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profileUla V. Jurkunas, M.D.

TitleAssociate Professor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infrm
Ophthalmology
243 Charles St
Boston MA 02114
Phone617/573-4331
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01EY020581     (JURKUNAS, ULA V.)Jul 1, 2010 - Jul 31, 2020
NIH/NEI
Role of Oxidative Stress in Pathogenesis of Fuchs Endothelial Corneal Dystrophy
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Katikireddy KR, Schmedt T, Price MO, Price FW, Jurkunas UV. Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium. Am J Pathol. 2016 Oct; 186(10):2736-50. PMID: 27639969.
    View in: PubMed
  2. Qazi Y, Hurwitz S, Khan S, Jurkunas UV, Dana R, Hamrah P. Validity and Reliability of a Novel Ocular Pain Assessment Survey (OPAS) in Quantifying and Monitoring Corneal and Ocular Surface Pain. Ophthalmology. 2016 Jul; 123(7):1458-68. PMID: 27089999.
    View in: PubMed
  3. Halilovic A, Schmedt T, Benischke AS, Hamill C, Chen Y, Santos JH, Jurkunas UV. Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy. Antioxid Redox Signal. 2016 Jun 20; 24(18):1072-83. PMID: 26935406.
    View in: PubMed
  4. Liu C, Vojnovic D, Kochevar IE, Jurkunas UV. UV-A Irradiation Activates Nrf2-Regulated Antioxidant Defense and Induces p53/Caspase3-Dependent Apoptosis in Corneal Endothelial Cells. Invest Ophthalmol Vis Sci. 2016 Apr 1; 57(4):2319-27. PMID: 27127932.
    View in: PubMed
  5. Katikireddy KR, Jurkunas UV. Limbal Stromal Tissue Specific Stem Cells and Their Differentiation Potential to Corneal Epithelial Cells. Methods Mol Biol. 2016; 1341:437-44. PMID: 25762299.
    View in: PubMed
  6. Saboo US, Amparo F, Shikari H, Jurkunas UV, Dana R. Outcomes of phacoemulsification in patients with chronic ocular graft-versus-host disease. Graefes Arch Clin Exp Ophthalmol. 2015 Jun; 253(6):901-7. PMID: 25619668; PMCID: PMC4447562 [Available on 06/01/16].
  7. Chauhan SK, Jurkunas U, Funaki T, Dastjerdi M, Dana R. Quantification of allospecific and nonspecific corneal endothelial cell damage after corneal transplantation. Eye (Lond). 2015 Jan; 29(1):136-44. PMID: 25323855; PMCID: PMC4289838 [Available on 01/01/16].
  8. Katikireddy KR, Dana R, Jurkunas UV. Differentiation potential of limbal fibroblasts and bone marrow mesenchymal stem cells to corneal epithelial cells. Stem Cells. 2014 Mar; 32(3):717-29. PMID: 24022965.
    View in: PubMed
  9. Hamill CE, Schmedt T, Jurkunas U. Fuchs endothelial cornea dystrophy: a review of the genetics behind disease development. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):281-6. PMID: 24138036; PMCID: PMC3997056.
  10. Amparo F, Dastjerdi MH, Okanobo A, Ferrari G, Smaga L, Hamrah P, Jurkunas U, Schaumberg DA, Dana R. Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial. JAMA Ophthalmol. 2013 Jun; 131(6):715-23. PMID: 23599118; PMCID: PMC4167802.
  11. Amparo F, Sadrai Z, Jin Y, Alfonso-Bartolozzi B, Wang H, Shikari H, Ciolino JB, Chodosh J, Jurkunas U, Schaumberg DA, Dana R. Safety and efficacy of the multitargeted receptor kinase inhibitor pazopanib in the treatment of corneal neovascularization. Invest Ophthalmol Vis Sci. 2013 Jan 17; 54(1):537-44. PMID: 23233252; PMCID: PMC3558296.
  12. JaĊĦinskas V, Rudalevicius P, Miliauskas A, Milcius D, Jurkunas UV. Keratoprosthesis surgery as an alternative to keratoplasty. Medicina (Kaunas). 2013; 49(6):291-9. PMID: 24248010.
    View in: PubMed
  13. Schmedt T, Chen Y, Nguyen TT, Li S, Bonanno JA, Jurkunas UV. Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. PLoS One. 2012; 7(12):e51427. PMID: 23284695; PMCID: PMC3528758.
  14. Riazuddin SA, Parker DS, McGlumphy EJ, Oh EC, Iliff BW, Schmedt T, Jurkunas U, Schleif R, Katsanis N, Gottsch JD. Mutations in LOXHD1, a recessive-deafness locus, cause dominant late-onset Fuchs corneal dystrophy. Am J Hum Genet. 2012 Mar 9; 90(3):533-9. PMID: 22341973; PMCID: PMC3309196.
  15. Azizi B, Ziaei A, Fuchsluger T, Schmedt T, Chen Y, Jurkunas UV. p53-regulated increase in oxidative-stress--induced apoptosis in Fuchs endothelial corneal dystrophy: a native tissue model. Invest Ophthalmol Vis Sci. 2011 Dec 02; 52(13):9291-7. PMID: 22064994; PMCID: PMC3250096.
  16. Schmedt T, Silva MM, Ziaei A, Jurkunas U. Molecular bases of corneal endothelial dystrophies. Exp Eye Res. 2012 Feb; 95(1):24-34. PMID: 21855542; PMCID: PMC3273549.
  17. Cruzat A, Witkin D, Baniasadi N, Zheng L, Ciolino JB, Jurkunas UV, Chodosh J, Pavan-Langston D, Dana R, Hamrah P. Inflammation and the nervous system: the connection in the cornea in patients with infectious keratitis. Invest Ophthalmol Vis Sci. 2011 Jul 11; 52(8):5136-43. PMID: 21460259; PMCID: PMC3176064.
  18. Fuchsluger TA, Jurkunas U, Kazlauskas A, Dana R. [Viral vectors for gene delivery to corneal endothelial cells]. Klin Monbl Augenheilkd. 2011 Jun; 228(6):498-503. PMID: 21656431.
    View in: PubMed
  19. Fuchsluger TA, Jurkunas U, Kazlauskas A, Dana R. Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage. Gene Ther. 2011 Aug; 18(8):778-87. PMID: 21412281; PMCID: PMC3587653.
  20. Fuchsluger TA, Jurkunas U, Kazlauskas A, Dana R. Corneal endothelial cells are protected from apoptosis by gene therapy. Hum Gene Ther. 2011 May; 22(5):549-58. PMID: 21158568; PMCID: PMC3081440.
  21. Elhalis H, Azizi B, Jurkunas UV. Fuchs endothelial corneal dystrophy. Ocul Surf. 2010 Oct; 8(4):173-84. PMID: 20964980; PMCID: PMC3061348.
  22. Jurkunas UV, Bitar MS, Funaki T, Azizi B. Evidence of oxidative stress in the pathogenesis of fuchs endothelial corneal dystrophy. Am J Pathol. 2010 Nov; 177(5):2278-89. PMID: 20847286; PMCID: PMC2966787.
  23. Mandell KJ, Jurkunas UV, Pineda R. Intraocular lens calculations after corneal refractive surgery. Int Ophthalmol Clin. 2010; 50(1):181-9. PMID: 20057306.
    View in: PubMed
  24. Jurkunas U, Behlau I, Colby K. Fungal keratitis: changing pathogens and risk factors. Cornea. 2009 Jul; 28(6):638-43. PMID: 19512908.
    View in: PubMed
  25. Lim P, Fuchsluger TA, Jurkunas UV. Limbal stem cell deficiency and corneal neovascularization. Semin Ophthalmol. 2009 May-Jun; 24(3):139-48. PMID: 19437349.
    View in: PubMed
  26. Harissi-Dagher M, Dana MR, Jurkunas UV. Keratoglobus in association with posterior polymorphous dystrophy. Cornea. 2007 Dec; 26(10):1288-91. PMID: 18043197.
    View in: PubMed
  27. Lee BW, Jurkunas UV, Harissi-Dagher M, Poothullil AM, Tobaigy FM, Azar DT. Ectatic disorders associated with a claw-shaped pattern on corneal topography. Am J Ophthalmol. 2007 Jul; 144(1):154-156. PMID: 17601448.
    View in: PubMed
  28. Jurkunas UV, Langston DP, Colby K. Use of voriconazole in the treatment of fungal keratitis. Int Ophthalmol Clin. 2007; 47(2):47-59. PMID: 17450006.
    View in: PubMed
  29. Yu EN, Jurkunas U, Rubin PA, Baltatzis S, Foster CS. Obliterative microangiopathy presenting as chronic conjunctivitis in a patient with relapsing polychondritis. Cornea. 2006 Jun; 25(5):621-2. PMID: 16783155.
    View in: PubMed
  30. Kopplin LJ, Przepyszny K, Schmotzer B, Rudo K, Babineau DC, Patel SV, Verdier DD, Jurkunas U, Iyengar SK, Lass JH. Relationship of Fuchs endothelial corneal dystrophy severity to central corneal thickness. Arch Ophthalmol. 2012 Apr; 130(4):433-9. PMID: 22491913; PMCID: PMC3859299.
  31. Jurkunas UV, Jakobiec FA, Shin J, Zakka FR, Michaud N, Jethva R. Reversible corneal epitheliopathy caused by vitamin B12 and folate deficiency in a vegan with a genetic mutation: a new disease. Eye (Lond). 2011 Nov; 25(11):1512-4. PMID: 21818128; PMCID: PMC3213645.
  32. Dastjerdi MH, Al-Arfaj KM, Nallasamy N, Hamrah P, Jurkunas UV, Pineda R, Pavan-Langston D, Dana R. Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study. Arch Ophthalmol. 2009 Apr; 127(4):381-9. PMID: 19365012; PMCID: PMC2703579.
  33. Ahmad S, Osei-Bempong C, Dana R, Jurkunas U. The culture and transplantation of human limbal stem cells. J Cell Physiol. 2010 Oct; 225(1):15-9. PMID: 20506173.
    View in: PubMed
  34. Ziaei A, Schmedt T, Chen Y, Jurkunas UV. Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment. Invest Ophthalmol Vis Sci. 2013 Oct 15; 54(10):6724-34. PMID: 24030461; PMCID: PMC3797593.
  35. Liu C, Chen Y, Kochevar IE, Jurkunas UV. Decreased DJ-1 leads to impaired Nrf2-regulated antioxidant defense and increased UV-A-induced apoptosis in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2014 Jul 31; 55(9):5551-60. PMID: 25082883; PMCID: PMC4160071.
  36. Lam HY, Wiggs JL, Jurkunas UV. Unusual presentation of presumed posterior polymorphous dystrophy associated with iris heterochromia, band keratopathy, and keratoconus. Cornea. 2010 Oct; 29(10):1180-5. PMID: 20567203; PMCID: PMC2945457.
  37. Schrems-Hoesl LM, Schrems WA, Cruzat A, Shahatit BM, Bayhan HA, Jurkunas UV, Hamrah P. Cellular and subbasal nerve alterations in early stage Fuchs' endothelial corneal dystrophy: an in vivo confocal microscopy study. Eye (Lond). 2013 Jan; 27(1):42-9. PMID: 23154490; PMCID: PMC3545379.
  38. Jurkunas UV, Bitar MS, Rawe I, Harris DL, Colby K, Joyce NC. Increased clusterin expression in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):2946-55. PMID: 18378577; PMCID: PMC2789477.
  39. Bitar MS, Liu C, Ziaei A, Chen Y, Schmedt T, Jurkunas UV. Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2012 Aug 24; 53(9):5806-13. PMID: 22836768; PMCID: PMC3428112.
  40. Sharma SM, Fuchsluger T, Ahmad S, Katikireddy KR, Armant M, Dana R, Jurkunas UV. Comparative analysis of human-derived feeder layers with 3T3 fibroblasts for the ex vivo expansion of human limbal and oral epithelium. Stem Cell Rev. 2012 Sep; 8(3):696-705. PMID: 21964568.
    View in: PubMed
  41. Jurkunas U, Azar DT. Potential complications of ocular surgery in patients with coexistent keratoconus and Fuchs' endothelial dystrophy. Ophthalmology. 2006 Dec; 113(12):2187-97. PMID: 16996603.
    View in: PubMed
  42. Jurkunas UV, Bitar M, Rawe I. Colocalization of increased transforming growth factor-beta-induced protein (TGFBIp) and Clusterin in Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1129-36. PMID: 19011008; PMCID: PMC2719557.
  43. Jurkunas UV, Rawe I, Bitar MS, Zhu C, Harris DL, Colby K, Joyce NC. Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):2956-63. PMID: 18378575; PMCID: PMC2773676.
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