Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileMartha R. Herbert, M.D., PH.D.

TitleAssistant Professor of Neurology
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
TRANSCEND/Pediatric Neurology, Room 10.043
149 13th Street
Charlestown MA 02129
vCardDownload vCard (login for email)
Profile Picture

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Wen Y, Alshikho MJ, Herbert MR. Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling. PLoS One. 2016; 11(4):e0153329. PMID: 27055244.
    View in: PubMed
  2. Goldman AW, Burmeister Y, Cesnulevicius K, Herbert M, Kane M, Lescheid D, McCaffrey T, Schultz M, Seilheimer B, Smit A, St Laurent G, Berman B. Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity? Front Physiol. 2015; 6:225. PMID: 26347656; PMCID: PMC4541032.
  3. Khan S, Michmizos K, Tommerdahl M, Ganesan S, Kitzbichler MG, Zetino M, Garel KL, Herbert MR, Hämäläinen MS, Kenet T. Somatosensory cortex functional connectivity abnormalities in autism show opposite trends, depending on direction and spatial scale. Brain. 2015 May; 138(Pt 5):1394-409. PMID: 25765326.
    View in: PubMed
  4. Kitzbichler MG, Khan S, Ganesan S, Vangel MG, Herbert MR, Hämäläinen MS, Kenet T. Altered development and multifaceted band-specific abnormalities of resting state networks in autism. Biol Psychiatry. 2015 May 1; 77(9):794-804. PMID: 25064418; PMCID: PMC4270956 [Available on 05/01/16].
  5. Herbert MR, Sage C. Autism and EMF? Plausibility of a pathophysiological link part II. Pathophysiology. 2013 Jun; 20(3):211-34. PMID: 24113318.
    View in: PubMed
  6. Herbert MR, Sage C. Autism and EMF? Plausibility of a pathophysiological link - Part I. Pathophysiology. 2013 Jun; 20(3):191-209. PMID: 24095003.
    View in: PubMed
  7. Herbert, MR. North American Journal of Medicine and Science. Everyday Epigenetics: From molecular intervention to public health and lifestyle medicine. 2013; 6(3):167-170AC.
  8. Herbert MR, Buckley JA. Autism and dietary therapy: case report and review of the literature. J Child Neurol. 2013 Aug; 28(8):975-82. PMID: 23666039.
    View in: PubMed
  9. Khan S, Gramfort A, Shetty NR, Kitzbichler MG, Ganesan S, Moran JM, Lee SM, Gabrieli JD, Tager-Flusberg HB, Joseph RM, Herbert MR, Hämäläinen MS, Kenet T. Local and long-range functional connectivity is reduced in concert in autism spectrum disorders. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3107-12. PMID: 23319621; PMCID: PMC3581984.
  10. Herbert, MR. Genetic Explanations: Sense and Nonsense (Krimsky, S and Gruber, J, eds). Chapter 10: Autism: From Static Genetic Brain Defect to Dynamic Gene-Environment Modulated Pathophysiology. 2013.
  11. Herbert, MR. Metrodocs: The Journal of the Twin Cities Medical Society. Autism: From How it Works to How We Can Help More Effectively. 2013; 15(5):15-18.
  12. Goldman S., O'Brien, L.M., Filipek P.A., Rapin, I., Herbert, M.R. . Research in Autism Spectrum Disorders. Motor stereotypies and volumetric brain alterations in children with Autistic Disorder. 2013; 7:82-92.
  13. Herbert, MR with Weintraub, K. Harvard Health Publications (book). The Autism Revolution: Whole Body Strategies for Making Life All It Can Be. 2012.
  14. Herbert, M.R. Developmental Dyslexia: Cross-Disciplinary Insights on Early Precursors, Expression, and Remediation, A volume in the Extraordinary Brain Series (Benasich, AA and Fitch, HR, eds). Transcending gaps among disciplines in neurodevelopmental disorders: From brain volumetrics to collaborative multidisciplinary assessment. 2012.
  15. Herbert, MR. Website for book, The Autism Revolution (2012) ( 2012.
  16. Autism Why and How: Spirit of Inquiry and Multiple Perspectives on Autism ( 2012.
  17. O'Brien LM, Ziegler DA, Deutsch CK, Frazier JA, Herbert MR, Locascio JJ. Statistical adjustments for brain size in volumetric neuroimaging studies: some practical implications in methods. Psychiatry Res. 2011 Aug 30; 193(2):113-22. PMID: 21684724; PMCID: PMC3510982.
  18. Herbert MR. SHANK3, the synapse, and autism. N Engl J Med. 2011 Jul 14; 365(2):173-5. PMID: 21751912.
    View in: PubMed
  19. Herbert MR. Reply to letter of Peter Good. Neuropsychol Rev. 2011 Mar; 21(1):70-1. PMID: 21246288.
    View in: PubMed
  20. Herbert MR. The Neuropsychology of autism. Neuroanatomy in Autism. 2011.
  21. Corrales M., Herbert MR. Autism Spectrum Disorders (Amaral, Dawson, Geschwind, eds.). Autism and Environmental Genomics: Synergistic systems approaches to autism complexity. 2011.
  22. Herbert M.R. The Neuropsychology of Autism. A Whole Body Systems Approach to Autism. 2011.
  23. Isler JR, Martien KM, Grieve PG, Stark RI, Herbert MR. Reduced functional connectivity in visual evoked potentials in children with autism spectrum disorder. Clin Neurophysiol. 2010 Dec; 121(12):2035-43. PMID: 20605520.
    View in: PubMed
  24. Herbert MR. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol. 2010 Apr; 23(2):103-10. PMID: 20087183.
    View in: PubMed
  25. Granpeesheh D, Tarbox J, Dixon DR, Carr E, Herbert M. Retrospective analysis of clinical records in 38 cases of recovery from autism. Ann Clin Psychiatry. 2009 Oct-Dec; 21(4):195-204. PMID: 19917210.
    View in: PubMed
  26. Herbert, MR. Autism: Oxidative stress, inflammation and immune abnormalities. Autism: The Centrality of Pathophysiology and the Shift from Static to Chronic Dynamic Encephalopathy. 2009.
  27. Helt M, Kelley E, Kinsbourne M, Pandey J, Boorstein H, Herbert M, Fein D. Can children with autism recover? If so, how? Neuropsychol Rev. 2008 Dec; 18(4):339-66. PMID: 19009353.
    View in: PubMed
  28. Herbert MR. Learning from the autism catastrophe: key leverage points. Altern Ther Health Med. 2008 Nov-Dec; 14(6):28-30. PMID: 19043935.
    View in: PubMed
  29. Herbert MR, Anderson M. Autism: Current Theories and Evidence (Zimmerman, A., ed). An Expanding Spectrum of Autism Models: From Fixed Developmental Defects to Reversible Functional Impairments. 2008; ch 18 of 18.
  30. Herbert M. Martha Herbert, MD: transcending the gaps in autism research. Interview by Frank Lampe and Suzanne Snyder. Altern Ther Health Med. 2007 Nov-Dec; 13(6):62-73. PMID: 17985813.
    View in: PubMed
  31. Herbert MR, Kenet T. Brain abnormalities in language disorders and in autism. Pediatr Clin North Am. 2007 Jun; 54(3):563-83, vii. PMID: 17543910.
    View in: PubMed
  32. Ahn MS, Breeze JL, Makris N, Kennedy DN, Hodge SM, Herbert MR, Seidman LJ, Biederman J, Caviness VS, Frazier JA. Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder. J Affect Disord. 2007 Dec; 104(1-3):147-54. PMID: 17532475.
    View in: PubMed
  33. Belmonte MK, Mazziotta JC, Minshew NJ, Evans AC, Courchesne E, Dager SR, Bookheimer SY, Aylward EH, Amaral DG, Cantor RM, Chugani DC, Dale AM, Davatzikos C, Gerig G, Herbert MR, Lainhart JE, Murphy DG, Piven J, Reiss AL, Schultz RT, Zeffiro TA, Levi-Pearl S, Lajonchere C, Colamarino SA. Offering to share: how to put heads together in autism neuroimaging. J Autism Dev Disord. 2008 Jan; 38(1):2-13. PMID: 17347882; PMCID: PMC3076291.
  34. Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, Buxbaum JD, Davis KL, Hollander E, Silverman JM, Hallmayer J, Lotspeich L, Sutcliffe JS, Haines JL, Folstein SE, Piven J, Wassink TH, Sheffield V, Geschwind DH, Bucan M, Brown WT, Cantor RM, Constantino JN, Gilliam TC, Herbert M, Lajonchere C, Ledbetter DH, Lese-Martin C, Miller J, Nelson S, Samango-Sprouse CA, Spence S, State M, Tanzi RE, Coon H, Dawson G, Devlin B, Estes A, Flodman P, Klei L, McMahon WM, Minshew N, Munson J, Korvatska E, Rodier PM, Schellenberg GD, Smith M, Spence MA, Stodgell C, Tepper PG, Wijsman EM, Yu CE, Rogé B, Mantoulan C, Wittemeyer K, Poustka A, Felder B, Klauck SM, Schuster C, Poustka F, Bölte S, Feineis-Matthews S, Herbrecht E, Schmötzer G, Tsiantis J, Papanikolaou K, Maestrini E, Bacchelli E, Blasi F, Carone S, Toma C, Van Engeland H, de Jonge M, Kemner C, Koop F, Koop F, Langemeijer M, Langemeijer M, Hijmans C, Hijimans C, Staal WG, Baird G, Bolton PF, Rutter ML, Weisblatt E, Green J, Aldred C, Wilkinson JA, Pickles A, Le Couteur A, Berney T, McConachie H, Bailey AJ, Francis K, Honeyman G, Hutchinson A, Parr JR, Wallace S, Monaco AP, Barnby G, Kobayashi K, Lamb JA, Sousa I, Sykes N, Cook EH, Guter SJ, Leventhal BL, Salt J, Lord C, Corsello C, Hus V, Weeks DE, Volkmar F, Tauber M, Fombonne E, Shih A, Meyer KJ. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 2007 Mar; 39(3):319-28. PMID: 17322880.
    View in: PubMed
  35. Herbert MR. Clinical implications of environmental toxicology for children's neurodevelopment in autism. 2007; 2(2):167-171.
  36. O'Brien LM, Ziegler DA, Deutsch CK, Kennedy DN, Goldstein JM, Seidman LJ, Hodge S, Makris N, Caviness V, Frazier JA, Herbert MR. Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods. Harv Rev Psychiatry. 2006 May-Jun; 14(3):141-51. PMID: 16787886.
    View in: PubMed
  37. Herbert MR, Russo JP, Yang S, Roohi J, Blaxill M, Kahler SG, Cremer L, Hatchwell E. Autism and environmental genomics. Neurotoxicology. 2006 Sep; 27(5):671-84. PMID: 16644012.
    View in: PubMed
  38. Herbert MR. The Neurobiology of Disease (Gilman, S., ed). Autism. 2006.
  39. Herbert, MR, Caviness, VS. Autism: A neurobiological disorder of early brain development (Rapin, I and Tuchman, R, eds). Neuroanatomical and Imaging Studies. 2006; 115-140.
  40. Frazier JA, Breeze JL, Makris N, Giuliano AS, Herbert MR, Seidman L, Biederman J, Hodge SM, Dieterich ME, Gerstein ED, Kennedy DN, Rauch SL, Cohen BM, Caviness VS. Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Bipolar Disord. 2005 Dec; 7(6):555-69. PMID: 16403181; PMCID: PMC2072813.
  41. Herbert MR. Large brains in autism: the challenge of pervasive abnormality. Neuroscientist. 2005 Oct; 11(5):417-40. PMID: 16151044.
    View in: PubMed
  42. Herbert MR, Ziegler DA. Volumetric neuroimaging and low-dose early-life exposures: loose coupling of pathogenesis-brain-behavior links. Neurotoxicology. 2005 Aug; 26(4):565-72. PMID: 16112322.
    View in: PubMed
  43. Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, Herbert MR, Bent EK, Koneru VK, Dieterich ME, Hodge SM, Rauch SL, Grant PE, Cohen BM, Seidman LJ, Caviness VS, Biederman J. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry. 2005 Jul; 162(7):1256-65. PMID: 15994707.
    View in: PubMed
  44. Herbert, MR. Clinical Neuropsychiatry. Autism: A brain disorder or a disorder that affects the brain?. 2005.
  45. De Fossé L, Hodge SM, Makris N, Kennedy DN, Caviness VS, McGrath L, Steele S, Ziegler DA, Herbert MR, Frazier JA, Tager-Flusberg H, Harris GJ. Language-association cortex asymmetry in autism and specific language impairment. Ann Neurol. 2004 Dec; 56(6):757-66. PMID: 15478219.
    View in: PubMed
  46. Herbert MR, Ziegler DA, Deutsch CK, O'Brien LM, Kennedy DN, Filipek PA, Bakardjiev AI, Hodgson J, Takeoka M, Makris N, Caviness VS. Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain. 2005 Jan; 128(Pt 1):213-26. PMID: 15563515.
    View in: PubMed
  47. Herbert MR. Neuroimaging in disorders of social and emotional functioning: what is the question? J Child Neurol. 2004 Oct; 19(10):772-84. PMID: 15559893.
    View in: PubMed
  48. Herbert MR, Ziegler DA, Makris N, Filipek PA, Kemper TL, Normandin JJ, Sanders HA, Kennedy DN, Caviness VS. Localization of white matter volume increase in autism and developmental language disorder. Ann Neurol. 2004 Apr; 55(4):530-40. PMID: 15048892.
    View in: PubMed
  49. Herbert MR, Ziegler DA, Deutsch CK, O'Brien LM, Lange N, Bakardjiev A, Hodgson J, Adrien KT, Steele S, Makris N, Kennedy D, Harris GJ, Caviness VS. Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain. 2003 May; 126(Pt 5):1182-92. PMID: 12690057.
    View in: PubMed
  50. Herbert MR, Harris GJ, Adrien KT, Ziegler DA, Makris N, Kennedy DN, Lange NT, Chabris CF, Bakardjiev A, Hodgson J, Takeoka M, Tager-Flusberg H, Caviness VS. Abnormal asymmetry in language association cortex in autism. Ann Neurol. 2002 Nov; 52(5):588-96. PMID: 12402256.
    View in: PubMed
  51. Herbert, MR. Critical Public Health. Genetics finding its place in larger living schemes. 2002; 12(3):221-236.
  52. Caviness VS, Makris N, Lange NT, Herbert M, Kennedy DN. Advanced applications of MRI in human brain science. Keio J Med. 2000 Jun; 49(2):66-73. PMID: 10900831.
    View in: PubMed
  53. Nader C, Herbert MR, Billings PR, Bereano PL, Hubbard R, King J, Krimsky S, Newman SA, Stabinsky D. Redesigning evolution? Science. 1999 Sep 3; 285(5433):1491; author reply 1492. PMID: 10498533.
    View in: PubMed
  54. Caviness VS, Lange NT, Makris N, Herbert MR, Kennedy DN. MRI-based brain volumetrics: emergence of a developmental brain science. Brain Dev. 1999 Jul; 21(5):289-95. PMID: 10413014.
    View in: PubMed
  55. So GM, Herbert MR, Dooling EC, Buonanno F, Kosofsky BE, Ebb D. Multifocal embolic strokes following cardiac surgery in a protein C-deficient child. J Child Neurol. 1998 Dec; 13(12):629-31. PMID: 9881534.
    View in: PubMed
  56. Cher LM, Hochberg FH, Teruya J, Nitschke M, Valenzuela RF, Schmahmann JD, Herbert M, Rosas HD, Stowell C. Therapy for paraneoplastic neurologic syndromes in six patients with protein A column immunoadsorption. Cancer. 1995 Apr 1; 75(7):1678-83. PMID: 8826927.
    View in: PubMed
  57. Herbert, MR. Telos. Evolutionary Theory in Ferment. 1983; 57:107-128.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For demographic and contact information changes only, HMS/HSDM faculty should contact Human Resources at
Herbert's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
Co-Authors Expand Description
Similar People Expand Description
Same Department Expand Description
Physical Neighbors Expand Description