Harvard Catalyst Profiles

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Jinjun Shi, Ph.D.

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Biography
2011
NIH Pathway to Independence Award (K99/R00)
2013
Movember-PCF Challenge Award
2014
PCF Young Investigator Award
2018
DoD LCRP Concept Award
2019
DoD PRCRP Idea Award with Special Focus
2019
ALA Lung Cancer Discovery Award
2021
Elected Fellow of the AIMBE
2021
MGB Innovation Discovery Award

Overview
Our laboratory has a broad interest in nanotechnology, biomaterials, RNA therapy, oxidative therapy, and immunotherapy for transformative biomedical applications. In particular, we are interested in i) RNAi delivery for gene silencing; ii) mRNA delivery for protein replacement; iii) nanoparticle-mediated immune modulation; and iv) development of stimuli-responsive nanomaterials and bioinspired antioxidative polymers.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL159012 (SHI, JINJUN) Jul 1, 2021 - Jun 30, 2025
    NIH
    Long-Acting RNAi Therapy for Atherosclerosis and Insulin Resistance
    Role: Principal Investigator
  2. R01HL156362 (CHEN, HONG) Dec 15, 2020 - Nov 30, 2024
    NIH
    The role of signaling adaptor protein epsin in atherosclerosis
    Role: Co-Principal Investigator
  3. R01HL127464 (TABAS, IRA A) Jan 1, 2016 - Dec 31, 2020
    NIH
    Enhancing Inflammation Resolution in Atherosclerosis via Targeted Nanoparticle-Mediated Delivery of Biologics
    Role: Co-Principal Investigator
  4. R01CA200900 (SHI, JINJUN) Dec 21, 2015 - Jun 30, 2026
    NIH
    Systemic RNA Delivery to Tumors
    Role: Principal Investigator
  5. R00CA160350 (SHI, JINJUN) Aug 1, 2013 - Jul 31, 2017
    NIH
    Nanoparticle Co-delivery of RNAi and Chemotherapy for Multidrug Resistant Cancers
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gerlach BD, Ampomah PB, Yurdagul A, Liu C, Lauring MC, Wang X, Kasikara C, Kong N, Shi J, Tao W, Tabas I. Efferocytosis induces macrophage proliferation to help resolve tissue injury. Cell Metab. 2021 Nov 10. PMID: 34784501.
    Citations:    
  2. Chen W, Schilperoort M, Cao Y, Shi J, Tabas I, Tao W. Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis. Nat Rev Cardiol. 2021 Nov 10. PMID: 34759324.
    Citations:    
  3. Huang X, Wu G, Liu C, Hua X, Tang Z, Xiao Y, Chen W, Zhou J, Kong N, Huang P, Shi J, Tao W. Intercalation-Driven Formation of siRNA Nanogels for Cancer Therapy. Nano Lett. 2021 Nov 01. PMID: 34723546.
    Citations:    
  4. Xiao Y, Shi J. Lipids and the Emerging RNA Medicines. Chem Rev. 2021 Oct 27; 121(20):12109-12111. PMID: 34702039.
    Citations:    Fields:    
  5. Zhao C, Li Z, Chen J, Su L, Wang J, Chen DS, Ye J, Liao N, Yang H, Song J, Shi J. Site-Specific Biomimicry of Antioxidative Melanin Formation and Its Application for Acute Liver Injury Therapy and Imaging. Adv Mater. 2021 Aug; 33(34):e2102391. PMID: 34278624.
    Citations:    Fields:    
  6. Lin YX, Wang Y, Ding J, Jiang A, Wang J, Yu M, Blake S, Liu S, Bieberich CJ, Farokhzad OC, Mei L, Wang H, Shi J. Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models. Sci Transl Med. 2021 06 23; 13(599). PMID: 34162754.
    Citations: 1     Fields:    Translation:HumansCells
  7. Zhao C, Chen J, Ye J, Li Z, Su L, Wang J, Zhang Y, Chen J, Yang H, Shi J, Song J. Structural Transformative Antioxidants for Dual-Responsive Anti-Inflammatory Delivery and Photoacoustic Inflammation Imaging. Angew Chem Int Ed Engl. 2021 06 21; 60(26):14458-14466. PMID: 33835672.
    Citations:    Fields:    Translation:Humans
  8. Molinaro R, Yu M, Sausen G, Bichsel CA, Corbo C, Folco EJ, Lee GY, Liu Y, Tesmenitsky Y, Shvartz E, Sukhova GK, Kloss F, Croce KJ, Farokhzad OC, Shi J, Libby P. Targeted delivery of Protein Arginine Deiminase-4 inhibitors to limit arterial intimal NETosis and preserve endothelial integrity. Cardiovasc Res. 2021 Mar 05. PMID: 33751034.
    Citations: 3     Fields:    
  9. Yurdagul A, Kong N, Gerlach BD, Wang X, Ampomah P, Kuriakose G, Tao W, Shi J, Tabas I. ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution. Arterioscler Thromb Vasc Biol. 2021 03; 41(3):e144-e159. PMID: 33406854.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Zhao C, Chen J, Zhong R, Chen DS, Shi J, Song J. Oxidative-Species-Selective Materials for Diagnostic and Therapeutic Applications. Angew Chem Int Ed Engl. 2021 04 26; 60(18):9804-9827. PMID: 32285531.
    Citations:    Fields:    Translation:HumansCells
  11. Islam MA, Rice J, Reesor E, Zope H, Tao W, Lim M, Ding J, Chen Y, Aduluso D, Zetter BR, Farokhzad OC, Shi J. Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice. Biomaterials. 2021 01; 266:120431. PMID: 33099060.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Fu L, Zou F, Liu Q, Wang B, Wang J, Liang H, Liang X, Liu J, Shi J, Liu Q. An ultra-long circulating nanoparticle for reviving a highly selective BCR-ABL inhibitor in long-term effective and safe treatment of chronic myeloid leukemia. Nanomedicine. 2020 10; 29:102283. PMID: 32777451.
    Citations:    Fields:    Translation:HumansCells
  13. Wang J, Zope H, Islam MA, Rice J, Dodman S, Lipert K, Chen Y, Zetter BR, Shi J. Lipidation Approaches Potentiate Adjuvant-Pulsed Immune Surveillance: A Design Rationale for Cancer Nanovaccine. Front Bioeng Biotechnol. 2020; 8:787. PMID: 32850698.
    Citations: 3     
  14. Tao W, Yurdagul A, Kong N, Li W, Wang X, Doran AC, Feng C, Wang J, Islam MA, Farokhzad OC, Tabas I, Shi J. siRNA nanoparticles targeting CaMKII? in lesional macrophages improve atherosclerotic plaque stability in mice. Sci Transl Med. 2020 07 22; 12(553). PMID: 32718990.
    Citations: 11     Fields:    Translation:AnimalsCells
  15. Shi J. Transforming platelets into microrobots. Sci Robot. 2020 Jun 10; 5(43). PMID: 33022615.
    Citations:    Translation:HumansCells
  16. Li Y, Ding J, Xu X, Shi R, Saw PE, Wang J, Chung S, Li W, Aljaeid BM, Lee RJ, Tao W, Teng L, Farokhzad OC, Shi J. Dual Hypoxia-Targeting RNAi Nanomedicine for Precision Cancer Therapy. Nano Lett. 2020 07 08; 20(7):4857-4863. PMID: 32479088.
    Citations: 4     Fields:    Translation:HumansCells
  17. Son S, Nam J, Zenkov I, Ochyl LJ, Xu Y, Scheetz L, Shi J, Farokhzad OC, Moon JJ. Sugar-Nanocapsules Imprinted with Microbial Molecular Patterns for mRNA Vaccination. Nano Lett. 2020 03 11; 20(3):1499-1509. PMID: 32023415.
    Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
  18. Xiong Q, Li Y, Zhou K, Chen P, Guo H, Chen L, Ding J, Song T, Shi J. Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery. Biomater Sci. 2020 Feb 07; 8(3):758-762. PMID: 31965126.
    Citations: 1     Fields:    Translation:HumansCells
  19. Kim NY, Blake S, De D, Ouyang J, Shi J, Kong N. Two-Dimensional Nanosheet-Based Photonic Nanomedicine for Combined Gene and Photothermal Therapy. Front Pharmacol. 2019; 10:1573. PMID: 32038249.
    Citations: 1     
  20. Lin YX, Wang Y, Blake S, Yu M, Mei L, Wang H, Shi J. RNA Nanotechnology-Mediated Cancer Immunotherapy. Theranostics. 2020; 10(1):281-299. PMID: 31903120.
    Citations: 20     Fields:    Translation:Humans
  21. Kong N, Tao W, Ling X, Wang J, Xiao Y, Shi S, Ji X, Shajii A, Gan ST, Kim NY, Duda DG, Xie T, Farokhzad OC, Shi J. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition. Sci Transl Med. 2019 12 18; 11(523). PMID: 31852795.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  22. Wang SJ, Jiang D, Zhang ZZ, Chen YR, Yang ZD, Zhang JY, Shi J, Wang X, Yu JK. Biomimetic Nanosilica-Collagen Scaffolds for In Situ Bone Regeneration: Toward a Cell-Free, One-Step Surgery. . 2019 Dec; 31(49):e1904341. PMID: 31621958.
    Citations: 22     Translation:AnimalsCells
  23. Guo Z, Ouyang J, Kim NY, Shi J, Ji X. Emerging Two-Dimensional Nanomaterials for Cancer Therapy. Chemphyschem. 2019 10 02; 20(19):2417-2433. PMID: 31342629.
    Citations: 2     Fields:    Translation:Humans
  24. Tao W, Wang J, Parak WJ, Farokhzad OC, Shi J. Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications. ACS Nano. 2019 05 28; 13(5):4876-4882. PMID: 30985108.
    Citations: 7     Fields:    
  25. Zhang ZZ, Chen YR, Wang SJ, Zhao F, Wang XG, Yang F, Shi JJ, Ge ZG, Ding WY, Yang YC, Zou TQ, Zhang JY, Yu JK, Jiang D. Orchestrated biomechanical, structural, and biochemical stimuli for engineering anisotropic meniscus. Sci Transl Med. 2019 04 10; 11(487). PMID: 30971451.
    Citations: 13     Fields:    Translation:AnimalsCells
  26. Lin YX, Wang Y, An HW, Qi B, Wang J, Wang L, Shi J, Mei L, Wang H. Peptide-Based Autophagic Gene and Cisplatin Co-delivery Systems Enable Improved Chemotherapy Resistance. . 2019 05 08; 19(5):2968-2978. PMID: 30924343.
    Citations: 10     Translation:HumansAnimalsCells
  27. Zheng M, Jiang T, Yang W, Zou Y, Wu H, Liu X, Zhu F, Qian R, Ling D, McDonald K, Shi J, Shi B. The siRNAsome: A Cation-Free and Versatile Nanostructure for siRNA and Drug Co-delivery. Angew Chem Int Ed Engl. 2019 04 01; 58(15):4938-4942. PMID: 30737876.
    Citations: 5     Fields:    Translation:HumansCells
  28. Yu M, Ortega CA, Si K, Molinaro R, Schoen FJ, Leitao RFC, Xu X, Mahmoudi M, Ahn S, Liu J, Saw PE, Lee IH, Brayner MMB, Lotfi A, Shi J, Libby P, Jon S, Farokhzad OC. Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery. Theranostics. 2018; 8(21):6008-6024. PMID: 30613278.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  29. Xu X, Wu J, Liu S, Saw PE, Tao W, Li Y, Krygsman L, Yegnasubramanian S, De Marzo AM, Shi J, Bieberich CJ, Farokhzad OC. Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy. Small. 2018 10; 14(41):e1802565. PMID: 30230235.
    Citations: 12     Fields:    Translation:HumansCells
  30. Islam MA, Xu Y, Tao W, Ubellacker JM, Lim M, Aum D, Lee GY, Zhou K, Zope H, Yu M, Cao W, Oswald JT, Dinarvand M, Mahmoudi M, Langer R, Kantoff PW, Farokhzad OC, Zetter BR, Shi J. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Nat Biomed Eng. 2018 11; 2(11):850-864. PMID: 31015614.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  31. Xiong Q, Lee GY, Ding J, Li W, Shi J. Biomedical applications of mRNA nanomedicine. Nano Res. 2018 Oct; 11(10):5281-5309. PMID: 31007865.
    Citations: 18     
  32. Ji X, Kong N, Wang J, Li W, Xiao Y, Gan ST, Zhang Y, Li Y, Song X, Xiong Q, Shi S, Li Z, Tao W, Zhang H, Mei L, Shi J. A Novel Top-Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging-Guided Cancer Therapy. . 2018 Jul 18; e1803031. PMID: 30019786.
    Citations: 32     
  33. Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Lippard SJ, Farokhzad OC, Shi J, Wu J. Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. . 2018 07 11; 18(7):4618-4625. PMID: 29902013.
    Citations: 14     Translation:HumansAnimalsCells
  34. Liu Y, Ji X, Tong WWL, Askhatova D, Yang T, Cheng H, Wang Y, Shi J. Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy. Angew Chem Int Ed Engl. 2018 02 05; 57(6):1510-1513. PMID: 29276823.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. Liu Y, Ji X, Liu J, Tong WWL, Askhatova D, Shi J. Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy. Adv Funct Mater. 2017 Oct 19; 27(39). PMID: 29290753.
    Citations: 6     
  36. Yu M, Amengual J, Menon A, Kamaly N, Zhou F, Xu X, Saw PE, Lee SJ, Si K, Ortega CA, Choi WI, Lee IH, Bdour Y, Shi J, Mahmoudi M, Jon S, Fisher EA, Farokhzad OC. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice. Adv Healthc Mater. 2017 Oct; 6(20). PMID: 28730752.
    Citations: 13     Fields:    Translation:AnimalsCells
  37. Tao W, Ji X, Xu X, Islam MA, Li Z, Chen S, Saw PE, Zhang H, Bharwani Z, Guo Z, Shi J, Farokhzad OC. Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy. Angew Chem Int Ed Engl. 2017 09 18; 56(39):11896-11900. PMID: 28640986.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  38. Xu X, Saw PE, Tao W, Li Y, Ji X, Bhasin S, Liu Y, Ayyash D, Rasmussen J, Huo M, Shi J, Farokhzad OC. ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy. . 2017 Sep; 29(33). PMID: 28681981.
    Citations: 30     Translation:Humans
  39. Xu X, Saw PE, Tao W, Li Y, Ji X, Yu M, Mahmoudi M, Rasmussen J, Ayyash D, Zhou Y, Farokhzad OC, Shi J. Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy. . 2017 07 12; 17(7):4427-4435. PMID: 28636389.
    Citations: 29     Translation:HumansAnimalsCells
  40. Zhu X, Tao W, Liu D, Wu J, Guo Z, Ji X, Bharwani Z, Zhao L, Zhao X, Farokhzad OC, Shi J. Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo. Theranostics. 2017; 7(7):1990-2002. PMID: 28638484.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  41. Xu X, Wu J, Liu Y, Saw PE, Tao W, Yu M, Zope H, Si M, Victorious A, Rasmussen J, Ayyash D, Farokhzad OC, Shi J. Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy. ACS Nano. 2017 03 28; 11(3):2618-2627. PMID: 28240870.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  42. Liu Y, Ai K, Ji X, Askhatova D, Du R, Lu L, Shi J. Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke. J Am Chem Soc. 2017 01 18; 139(2):856-862. PMID: 27997170.
    Citations: 49     Fields:    Translation:Animals
  43. Shi J, Kantoff PW, Wooster R, Farokhzad OC. Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2017 01; 17(1):20-37. PMID: 27834398.
    Citations: 667     Fields:    Translation:Humans
  44. Tao W, Zhu X, Yu X, Zeng X, Xiao Q, Zhang X, Ji X, Wang X, Shi J, Zhang H, Mei L. Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics. . 2017 Jan; 29(1). PMID: 27797119.
    Citations: 92     Translation:Humans
  45. Liu Y, Gunda V, Zhu X, Xu X, Wu J, Askhatova D, Farokhzad OC, Parangi S, Shi J. Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7750-5. PMID: 27342857.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  46. Xu X, Wu J, Liu Y, Yu M, Zhao L, Zhu X, Bhasin S, Li Q, Ha E, Shi J, Farokhzad OC. Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy. Angew Chem Int Ed Engl. 2016 06 13; 55(25):7091-7094. PMID: 27140428.
    Citations: 37     Fields:    Translation:HumansCells
  47. Xu Y, Yang W, Shi J, Zetter BR. Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein. J Mol Cell Biol. 2016 06; 8(3):282-5. PMID: 27025967.
    Citations: 3     Fields:    Translation:HumansCells
  48. Zhu X, Wu J, Shan W, Tao W, Zhao L, Lim JM, D'Ortenzio M, Karnik R, Huang Y, Shi J, Farokhzad OC. Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins. Angew Chem Int Ed Engl. 2016 Mar 01; 55(10):3309-12. PMID: 26846161.
    Citations: 13     Fields:    Translation:HumansCells
  49. Yu M, Wu J, Shi J, Farokhzad OC. Nanotechnology for protein delivery: Overview and perspectives. J Control Release. 2016 10 28; 240:24-37. PMID: 26458789.
    Citations: 41     Fields:    Translation:HumansAnimals
  50. Islam MA, Reesor EK, Xu Y, Zope HR, Zetter BR, Shi J. Biomaterials for mRNA delivery. Biomater Sci. 2015 Dec; 3(12):1519-33. PMID: 26280625.
    Citations: 40     Fields:    Translation:Humans
  51. Wu J, Zhao L, Xu X, Bertrand N, Choi WI, Yameen B, Shi J, Shah V, Mulvale M, MacLean JL, Farokhzad OC. Hydrophobic Cysteine Poly(disulfide)-based Redox-Hypersensitive Nanoparticle Platform for Cancer Theranostics. Angew Chem Int Ed Engl. 2015 Aug 03; 54(32):9218-23. PMID: 26119453.
    Citations: 15     Fields:    Translation:HumansCells
  52. Mitragotri S, Anderson DG, Chen X, Chow EK, Ho D, Kabanov AV, Karp JM, Kataoka K, Mirkin CA, Petrosko SH, Shi J, Stevens MM, Sun S, Teoh S, Venkatraman SS, Xia Y, Wang S, Gu Z, Xu C. Accelerating the Translation of Nanomaterials in Biomedicine. ACS Nano. 2015 Jul 28; 9(7):6644-54. PMID: 26115196.
    Citations: 51     Fields:    
  53. Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH. VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science. 2015 Jun 19; 348(6241):aaa8205. PMID: 26089520.
    Citations: 144     Fields:    Translation:AnimalsCellsPHPublic Health
  54. Zhu X, Xu Y, Solis LM, Tao W, Wang L, Behrens C, Xu X, Zhao L, Liu D, Wu J, Zhang N, Wistuba II, Farokhzad OC, Zetter BR, Shi J. Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7779-84. PMID: 26056316.
    Citations: 39     Fields:    Translation:Humans
  55. Choi WI, Kamaly N, Riol-Blanco L, Lee IH, Wu J, Swami A, Vilos C, Yameen B, Yu M, Shi J, Tabas I, von Andrian UH, Jon S, Farokhzad OC. A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins. Nano Lett. 2014 Nov 12; 14(11):6449-55. PMID: 25333768.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  56. Zhu X, Radovic-Moreno AF, Wu J, Langer R, Shi J. Nanomedicine in the Management of Microbial Infection - Overview and Perspectives. Nano Today. 2014 Aug 01; 9(4):478-498. PMID: 25267927.
    Citations: 49     
  57. Wu J, Kamaly N, Shi J, Zhao L, Xiao Z, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW, Farokhzad OC. Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8975-9. PMID: 24990548.
    Citations: 28     Fields:    
  58. Swami A, Reagan MR, Basto P, Mishima Y, Kamaly N, Glavey S, Zhang S, Moschetta M, Seevaratnam D, Zhang Y, Liu J, Memarzadeh M, Wu J, Manier S, Shi J, Bertrand N, Lu ZN, Nagano K, Baron R, Sacco A, Roccaro AM, Farokhzad OC, Ghobrial IM. Engineered nanomedicine for myeloma and bone microenvironment targeting. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10287-92. PMID: 24982170.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  59. Yameen B, Choi WI, Vilos C, Swami A, Shi J, Farokhzad OC. Insight into nanoparticle cellular uptake and intracellular targeting. J Control Release. 2014 Sep 28; 190:485-99. PMID: 24984011.
    Citations: 135     Fields:    Translation:HumansCells
  60. Gadde S, Even-Or O, Kamaly N, Hasija A, Gagnon PG, Adusumilli KH, Erakovic A, Pal AK, Zhang XQ, Kolishetti N, Shi J, Fisher EA, Farokhzad OC. Development of therapeutic polymeric nanoparticles for the resolution of inflammation. Adv Healthc Mater. 2014 Sep; 3(9):1448-1456. PMID: 24659608.
    Citations: 10     Fields:    Translation:Animals
  61. Shi J, Xu Y, Xu X, Zhu X, Pridgen E, Wu J, Votruba AR, Swami A, Zetter BR, Farokhzad OC. Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing. Nanomedicine. 2014 Jul; 10(5):897-900. PMID: 24650883.
    Citations: 13     Fields:    Translation:HumansCells
  62. Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK. Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine. 2014 May 19; 32(24):2882-95. PMID: 24593999.
    Citations: 49     Fields:    Translation:AnimalsCells
  63. Xu X, Xie K, Zhang XQ, Pridgen EM, Park GY, Cui DS, Shi J, Wu J, Kantoff PW, Lippard SJ, Langer R, Walker GC, Farokhzad OC. Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18638-43. PMID: 24167294.
    Citations: 82     Fields:    Translation:HumansCells
  64. Xiao Z, Ji C, Shi J, Pridgen EM, Frieder J, Wu J, Farokhzad OC. DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed Engl. 2012 Nov 19; 51(47):11853-7. PMID: 23081716.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  65. Xiao Z, Levy-Nissenbaum E, Alexis F, Lupták A, Teply BA, Chan JM, Shi J, Digga E, Cheng J, Langer R, Farokhzad OC. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano. 2012 Jan 24; 6(1):696-704. PMID: 22214176.
    Citations: 45     Fields:    Translation:HumansCells
  66. Shi J, Xiao Z, Votruba AR, Vilos C, Farokhzad OC. Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering RNA delivery. Angew Chem Int Ed Engl. 2011 Jul 25; 50(31):7027-31. PMID: 21698724.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  67. Shi J, Xiao Z, Kamaly N, Farokhzad OC. Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation. Acc Chem Res. 2011 Oct 18; 44(10):1123-34. PMID: 21692448.
    Citations: 104     Fields:    Translation:HumansAnimals
  68. Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett. 2010 Sep 08; 10(9):3223-30. PMID: 20726522.
    Citations: 233     Fields:    
  69. Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR, Langer R, von Andrian U, Farokhzad OC. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine (Lond). 2010 Feb; 5(2):269-85. PMID: 20148638.
    Citations: 51     Fields:    Translation:HumansAnimalsPHPublic Health
  70. Gao W, Xiao Z, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC. Progress in siRNA delivery using multifunctional nanoparticles. Methods Mol Biol. 2010; 629:53-67. PMID: 20387142.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  71. Shi J, Yang T, Cremer PS. Multiplexing ligand-receptor binding measurements by chemically patterning microfluidic channels. Anal Chem. 2008 Aug 01; 80(15):6078-84. PMID: 18570383.
    Citations: 8     Fields:    Translation:AnimalsCells
  72. Shi J, Chen J, Cremer PS. Sub-100 nm patterning of supported bilayers by nanoshaving lithography. J Am Chem Soc. 2008 Mar 05; 130(9):2718-9. PMID: 18257567.
    Citations: 15     Fields:    
  73. Jung H, Yang T, Lasagna MD, Shi J, Reinhart GD, Cremer PS. Impact of hapten presentation on antibody binding at lipid membrane interfaces. Biophys J. 2008 Apr 15; 94(8):3094-103. PMID: 18199665.
    Citations: 14     Fields:    Translation:Cells
  74. Shi J, Yang T, Kataoka S, Zhang Y, Diaz AJ, Cremer PS. GM1 clustering inhibits cholera toxin binding in supported phospholipid membranes. J Am Chem Soc. 2007 May 09; 129(18):5954-61. PMID: 17429973.
    Citations: 61     Fields:    Translation:Cells
  75. Shi J, Yan R, Zhu Y, Zhang X. Determination of NH(3) gas by combination of nanosized LaCoO(3) converter with chemiluminescence detector. Talanta. 2003 Oct 17; 61(2):157-64. PMID: 18969174.
    Citations: 1     Fields:    
  76. Zhang C, Zhang Z, Yu B, Shi J, Zhang X. Application of the biological conjugate between antibody and colloid Au nanoparticles as analyte to inductively coupled plasma mass spectrometry. Anal Chem. 2002 Jan 01; 74(1):96-9. PMID: 11795824.
    Citations: 12     Fields:    Translation:HumansAnimals
  77. Zhu Y, Shi J, Zhang Z, Zhang C, Zhang X. Development of a gas sensor utilizing chemiluminescence on nanosized titanium dioxide. Anal Chem. 2002 Jan 01; 74(1):120-4. PMID: 11795779.
    Citations: 9     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.