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profileHenryk Koziel, M.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Pulmonary Div, KSB-023
One Deaconess Rd
Boston MA 02215
Phone617/632-9975
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ordija CM, Chiou TT, Yang Z, Deloid GM, de Oliveira Valdo M, Wang Z, Bedugnis A, Noah TL, Jones S, Koziel H, Kobzik L. Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 01; 312(6):L1018-L1028. PMID: 28385809.
    View in: PubMed
  2. Harris RM, Arnaout R, Koziel H, Folch E, Majid A, Kirby JE. Utility of microbiological testing of thoracic lymph nodes sampled by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with mediastinal lymphadenopathy. Diagn Microbiol Infect Dis. 2016 Feb; 84(2):170-4. PMID: 26602949.
    View in: PubMed
  3. Mendivil CO, Koziel H, Brain JD. Metabolic hormones, apolipoproteins, adipokines, and cytokines in the alveolar lining fluid of healthy adults: compartmentalization and physiological correlates. PLoS One. 2015; 10(4):e0123344. PMID: 25848795; PMCID: PMC4388476.
  4. Yang Z, Huang YC, Koziel H, de Crom R, Ruetten H, Wohlfart P, Thomsen RW, Kahlert JA, Sørensen HT, Jozefowski S, Colby A, Kobzik L. Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target. Elife. 2014 Oct 15; 3. PMID: 25317947; PMCID: PMC4215537.
  5. Bernard MA, Zhao H, Yue SC, Anandaiah A, Koziel H, Tachado SD. Novel HIV-1 miRNAs stimulate TNFa release in human macrophages via TLR8 signaling pathway. PLoS One. 2014; 9(9):e106006. PMID: 25191859; PMCID: PMC4156304.
  6. Bernard MA, Han X, Inderbitzin S, Agbim I, Zhao H, Koziel H, Tachado SD. HIV-derived ssRNA binds to TLR8 to induce inflammation-driven macrophage foam cell formation. PLoS One. 2014; 9(8):e104039. PMID: 25090652; PMCID: PMC4121254.
  7. Nelson B, Zhou X, White M, Hartshorn K, Takahashi K, Kinane TB, Anandaiah A, Koziel H. Recombinant human mannose-binding lectin dampens human alveolar macrophage inflammatory responses to influenza A virus in vitro. J Leukoc Biol. 2014 May; 95(5):715-722. PMID: 24399838.
    View in: PubMed
  8. Anandaiah A, Sinha S, Bole M, Sharma SK, Kumar N, Luthra K, Li X, Zhou X, Nelson B, Han X, Tachado SD, Patel NR, Koziel H. Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals through an enhanced Toll-like receptor signaling pathway in vitro. Infect Immun. 2013 Jan; 81(1):2-10. PMID: 23071135; PMCID: PMC3536131.
  9. Patel NR, Bole M, Chen C, Hardin CC, Kho AT, Mih J, Deng L, Butler J, Tschumperlin D, Fredberg JJ, Krishnan R, Koziel H. Cell elasticity determines macrophage function. PLoS One. 2012; 7(9):e41024. PMID: 23028423; PMCID: PMC3445606.
  10. Han X, Tachado SD, Koziel H, Boisvert WA. Leu128(3.43) (l128) and Val247(6.40) (V247) of CXCR1 are critical amino acid residues for g protein coupling and receptor activation. PLoS One. 2012; 7(8):e42765. PMID: 22936990; PMCID: PMC3427349.
  11. Han X, Li X, Yue SC, Anandaiah A, Hashem F, Reinach PS, Koziel H, Tachado SD. Epigenetic regulation of tumor necrosis factor a (TNFa) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 signaling. J Biol Chem. 2012 Apr 20; 287(17):13778-86. PMID: 22393042; PMCID: PMC3340209.
  12. Zhou H, DeLoid G, Browning E, Gregory DJ, Tan F, Bedugnis AS, Imrich A, Koziel H, Kramnik I, Lu Q, Kobzik L. Genome-wide RNAi screen in IFN-?-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis. PLoS One. 2012; 7(2):e31752. PMID: 22359626; PMCID: PMC3281001.
  13. Li X, Han X, Llano J, Bole M, Zhou X, Swan K, Anandaiah A, Nelson B, Patel NR, Reinach PS, Koziel H, Tachado SD. Mammalian target of rapamycin inhibition in macrophages of asymptomatic HIV+ persons reverses the decrease in TLR-4-mediated TNF-a release through prolongation of MAPK pathway activation. J Immunol. 2011 Dec 01; 187(11):6052-8. PMID: 22025552; PMCID: PMC3221743.
  14. Anandaiah A, Dheda K, Keane J, Koziel H, Moore DA, Patel NR. Novel developments in the epidemic of human immunodeficiency virus and tuberculosis coinfection. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):987-97. PMID: 21177884; PMCID: PMC3086746.
  15. Chang WC, Hartshorn KL, White MR, Moyo P, Michelow IC, Koziel H, Kinane BT, Schmidt EV, Fujita T, Takahashi K. Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin. Biochem Pharmacol. 2011 Feb 01; 81(3):388-95. PMID: 21035429; PMCID: PMC3053085.
  16. Tachado SD, Li X, Bole M, Swan K, Anandaiah A, Patel NR, Koziel H. MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons. Blood. 2010 Apr 29; 115(17):3606-15. PMID: 20197549; PMCID: PMC2867269.
  17. Patel NR, Swan K, Li X, Tachado SD, Koziel H. Impaired M. tuberculosis-mediated apoptosis in alveolar macrophages from HIV+ persons: potential role of IL-10 and BCL-3. J Leukoc Biol. 2009 Jul; 86(1):53-60. PMID: 19383626; PMCID: PMC2704623.
  18. Lu TS, Avraham HK, Seng S, Tachado SD, Koziel H, Makriyannis A, Avraham S. Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. J Immunol. 2008 Nov 01; 181(9):6406-16. PMID: 18941231; PMCID: PMC3735224.
  19. Pan Z, Yang H, Mergler S, Liu H, Tachado SD, Zhang F, Kao WW, Koziel H, Pleyer U, Reinach PS. Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells. Cell Calcium. 2008 Oct; 44(4):374-85. PMID: 18355916; PMCID: PMC2588056.
  20. Tachado SD, Li X, Swan K, Patel N, Koziel H. Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-alpha release in alveolar macrophages from asymptomatic HIV-positive persons in vitro. J Biol Chem. 2008 Nov 28; 283(48):33191-8. PMID: 18826950; PMCID: PMC2586243.
  21. Koziel H. Rho GTPases in alveolar macrophage phagocytosis. Methods Enzymol. 2008; 439:303-13. PMID: 18374173.
    View in: PubMed
  22. Zhang F, Yang H, Wang Z, Mergler S, Liu H, Kawakita T, Tachado SD, Pan Z, Capó-Aponte JE, Pleyer U, Koziel H, Kao WW, Reinach PS. Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling. J Cell Physiol. 2007 Dec; 213(3):730-9. PMID: 17508360.
    View in: PubMed
  23. Patel NR, Zhu J, Tachado SD, Zhang J, Wan Z, Saukkonen J, Koziel H. HIV impairs TNF-alpha mediated macrophage apoptotic response to Mycobacterium tuberculosis. J Immunol. 2007 Nov 15; 179(10):6973-80. PMID: 17982088.
    View in: PubMed
  24. Wang Z, Yang H, Tachado SD, Capó-Aponte JE, Bildin VN, Koziel H, Reinach PS. Phosphatase-mediated crosstalk control of ERK and p38 MAPK signaling in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5267-75. PMID: 17122112.
    View in: PubMed
  25. Du JW, Zhang F, Capó-Aponte JE, Tachado SD, Zhang J, Yu FS, Sack RA, Koziel H, Reinach PS. AsialoGM1-mediated IL-8 release by human corneal epithelial cells requires coexpression of TLR5. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):4810-8. PMID: 17065492.
    View in: PubMed
  26. Tachado SD, Zhang J, Zhu J, Patel N, Cushion M, Koziel H. Pneumocystis-mediated IL-8 release by macrophages requires coexpression of mannose receptors and TLR2. J Leukoc Biol. 2007 Jan; 81(1):205-11. PMID: 17020928.
    View in: PubMed
  27. Arredouani MS, Palecanda A, Koziel H, Huang YC, Imrich A, Sulahian TH, Ning YY, Yang Z, Pikkarainen T, Sankala M, Vargas SO, Takeya M, Tryggvason K, Kobzik L. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol. 2005 Nov 01; 175(9):6058-64. PMID: 16237101.
    View in: PubMed
  28. Tachado SD, Zhang J, Zhu J, Patel N, Koziel H. HIV impairs TNF-alpha release in response to Toll-like receptor 4 stimulation in human macrophages in vitro. Am J Respir Cell Mol Biol. 2005 Dec; 33(6):610-21. PMID: 16109884.
    View in: PubMed
  29. Zhang J, Tachado SD, Patel N, Zhu J, Imrich A, Manfruelli P, Cushion M, Kinane TB, Koziel H. Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro. J Leukoc Biol. 2005 Sep; 78(3):665-74. PMID: 16000387.
    View in: PubMed
  30. Patel NR, Lee PS, Kim JH, Weinhouse GL, Koziel H. The influence of diagnostic bronchoscopy on clinical outcomes comparing adult autologous and allogeneic bone marrow transplant patients. Chest. 2005 Apr; 127(4):1388-96. PMID: 15821221.
    View in: PubMed
  31. Zhang J, Zhu J, Bu X, Cushion M, Kinane TB, Avraham H, Koziel H. Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. Mol Biol Cell. 2005 Feb; 16(2):824-34. PMID: 15574879; PMCID: PMC545914.
  32. Zhang J, Zhu J, Imrich A, Cushion M, Kinane TB, Koziel H. Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors. Infect Immun. 2004 Jun; 72(6):3147-60. PMID: 15155616; PMCID: PMC415687.
  33. Patel N, Koziel H. Pneumocystis jiroveci pneumonia in adult patients with AIDS: treatment strategies and emerging challenges to antimicrobial therapy. Treat Respir Med. 2004; 3(6):381-97. PMID: 15658884.
    View in: PubMed
  34. Zhang J, Geula C, Lu C, Koziel H, Hatcher LM, Roisen FJ. Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro. Exp Neurol. 2003 Oct; 183(2):469-81. PMID: 14552887.
    View in: PubMed
  35. Mansharamani NG, Koziel H. Chronic lung sepsis: lung abscess, bronchiectasis, and empyema. Curr Opin Pulm Med. 2003 May; 9(3):181-5. PMID: 12682562.
    View in: PubMed
  36. Mansharamani N, Balachandran D, Delaney D, Zibrak JD, Silvestri RC, Koziel H. Lung abscess in adults: clinical comparison of immunocompromised to non-immunocompromised patients. Respir Med. 2002 Mar; 96(3):178-85. PMID: 11905552.
    View in: PubMed
  37. Rämet M, Pearson A, Manfruelli P, Li X, Koziel H, Göbel V, Chung E, Krieger M, Ezekowitz RA. Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria. Immunity. 2001 Dec; 15(6):1027-38. PMID: 11754822.
    View in: PubMed
  38. Koziel H, Li X, Armstrong MY, Richards FF, Rose RM. Alveolar macrophages from human immunodeficiency virus-infected persons demonstrate impaired oxidative burst response to Pneumocystis carinii in vitro. Am J Respir Cell Mol Biol. 2000 Oct; 23(4):452-9. PMID: 11017909.
    View in: PubMed
  39. Mansharamani NG, Balachandran D, Vernovsky I, Garland R, Koziel H. Peripheral blood CD4 + T-lymphocyte counts during Pneumocystis carinii pneumonia in immunocompromised patients without HIV infection. Chest. 2000 Sep; 118(3):712-20. PMID: 10988193.
    View in: PubMed
  40. Fraser IP, Takahashi K, Koziel H, Fardin B, Harmsen A, Ezekowitz RA. Pneumocystis carinii enhances soluble mannose receptor production by macrophages. Microbes Infect. 2000 Sep; 2(11):1305-10. PMID: 11018446.
    View in: PubMed
  41. Mansharamani NG, Garland R, Delaney D, Koziel H. Management and outcome patterns for adult Pneumocystis carinii pneumonia, 1985 to 1995: comparison of HIV-associated cases to other immunocompromised states. Chest. 2000 Sep; 118(3):704-11. PMID: 10988192.
    View in: PubMed
  42. Mansharamani NG, Koziel H, Garland R, LoCicero J, Critchlow J, Ernst A. Safety of bedside percutaneous dilatational tracheostomy in obese patients in the ICU. Chest. 2000 May; 117(5):1426-9. PMID: 10807832.
    View in: PubMed
  43. Mathys JM, Melanson SM, Schiffer-Alberts DJ, Ioannidis JP, Koziel H, Skolnik PR. NF-kappa B modulates TNF-alpha production by alveolar macrophages in asymptomatic HIV-seropositive individuals. J Immunol. 2000 Feb 01; 164(3):1588-94. PMID: 10640779.
    View in: PubMed
  44. Koziel H, Kim S, Reardon C, Li X, Garland R, Pinkston P, Kornfeld H. Enhanced in vivo human immunodeficiency virus-1 replication in the lungs of human immunodeficiency virus-infected persons with Pneumocystis carinii pneumonia. Am J Respir Crit Care Med. 1999 Dec; 160(6):2048-55. PMID: 10588627.
    View in: PubMed
  45. Imrich A, Ning YY, Koziel H, Coull B, Kobzik L. Lipopolysaccharide priming amplifies lung macrophage tumor necrosis factor production in response to air particles. Toxicol Appl Pharmacol. 1999 Sep 01; 159(2):117-24. PMID: 10495775.
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  46. Palecanda A, Paulauskis J, Al-Mutairi E, Imrich A, Qin G, Suzuki H, Kodama T, Tryggvason K, Koziel H, Kobzik L. Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. J Exp Med. 1999 May 03; 189(9):1497-506. PMID: 10224290; PMCID: PMC2193067.
  47. Park IW, Koziel H, Hatch W, Li X, Du B, Groopman JE. CD4 receptor-dependent entry of human immunodeficiency virus type-1 env-pseudotypes into CCR5-, CCR3-, and CXCR4-expressing human alveolar macrophages is preferentially mediated by the CCR5 coreceptor. Am J Respir Cell Mol Biol. 1999 May; 20(5):864-71. PMID: 10226056.
    View in: PubMed
  48. Koziel H, Eichbaum Q, Kruskal BA, Pinkston P, Rogers RA, Armstrong MY, Richards FF, Rose RM, Ezekowitz RA. Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation. J Clin Invest. 1998 Oct 01; 102(7):1332-44. PMID: 9769325; PMCID: PMC508980.
  49. Fraser IP, Koziel H, Ezekowitz RA. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity. Semin Immunol. 1998 Oct; 10(5):363-72. PMID: 9799711.
    View in: PubMed
  50. Koziel H, Phelps DS, Fishman JA, Armstrong MY, Richards FF, Rose RM. Surfactant protein-A reduces binding and phagocytosis of pneumocystis carinii by human alveolar macrophages in vitro. Am J Respir Cell Mol Biol. 1998 Jun; 18(6):834-43. PMID: 9618388.
    View in: PubMed
  51. Pareja JG, Garland R, Koziel H. Use of adjunctive corticosteroids in severe adult non-HIV Pneumocystis carinii pneumonia. Chest. 1998 May; 113(5):1215-24. PMID: 9596297.
    View in: PubMed
  52. Pareja J, Gupta K, Koziel H. The toxic shock syndrome and Staphylococcus lugdunensis bacteremia. Ann Intern Med. 1998 Apr 01; 128(7):603-4. PMID: 9518418.
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  53. Ernst A, Gordon FD, Hayek J, Silvestri RC, Koziel H. Lung abcess complicating Legionella micdadei pneumonia in an adult liver transplant recipient: case report and review. Transplantation. 1998 Jan 15; 65(1):130-4. PMID: 9448158.
    View in: PubMed
  54. Furlong ST, Koziel H, Bartlett MS, McLaughlin GL, Shaw MM, Jack RM. Lipid transfer from human epithelial cells to Pneumocystis carinii in vitro. J Infect Dis. 1997 Mar; 175(3):661-8. PMID: 9041339.
    View in: PubMed
  55. Reardon CC, Kim SJ, Wagner RP, Koziel H, Kornfeld H. Phagocytosis and growth inhibition of Cryptococcus neoformans by human alveolar macrophages: effects of HIV-1 infection. AIDS. 1996 Jun; 10(6):613-8. PMID: 8780815.
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  56. Saukkonen K, Garland R, Koziel H. Aerosolized pentamidine as alternative primary prophylaxis against Pneumocystis carinii pneumonia in adult hepatic and renal transplant recipients. Chest. 1996 May; 109(5):1250-5. PMID: 8625676.
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  57. Koziel H, Koziel MJ. Pulmonary complications of diabetes mellitus. Pneumonia. Infect Dis Clin North Am. 1995 Mar; 9(1):65-96. PMID: 7769221.
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  58. Koziel H, Haley K, Nasser I, Filderman AE. Pulmonary hemorrhage. An uncommon cause of pulmonary infiltrates in patients with AIDS. Chest. 1994 Dec; 106(6):1891-4. PMID: 7988220.
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  59. Rose RM, Catalano PJ, Koziel H, Furlong ST. Abnormal lipid composition of bronchoalveolar lavage fluid obtained from individuals with AIDS-related lung disease. Am J Respir Crit Care Med. 1994 Feb; 149(2 Pt 1):332-8. PMID: 8306026.
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  60. Kandil O, Fishman JA, Koziel H, Pinkston P, Rose RM, Remold HG. Human immunodeficiency virus type 1 infection of human macrophages modulates the cytokine response to Pneumocystis carinii. Infect Immun. 1994 Feb; 62(2):644-50. PMID: 8300221; PMCID: PMC186152.
  61. Koziel H, O'Riordan D, Warner A, Rose RM. Alveolar macrophage interaction with Pneumocystis carinii. Immunol Ser. 1994; 60:417-36. PMID: 8251584.
    View in: PubMed
  62. Koziel H, Kruskal BA, Ezekowitz RA, Rose RM. HIV impairs alveolar macrophage mannose receptor function against Pneumocystis carinii. Chest. 1993 Feb; 103(2 Suppl):111S-112S. PMID: 8428526.
    View in: PubMed
  63. Armstrong MY, Koziel H, Rose RM, Arena C, Richards FF. Indicators of Pneumocystis carinii viability in short-term cell culture. J Protozool. 1991 Nov-Dec; 38(6):88S-90S. PMID: 1840149.
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  64. Koziel H, Williams DJ, Armstrong MY, Richards FF, Fishman JA, Ezekowitz RA, Warner A, Fuglestad J, Rose RM. New rapid method for the study of Pneumocystis carinii interaction with alveolar macrophages. J Protozool. 1991 Nov-Dec; 38(6):173S-174S. PMID: 1818154.
    View in: PubMed
  65. Ezekowitz RA, Williams DJ, Koziel H, Armstrong MY, Warner A, Richards FF, Rose RM. Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor. Nature. 1991 May 09; 351(6322):155-8. PMID: 1903183.
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  66. Koziel H. Effect of selective attention on somatosensory evoked potentials in healthy people. Acta Physiol Pol. 1985 Mar-Apr; 36(2):117-25. PMID: 3837590.
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  67. Zakrzewska F, Koziel H. [Effect of polysynaptic flexion reflex on monosynaptic reflexes of calf muscles prior to and following intramuscular injection of ethylbenzatropine in drug-induced muscle rigidity]. Neurol Neurochir Pol. 1977 Sep-Oct; 11(5):529-37. PMID: 201879.
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  68. Koziel H, Kuran W, Zakrzewska F. [Somatosensory evoked potentials in patients with parkinsonism during L-dopa decarboxylase inhibitor treatment]. Neurol Neurochir Pol. 1977 Jan-Feb; 11(1):73-80. PMID: 840365.
    View in: PubMed
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