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Jinjun Shi, Ph.D.

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Biography
2011
NIH Pathway to Independence Award (K99/R00)
2013
Movember-PCF Challenge Award
2014
PCF Young Investigator Award
2018
DoD LCRP Concept Award

Overview
Our research involves a highly interdisciplinary combination of nanotechnology, biomaterials, drug delivery, and immunotherapy. In particular, we are interested in i) RNAi nanotechnology for gene silencing; ii) mRNA delivery for restoration of tumor suppressors; iii) nanoparticle co-delivery of antigens and adjuvants for effective vaccination; and iv) development of stimuli-responsive nanomaterials and bioinspired antioxidative polymers.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL127464 (TABAS, IRA A) Jan 1, 2016 - Dec 31, 2019
    NIH/NHLBI
    Enhancing Inflammation Resolution in Atherosclerosis via Targeted Nanoparticle-Mediated Delivery of Biologics
    Role: Co-Principal Investigator
  2. R01CA200900 (SHI, JINJUN) Dec 21, 2015 - Nov 30, 2020
    NIH/NCI
    Systemic RNA Delivery to Tumors
    Role: Principal Investigator
  3. R00CA160350 (SHI, JINJUN) Aug 1, 2013 - Jul 31, 2016
    NIH/NCI
    Nanoparticle Co-delivery of RNAi and Chemotherapy for Multidrug Resistant Cancers
    Role: Principal Investigator
  4. K99CA160350 (SHI, JINJUN) Aug 1, 2011 - Jul 31, 2013
    NIH/NCI
    Nanoparticle Co-delivery of RNAi and Chemotherapy for Multidrug Resistant Cancers
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tao W, Wang J, Parak WJ, Farokhzad OC, Shi J. Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications. ACS Nano. 2019 May 28; 13(5):4876-4882. PMID: 30985108.
    Citations:    
  2. Zhang ZZ, Chen YR, Wang SJ, Zhao F, Wang XG, Yang F, Shi JJ, Ge ZG, Ding WY, Yang YC, Zou TQ, Zhang JY, Yu JK, Jiang D. Orchestrated biomechanical, structural, and biochemical stimuli for engineering anisotropic meniscus. Sci Transl Med. 2019 Apr 10; 11(487). PMID: 30971451.
    Citations:    
  3. Lin YX, Wang Y, An HW, Qi B, Wang J, Wang L, Shi J, Mei L, Wang H. Peptide-Based Autophagic Gene and Cisplatin Co-delivery Systems Enable Improved Chemotherapy Resistance. Nano Lett. 2019 05 08; 19(5):2968-2978. PMID: 30924343.
    Citations:    
  4. Zheng M, Jiang T, Yang W, Zou Y, Wu H, Liu X, Zhu F, Qian R, Ling D, McDonald K, Shi J, Shi B. The siRNAsome: A Cation-Free and Versatile Nanostructure for siRNA and Drug Co-delivery. Angew Chem Int Ed Engl. 2019 Apr 01; 58(15):4938-4942. PMID: 30737876.
    Citations:    
  5. Yu M, Ortega CA, Si K, Molinaro R, Schoen FJ, Leitao RFC, Xu X, Mahmoudi M, Ahn S, Liu J, Saw PE, Lee IH, Brayner MMB, Lotfi A, Shi J, Libby P, Jon S, Farokhzad OC. Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery. Theranostics. 2018; 8(21):6008-6024. PMID: 30613278.
    Citations:    Fields:    
  6. Islam MA, Xu Y, Tao W, Ubellacker JM, Lim M, Aum D, Lee GY, Zhou K, Zope H, Yu M, Cao W, Oswald JT, Dinarvand M, Mahmoudi M, Langer R, Kantoff PW, Farokhzad OC, Zetter BR, Shi J. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Nat Biomed Eng. 2018 Nov; 2(11):850-864. PMID: 31015614.
    Citations:    
  7. Xu X, Wu J, Liu S, Saw PE, Tao W, Li Y, Krygsman L, Yegnasubramanian S, De Marzo AM, Shi J, Bieberich CJ, Farokhzad OC. Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy. Small. 2018 Oct; 14(41):e1802565. PMID: 30230235.
    Citations:    
  8. Xiong Q, Lee GY, Ding J, Li W, Shi J. Biomedical applications of mRNA nanomedicine. Nano Res. 2018 Oct; 11(10):5281-5309. PMID: 31007865.
    Citations:    
  9. Ji X, Kong N, Wang J, Li W, Xiao Y, Gan ST, Zhang Y, Li Y, Song X, Xiong Q, Shi S, Li Z, Tao W, Zhang H, Mei L, Shi J. A Novel Top-Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging-Guided Cancer Therapy. Adv Mater. 2018 Jul 18; e1803031. PMID: 30019786.
    Citations: 1     Fields:    
  10. Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Lippard SJ, Farokhzad OC, Shi J, Wu J. Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. Nano Lett. 2018 07 11; 18(7):4618-4625. PMID: 29902013.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Liu Y, Ji X, Tong WWL, Askhatova D, Yang T, Cheng H, Wang Y, Shi J. Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy. Angew Chem Int Ed Engl. 2018 02 05; 57(6):1510-1513. PMID: 29276823.
    Citations:    Fields:    
  12. Liu Y, Ji X, Liu J, Tong WWL, Askhatova D, Shi J. Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy. Adv Funct Mater. 2017 Oct 19; 27(39). PMID: 29290753.
    Citations:    
  13. Yu M, Amengual J, Menon A, Kamaly N, Zhou F, Xu X, Saw PE, Lee SJ, Si K, Ortega CA, Choi WI, Lee IH, Bdour Y, Shi J, Mahmoudi M, Jon S, Fisher EA, Farokhzad OC. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice. Adv Healthc Mater. 2017 Oct; 6(20). PMID: 28730752.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Tao W, Ji X, Xu X, Islam MA, Li Z, Chen S, Saw PE, Zhang H, Bharwani Z, Guo Z, Shi J, Farokhzad OC. Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy. Angew Chem Int Ed Engl. 2017 09 18; 56(39):11896-11900. PMID: 28640986.
    Citations: 14     Fields:    
  15. Xu X, Saw PE, Tao W, Li Y, Ji X, Bhasin S, Liu Y, Ayyash D, Rasmussen J, Huo M, Shi J, Farokhzad OC. ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy. Adv Mater. 2017 Sep; 29(33). PMID: 28681981.
    Citations: 4     Fields:    Translation:Humans
  16. Xu X, Saw PE, Tao W, Li Y, Ji X, Yu M, Mahmoudi M, Rasmussen J, Ayyash D, Zhou Y, Farokhzad OC, Shi J. Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy. Nano Lett. 2017 07 12; 17(7):4427-4435. PMID: 28636389.
    Citations: 5     Fields:    
  17. Zhu X, Tao W, Liu D, Wu J, Guo Z, Ji X, Bharwani Z, Zhao L, Zhao X, Farokhzad OC, Shi J. Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo. Theranostics. 2017; 7(7):1990-2002. PMID: 28638484.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Xu X, Wu J, Liu Y, Saw PE, Tao W, Yu M, Zope H, Si M, Victorious A, Rasmussen J, Ayyash D, Farokhzad OC, Shi J. Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy. ACS Nano. 2017 03 28; 11(3):2618-2627. PMID: 28240870.
    Citations: 7     Fields:    
  19. Liu Y, Ai K, Ji X, Askhatova D, Du R, Lu L, Shi J. Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke. J Am Chem Soc. 2017 01 18; 139(2):856-862. PMID: 27997170.
    Citations: 8     Fields:    Translation:Animals
  20. Shi J, Kantoff PW, Wooster R, Farokhzad OC. Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2017 01; 17(1):20-37. PMID: 27834398.
    Citations: 123     Fields:    Translation:Humans
  21. Tao W, Zhu X, Yu X, Zeng X, Xiao Q, Zhang X, Ji X, Wang X, Shi J, Zhang H, Mei L. Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics. Adv Mater. 2017 Jan; 29(1). PMID: 27797119.
    Citations: 27     Fields:    Translation:Humans
  22. Liu Y, Gunda V, Zhu X, Xu X, Wu J, Askhatova D, Farokhzad OC, Parangi S, Shi J. Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7750-5. PMID: 27342857.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  23. Xu X, Wu J, Liu Y, Yu M, Zhao L, Zhu X, Bhasin S, Li Q, Ha E, Shi J, Farokhzad OC. Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy. Angew Chem Int Ed Engl. 2016 06 13; 55(25):7091-7094. PMID: 27140428.
    Citations: 11     Fields:    Translation:HumansCells
  24. Xu Y, Yang W, Shi J, Zetter BR. Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein. J Mol Cell Biol. 2016 06; 8(3):282-5. PMID: 27025967.
    Citations: 1     Fields:    Translation:HumansCells
  25. Zhu X, Wu J, Shan W, Tao W, Zhao L, Lim JM, D'Ortenzio M, Karnik R, Huang Y, Shi J, Farokhzad OC. Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins. Angew Chem Int Ed Engl. 2016 Mar 01; 55(10):3309-12. PMID: 26846161.
    Citations: 7     Fields:    Translation:HumansCells
  26. Yu M, Wu J, Shi J, Farokhzad OC. Nanotechnology for protein delivery: Overview and perspectives. J Control Release. 2016 10 28; 240:24-37. PMID: 26458789.
    Citations: 5     Fields:    Translation:HumansAnimals
  27. Islam MA, Reesor EK, Xu Y, Zope HR, Zetter BR, Shi J. Biomaterials for mRNA delivery. Biomater Sci. 2015 Dec; 3(12):1519-33. PMID: 26280625.
    Citations: 11     Fields:    Translation:Humans
  28. Wu J, Zhao L, Xu X, Bertrand N, Choi WI, Yameen B, Shi J, Shah V, Mulvale M, MacLean JL, Farokhzad OC. Hydrophobic Cysteine Poly(disulfide)-based Redox-Hypersensitive Nanoparticle Platform for Cancer Theranostics. Angew Chem Int Ed Engl. 2015 Aug 03; 54(32):9218-23. PMID: 26119453.
    Citations: 4     Fields:    Translation:HumansCells
  29. Mitragotri S, Anderson DG, Chen X, Chow EK, Ho D, Kabanov AV, Karp JM, Kataoka K, Mirkin CA, Petrosko SH, Shi J, Stevens MM, Sun S, Teoh S, Venkatraman SS, Xia Y, Wang S, Gu Z, Xu C. Accelerating the Translation of Nanomaterials in Biomedicine. ACS Nano. 2015 Jul 28; 9(7):6644-54. PMID: 26115196.
    Citations: 20     Fields:    
  30. Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH. VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science. 2015 Jun 19; 348(6241):aaa8205. PMID: 26089520.
    Citations: 72     Fields:    Translation:AnimalsCellsPHPublic Health
  31. Zhu X, Xu Y, Solis LM, Tao W, Wang L, Behrens C, Xu X, Zhao L, Liu D, Wu J, Zhang N, Wistuba II, Farokhzad OC, Zetter BR, Shi J. Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7779-84. PMID: 26056316.
    Citations: 23     Fields:    Translation:Humans
  32. Choi WI, Kamaly N, Riol-Blanco L, Lee IH, Wu J, Swami A, Vilos C, Yameen B, Yu M, Shi J, Tabas I, von Andrian UH, Jon S, Farokhzad OC. A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins. Nano Lett. 2014 Nov 12; 14(11):6449-55. PMID: 25333768.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  33. Zhu X, Radovic-Moreno AF, Wu J, Langer R, Shi J. Nanomedicine in the Management of Microbial Infection - Overview and Perspectives. Nano Today. 2014 Aug 01; 9(4):478-498. PMID: 25267927.
    Citations: 17     
  34. Wu J, Kamaly N, Shi J, Zhao L, Xiao Z, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW, Farokhzad OC. Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8975-9. PMID: 24990548.
    Citations: 16     Fields:    
  35. Swami A, Reagan MR, Basto P, Mishima Y, Kamaly N, Glavey S, Zhang S, Moschetta M, Seevaratnam D, Zhang Y, Liu J, Memarzadeh M, Wu J, Manier S, Shi J, Bertrand N, Lu ZN, Nagano K, Baron R, Sacco A, Roccaro AM, Farokhzad OC, Ghobrial IM. Engineered nanomedicine for myeloma and bone microenvironment targeting. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10287-92. PMID: 24982170.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  36. Yameen B, Choi WI, Vilos C, Swami A, Shi J, Farokhzad OC. Insight into nanoparticle cellular uptake and intracellular targeting. J Control Release. 2014 Sep 28; 190:485-99. PMID: 24984011.
    Citations: 42     Fields:    Translation:HumansCells
  37. Gadde S, Even-Or O, Kamaly N, Hasija A, Gagnon PG, Adusumilli KH, Erakovic A, Pal AK, Zhang XQ, Kolishetti N, Shi J, Fisher EA, Farokhzad OC. Development of therapeutic polymeric nanoparticles for the resolution of inflammation. Adv Healthc Mater. 2014 Sep; 3(9):1448-1456. PMID: 24659608.
    Citations: 7     Fields:    Translation:Animals
  38. Shi J, Xu Y, Xu X, Zhu X, Pridgen E, Wu J, Votruba AR, Swami A, Zetter BR, Farokhzad OC. Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing. Nanomedicine. 2014 Jul; 10(5):897-900. PMID: 24650883.
    Citations: 9     Fields:    Translation:HumansCells
  39. Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK. Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine. 2014 May 19; 32(24):2882-95. PMID: 24593999.
    Citations: 25     Fields:    Translation:AnimalsCells
  40. Xu X, Xie K, Zhang XQ, Pridgen EM, Park GY, Cui DS, Shi J, Wu J, Kantoff PW, Lippard SJ, Langer R, Walker GC, Farokhzad OC. Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18638-43. PMID: 24167294.
    Citations: 40     Fields:    Translation:HumansCells
  41. Xiao Z, Ji C, Shi J, Pridgen EM, Frieder J, Wu J, Farokhzad OC. DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed Engl. 2012 Nov 19; 51(47):11853-7. PMID: 23081716.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  42. Xiao Z, Levy-Nissenbaum E, Alexis F, Lupták A, Teply BA, Chan JM, Shi J, Digga E, Cheng J, Langer R, Farokhzad OC. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano. 2012 Jan 24; 6(1):696-704. PMID: 22214176.
    Citations: 25     Fields:    Translation:HumansCells
  43. Shi J, Xiao Z, Votruba AR, Vilos C, Farokhzad OC. Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering RNA delivery. Angew Chem Int Ed Engl. 2011 Jul 25; 50(31):7027-31. PMID: 21698724.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  44. Shi J, Xiao Z, Kamaly N, Farokhzad OC. Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation. Acc Chem Res. 2011 Oct 18; 44(10):1123-34. PMID: 21692448.
    Citations: 67     Fields:    Translation:HumansAnimals
  45. Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett. 2010 Sep 08; 10(9):3223-30. PMID: 20726522.
    Citations: 132     Fields:    
  46. Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR, Langer R, von Andrian U, Farokhzad OC. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine (Lond). 2010 Feb; 5(2):269-85. PMID: 20148638.
    Citations: 36     Fields:    Translation:HumansAnimalsPHPublic Health
  47. Gao W, Xiao Z, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC. Progress in siRNA delivery using multifunctional nanoparticles. Methods Mol Biol. 2010; 629:53-67. PMID: 20387142.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  48. Shi J, Yang T, Cremer PS. Multiplexing ligand-receptor binding measurements by chemically patterning microfluidic channels. Anal Chem. 2008 Aug 01; 80(15):6078-84. PMID: 18570383.
    Citations: 8     Fields:    Translation:AnimalsCells
  49. Shi J, Chen J, Cremer PS. Sub-100 nm patterning of supported bilayers by nanoshaving lithography. J Am Chem Soc. 2008 Mar 05; 130(9):2718-9. PMID: 18257567.
    Citations: 12     Fields:    
  50. Jung H, Yang T, Lasagna MD, Shi J, Reinhart GD, Cremer PS. Impact of hapten presentation on antibody binding at lipid membrane interfaces. Biophys J. 2008 Apr 15; 94(8):3094-103. PMID: 18199665.
    Citations: 11     Fields:    Translation:Cells
  51. Shi J, Yang T, Kataoka S, Zhang Y, Diaz AJ, Cremer PS. GM1 clustering inhibits cholera toxin binding in supported phospholipid membranes. J Am Chem Soc. 2007 May 09; 129(18):5954-61. PMID: 17429973.
    Citations: 47     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.