova SV, Zalevskaya EV. Using of MRCA for brain ischemia. Book of Abstracts IV Russian National Congress "Man and Medicament" (8-12 April 1997), Moscow. - M.: RC «Pharmedino». 1997; 275.
  32. Panov V, Egorova S, Bolotova E, Korovin Yu, Semenova I, Zalevskaya E, Shimanovsky N, Popov K, Akhadov T, Sergeev P. Known and New MRI Contrast Agents in Rats with Experimental Pathological Processes. Contrast Media Research Programm & Abstracts Book (May 1997), Kyoto, Japan. 1997; 87.
  33. Panov V, Egorova S, Bolotova E, Shimanovsky N, Shabunin I, Kulakov V, Sorokin V, Nikitin S, Popov K, Goltyapin Yu, Pestereva L, Akhadov T, Sibeldina L, Sergeev P. Comparison of known and new MRI contrast media efficacy in the model system and in tissues of rats with experimental pathological processes. Scientific program and book of abstracts ESMRMB-97 14th annual meeting European society for magnetic resonance in medicine and biology, (September 18-21, 1997) Brussels. In Official Journal "MAG*MA" of European Society Magnetic Resonance in Medicine and Biology (ESMRMB). 1997; Suppl. Vol V Number II :186.
  34. Bolotova EN, Panov VO, Egorova SV, Zalevskaya EA, Shabunin IV, Kalinina AA. Pharmacokinetic of Omniscan in normal rats and in rats with kidney pathology. Book of Abstracts of 1-st Russian Congress of Pathophysiology (1996), Moscow, Russia. 1996; 128.
  35. Panov V, Egorova S, Zalevskaya E, Semenova I, Korovin I, Bolotova E, Topchiyan A, Simonyan R, Shimanovsky N, Popov K. Known and new MRI contrast media in rats with experimental pathological process. In Scientific program and book of abstracts ESMRMB’96 13th annual meeting European society for magnetic resonance in medicine and biology, (Prague, September 12-15, 1996). In Official Journal "MAG*MA" of European Society Magnetic Resonance in Medicine and Biology (ESMRMB). 1996; Suppl. Vol IV (II):295.
  36. Sergeev PV, Korovin YuV, Popov YuA, Rusakova NV, Nazarenko NA, Paevsky AS, Shimanovsky NL, Panov VO, Bolotova EN, Egorova SV, Zalevskaya EV, Shabunin IV. New contrast agent for MRT. In Book of Abstracts 111 II Russian National Congress "Man and Medicament" (16-20 April 1996), Moscow. - M.: RC «Pharmedino», 1996. 1996; 48.
  37. Sergeev PV, Shimanovsky NL, Napolov YuK, Bolotova EN, Panov VO, Egorova SV. The role of the histamine release effect of RCM on human basophils. The Abstract book of First European Congress of Pharmacology (1995), Milan, Itali. 1995; 214.
  38. Panov V, Vetrov O, Shabunin I, Avdienko V, Egorova S, Lyashenko S, Kondrashov , Akhadov TA , Shimanovsky N, Sergeev P. The Influence of new nonionic roentgen contrast media on the human blood plasma gamma-globulins. Contrast Media Research (June 17-22, 1995), Naantali, Finland. 1995; 49.
  39. Shimanovsky NL, Bolotova EN, Egorova SV, Panov VO, Shabunin IV, Urinovich EM, Popov KI. Design new MRCA. Book of Abstracts II Russian National Congress "Man and Medicament" (10-15 April 1995), Moscow. - M: RC «Pharmedino», 1995. 1995; 21-22.
  40. Sergeev P, Panov V, Shimanovsky N, Popov K, Akhadov T, Bolotova E, Egorova S, Vetrov O, Moscalev D, Gladky A . Original Chelates Gd-complexes as the possible base of the new MRI Contrast Agents. In Contrast Media Research ( June 17-22, 1995), Naantali, Finland. 1995; 62.
  41. Sergeev PV, Panov VO, Egorova SV, Bolotova EN. Artificial contrast during MRT. Book of Abstracts of Scientific-Practical Conference «MRT in medical practice» (1995), Moscow, Russia. 1995; 77-95.
  42. Panov V, Shimanovsky N, Vetrov O, Shabunin I, Egorova S, Avdienko V, Kondrashev S, Sergeev P. New effect Roentgen Contrast Media Dehydrotation influence on the blood plasma proteins discovered by relaxation proton NMR methods. Proceedings of the Society of Magnetic Resonance IIIrd Scientific Meeting and Exhibition and European Society for Magnetic Resonance in Medicine and Biology 12-th Annual Meeting and Exhibition (August 19-25, 1995), Nice, France. 1995; 1748.
  43. Shchipanova I, Panov V, Egorova S, Shimanovskii N, Sergeev P, Sibel'dina L. [The interaction of serum albumin and chloramphenicol]. Antibiot Khimioter. 1995 Jan; 40(1):8-10.
    View in: PubMed
  44. Shimanovsky NL, Sergeev PV, Napolov YuK, Egorova SV, Panov VO, Bolotova EN . Investigation of molecular mechanisms of RCM induced anaphilactoidal reactions. Scientific programme and book of Abstracts 9th European Congress of Radiology (March 5-10, 1995), Vienna, Ausria. 1995; 122.
  45. Egorova SV, Bolotova EN. . Design, effectivity and possibility of using new MR contrast Agents. Book of Abstracts of Russian Meeting of Pharmacologists (1995), Volgograd Russia. 1995; 383.
  46. Sergeev PV, Shimanovsky NL, Firsov NV, Smirnova OYu, Bolotova EN, Panov VO, Egorova SV. . Effect of roentgen contrast media on rheological properties of the human blood. The Abstract book of First European Congress of Pharmacology (1995), Milan, Itali. 1995; 146.
  47. Sergeev PV, Shimanovsky NL, YuK Napolov, Bolotova EN, Panov VO, Egorova SV. . Radiopaque agents effect on in vitro human peripheral blood T-lymphocytes blasttransformation. The Abstract book of First European Congress of Pharmacology (1995), Milan, Itali. 1995; 215.
  48. Sergeev PV, Bolotova EN, Panov VO, Shimanovsky NL, Egorova SV. The ultravist and melitrast influence on renal function in normal and pathological animals. The Abstract book of First European Congress of Pharmacology (1995), Milan, Itali. 1995; 365.
  49. Sergeev P, Panov V, Shimanovsky N, Popov K, Bolotova E, Egorova S. New chelates Gd-complexes as the future MRI contrast agents. Scientific programme and book of Abstracts 9th European Congress of Radiology (March 5-10, 1995), Vienna, Ausria. 1995; 230.
  50. Sergeev PV, Shimanovsky NL, Panov VO, Shabunin IV, Egorova SV, Vetrov OD, Moskalev DA, Ahadov TA. Investigation of influence of new nonionic rentgen contrast media on water balance in SAH and g-globulin solutions by MR relaxometry. Chemical Pharmaceutical Journal. 1995; 4:3-8.
  51. Shimanovsky N, Sergeev P, Napolov Yu, Panov V, Egorova S, Sviridov N, Akhadov T. Molecular Mechanisms of RCM induced anaphylactoidal reactions. Programme and Abstracts of Roentgen Centenary Congress (June 12-16 1995), Birmingham, England. 1995; 364.
  52. Sergeev P, Panov V, Shimanovsky N, Popov K, Akhadov T, Bolotova E, Egorova S, Vetrov O, Moscalev D, Gladky A . Original chelated Gd-complexes as the base of new MRI contrast agent. Programme and Abstracts Roentgen Centenary Congress (12-16 June 1995), Birmingham, England. 1995; 472-473.
  53. Sergeev P, Shimanovsky NL, Firsov NV, Smirnova OYu, Egorova SV, Panov PO. Effect of roentgen contrast agent on blood rheological properties. Scientific programme and book of Abstracts 9th European Congress of Radiology (March 5-10, 1995), Vienna, Ausria. 1995; 122.
  54. Sergeev PV, Panov VO, Egorova SV, Bolotova EN. . Effectivity MRT with contrast enhancement for brain and spine diseases and liver. Book of Abstructs of Scientific-Practical Conference «MRT in medical practice» (1995), Moscow, Russia. 1995; 98.
  55. Sergeev P, Panov V, Shimanovsky N, Popov K, Akhadov TA, Bolotova E, Egorova S, Vetrov O, Moscalev D, Gladky A. MRI Contrast Agents: new chelates Gd-complexes. Book of Abstracts, 11th Annual Scientific Meeting The European Society for Magnetic resonance in Medicine and Biology (April 1994), Vienna, Austria. 1994; 439.
  56. Akhadov T , Panov V, Belova M, Kravtcov A, Semenova N, Schipanova I, Belov S, Satchkova I, Egorova S, Shabunin I, Vetrov O, Moscalev D. Differential Diagnosis of cyst gynecopathy by complex of NMR methods: 31P high resolution NMR spectroscopy, 1H NMR relaxometry and MR imaging. Book of Abstracts 12th European Experimental NMR Conference (June 5-10, 1994), Oulu, Finland. 1994; 240.
  57. Sergeev P, Panov P, Shimanovsky N, Popov K, Akhadov TA, Bolotova E, Egorova S, Vetrov O, Moscalev A, Gladky A. Proton NMR relaxation activity of new chelates Gd-complexes (potential MRI Contrast Agents) in water solutions and in rats tissues. Book of Abstracts 12th European Experimental NMR Conference (June 5-10, 1994), Oulu, Finland. 1994; 272.
  58. Panov O, Edneral I, Shimanovsky N, Vetrov O, Egorova S, Shabunin I, Moscalev D, Krupyansky Yu, Akhadov TA, Sergeev P. Proton NMR relaxation methods and NMR with pulsed gradient of magnetic field in studied of water molecular motion in human blood plasma protein solutions. Book of Abstracts 12th European Experimental NMR Conference (June 5-10, 1994), Oulu, Finland. 1994; 268.
  59. Sergeev P, Panov V, Edneral I, Shimanovsky N, Vetrov O, Shabunin I, Egorova S, Moscalev D, Akhadov TA, Krupyansky Yu. Use of relaxation proton NMR methods for investigation of influence of organic threeiodine containing ionic and nonionic roentgen contrast media on the water in solutions and on the blood plasma water-protein balance. Book of Abstracts 12th European Experimental NMR Conference (June 5-10, 1994) Oulu, Finland. 1994; 271.
  60. Panov VO, Bolotova EN, Egorova SV, Shabunin IV, Leshkevich AV, Vetrov OD, Moskalev DA, Shimanovsky NL, Sergeev PV. Interaction of Magnevist with renal tissue intact animals and with glicerol nephritis. Vestn Rentgenol Radiol. 1994; Suppl. Vol 2.
  61. Sergeev PV, Panov VO, Egorova SV, Shabunin IV, Moskalev DA, Gladkii A, Vetrov OD, Stepanyants AU, Akhadov TA, Kravtcov A, Popov KI, Bolotova EN, Shimanovsky NL. New Developments in oral MRI Contrast Agent Research. Book of Abstracts of 10th Annual Scientific Meeting of ESMRMB (1993) Rome, Italy. 1993; 350.
  62. Sergeev PV, Panov VO, Edneral IV, Shimanovsky NL, Shabunin IV, Egorova SV, Moscalev DA, Gladkii AM, Stewpanyants AU, Vetrov OD . Influence of RCM on the blood plasma water - protein balance studied by relaxation proton NMR methods. Book of Abstracts of 10th Annual Scientific Meeting of ESMRMB (1993), Rome, Italy. 1993; 526.
  63. Panov V, Edneral I, Krasnova M, Moscalev D, Gladkii A, Egorova S, Vetrov O, Stepanyants A, Shimanovsky N, Sergeev P. Molecular motions of water in serum albumin solutions studied by relaxation proton NMR methods. Proceedings of the Society Magnetic Resonance in Medicine 12th Annual Scientific Meeting (August 1993), New York, USA. 1993; 1278.
  64. Panov VO, Edneral IV, Krasnova MM, Moscalev DA, Gladkii AM, Egorova SV, Vetrov OD, Stepanyants AU, Shimanovsky NL, Sergeev PV. Molecular motion of water in serum albumin solution studied by relaxation proton NMR methods. Book of Abstracts of 10th Annual Scientific Meeting of ESMRMB (1993), Rome, Italy. 1993; 527.
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