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profileDaniel Bruce Kramer, M.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Baker 4, West
330 Brookline Ave
Boston MA 02215
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2016 - 2019Greenwall Faculty Scholar
2013 - 2017Paul B. Beeson Scholar
2012 - 2013KL2 MeRIT Award
2012 - 2012John A. Hartford Center of Excellence in Geriatric Medicine Scholar

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Dr. Daniel Kramer studied Philosophy at Brown University prior to earning his MD from Harvard Medical School and MPH from the Harvard TH Chan School of Public Health. He completed internal medicine training at Massachusetts General Hospital and fellowships in cardiovascular disease at clinical cardiac electrophysiology at Beth Israel Deaconess Medical Center, as well as the Medical Device Fellowship Program with the FDA. He is a member of the cardiac electrophysiology service at BIDMC, where he is part of the Richard and Susan Smith Center for Outcomes Research in Cardiology.

Dr. Kramer’s research focuses on ethics, policy, and clinical outcomes related to the use of cardiac devices, with funding support from the Harvard Catalyst, Paul Beeson Scholars Program, and Greenwall Faculty Scholars Program in Bioethics.


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K23AG045963     (KRAMER, DANIEL BRUCE)Sep 30, 2013 - Jun 30, 2017
NIH/NIA
Patient-centered Outcomes of Implantable Defibrillator Therapy in Older Patients
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ransford B, Kramer DB, Foo Kune D, Auto de Medeiros J, Yan C, Xu W, Crawford T, Fu K. Cybersecurity and medical devices: A Practical guide for cardiac electrophysiologists. Pacing Clin Electrophysiol. 2017 May 17. PMID: 28512774.
    View in: PubMed
  2. Kramer DB, Kesselheim AS. Coverage of Magnetic Resonance Imaging for Patients With Cardiac Devices: Improving the Coverage With Evidence Development Program. JAMA Cardiol. 2017 May 08. PMID: 28492917.
    View in: PubMed
  3. DeMartino ES, Dudzinski DM, Doyle CK, Sperry BP, Gregory SE, Siegler M, Sulmasy DP, Mueller PS, Kramer DB. Who Decides When a Patient Can't? Statutes on Alternate Decision Makers. N Engl J Med. 2017 Apr 13; 376(15):1478-1482. PMID: 28402767.
    View in: PubMed
  4. Strom JB, Whelan JB, Shen C, Zheng SQ, Mortele KJ, Kramer DB. Safety and utility of magnetic resonance imaging in patients with cardiac implantable electronic devices. Heart Rhythm. 2017 Apr 03. PMID: 28385671.
    View in: PubMed
  5. Yeh RW, Kramer DB. Decision Tools to Improve Personalized Care in Cardiovascular Disease: Moving the Art of Medicine Toward Science. Circulation. 2017 Mar 21; 135(12):1097-1100. PMID: 28320801.
    View in: PubMed
  6. Kramer DB, Tsai T, Natarajan P, Tewksbury E, Mitchell SL, Travison TG. Frailty, Physical Activity, and Mobility in Patients With Cardiac Implantable Electrical Devices. J Am Heart Assoc. 2017 Feb 10; 6(2). PMID: 28188253.
    View in: PubMed
  7. Mehrotra P, Gupta K, Strymish J, Kramer DB, Lambert-Kerzner A, Ho PM, Branch-Elliman W. Implementation of Infection Prevention and Antimicrobial Stewardship in Cardiac Electrophysiology Laboratories: Results from the SHEA Research Network. Infect Control Hosp Epidemiol. 2017 Apr; 38(4):496-498. PMID: 28103958.
    View in: PubMed
  8. Kramer DB, Reynolds MR, Normand SL, Parzynski CS, Spertus JA, Mor V, Mitchell SL. Nursing Home Use After Implantable Cardioverter-Defibrillator Implantation in Older Adults: Results from the National Cardiovascular Data Registry. J Am Geriatr Soc. 2017 Feb; 65(2):340-347. PMID: 28198561.
    View in: PubMed
  9. Kramer DB, Steinhaus DA. Cardiac Resynchronization Therapy in Older Patients: Age Is Just a Number, and Yet …. J Card Fail. 2016 Dec; 22(12):978-980. PMID: 27765669.
    View in: PubMed
  10. Kramer DB, Jones PW, Rogers T, Mitchell SL, Reynolds MR. Patterns of physical activity and survival following cardiac resynchronization therapy implantation: the ALTITUDE activity study. Europace. 2016 Oct 04. PMID: 27702867.
    View in: PubMed
  11. Sistla SA, Roddy AB, Williams NE, Kramer DB, Stevens K, Allison SD. Agroforestry Practices Promote Biodiversity and Natural Resource Diversity in Atlantic Nicaragua. PLoS One. 2016; 11(9):e0162529. PMID: 27606619; PMCID: PMC5015841.
    View in: PubMed, PubMed Central
  12. Hatfield LA, Kramer DB, Volya R, Reynolds MR, Normand SL. Geographic and Temporal Variation in Cardiac Implanted Electric Devices to Treat Heart Failure. J Am Heart Assoc. 2016 Jul 28; 5(8). PMID: 27468928.
    View in: PubMed
  13. Cutlip DE, Kramer DB. Value-Based Hypothesis Testing for Cardiac Device Clinical Trials: A Pathway for Accelerated Reimbursement Decisions. Circ Cardiovasc Interv. 2016 May; 9(5):e003627. PMID: 27094322; PMCID: PMC4995447.
    View in: PubMed, PubMed Central
  14. Kramer DB, Reynolds MR, Normand SL, Parzynski CS, Spertus JA, Mor V, Mitchell SL. Hospice Use Following Implantable Cardioverter-Defibrillator Implantation in Older Patients: Results From the National Cardiovascular Data Registry. Circulation. 2016 May 24; 133(21):2030-7. PMID: 27016104; PMCID: PMC4872640.
    View in: PubMed, PubMed Central
  15. Madhavan M, Waks JW, Friedman PA, Kramer DB, Buxton AE, Noseworthy PA, Mehta RA, Hodge DO, Higgins AY, Webster TL, Witt CM, Cha YM, Gersh BJ. Outcomes After Implantable Cardioverter-Defibrillator Generator Replacement for Primary Prevention of Sudden Cardiac Death. Circ Arrhythm Electrophysiol. 2016 Mar; 9(3):e003283. PMID: 26921377; PMCID: PMC4998185.
    View in: PubMed, PubMed Central
  16. Kramer DB, Yeh RW, Zimetbaum PJ. Editorial Commentary: Hard questions for mobile technology in cardiology. Trends Cardiovasc Med. 2016 May; 26(4):387-8. PMID: 26919932; PMCID: PMC4838996.
    View in: PubMed, PubMed Central
  17. Providência R, Kramer DB, Pimenta D, Babu GG, Hatfield LA, Ioannou A, Novak J, Hauser RG, Lambiase PD. Transvenous Implantable Cardioverter-Defibrillator (ICD) Lead Performance: A Meta-Analysis of Observational Studies. J Am Heart Assoc. 2015 Oct 30; 4(11). PMID: 26518666; PMCID: PMC4845221.
    View in: PubMed, PubMed Central
  18. Waks JW, Steinhaus DA, Shvilkin A, Kramer DB. Post-pacemaker T-wave Inversions: Cardiac Memory. Am J Med. 2016 Feb; 129(2):170-2. PMID: 26440583; PMCID: PMC4995449.
    View in: PubMed, PubMed Central
  19. Kramer DB, Hatfield LA, Normand SL. Comparative effectiveness of cardiac implantable electrical devices. Heart. 2015 Nov; 101(22):1773-5. PMID: 26303153; PMCID: PMC4699558.
    View in: PubMed, PubMed Central
  20. Kramer DB, Cutlip DE. Regulatory science: Trust and transparency in clinical trials of medical devices. Nat Rev Cardiol. 2015 Sep; 12(9):503-4. PMID: 26194550; PMCID: PMC4698975.
    View in: PubMed, PubMed Central
  21. Kramer DB, Matlock DD, Buxton AE, Goldstein NE, Goodwin C, Green AR, Kirkpatrick JN, Knoepke C, Lampert R, Mueller PS, Reynolds MR, Spertus JA, Stevenson LW, Mitchell SL. Implantable Cardioverter-Defibrillator Use in Older Adults: Proceedings of a Hartford Change AGEnts Symposium. Circ Cardiovasc Qual Outcomes. 2015 Jul; 8(4):437-46. PMID: 26038525; PMCID: PMC4512855.
    View in: PubMed, PubMed Central
  22. Kramer DB, Hatfield LA, McGriff D, Ellis CR, Gura MT, Samuel M, Retel LK, Hauser RG. Transvenous implantable cardioverter-defibrillator lead reliability: implications for postmarket surveillance. J Am Heart Assoc. 2015 May 29; 4(6):e001672. PMID: 26025935; PMCID: PMC4599526.
    View in: PubMed, PubMed Central
  23. Kramer DB, Mitchell SL, Monteiro J, Jones PW, Normand SL, Hayes DL, Reynolds MR. Patient Activity and Survival Following Implantable Cardioverter-Defibrillator Implantation: The ALTITUDE Activity Study. J Am Heart Assoc. 2015 May 15; 4(5). PMID: 25979902; PMCID: PMC4599410.
    View in: PubMed, PubMed Central
  24. Steinhaus DA, Waks JW, Collins R, Kleckner K, Kramer DB, Zimetbaum PJ. Effect of Smaller Left Ventricular Capture Threshold Safety Margins to Improve Device Longevity in Recipients of Cardiac Resynchronization-Defibrillation Therapy. Am J Cardiol. 2015 Jul 01; 116(1):85-7. PMID: 25933732; PMCID: PMC4480976.
    View in: PubMed, PubMed Central
  25. Kramer DB, Kesselheim AS. The Watchman saga--closure at last? N Engl J Med. 2015 Mar 12; 372(11):994-5. PMID: 25760353; PMCID: PMC4394200.
    View in: PubMed, PubMed Central
  26. Levine YC, Tuttle MK, Rosenberg MA, Goldberg R, Matos J, Samuel M, Kramer DB, Buxton AE. Prevalence and outcomes of patients receiving implantable cardioverter-defibrillators for primary prevention not based on guidelines. Am J Cardiol. 2015 Jun 01; 115(11):1539-44. PMID: 25840578; PMCID: PMC4433567.
    View in: PubMed, PubMed Central
  27. Rajan PV, Kramer DB, Kesselheim AS. Medical device postapproval safety monitoring: where does the United States stand? Circ Cardiovasc Qual Outcomes. 2015 Jan; 8(1):124-31. PMID: 25563662; PMCID: PMC4385582.
    View in: PubMed, PubMed Central
  28. Kramer DB, Kennedy KF, Spertus JA, Normand SL, Noseworthy PA, Buxton AE, Josephson ME, Zimetbaum PJ, Mitchell SL, Reynolds MR. Mortality risk following replacement implantable cardioverter-defibrillator implantation at end of battery life: results from the NCDR. Heart Rhythm. 2014 Feb; 11(2):216-21. PMID: 24513917; PMCID: PMC4001927.
    View in: PubMed, PubMed Central
  29. Rome BN, Kramer DB, Kesselheim AS. Approval of high-risk medical devices in the US: implications for clinical cardiology. Curr Cardiol Rep. 2014; 16(6):489. PMID: 24760423; PMCID: PMC4080312.
    View in: PubMed, PubMed Central
  30. Kramer DB, Tan YT, Sato C, Kesselheim AS. Ensuring medical device effectiveness and safety: a cross--national comparison of approaches to regulation. Food Drug Law J. 2014; 69(1):1-23, i. PMID: 24772683; PMCID: PMC4091615.
    View in: PubMed, PubMed Central
  31. Rome BN, Kramer DB, Kesselheim AS. FDA approval of cardiac implantable electronic devices via original and supplement premarket approval pathways, 1979-2012. JAMA. 2014 Jan 22-29; 311(4):385-91. PMID: 24449317; PMCID: PMC4142419.
    View in: PubMed, PubMed Central
  32. Kramer DB, Zimetbaum PJ. Ectopy and expectations: can we predict atrial fibrillation, and should we try? Ann Intern Med. 2013 Dec 03; 159(11):787-8. PMID: 24297197; PMCID: PMC4088932.
    View in: PubMed, PubMed Central
  33. Kramer DB, Tan YT, Sato C, Kesselheim AS. Postmarket surveillance of medical devices: a comparison of strategies in the US, EU, Japan, and China. PLoS Med. 2013; 10(9):e1001519. PMID: 24223035; PMCID: PMC3815401.
    View in: PubMed, PubMed Central
  34. Kramer DB, Kesselheim AS. The medical device excise tax--over before it begins? N Engl J Med. 2013 09 05; 369(10):984-5. PMID: 24004137.
    View in: PubMed
  35. Kramer DB, Kennedy KF, Noseworthy PA, Buxton AE, Josephson ME, Normand SL, Spertus JA, Zimetbaum PJ, Reynolds MR, Mitchell SL. Characteristics and outcomes of patients receiving new and replacement implantable cardioverter-defibrillators: results from the NCDR. Circ Cardiovasc Qual Outcomes. 2013 Jul; 6(4):488-97. PMID: 23759471; PMCID: PMC3839636.
    View in: PubMed, PubMed Central
  36. Kramer DB, Kesselheim AS. The medical device excise tax--over before it begins? N Engl J Med. 2013 May 09; 368(19):1767-9. PMID: 23614473; PMCID: PMC3733084.
    View in: PubMed, PubMed Central
  37. Fein AS, Shvilkin A, Shah D, Haffajee CI, Das S, Kumar K, Kramer DB, Zimetbaum PJ, Buxton AE, Josephson ME, Anter E. Treatment of obstructive sleep apnea reduces the risk of atrial fibrillation recurrence after catheter ablation. J Am Coll Cardiol. 2013 Jul 23; 62(4):300-5. PMID: 23623910.
    View in: PubMed
  38. Kramer DB, Reynolds MR, Mitchell SL. Resynchronization: considering device-based cardiac therapy in older adults. J Am Geriatr Soc. 2013 Apr; 61(4):615-21. PMID: 23581915; PMCID: PMC3628731.
    View in: PubMed, PubMed Central
  39. Kramer DB, Mitchell SL. Weighing the benefits and burdens of witnessed resuscitation. N Engl J Med. 2013 Mar 14; 368(11):1058-9. PMID: 23484835; PMCID: PMC3601383.
    View in: PubMed, PubMed Central
  40. Abdelhadi RH, Saba SF, Ellis CR, Mason PK, Kramer DB, Friedman PA, Gura MT, DiMarco JP, Mugglin AS, Reynolds MR, Bazaz RR, Retel LK, Hayes DL, Hauser RG. Independent multicenter study of Riata and Riata ST implantable cardioverter-defibrillator leads. Heart Rhythm. 2013 Mar; 10(3):361-5. PMID: 23128017.
    View in: PubMed
  41. Kramer DB, Mitchell SL, Brock DW. Deactivation of pacemakers and implantable cardioverter-defibrillators. Prog Cardiovasc Dis. 2012 Nov-Dec; 55(3):290-9. PMID: 23217433; PMCID: PMC3583554.
    View in: PubMed, PubMed Central
  42. Kramer DB, Kesselheim AS. User fees and beyond--the FDA Safety and Innovation Act of 2012. N Engl J Med. 2012 Oct 04; 367(14):1277-9. PMID: 23034017; PMCID: PMC4258823.
    View in: PubMed, PubMed Central
  43. Kramer DB, Xu S, Kesselheim AS. How does medical device regulation perform in the United States and the European union? A systematic review. PLoS Med. 2012; 9(7):e1001276. PMID: 22912563; PMCID: PMC3418047.
    View in: PubMed, PubMed Central
  44. Kramer DB, Baker M, Ransford B, Molina-Markham A, Stewart Q, Fu K, Reynolds MR. Security and privacy qualities of medical devices: an analysis of FDA postmarket surveillance. PLoS One. 2012; 7(7):e40200. PMID: 22829874; PMCID: PMC3400651.
    View in: PubMed, PubMed Central
  45. Hauser RG, Mugglin AS, Friedman PA, Kramer DB, Kallinen L, McGriff D, Hayes DL. Early detection of an underperforming implantable cardiovascular device using an automated safety surveillance tool. Circ Cardiovasc Qual Outcomes. 2012 Mar 01; 5(2):189-96. PMID: 22396584.
    View in: PubMed
  46. Kramer DB, Xu S, Kesselheim AS. Regulation of medical devices in the United States and European Union. N Engl J Med. 2012 Mar 01; 366(9):848-55. PMID: 22332952.
    View in: PubMed
  47. Kramer DB, Buxton AE, Zimetbaum PJ. Time for a change--a new approach to ICD replacement. N Engl J Med. 2012 Jan 26; 366(4):291-3. PMID: 22276818.
    View in: PubMed
  48. Kramer DB. Nesiritide in acute decompensated heart failure. N Engl J Med. 2011 Oct 20; 365(16):1547; discussion 1547. PMID: 22010930.
    View in: PubMed
  49. Kramer DB, Friedman PA, Kallinen LM, Morrison TB, Crusan DJ, Hodge DO, Reynolds MR, Hauser RG. Development and validation of a risk score to predict early mortality in recipients of implantable cardioverter-defibrillators. Heart Rhythm. 2012 Jan; 9(1):42-6. PMID: 21893137.
    View in: PubMed
  50. Kramer DB, Zimetbaum PJ. Long-QT syndrome. Cardiol Rev. 2011 Sep-Oct; 19(5):217-25. PMID: 21808164.
    View in: PubMed
  51. Kramer DB, Brock DW, Tedrow UB. Informed consent in cardiac resynchronization therapy: what should be said? Circ Cardiovasc Qual Outcomes. 2011 Sep; 4(5):573-7. PMID: 21934080; PMCID: PMC3641533.
    View in: PubMed, PubMed Central
  52. Kramer DB, Ottenberg AL, Gerhardson S, Mueller LA, Kaufman SR, Koenig BA, Mueller PS. "Just Because We Can Doesn't Mean We Should": views of nurses on deactivation of pacemakers and implantable cardioverter-defibrillators. J Interv Card Electrophysiol. 2011 Dec; 32(3):243-52. PMID: 21805140; PMCID: PMC3733086.
    View in: PubMed, PubMed Central
  53. Wessler BS, Kramer DG, Kelly JL, Trikalinos TA, Kent DM, Konstam MA, Udelson JE. Drug and device effects on peak oxygen consumption, 6-minute walk distance, and natriuretic peptides as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction. Circ Heart Fail. 2011 Sep; 4(5):578-88. PMID: 21705485.
    View in: PubMed
  54. Miller AL, Kramer DB, Lewis EF, Koplan B, Epstein LM, Tedrow U. Event-free survival following CRT with surgically implanted LV leads versus standard transvenous approach. Pacing Clin Electrophysiol. 2011 Apr; 34(4):490-500. PMID: 21463344; PMCID: PMC3079428.
    View in: PubMed, PubMed Central
  55. Kramer DB, Kesselheim AS, Salberg L, Brock DW, Maisel WH. Ethical and legal views regarding deactivation of cardiac implantable electrical devices in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2011 Apr 01; 107(7):1071-1075.e5. PMID: 21296323; PMCID: PMC3601901.
    View in: PubMed, PubMed Central
  56. Konstam MA, Kramer DG, Patel AR, Maron MS, Udelson JE. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. JACC Cardiovasc Imaging. 2011 Jan; 4(1):98-108. PMID: 21232712.
    View in: PubMed
  57. Kramer DB, Ottenberg AL, Mueller PS. Management of cardiac electrical implantable devices in patients nearing the end of life or requesting withdrawal of therapy: review of the Heart Rhythm Society 2010 consensus statement. Pol Arch Med Wewn. 2010 Dec; 120(12):497-502. PMID: 21178906.
    View in: PubMed
  58. Kramer DB, Josephson ME. Three questions for evidence-based cardiac electrophysiology. Circ Cardiovasc Qual Outcomes. 2010 Nov; 3(6):704-9. PMID: 21081751.
    View in: PubMed
  59. Kramer DG, Trikalinos TA, Kent DM, Antonopoulos GV, Konstam MA, Udelson JE. Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach. J Am Coll Cardiol. 2010 Jul 27; 56(5):392-406. PMID: 20650361; PMCID: PMC4523221.
    View in: PubMed, PubMed Central
  60. Kramer DB, Kesselheim AS, Brock DW, Maisel WH. Ethical and legal views of physicians regarding deactivation of cardiac implantable electrical devices: a quantitative assessment. Heart Rhythm. 2010 Nov; 7(11):1537-42. PMID: 20650332; PMCID: PMC3001282.
    View in: PubMed, PubMed Central
  61. Maisel WH, Kramer DB. Extracting guidance from extraction data. J Am Coll Cardiol. 2010 Aug 17; 56(8):651-2. PMID: 20598468.
    View in: PubMed
  62. Konstantino Y, Zimetbaum PJ, Hsing J, Kramer DB, Chang JD. Cardiac resynchronization therapy for low-flow, low-gradient aortic stenosis. Eur J Heart Fail. 2010 Aug; 12(8):889-92. PMID: 20494924.
    View in: PubMed
  63. Lampert R, Hayes DL, Annas GJ, Farley MA, Goldstein NE, Hamilton RM, Kay GN, Kramer DB, Mueller PS, Padeletti L, Pozuelo L, Schoenfeld MH, Vardas PE, Wiegand DL, Zellner R. HRS Expert Consensus Statement on the Management of Cardiovascular Implantable Electronic Devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm. 2010 Jul; 7(7):1008-26. PMID: 20471915.
    View in: PubMed
  64. Kramer DB, Maisel WH. An unusual cause of abnormal intrathoracic impedance in a patient with arrhythmogenic right ventricular cardiomyopathy. Pacing Clin Electrophysiol. 2011 Jul; 34(7):e60-3. PMID: 20456645.
    View in: PubMed
  65. Lubitz SA, Leong-Sit P, Fine N, Kramer DB, Singh J, Ellinor PT. Effectiveness of cardiac resynchronization therapy in mild congestive heart failure: systematic review and meta-analysis of randomized trials. Eur J Heart Fail. 2010 Apr; 12(4):360-6. PMID: 20335354; PMCID: PMC2844759.
    View in: PubMed, PubMed Central
  66. Kramer DB, Mallis E, Zuckerman BD, Zimmerman BA, Maisel WH. Premarket clinical evaluation of novel cardiovascular devices: quality analysis of premarket clinical studies submitted to the Food and Drug Administration 2000-2007. Am J Ther. 2010 Jan-Feb; 17(1):2-7. PMID: 20038828.
    View in: PubMed
  67. Maisel WH, Kramer DB. Implantable cardioverter-defibrillator lead performance. Circulation. 2008 May 27; 117(21):2721-3. PMID: 18506015.
    View in: PubMed
  68. Kramer DB. Changing premedical requirements. JAMA. 2007 Jan 03; 297(1):37; author reply 38-9. PMID: 17200468.
    View in: PubMed
  69. Field ME, Solomon SD, Lewis EF, Kramer DB, Baughman KL, Stevenson LW, Tedrow UB. Right ventricular dysfunction and adverse outcome in patients with advanced heart failure. J Card Fail. 2006 Oct; 12(8):616-20. PMID: 17045180.
    View in: PubMed
  70. Tedrow UB, Kramer DB, Stevenson LW, Stevenson WG, Baughman KL, Epstein LM, Lewis EF. Relation of right ventricular peak systolic pressure to major adverse events in patients undergoing cardiac resynchronization therapy. Am J Cardiol. 2006 Jun 15; 97(12):1737-40. PMID: 16765124.
    View in: PubMed
  71. Mehta NP, Kramer DB. A Critique of the USMLE clinical skills examination. MedGenMed. 2005 May 23; 7(2):76. PMID: 16369454; PMCID: PMC1681601.
    View in: PubMed, PubMed Central
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