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Jin-Rong Zhou, PH.D.

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Biography
1991 - 1992
University Fellowship
1994
Graduate Student Award in Vitamin Research
1996 - 1999
National Individual Research Service Award

Overview
The laboratory has a priority to investigate the most complex issues dealing with nutrition and health. The long-term goal of our research is to identify bioactive dietary, nutritional and natural botanical components for the prevention and treatment of chronic diseases, such as cancer, obesity and metabolic syndrome. We establish an integrated system for identification, efficacy evaluation and mechanism elucidation of candidate bioactive components. We apply a series of clinically relevant animal models for chronic diseases, such as the cancers of prostate, breast, pancreatic and bladder and obesity/metabolic syndrome, to evaluate the efficacy of candidate components . We apply advanced techniques for cellular and molecular biology and genetics/epigenetics to elucidate the mechanisms of action of candidate components. By combining efficacy evaluation and mechanistic study, we are able to identify effective dietary and nutritional regimens for prevention and treatment of cancer and obesity/metabolic syndrome. Our research findings can be directly translated to clinical practice and provide evidence to make dietary guidelines for prevention of related diseases.

By using integrated approaches, we have made significant achievements in identifying effective dietary/nutritional regimens for cancer prevention. We are the first group to demonstrate the synergistic combination effect between soybean and tea active components on preventing breast and prostate cancers. Now more research groups are actively investigating the effects of dietary/nutritional component combinations on cancer prevention. We are also among the first few research groups to propose metabolic syndrome as a potential etiological risk factor for the development and progression of several types of cancer, and in particular, maternal metabolic disorder status as a risk factor for cancer in offspring. We are actively conducting the related research. We are applying cell function-guided extraction, fractionation and purification strategies to identify active components from Chinese herbal medicines for the prevention and therapy of cancer. In addition, we are investigating the roles that nutritional/natural components may play in targeting cancer stem cells. Our research findings can be directly translated into future clinical investigations.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA159348 (ZHOU, JIN-RONG) Jul 5, 2011 - Jun 30, 2013
    NIH/NCI
    Tanshinones for prevention of bladder cancer progression
    Role: Principal Investigator
  2. R21CA153355 (ZHOU, JIN-RONG) Jul 1, 2011 - Dec 30, 2013
    NIH/NCI
    Targeting prostate cancer stem cells to delay prostate cancer progression
    Role: Principal Investigator
  3. R21CA127794 (ZHOU, JIN-RONG) Apr 8, 2008 - Mar 31, 2011
    NIH/NCI
    Metabolic Syndrome as Pancreatic Cancer Etiology
    Role: Principal Investigator
  4. R21CA133865 (ZHOU, JIN-RONG) Sep 14, 2007 - Aug 31, 2010
    NIH/NCI
    Oldenlandia diffusa for prostate cancer treatment
    Role: Principal Investigator
  5. R03CA130131 (ZHOU, JIN-RONG) Sep 1, 2007 - Aug 31, 2010
    NIH/NCI
    Parental metabolic status and offspring cancer risks
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. N. Feng, Y. Gong, L. Li, H.M. Abdolmaleky, J.-R. Zhou. Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. PLoS ONE. 2012; 7(6):e38802.
  2. Y. Gong, Y. Li, H.M. Abdolmaleky, L. Li, J.-R. Zhou. Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function. PLoS ONE. 2012; 7(4):e33656.
  3. Y. Li, Y. Gong, L. Li, H.M. Abdolmaleky, J.-R. Zhou. Bioactive tanshinone I inhibits the growth of lung cancer via downregulation of Aurora A function. Mol. Carcinogenesis. 2012; Doi:10.1002/mc.21888. .
  4. J.M. Nagel, M. Brinkoetter, F. Magkos, X. Liu, J.P. Chamberland, S. Shah, J. Zhou, G. Blackburn, C. Mantzoros. Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. 2012; 28(1):67-75.
  5. Y.W. Zhang, D.L. Yan, W. Wang, H.W. Zhao, X. Lu, J.Z. Wu, J.R. Zhou. Knockdown of insulin-like growth factor I receptor inhibits the growth and enhances chemo-sensitivity of liver cancer cells. Curr Cancer Drug Targets. 2012; 12(1):74-84.
  6. L.F. Zerbini, J.F. de Vasconcellos, A. Czibere, Y. Wang, J.D. Paccez, X. Gu, J. Zhou, T.A. Libermann. JunD-mediated repression of GADD45a and ? regulates escape from cell death in prostate cancer. Cell Cycle. 2011; 10:2583-91.
  7. P. Papageorgis, K. Cheng, S. Ozturk, Y. Gong, A.W. Lambert, H.M. Abdolmaleky, J.-R. Zhou, S. Thiagalingam. Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Research. 2011; 71:998-1008.
  8. LF Zerbini, RE Tamura, RG Correa, A Czibere, J Cordeiro, F Simabuco, Y Wang, X Gu, L Li, D Sarkar, J Zhou, PB Fisher, TA Libermann. Combinatorial effect of Non-Steroidal Anti-inflammatory Drugs and NF-kB inhibitors in ovarian cancer therapy. PLoS ONE. 2011; 6(9):e24285.
  9. Gong Y, Li Y, Lu Y, Li L, Abdolmaleky H, Blackburn GL, Zhou JR. Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice. Int J Cancer. 2011 Sep 01; 129(5):1042-52. PMID: 20848589.
    View in: PubMed
  10. M. Li, R.-W. Jiang, P.-M. Hon, L. Cheng, L.-L. Li, J.-R. Zhou, P.-C. Shaw, P. P.-H. But. Authentication of the anti-tumor herb Baihuasheshecao with bioactive marker compounds and molecular sequences. Food Chem. 2010; 119:1239-45.
  11. Hagen SJ, Ohtani M, Zhou JR, Taylor NS, Rickman BH, Blackburn GL, Fox JG. Inflammation and foveolar hyperplasia are reduced by supplemental dietary glutamine during Helicobacter pylori infection in mice. J Nutr. 2009 May; 139(5):912-8. PMID: 19261732; PMCID: PMC2714391.
  12. J.-F. Feng, J.-Z. Wu, S.-N. Hu, C.-M. Gao, M.-Q. Shi, Z.-H. Lu, X.-C. Sun, J.-R. Zhou, B.-A. Chen. Polymorphisms of the ribonucleotide reductase M1 gene and sensitivity to platin-based chemotherapy in non-small cell lung cancer. Lung Cancer. 2009; 66:344-349.
  13. Nasca MM, Zhou JR, Welty FK. Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women. Am J Cardiol. 2008 Jul 01; 102(1):84-6. PMID: 18572041; PMCID: PMC3229929.
  14. Khaodhiar L, Ricciotti HA, Li L, Pan W, Schickel M, Zhou J, Blackburn GL. Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women. Menopause. 2008 Jan-Feb; 15(1):125-32. PMID: 18257146; PMCID: PMC3207039.
  15. Abdolmaleky HM, Smith CL, Zhou J-R, Thiagalingam S. In: Walker J, Yan W, editors. Methods in Molecular Biology. Totowa: Humana Press Inc. Epigenetic alterations of the dopaminergic system in major psychiatric disorders. Pharmacogenomics in drug discovery and development. 2008; 448:187-212.
  16. Abdolmaleky HM, Smith CL, Zhou J-R, Thiagalingam S. In: Fatemi SH, editor. Reelin Glycoprotein Biology, Structure and Roles in Health and Disease. Springer. Epigenetic modulation of reelin function in schizophrenia and bipolar disorder. 2008; 366-84.
  17. Abdolmaleky HM, Zhou J-R, Thiagalingam S, Smith CL. Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. Pharmacogenomics. 2008; 9:1809-23.
  18. Zhou JR, Blackburn GL, Walker WA. Symposium introduction: metabolic syndrome and the onset of cancer. Am J Clin Nutr. 2007 09; 86(3):s817-9. PMID: 18265474.
    View in: PubMed
  19. Zhou JR, Li L, Pan W. Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice. Am J Clin Nutr. 2007 09; 86(3):s882-8. PMID: 18265483.
    View in: PubMed
  20. Mai Z, Blackburn GL, Zhou JR. Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells. Mol Carcinog. 2007 Jul; 46(7):534-42. PMID: 17295235; PMCID: PMC2683254.
  21. Welty FK, Lee KS, Lew NS, Zhou JR. Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women. Arch Intern Med. 2007 May 28; 167(10):1060-7. PMID: 17533209.
    View in: PubMed
  22. Mai Z, Blackburn GL, Zhou JR. Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice. Carcinogenesis. 2007 Jun; 28(6):1217-23. PMID: 17234721; PMCID: PMC2747475.
  23. Zhou J-R, Blackburn GL, Walker WA. Symposium introduction: Metabolic syndrome and the onset of cancer. Am J Clin Nutr. 2007; 86:817s-9s.
  24. Pan W, Blackburn GL, Zhou J-R. Effects of a daidzein-rich isoflavone aglycone extract on diet-induced obesity in an ovariectomized mouse model. Clin Exp Pharmacol Physiol. 2007; 34:S55-7.
  25. R.-W. Jiang, J.-R. Zhou, P.-M. Hon, S.-L. Li, Y. Zhou, L. Li, W.-C. Ye, H.-X. Xu, P.-C. Shaw, P. P.-H. But. Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. J. Natural Products. 2007; 70:283-286.
  26. Welty FK, Lee SK, Lew NS, Nasca M, Zhou J-R. The association between soy nut consumption and decreased menopausal symptoms. J Women’s Health. 2007; 16:361-7.
  27. Zerbini LF, Czibere A, Wang Y, Correa RG, Otu H, Joseph M, Takayasu Y, Silver M, Gu X, Ruchusatsawat K, Li L, Sarkar D, Zhou JR, Fisher PB, Libermann TA. A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells. Cancer Res. 2006 Dec 15; 66(24):11922-31. PMID: 17178890.
    View in: PubMed
  28. Singh AV, Franke AA, Blackburn GL, Zhou JR. Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis. Cancer Res. 2006 Feb 01; 66(3):1851-8. PMID: 16452247; PMCID: PMC2683370.
  29. Zhou J-R. In: Heber D, Blackburn GL, Go VLW, Milner J, editors. Nutritional Oncology (2nd Edition). San Diego: Academic Press Inc. Animal models in nutritional oncology. 2006; 333-47.
  30. Zhou J-R. In: Thompson LU, Ward WE, editors. Food Drug Synergy and Safety. CRC Press. Soy-food and soy-drug interactions in prevention and treatment of cancer. 2005; 125-46.
  31. Zhou J-R. In: Awad AB, Bradford PG, editors. Nutrition and Cancer Prevention. Marcel Dekker Inc. Flavonoids as inhibitors of tumor metastasis. 2005; 325-49.
  32. Zhou JR. Soy and the prevention of lifestyle-related diseases. Clin Exp Pharmacol Physiol. 2004 Dec; 31 Suppl 2:S14-9. PMID: 15649276.
    View in: PubMed
  33. Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K, Wei W, Joseph M, Gu X, Grall F, Goldring MB, Zhou JR, Libermann TA, Zhou JR. NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13618-23. PMID: 15353598.
    View in: PubMed
  34. Zhou JR, Yu L, Zerbini LF, Libermann TA, Blackburn GL. Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations. Int J Cancer. 2004 Jul 20; 110(6):800-6. PMID: 15170660.
    View in: PubMed
  35. Zhou J-R, Erdman JW Jr. In: Bendich A, Deckelbaum R, editors. Preventive Nutrition (3rd Edition). Totowa: Humana Press Inc. Soy consumption and cancer prevention: a critical review. 2004; 123-155.
  36. Zhou JR, Yu L, Mai Z, Blackburn GL. Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int J Cancer. 2004 Jan 01; 108(1):8-14. PMID: 14618609.
    View in: PubMed
  37. Yu L, Blackburn GL, Zhou JR. Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells. J Nutr. 2003 Feb; 133(2):389-92. PMID: 12566472.
    View in: PubMed
  38. Zhou JR, Yu L, Zhong Y, Blackburn GL. Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice. J Nutr. 2003 Feb; 133(2):516-21. PMID: 12566493.
    View in: PubMed
  39. Zhou JR, Yu L, Zhong Y, Nassr RL, Franke AA, Gaston SM, Blackburn GL. Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components. Prostate. 2002 Oct 01; 53(2):143-53. PMID: 12242729; PMCID: PMC2777759.
  40. Jones JL, Daley BJ, Enderson BL, Zhou J-R, Karlstad MD. Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells. Am Surg. 2002; 68(6):575-7.
  41. Williams AW, Boileau TW-M, Zhou J-R, Clinton SK, Erdman JW Jr. Beta-carotene modulates human prostate cancer cell growth and may undergo intracellular metabolism to retinol. J Nutr. 2000; 130:728-32.
  42. Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr. 1999 Sep; 129(9):1628-35. PMID: 10460196.
    View in: PubMed
  43. Mukherjee P, Zhou J-R, Sotnikov A, Clinton SK. In: Teicher BA, editor. Antiangiogenic Agents in Cancer Therapy. Totowa: Humana Press Inc. Dietary and nutritional modulation of tumor angiogenesis. 1999; 237-262.
  44. Zhou JR, Mukherjee P, Gugger ET, Tanaka T, Blackburn GL, Clinton SK. Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res. 1998 Nov 15; 58(22):5231-8. PMID: 9823337.
    View in: PubMed
  45. Zhou J-R, Blackburn GL. In: Heber D, Blackburn GL, Go VLW, editors. Nutritional Oncology. San Diego: Academic Press Inc.;. Dietary lipid modulation of immune response in tumorigenesis. 1998; 195-213.
  46. Zhou JR, Blackburn GL. Bridging animal and human studies: what are the missing segments in dietary fat and prostate cancer? Am J Clin Nutr. 1997 12; 66(6 Suppl):1572S-1580S. PMID: 9394717.
    View in: PubMed
  47. Zhou J-R, Erdman JW Jr. In: Lachance PA, editor. Nutraeuticals: Designer Food III. Trumbull; Food and Nutrition Press Inc. Chemical effects of processing and food preparation on carotenoids and soy and garlic phytochemicals. 1997; 23-37.
  48. Zhou J-R, Gugger ET, Erdman JW Jr. The crystalline form of carotenes and the food matrix in carrot root decrease the bioavailability of beta- and alpha-carotene in the ferret model. J Am Coll Nutr. 1996; 15(1):84-91.
  49. Zhou J-R, Erdman JW Jr. Crit Rev Food Sci Nutr. Phytic acid in health and disease. 1995; 35(6):495-508.
  50. Zhou J-R, Gugger ET, Erdman JW Jr. Isolation and partial characterization of an 18 kDa carotenoid-protein complex from carrot roots. J Agri Food Chem. 1994; 42:2386-90.
  51. Zhou J-R, Canar MM, Erdman JW Jr. Bone zinc is poorly released in young, growing rats fed marginal zinc restricted diet. J Nutr. 1993; 123:1383-8.
  52. Zhou J-R, Fordyce EJ, Raboy V, Dickinson DB, Song M-S, Burns RA, Erdman JW Jr. Reduction of phytic acid in soybean products improves zinc bioavailability in rats. J Nutr. 1992; 122:2466-73.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.