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Luminita Pojoga, Ph.D.

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Biography
1998 - 2000
Greenville Hospital System Biomedical Research Graduate Fellowship Award
2000
R.C. Edwards Research Fellowship Award
2004 - 2006
Ruth L. Kirschstein National Service Award
2007
Aldosterone Conference - Young Investigator Award Finalist
2007
Endocrine Fellows Day Award
2007 - 2010
Scientist Development Grant
2008 - 2010
KL2 MeRIT Award
2010
New Investigator Award
2013
Nomination, Early Career Mentoring Award, Department of Medicine
2013
Research Obesity and Sex Differences Workshop – Research Award
2013
Young Investigators Award Review Panel
2013 - -
Vascular BioBP BSc2 review panel
2014
Fellow of the American Heart Association
2014
Mentored Transition to Independence review panel

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL104032 (POJOGA, LUMINITA) Sep 1, 2010 - May 31, 2015
    NIH/NHLBI
    Caveolin-1 and vascular dysfunction
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Huang Y, Ting PY, Yao TM, Homma T, Brooks D, Katayama Rangel IA, Adler GK, Romero JR, Williams JS, Pojoga LH, Williams GH. Histone demethylase LSD1 and biological sex: impact on blood pressure and aldosterone production. J Endocrinol. 2018 Nov 01. PMID: 30400034.
    View in: PubMed
  2. Shukri MZ, Tan JW, Manosroi W, Pojoga LH, Rivera A, Williams JS, Seely EW, Adler GK, Jaffe IZ, Karas RH, Williams GH, Romero JR. Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II. Hypertension. 2018 Jun; 71(6):1083-1090. PMID: 29686001.
    View in: PubMed
  3. Mayurasakorn K, Hasanah N, Homma T, Homma M, Rangel IK, Garza AE, Romero JR, Adler GK, Williams GH, Pojoga LH. Caloric restriction improves glucose homeostasis, yet increases cardiometabolic risk in caveolin-1-deficient mice. Metabolism. 2018 Jun; 83:92-101. PMID: 29410348.
    View in: PubMed
  4. Manosroi W, Tan JW, Rariy CM, Sun B, Goodarzi MO, Saxena AR, Williams JS, Pojoga LH, Lasky-Su J, Cui J, Guo X, Taylor KD, Chen YI, Xiang AH, Hsueh WA, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Seely EW. The Association of Estrogen Receptor-ß Gene Variation With Salt-Sensitive Blood Pressure. J Clin Endocrinol Metab. 2017 11 01; 102(11):4124-4135. PMID: 28938457.
    View in: PubMed
  5. Homma T, Homma M, Huang Y, Mayurasakorn K, Rodi NM, Hamid AAA, Hurwitz S, Yao T, Adler GK, Pojoga LH, Williams GH, Romero JR. Combined Salt and Caloric Restrictions: Potential Adverse Outcomes. J Am Heart Assoc. 2017 Oct 11; 6(10). PMID: 29021272.
    View in: PubMed
  6. Chong C, Hamid A, Yao T, Garza AE, Pojoga LH, Adler GK, Romero JR, Williams GH. Regulation of aldosterone secretion by mineralocorticoid receptor-mediated signaling. J Endocrinol. 2017 03; 232(3):525-534. PMID: 28096435.
    View in: PubMed
  7. Baudrand R, Gupta N, Garza AE, Vaidya A, Leopold JA, Hopkins PN, Jeunemaitre X, Ferri C, Romero JR, Williams J, Loscalzo J, Adler GK, Williams GH, Pojoga LH. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016 09 28; 5(10). PMID: 27680666.
    View in: PubMed
  8. Baudrand R, Pojoga L, Vaidya A, Garza A, Vöhringer P, Jeunemaitre X, Hopkins P, Yao T, Williams J, Adler G, Williams G. Response to Letter Regarding Article, "Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects". Circulation. 2016 Apr 19; 133(16):e606. PMID: 27142613; PMCID: PMC4862598 [Available on 04/19/17].
  9. Baudrand R, Pojoga LH, Vaidya A, Garza AE, Vöhringer PA, Jeunemaitre X, Hopkins PN, Yao TM, Williams J, Adler GK, Williams GH. Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects. Circulation. 2015 Nov 10; 132(19):1825-33. PMID: 26432671; PMCID: PMC4641753 [Available on 11/10/16].
  10. Baudrand R, Goodarzi MO, Vaidya A, Underwood PC, Williams JS, Jeunemaitre X, Hopkins PN, Brown N, Raby BA, Lasky-Su J, Adler GK, Cui J, Guo X, Taylor KD, Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Pojoga LH. A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics. Metabolism. 2015 Dec; 64(12):1674-81. PMID: 26475177; PMCID: PMC4641791 [Available on 12/01/16].
  11. Pojoga LH, Yao TM, Opsasnick LA, Siddiqui WT, Reslan OM, Adler GK, Williams GH, Khalil RA. Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide-High Angiotensin II-Induced Cardiovascular Injury. J Pharmacol Exp Ther. 2015 Oct; 355(1):32-47. PMID: 26183312; PMCID: PMC4576669 [Available on 10/01/16].
  12. Garza AE, Pojoga LH, Moize B, Hafiz WM, Opsasnick LA, Siddiqui WT, Horenstein M, Adler GK, Williams GH, Khalil RA. Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake. Hypertension. 2015 Sep; 66(3):674-80. PMID: 26169051.
    View in: PubMed
  13. Garza AE, Rariy CM, Sun B, Williams J, Lasky-Su J, Baudrand R, Yao T, Moize B, Hafiz WM, Romero JR, Adler GK, Ferri C, Hopkins PN, Pojoga LH, Williams GH. Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans. Hypertension. 2015 Jan; 65(1):211-217. PMID: 25368024.
    View in: PubMed
  14. Coutinho P, Vega C, Pojoga LH, Rivera A, Prado GN, Yao TM, Adler G, Torres-Grajales M, Maldonado ER, Ramos-Rivera A, Williams JS, Williams G, Romero JR. Aldosterone's rapid, nongenomic effects are mediated by striatin: a modulator of aldosterone's effect on estrogen action. Endocrinology. 2014 Jun; 155(6):2233-43. PMID: 24654783; PMCID: PMC4020933.
  15. Baudrand R, Pojoga LH, Romero JR, Williams GH. Aldosterone's mechanism of action: roles of lysine-specific demethylase 1, caveolin and striatin. Curr Opin Nephrol Hypertens. 2014 Jan; 23(1):32-7. PMID: 24275769.
    View in: PubMed
  16. Pojoga LH, Yao TM, Opsasnick LA, Garza AE, Reslan OM, Adler GK, Williams GH, Khalil RA. Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther. 2014 Feb; 348(2):260-70. PMID: 24281385; PMCID: PMC3912545.
  17. Brown JM, Williams JS, Luther JM, Garg R, Garza AE, Pojoga LH, Ruan DT, Williams GH, Adler GK, Vaidya A. Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone. Hypertension. 2014 Feb; 63(2):273-80. PMID: 24191286; PMCID: PMC3898197.
  18. Pojoga LH, Baudrand R, Adler GK. Mineralocorticoid receptor throughout the vessel: a key to vascular dysfunction in obesity. Eur Heart J. 2013 Dec; 34(45):3475-7. PMID: 23666249; PMCID: PMC3844150.
  19. Krug AW, Tille E, Sun B, Pojoga L, Williams J, Chamarthi B, Lichtman AH, Hopkins PN, Adler GK, Williams GH. Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake. Age (Dordr). 2013 Oct; 35(5):1809-20. PMID: 23054827.
    View in: PubMed
  20. Chuengsamarn S, Garza AE, Krug AW, Romero JR, Adler GK, Williams GH, Pojoga LH. Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice. Metabolism. 2013 Feb; 62(2):275-81. PMID: 22954672; PMCID: PMC3518593.
  21. Williams JS, Chamarthi B, Goodarzi MO, Pojoga LH, Sun B, Garza AE, Raby BA, Adler GK, Hopkins PN, Brown NJ, Jeunemaitre X, Ferri C, Fang R, Leonor T, Cui J, Guo X, Taylor KD, Ida Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Shi Y. Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens. 2012 Jul; 25(7):812-7. PMID: 22534796; PMCID: PMC3721725.
  22. Pojoga LH, Coutinho P, Rivera A, Yao TM, Maldonado ER, Youte R, Adler GK, Williams J, Turchin A, Williams GH, Romero JR. Activation of the mineralocorticoid receptor increases striatin levels. Am J Hypertens. 2012 Feb; 25(2):243-9. PMID: 22089104.
    View in: PubMed
  23. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H1862-71. PMID: 21873498; PMCID: PMC3213961.
  24. Ricchiuti V, Lapointe N, Pojoga L, Yao T, Tran L, Williams GH, Adler GK. Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart. J Endocrinol. 2011 Oct; 211(1):47-54. PMID: 21746791.
    View in: PubMed
  25. Pojoga LH, Underwood PC, Goodarzi MO, Williams JS, Adler GK, Jeunemaitre X, Hopkins PN, Raby BA, Lasky-Su J, Sun B, Cui J, Guo X, Taylor KD, Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH. Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension. J Clin Endocrinol Metab. 2011 Aug; 96(8):E1288-92. PMID: 21613355; PMCID: PMC3146791.
  26. Sun B, Williams JS, Pojoga L, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Ferri C, Williams GH. Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses. J Renin Angiotensin Aldosterone Syst. 2011 Dec; 12(4):564-71. PMID: 21490026; PMCID: PMC3444254.
  27. Krug AW, Pojoga LH, Williams GH, Adler GK. Cell membrane-associated mineralocorticoid receptors? New evidence. Hypertension. 2011 Jun; 57(6):1019-25. PMID: 21482958.
    View in: PubMed
  28. Vaidya A, Forman JP, Underwood PC, Hopkins PN, Williams GH, Pojoga LH, Williams JS. The influence of body mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men. Eur J Endocrinol. 2011 Jun; 164(6):995-1002. PMID: 21402748; PMCID: PMC3104074.
  29. Vaidya A, Pojoga L, Underwood PC, Forman JP, Hopkins PN, Williams GH, Williams JS. The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertension. Clin Endocrinol (Oxf). 2011 Mar; 74(3):294-9. PMID: 21050256; PMCID: PMC3059847.
  30. Underwood PC, Sun B, Williams JS, Pojoga LH, Raby B, Lasky-Su J, Hunt S, Hopkins PN, Jeunemaitre X, Adler GK, Williams GH. The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach. Metabolism. 2011 Aug; 60(8):1150-7. PMID: 21306748; PMCID: PMC3115454.
  31. Underwood PC, Sun B, Williams JS, Pojoga LH, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Adler GK, Williams GH. The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study. J Clin Endocrinol Metab. 2010 Sep; 95(9):E75-9. PMID: 20631015; PMCID: PMC2936061.
  32. Pojoga LH, Adamová Z, Kumar A, Stennett AK, Romero JR, Adler GK, Williams GH, Khalil RA. Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1776-88. PMID: 20363891; PMCID: PMC2886646.
  33. Pojoga LH, Romero JR, Yao TM, Loutraris P, Ricchiuti V, Coutinho P, Guo C, Lapointe N, Stone JR, Adler GK, Williams GH. Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II. Endocrinology. 2010 Mar; 151(3):1236-46. PMID: 20097717; PMCID: PMC2840694.
  34. Pojoga LH, Yao TM, Sinha S, Ross RL, Lin JC, Raffetto JD, Adler GK, Williams GH, Khalil RA. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1258-65. PMID: 18178722; PMCID: PMC2268616.
  35. Pojoga L, Kolatkar NS, Williams JS, Perlstein TS, Jeunemaitre X, Brown NJ, Hopkins PN, Raby BA, Williams GH. Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension. 2006 Nov; 48(5):892-900. PMID: 17015767.
    View in: PubMed
  36. Guo C, Martinez-Vasquez D, Mendez GP, Toniolo MF, Yao TM, Oestreicher EM, Kikuchi T, Lapointe N, Pojoga L, Williams GH, Ricchiuti V, Adler GK. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology. 2006 Nov; 147(11):5363-73. PMID: 16901964.
    View in: PubMed
  37. Pojoga LH, Moose JE, Hilderman RH. Characterization of the interaction of P1,P4-diadenosine 5'-tetraphosphate with luciferase. Biochem Biophys Res Commun. 2004 Mar 12; 315(3):756-62. PMID: 14975766.
    View in: PubMed
  38. Pojoga LH, Haghiac ML, Moose JE, Hilderman RH. Determination of ATP impurity in adenine dinucleotides. Nucleosides Nucleotides Nucleic Acids. 2004; 23(3):581-98. PMID: 15113025.
    View in: PubMed
  39. Pojoga LH, Hilderman RH. A theoretical and experimental approach to the use of single wavelength calcium indicators. J Theor Biol. 2003 Apr 21; 221(4):543-57. PMID: 12713939.
    View in: PubMed
  40. Pojoga LH, Haghiac M, Hilderman RH. Inhibition by adenine dinucleotides of ATP-induced prostacyclin release by bovine aortic endothelial cells. Biochem Pharmacol. 2002 Aug 01; 64(3):405-12. PMID: 12147291.
    View in: PubMed
  41. Haghiac M, Pojoga LH, Hilderman RH. Studies on the effect of diadenlyated nucleotides on calcium mobilization and prostacyclin synthesis in bovine aortic endothelial cells. Cell Signal. 2001 Feb; 13(2):145-50. PMID: 11257460.
    View in: PubMed
  42. Hilderman RH, Pojoga LH, Haghiac M, Cooper HM, Rosenberg CR. Rec Res Dev in Biophys Biochem. The role of extracellular adenosine dinucleotides as vasoregulators. 2001; 1:59-76.
  43. Hilderman RH, Casey TE, Pojoga LH. P(1),P(4)-Diadenosine 5'-tetraphosphate modulates l-arginine and l-citrulline uptake by bovine aortic endothelial cells. Arch Biochem Biophys. 2000 Mar 01; 375(1):124-30. PMID: 10683257.
    View in: PubMed
  44. Pojoga L, Gautier S, Blanc H, Guyene TT, Poirier O, Cambien F, Benetos A. Genetic determination of plasma aldosterone levels in essential hypertension. Am J Hypertens. 1998 Jul; 11(7):856-60. PMID: 9683048.
    View in: PubMed
  45. Raicu M, Pojoga L, Simionescu N, Simionescu M. The effect of ACE inhibitors on atheroma formation is potentiated by association with a calcium channel blocker. A biochemical and ultrastructural study. J Submicrosc Cytol Pathol. 1997 Jul; 29(3):317-28. PMID: 9267040.
    View in: PubMed
  46. Raicu M, Pojoga L, Simionescu N, Simionescu M. Differential effect of two calcium channel blockers--nifedipine and diltiazem--on atherogenesis in hypercholesterolemic hamster. J Submicrosc Cytol Pathol. 1996 Apr; 28(2):265-75. PMID: 8964051.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.