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Last Name

profileDaniel Bruce Kramer, M.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
AddressBeth Israel Deaconess Medical Center
Baker 4, West
330 Brookline Ave
Boston MA 02215
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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cutlip DE, Kramer DB. Value-Based Hypothesis Testing for Cardiac Device Clinical Trials: A Pathway for Accelerated Reimbursement Decisions. Circ Cardiovasc Interv. 2016 May; 9(5). PMID: 27094322.
    View in: PubMed
  2. Madhavan M, Waks JW, Friedman PA, Kramer DB, Buxton AE, Noseworthy PA, Mehta RA, Hodge DO, Higgins AY, Webster TL, Witt CM, Cha YM, Gersh BJ. Outcomes After Implantable Cardioverter-Defibrillator Generator Replacement for Primary Prevention of Sudden Cardiac Death. Circ Arrhythm Electrophysiol. 2016 Mar; 9(3):e003283. PMID: 26921377.
    View in: PubMed
  3. Kramer DB, Yeh RW, Zimetbaum PJ. Editorial Commentary: Hard questions for mobile technology in cardiology. Trends Cardiovasc Med. 2016 May; 26(4):387-8. PMID: 26919932.
    View in: PubMed
  4. ProvidĂȘncia R, Kramer DB, Pimenta D, Babu GG, Hatfield LA, Ioannou A, Novak J, Hauser RG, Lambiase PD. Transvenous Implantable Cardioverter-Defibrillator (ICD) Lead Performance: A Meta-Analysis of Observational Studies. J Am Heart Assoc. 2015; 4(11). PMID: 26518666.
    View in: PubMed
  5. Waks JW, Steinhaus DA, Shvilkin A, Kramer DB. Post-pacemaker T-wave Inversions: Cardiac Memory. Am J Med. 2016 Feb; 129(2):170-2. PMID: 26440583.
    View in: PubMed
  6. Kramer DB, Hatfield LA, Normand SL. Comparative effectiveness of cardiac implantable electrical devices. Heart. 2015 Nov 15; 101(22):1773-5. PMID: 26303153.
    View in: PubMed
  7. Kramer DB, Cutlip DE. Regulatory science: Trust and transparency in clinical trials of medical devices. Nat Rev Cardiol. 2015 Sep; 12(9):503-4. PMID: 26194550.
    View in: PubMed
  8. Kramer DB, Matlock DD, Buxton AE, Goldstein NE, Goodwin C, Green AR, Kirkpatrick JN, Knoepke C, Lampert R, Mueller PS, Reynolds MR, Spertus JA, Stevenson LW, Mitchell SL. Implantable Cardioverter-Defibrillator Use in Older Adults: Proceedings of a Hartford Change AGEnts Symposium. Circ Cardiovasc Qual Outcomes. 2015 Jul; 8(4):437-46. PMID: 26038525; PMCID: PMC4512855 [Available on 07/01/16].
  9. Kramer DB, Hatfield LA, McGriff D, Ellis CR, Gura MT, Samuel M, Retel LK, Hauser RG. Transvenous implantable cardioverter-defibrillator lead reliability: implications for postmarket surveillance. J Am Heart Assoc. 2015 Jun; 4(6):e001672. PMID: 26025935; PMCID: PMC4599526.
  10. Kramer DB, Mitchell SL, Monteiro J, Jones PW, Normand SL, Hayes DL, Reynolds MR. Patient Activity and Survival Following Implantable Cardioverter-Defibrillator Implantation: The ALTITUDE Activity Study. J Am Heart Assoc. 2015 May; 4(5). PMID: 25979902; PMCID: PMC4599410.
  11. Steinhaus DA, Waks JW, Collins R, Kleckner K, Kramer DB, Zimetbaum PJ. Effect of Smaller Left Ventricular Capture Threshold Safety Margins to Improve Device Longevity in Recipients of Cardiac Resynchronization-Defibrillation Therapy. Am J Cardiol. 2015 Jul 1; 116(1):85-7. PMID: 25933732; PMCID: PMC4480976.
  12. Kramer DB, Kesselheim AS. The Watchman saga--closure at last? N Engl J Med. 2015 Mar 12; 372(11):994-5. PMID: 25760353; PMCID: PMC4394200.
  13. Levine YC, Tuttle MK, Rosenberg MA, Goldberg R, Matos J, Samuel M, Kramer DB, Buxton AE. Prevalence and outcomes of patients receiving implantable cardioverter-defibrillators for primary prevention not based on guidelines. Am J Cardiol. 2015 Jun 1; 115(11):1539-44. PMID: 25840578; PMCID: PMC4433567.
  14. Rajan PV, Kramer DB, Kesselheim AS. Medical device postapproval safety monitoring: where does the United States stand? Circ Cardiovasc Qual Outcomes. 2015 Jan; 8(1):124-31. PMID: 25563662; PMCID: PMC4385582.
  15. Kramer DB, Kennedy KF, Spertus JA, Normand SL, Noseworthy PA, Buxton AE, Josephson ME, Zimetbaum PJ, Mitchell SL, Reynolds MR. Mortality risk following replacement implantable cardioverter-defibrillator implantation at end of battery life: results from the NCDR. Heart Rhythm. 2014 Feb; 11(2):216-21. PMID: 24513917; PMCID: PMC4001927.
  16. Rome BN, Kramer DB, Kesselheim AS. Approval of high-risk medical devices in the US: implications for clinical cardiology. Curr Cardiol Rep. 2014; 16(6):489. PMID: 24760423; PMCID: PMC4080312.
  17. Kramer DB, Tan YT, Sato C, Kesselheim AS. Ensuring medical device effectiveness and safety: a cross--national comparison of approaches to regulation. Food Drug Law J. 2014; 69(1):1-23, i. PMID: 24772683; PMCID: PMC4091615.
  18. Rome BN, Kramer DB, Kesselheim AS. FDA approval of cardiac implantable electronic devices via original and supplement premarket approval pathways, 1979-2012. JAMA. 2014 Jan 22-29; 311(4):385-91. PMID: 24449317; PMCID: PMC4142419.
  19. Kramer DB, Zimetbaum PJ. Ectopy and expectations: can we predict atrial fibrillation, and should we try? Ann Intern Med. 2013 Dec 3; 159(11):787-8. PMID: 24297197; PMCID: PMC4088932.
  20. Kramer DB, Tan YT, Sato C, Kesselheim AS. Postmarket surveillance of medical devices: a comparison of strategies in the US, EU, Japan, and China. PLoS Med. 2013; 10(9):e1001519. PMID: 24223035; PMCID: PMC3815401.
  21. Kramer DB, Kesselheim AS. The medical device excise tax--before it begins? N Engl J Med. 2013 Sep 5; 369(10):984-5. PMID: 24004137.
    View in: PubMed
  22. Kramer DB, Kennedy KF, Noseworthy PA, Buxton AE, Josephson ME, Normand SL, Spertus JA, Zimetbaum PJ, Reynolds MR, Mitchell SL. Characteristics and outcomes of patients receiving new and replacement implantable cardioverter-defibrillators: results from the NCDR. Circ Cardiovasc Qual Outcomes. 2013 Jul; 6(4):488-97. PMID: 23759471; PMCID: PMC3839636.
  23. Kramer DB, Kesselheim AS. The medical device excise tax--over before it begins? N Engl J Med. 2013 May 9; 368(19):1767-9. PMID: 23614473; PMCID: PMC3733084.
  24. Fein AS, Shvilkin A, Shah D, Haffajee CI, Das S, Kumar K, Kramer DB, Zimetbaum PJ, Buxton AE, Josephson ME, Anter E. Treatment of obstructive sleep apnea reduces the risk of atrial fibrillation recurrence after catheter ablation. J Am Coll Cardiol. 2013 Jul 23; 62(4):300-5. PMID: 23623910.
    View in: PubMed
  25. Kramer DB, Reynolds MR, Mitchell SL. Resynchronization: considering device-based cardiac therapy in older adults. J Am Geriatr Soc. 2013 Apr; 61(4):615-21. PMID: 23581915; PMCID: PMC3628731.
  26. Kramer DB, Mitchell SL. Weighing the benefits and burdens of witnessed resuscitation. N Engl J Med. 2013 Mar 14; 368(11):1058-9. PMID: 23484835; PMCID: PMC3601383.
  27. Abdelhadi RH, Saba SF, Ellis CR, Mason PK, Kramer DB, Friedman PA, Gura MT, DiMarco JP, Mugglin AS, Reynolds MR, Bazaz RR, Retel LK, Hayes DL, Hauser RG. Independent multicenter study of Riata and Riata ST implantable cardioverter-defibrillator leads. Heart Rhythm. 2013 Mar; 10(3):361-5. PMID: 23128017.
    View in: PubMed
  28. Kramer DB, Mitchell SL, Brock DW. Deactivation of pacemakers and implantable cardioverter-defibrillators. Prog Cardiovasc Dis. 2012 Nov-Dec; 55(3):290-9. PMID: 23217433; PMCID: PMC3583554.
  29. Kramer DB, Kesselheim AS. User fees and beyond--the FDA Safety and Innovation Act of 2012. N Engl J Med. 2012 Oct 4; 367(14):1277-9. PMID: 23034017; PMCID: PMC4258823.
  30. Kramer DB, Xu S, Kesselheim AS. How does medical device regulation perform in the United States and the European union? A systematic review. PLoS Med. 2012; 9(7):e1001276. PMID: 22912563; PMCID: PMC3418047.
  31. Kramer DB, Baker M, Ransford B, Molina-Markham A, Stewart Q, Fu K, Reynolds MR. Security and privacy qualities of medical devices: an analysis of FDA postmarket surveillance. PLoS One. 2012; 7(7):e40200. PMID: 22829874; PMCID: PMC3400651.
  32. Hauser RG, Mugglin AS, Friedman PA, Kramer DB, Kallinen L, McGriff D, Hayes DL. Early detection of an underperforming implantable cardiovascular device using an automated safety surveillance tool. Circ Cardiovasc Qual Outcomes. 2012 Mar 1; 5(2):189-96. PMID: 22396584.
    View in: PubMed
  33. Kramer DB, Xu S, Kesselheim AS. Regulation of medical devices in the United States and European Union. N Engl J Med. 2012 Mar 1; 366(9):848-55. PMID: 22332952.
    View in: PubMed
  34. Kramer DB, Buxton AE, Zimetbaum PJ. Time for a change--a new approach to ICD replacement. N Engl J Med. 2012 Jan 26; 366(4):291-3. PMID: 22276818.
    View in: PubMed
  35. Kramer DB. Nesiritide in acute decompensated heart failure. N Engl J Med. 2011 Oct 20; 365(16):1547; discussion 1547. PMID: 22010930.
    View in: PubMed
  36. Kramer DB, Friedman PA, Kallinen LM, Morrison TB, Crusan DJ, Hodge DO, Reynolds MR, Hauser RG. Development and validation of a risk score to predict early mortality in recipients of implantable cardioverter-defibrillators. Heart Rhythm. 2012 Jan; 9(1):42-6. PMID: 21893137.
    View in: PubMed
  37. Kramer DB, Zimetbaum PJ. Long-QT syndrome. Cardiol Rev. 2011 Sep-Oct; 19(5):217-25. PMID: 21808164.
    View in: PubMed
  38. Kramer DB, Brock DW, Tedrow UB. Informed consent in cardiac resynchronization therapy: what should be said? Circ Cardiovasc Qual Outcomes. 2011 Sep; 4(5):573-7. PMID: 21934080; PMCID: PMC3641533.
  39. Kramer DB, Ottenberg AL, Gerhardson S, Mueller LA, Kaufman SR, Koenig BA, Mueller PS. "Just Because We Can Doesn't Mean We Should": views of nurses on deactivation of pacemakers and implantable cardioverter-defibrillators. J Interv Card Electrophysiol. 2011 Dec; 32(3):243-52. PMID: 21805140; PMCID: PMC3733086.
  40. Wessler BS, Kramer DG, Kelly JL, Trikalinos TA, Kent DM, Konstam MA, Udelson JE. Drug and device effects on peak oxygen consumption, 6-minute walk distance, and natriuretic peptides as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction. Circ Heart Fail. 2011 Sep; 4(5):578-88. PMID: 21705485.
    View in: PubMed
  41. Miller AL, Kramer DB, Lewis EF, Koplan B, Epstein LM, Tedrow U. Event-free survival following CRT with surgically implanted LV leads versus standard transvenous approach. Pacing Clin Electrophysiol. 2011 Apr; 34(4):490-500. PMID: 21463344; PMCID: PMC3079428.
  42. Kramer DB, Kesselheim AS, Salberg L, Brock DW, Maisel WH. Ethical and legal views regarding deactivation of cardiac implantable electrical devices in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2011 Apr 1; 107(7):1071-1075.e5. PMID: 21296323; PMCID: PMC3601901.
  43. Konstam MA, Kramer DG, Patel AR, Maron MS, Udelson JE. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. JACC Cardiovasc Imaging. 2011 Jan; 4(1):98-108. PMID: 21232712.
    View in: PubMed
  44. Kramer DB, Ottenberg AL, Mueller PS. Management of cardiac electrical implantable devices in patients nearing the end of life or requesting withdrawal of therapy: review of the Heart Rhythm Society 2010 consensus statement. Pol Arch Med Wewn. 2010 Dec; 120(12):497-502. PMID: 21178906.
    View in: PubMed
  45. Kramer DB, Josephson ME. Three questions for evidence-based cardiac electrophysiology. Circ Cardiovasc Qual Outcomes. 2010 Nov; 3(6):704-9. PMID: 21081751.
    View in: PubMed
  46. Kramer DG, Trikalinos TA, Kent DM, Antonopoulos GV, Konstam MA, Udelson JE. Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach. J Am Coll Cardiol. 2010 Jul 27; 56(5):392-406. PMID: 20650361; PMCID: PMC4523221.
  47. Kramer DB, Kesselheim AS, Brock DW, Maisel WH. Ethical and legal views of physicians regarding deactivation of cardiac implantable electrical devices: a quantitative assessment. Heart Rhythm. 2010 Nov; 7(11):1537-42. PMID: 20650332; PMCID: PMC3001282.
  48. Maisel WH, Kramer DB. Extracting guidance from extraction data. J Am Coll Cardiol. 2010 Aug 17; 56(8):651-2. PMID: 20598468.
    View in: PubMed
  49. Konstantino Y, Zimetbaum PJ, Hsing J, Kramer DB, Chang JD. Cardiac resynchronization therapy for low-flow, low-gradient aortic stenosis. Eur J Heart Fail. 2010 Aug; 12(8):889-92. PMID: 20494924.
    View in: PubMed
  50. Lampert R, Hayes DL, Annas GJ, Farley MA, Goldstein NE, Hamilton RM, Kay GN, Kramer DB, Mueller PS, Padeletti L, Pozuelo L, Schoenfeld MH, Vardas PE, Wiegand DL, Zellner R. HRS Expert Consensus Statement on the Management of Cardiovascular Implantable Electronic Devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm. 2010 Jul; 7(7):1008-26. PMID: 20471915.
    View in: PubMed
  51. Kramer DB, Maisel WH. An unusual cause of abnormal intrathoracic impedance in a patient with arrhythmogenic right ventricular cardiomyopathy. Pacing Clin Electrophysiol. 2011 Jul; 34(7):e60-3. PMID: 20456645.
    View in: PubMed
  52. Lubitz SA, Leong-Sit P, Fine N, Kramer DB, Singh J, Ellinor PT. Effectiveness of cardiac resynchronization therapy in mild congestive heart failure: systematic review and meta-analysis of randomized trials. Eur J Heart Fail. 2010 Apr; 12(4):360-6. PMID: 20335354; PMCID: PMC2844759.
  53. Kramer DB, Mallis E, Zuckerman BD, Zimmerman BA, Maisel WH. Premarket clinical evaluation of novel cardiovascular devices: quality analysis of premarket clinical studies submitted to the Food and Drug Administration 2000-2007. Am J Ther. 2010 Jan-Feb; 17(1):2-7. PMID: 20038828.
    View in: PubMed
  54. Maisel WH, Kramer DB. Implantable cardioverter-defibrillator lead performance. Circulation. 2008 May 27; 117(21):2721-3. PMID: 18506015.
    View in: PubMed
  55. Kramer DB. Changing premedical requirements. JAMA. 2007 Jan 3; 297(1):37; author reply 38-9. PMID: 17200468.
    View in: PubMed
  56. Field ME, Solomon SD, Lewis EF, Kramer DB, Baughman KL, Stevenson LW, Tedrow UB. Right ventricular dysfunction and adverse outcome in patients with advanced heart failure. J Card Fail. 2006 Oct; 12(8):616-20. PMID: 17045180.
    View in: PubMed
  57. Tedrow UB, Kramer DB, Stevenson LW, Stevenson WG, Baughman KL, Epstein LM, Lewis EF. Relation of right ventricular peak systolic pressure to major adverse events in patients undergoing cardiac resynchronization therapy. Am J Cardiol. 2006 Jun 15; 97(12):1737-40. PMID: 16765124.
    View in: PubMed
  58. Mehta NP, Kramer DB. A Critique of the USMLE clinical skills examination. MedGenMed. 2005; 7(2):76. PMID: 16369454; PMCID: PMC1681601.
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