Harvard Catalyst Profiles

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David Borsook, Ph.D., M.B.,B.Ch.


The Lateralization of Trigeminal Pain Processing in the Brain
Summer, 06/15/09 - 07/31/09

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS105844 (FREEMAN, ROY) May 15, 2019 - Mar 31, 2024
    The functional neuroanatomy of the human physiological stress response
    Role: Co-Principal Investigator
  2. R01GM122405 (BORSOOK, DAVID) Sep 1, 2017 - Jul 31, 2021
    Perioperative Measures of Nociception using NIRS
    Role: Principal Investigator
  3. R01NS095655 (BORSOOK, DAVID) Sep 15, 2015 - Jun 30, 2021
    Post-Traumatic Headache (PTH) in Children: Alterations of Brain Function, Blood Flow and Inflammatory Processes
    Role: Principal Investigator
  4. R01HD083133 (BORSOOK, DAVID) Jul 1, 2015 - Nov 30, 2021
    Central and Peripheral Measures of Pain: Recovery and Resistance
    Role: Principal Investigator
  5. R01GM104986 (BOAS, DAVID A) Feb 1, 2013 - Jun 30, 2017
    Objective Pain Measures in Awake Sedated, Anesthetized Individuals with NIRS
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Szabo E, Green S, Karunakaran KD, Sieberg CB, Elman I, Burstein R, Borsook D. Migraine: interactions between brain's trait and state. CNS Spectr. 2021 Jun 21; 1-9. PMID: 34308820.
    Citations:    Fields:    
  2. Maallo AMS, Moulton EA, Sieberg CB, Giddon DB, Borsook D, Holmes SA. A lateralized model of the pain-depression dyad. Neurosci Biobehav Rev. 2021 08; 127:876-883. PMID: 34090918.
    Citations:    Fields:    Translation:Humans
  3. Dieckmann G, Borsook D, Moulton E. Neuropathic corneal pain and dry eye: a continuum of nociception. Br J Ophthalmol. 2021 Apr 30. PMID: 33931393.
    Citations:    Fields:    
  4. Sieberg CB, Lebel A, Silliman E, Holmes S, Borsook D, Elman I. Left to themselves: Time to target chronic pain in childhood rare diseases. Neurosci Biobehav Rev. 2021 07; 126:276-288. PMID: 33774086.
    Citations:    Fields:    Translation:Humans
  5. Youssef AM, Peng K, Kim PK, Lebel A, Sethna NF, Kronman C, Zurakowski D, Borsook D, Simons LE. Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens. Neurobiol Pain. 2021 Jan-Jul; 9:100062. PMID: 33732954.
  6. Martinelli D, Castellazzi G, De Icco R, Bacila A, Allena M, Faggioli A, Sances G, Pichiecchio A, Borsook D, Gandini Wheeler-Kingshott CAM, Tassorelli C. Thalamocortical Connectivity in Experimentally-Induced Migraine Attacks: A Pilot Study. Brain Sci. 2021 Jan 27; 11(2). PMID: 33514029.
  7. Lemme J, Holmes S, Sibai D, Mari J, Simons LE, Burstein R, Zurakowski D, Lebel A, O'Brien M, Upadhyay J, Borsook D. Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth. J Neurotrauma. 2021 Jun 15; 38(12):1632-1641. PMID: 33183144.
    Citations:    Fields:    
  8. Maleki N, Szabo E, Becerra L, Moulton E, Scrivani SJ, Burstein R, Borsook D. Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia. PLoS One. 2021; 16(1):e0244320. PMID: 33395413.
    Citations: 2     Fields:    Translation:Humans
  9. Elman I, Upadhyay J, Lowen S, Karunakaran K, Albanese M, Borsook D. Mechanisms Underlying Unconscious Processing and Their Alterations in Post-traumatic Stress Disorder: Neuroimaging of Zero Monetary Outcomes Contextually Framed as "No Losses" vs. "No Gains". Front Neurosci. 2020; 14:604867. PMID: 33390889.
  10. Holmes SA, Kim A, Borsook D. The brain and behavioral correlates of motor-related analgesia (MRA). Neurobiol Dis. 2021 01; 148:105158. PMID: 33157210.
    Citations:    Fields:    
  11. Karunakaran KD, Peng K, Berry D, Green S, Labadie R, Kussman B, Borsook D. NIRS measures in pain and analgesia: Fundamentals, features, and function. Neurosci Biobehav Rev. 2021 01; 120:335-353. PMID: 33159918.
    Citations:    Fields:    Translation:Humans
  12. Lunde CE, Szabo E, Holmes SA, Borsook D, Sieberg CB. Commentary: Novel Use of Offset Analgesia to Assess Adolescents and Adults with Treatment Resistant Endometriosis-Associated Pain. J Pain Res. 2020; 13:2775-2782. PMID: 33204144.
  13. Forstenpointner J, Berry D, Baron R, Borsook D. The cornucopia of central disinhibition pain - An evaluation of past and novel concepts. Neurobiol Dis. 2020 11; 145:105041. PMID: 32800994.
    Citations:    Fields:    
  14. Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, Crean C, Edwards R, Gaudilliere B, Hergenroeder GW, Iadarola MJ, Iyengar S, Jiang Y, Kong JT, Mackey S, Saab CY, Sang CN, Scholz J, Segerdahl M, Tracey I, Veasley C, Wang J, Wager TD, Wasan AD, Pelleymounter MA. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. Nat Rev Neurol. 2020 Jul; 16(7):381-400. PMID: 32541893.
    Citations: 17     Fields:    
  15. Todd N, McDannold N, Borsook D. Targeted manipulation of pain neural networks: The potential of focused ultrasound for treatment of chronic pain. Neurosci Biobehav Rev. 2020 08; 115:238-250. PMID: 32534900.
    Citations: 1     Fields:    Translation:Humans
  16. Todd N, Angolano C, Ferran C, Devor A, Borsook D, McDannold N. Secondary effects on brain physiology caused by focused ultrasound-mediated disruption of the blood-brain barrier. J Control Release. 2020 08 10; 324:450-459. PMID: 32470359.
    Citations: 4     Fields:    Translation:Animals
  17. Elman I, Howard M, Borodovsky JT, Mysels D, Rott D, Borsook D, Albanese M. Author Correction: Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone. Sci Rep. 2020 May 01; 10(1):7680. PMID: 32355247.
    Citations:    Fields:    
  18. Elman I, Howard M, Borodovsky JT, Mysels D, Rott D, Borsook D, Albanese M. Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone. Sci Rep. 2020 03 27; 10(1):5617. PMID: 32221389.
    Citations: 1     Fields:    
  19. Azqueta-Gavaldon M, Youssef AM, Storz C, Lemme J, Schulte-Göcking H, Becerra L, Azad SC, Reiners A, Ertl-Wagner B, Borsook D, Upadhyay J, Kraft E. Implications of the putamen in pain and motor deficits in complex regional pain syndrome. Pain. 2020 03; 161(3):595-608. PMID: 31693538.
    Citations: 3     Fields:    Translation:Humans
  20. Heathcote LC, Timmers I, Kronman CA, Mahmud F, Hernandez JM, Bentley J, Youssef AM, Pine DS, Borsook D, Simons LE. Brain signatures of threat-safety discrimination in adolescent chronic pain. Pain. 2020 03; 161(3):630-640. PMID: 31764389.
    Citations: 4     Fields:    Translation:Humans
  21. Borsook D, Upadhyay J, Hargreaves R, Wager T. Enhancing Choice and Outcomes for Therapeutic Trials in Chronic Pain: N-of-1 + Imaging (+ i). Trends Pharmacol Sci. 2020 02; 41(2):85-98. PMID: 31928747.
    Citations:    Fields:    Translation:Humans
  22. McEvoy H, Borsook D, Holmes SA. Clinical features and sex differences in pediatric post-traumatic headache: A retrospective chart review at a Boston area concussion clinic. Cephalalgia. 2020 06; 40(7):701-711. PMID: 31865762.
    Citations: 1     Fields:    Translation:Humans
  23. Sieberg CB, Lunde CE, Borsook D. Endometriosis and pain in the adolescent- striking early to limit suffering: A narrative review. Neurosci Biobehav Rev. 2020 01; 108:866-876. PMID: 31862211.
    Citations: 3     Fields:    Translation:HumansAnimals
  24. Holmes SA, Barakat N, Bhasin M, Lopez NI, Lebel A, Zurakowski D, Thomas B, Bhasin S, Silva KE, Borra R, Burstein R, Simons LE, Borsook D. Biological and behavioral markers of pain following nerve injury in humans. Neurobiol Pain. 2020 Jan-Jul; 7:100038. PMID: 31890990.
    Citations: 1     
  25. Panorgias A, Lee D, Silva KE, Borsook D, Moulton EA. Blue light activates pulvinar nuclei in longstanding idiopathic photophobia: A case report. Neuroimage Clin. 2019; 24:102096. PMID: 31795037.
    Citations: 1     Fields:    Translation:HumansCells
  26. Moulton EA, Borsook D. C-Fiber Assays in the Cornea vs. Skin. Brain Sci. 2019 Nov 12; 9(11). PMID: 31718074.
    Citations: 1     
  27. Hodkinson DJ, Lee D, Becerra L, Borsook D. Scale-free amplitude modulation of low-frequency fluctuations in episodic migraine. Pain. 2019 10; 160(10):2298-2304. PMID: 31162336.
    Citations:    Fields:    Translation:Humans
  28. Bishop J, Becerra L, Barmettler G, Chang PC, Kainz V, Burstein R, Borsook D. Modulation of brain networks by sumatriptan-naproxen in the inflammatory soup migraine model. Pain. 2019 09; 160(9):2161-2171. PMID: 31033778.
    Citations: 1     Fields:    Translation:Animals
  29. Holmes SA, Upadhyay J, Borsook D. Delineating conditions and subtypes in chronic pain using neuroimaging. Pain Rep. 2019 Jul-Aug; 4(4):e768. PMID: 31579859.
  30. Youssef AM, Azqueta-Gavaldon M, Silva KE, Barakat N, Lopez N, Mahmud F, Lebel A, Sethna NF, Zurakowski D, Simons LE, Kraft E, Borsook D. Shifting brain circuits in pain chronicity. Hum Brain Mapp. 2019 10 15; 40(15):4381-4396. PMID: 31298464.
    Citations: 2     Fields:    Translation:Humans
  31. Todd N, Zhang Y, Livingstone M, Borsook D, McDannold N. The neurovascular response is attenuated by focused ultrasound-mediated disruption of the blood-brain barrier. Neuroimage. 2019 11 01; 201:116010. PMID: 31302253.
    Citations: 3     Fields:    Translation:Animals
  32. Mayer EA, Labus J, Aziz Q, Tracey I, Kilpatrick L, Elsenbruch S, Schweinhardt P, Van Oudenhove L, Borsook D. Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report. Gut. 2019 09; 68(9):1701-1715. PMID: 31175206.
    Citations: 10     Fields:    Translation:Humans
  33. Elman I, Borsook D. The failing cascade: Comorbid post traumatic stress- and opioid use disorders. Neurosci Biobehav Rev. 2019 08; 103:374-383. PMID: 31063739.
    Citations: 5     Fields:    Translation:Humans
  34. Colon E, Ludwick A, Wilcox SL, Youssef AM, Danehy A, Fair DA, Lebel AA, Burstein R, Becerra L, Borsook D. Migraine in the Young Brain: Adolescents vs. Young Adults. Front Hum Neurosci. 2019; 13:87. PMID: 30967767.
    Citations: 4     
  35. Peng K, Cheung K, Lee A, Sieberg C, Borsook D, Upadhyay J. Longitudinal Evaluation of Pain, Flare-Up, and Emotional Health in Fibrodysplasia Ossificans Progressiva: Analyses of the International FOP Registry. JBMR Plus. 2019 Aug; 3(8):e10181. PMID: 31485551.
    Citations: 3     
  36. Bernstein CA, Nir RR, Noseda R, Fulton AB, Huntington S, Lee AJ, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. The migraine eye: distinct rod-driven retinal pathways' response to dim light challenges the visual cortex hyperexcitability theory. Pain. 2019 Mar; 160(3):569-578. PMID: 30376534.
    Citations: 6     Fields:    Translation:Humans
  37. Demartini C, Greco R, Zanaboni AM, Sances G, De Icco R, Borsook D, Tassorelli C. Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Prog Neurobiol. 2019 06; 177:15-32. PMID: 30771365.
    Citations: 13     Fields:    Translation:HumansAnimals
  38. Todd N, Zhang Y, Power C, Becerra L, Borsook D, Livingstone M, McDannold N. Modulation of brain function by targeted delivery of GABA through the disrupted blood-brain barrier. Neuroimage. 2019 04 01; 189:267-275. PMID: 30659957.
    Citations: 8     Fields:    Translation:Animals
  39. Hansen MS, Becerra L, Dahl JB, Borsook D, Mårtensson J, Christensen A, Nybing JD, Havsteen I, Boesen M, Asghar MS. Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men. Brain Struct Funct. 2019 Apr; 224(3):1119-1139. PMID: 30631932.
    Citations:    Fields:    Translation:Humans
  40. Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Schumacher M, Conley YP, Hammer M, Cheung S, Borsook D, Levine JD. Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients. Clin J Pain. 2019 01; 35(1):37-42. PMID: 30247200.
    Citations:    Fields:    Translation:HumansCells
  41. Borsook D, Youssef AM, Simons L, Elman I, Eccleston C. When pain gets stuck: the evolution of pain chronification and treatment resistance. Pain. 2018 Dec; 159(12):2421-2436. PMID: 30234696.
    Citations: 31     Fields:    Translation:HumansAnimals
  42. Elman I, Upadhyay J, Langleben DD, Albanese M, Becerra L, Borsook D. Reward and aversion processing in patients with post-traumatic stress disorder: functional neuroimaging with visual and thermal stimuli. Transl Psychiatry. 2018 11 02; 8(1):240. PMID: 30389908.
    Citations: 5     Fields:    Translation:Humans
  43. Vanderhoof TS, Gurvits TV, Baker-Nolan JE, Borsook D, Elman I. Visuospatial and Sensory Integration Tasks in Patients With Schizophrenia or Schizoaffective Disorder: Relationship to Body Mass Index and Smoking. Front Psychiatry. 2018; 9:473. PMID: 30386258.
  44. Peng K, Yücel MA, Steele SC, Bittner EA, Aasted CM, Hoeft MA, Lee A, George EE, Boas DA, Becerra L, Borsook D. Morphine Attenuates fNIRS Signal Associated With Painful Stimuli in the Medial Frontopolar Cortex (medial BA 10). Front Hum Neurosci. 2018; 12:394. PMID: 30349466.
    Citations: 4     
  45. Nir RR, Lee AJ, Huntington S, Noseda R, Bernstein CA, Fulton AB, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls. Pain. 2018 Oct; 159(10):2030-2034. PMID: 29905657.
    Citations: 3     Fields:    Translation:Humans
  46. Hubbard CS, Becerra L, Heinz N, Ludwick A, Rasooly T, Yendiki A, Wu R, Schechter NL, Nurko S, Borsook D. Microstructural White Matter Abnormalities in the Dorsal Cingulum of Adolescents with IBS. eNeuro. 2018 Jul-Aug; 5(4). PMID: 30109260.
    Citations: 2     Fields:    Translation:Humans
  47. Todd N, Zhang Y, Arcaro M, Becerra L, Borsook D, Livingstone M, McDannold N. Focused ultrasound induced opening of the blood-brain barrier disrupts inter-hemispheric resting state functional connectivity in the rat brain. Neuroimage. 2018 09; 178:414-422. PMID: 29852281.
    Citations: 7     Fields:    Translation:Animals
  48. Solstrand Dahlberg L, Becerra L, Borsook D, Linnman C. Brain changes after spinal cord injury, a quantitative meta-analysis and review. Neurosci Biobehav Rev. 2018 07; 90:272-293. PMID: 29702136.
    Citations: 9     Fields:    Translation:Humans
  49. Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Activation of pial and dural macrophages and dendritic cells by cortical spreading depression. Ann Neurol. 2018 03; 83(3):508-521. PMID: 29394508.
    Citations: 14     Fields:    Translation:AnimalsCells
  50. Basch MC, Chow ET, Logan DE, Borsook D, Schechter NL, Simons LE. Cumulative effects of multiple pain sites in youth with chronic pain. Eur J Pain. 2018 07; 22(6):1134-1141. PMID: 29436161.
    Citations: 2     Fields:    Translation:Humans
  51. Borsook D, Youssef AM, Barakat N, Sieberg CB, Elman I. Subliminal (latent) processing of pain and its evolution to conscious awareness. Neurosci Biobehav Rev. 2018 05; 88:1-15. PMID: 29476771.
    Citations: 2     Fields:    Translation:HumansAnimals
  52. Elman I, Borsook D. Threat Response System: Parallel Brain Processes in Pain vis-à-vis Fear and Anxiety. Front Psychiatry. 2018; 9:29. PMID: 29515465.
    Citations: 11     
  53. Solstrand Dahlberg L, Linnman CN, Lee D, Burstein R, Becerra L, Borsook D. Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine. Front Neurol. 2018; 9:61. PMID: 29487563.
    Citations: 8     
  54. Bajic D, Craig MM, Mongerson CRL, Borsook D, Becerra L. Identifying Rodent Resting-State Brain Networks with Independent Component Analysis. Front Neurosci. 2017; 11:685. PMID: 29311770.
    Citations: 12     
  55. Simons LE, Sieberg CB, Conroy C, Randall ET, Shulman J, Borsook D, Berde C, Sethna NF, Logan DE. Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment. J Pain. 2018 02; 19(2):207-218. PMID: 29102693.
    Citations: 12     Fields: