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profileJames Woodrow Weiss, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Medicine, Gz409
330 Brookline Ave
Boston MA 02215
Phone617/667-4895
Fax617/667-1604
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Collapse overview
My career has focused on understanding the connection between exposure to intermittent or continuous hypoxia and sustained activation of the sympathetic nervous system which results in arterial hypertension. This interest has, over time, led us to patient studies of sleep apnea, investigations of normal volunteers exposed to a novel model of cyclic intermittent hypoxia (CIH), and animal studies using a rodent model of CIH. In recent years we have concentrated on understanding the mechanisms of peripheral chemoreflex plasticity and the contribution of the carotid chemoreceptor to sympathoexcitation. In particular, our laboratory now focuses on the contribution of glutamatergic transmission in the carotid body between glomus cells and between glomus cells and neurons to sustained sympathoexcitation after exposure to intermittent hypoxia. This interest reflects growing recognition that peripheral chemoreceptor plasticity is essential for a variety of forms of neurogenic hypertension.


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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL074972     (WEISS, JAMES WOODROW)May 15, 2006 - Oct 31, 2011
NIH/NHLBI
Vascular Function after Exposure of Humans to Hypoxia
Role: Principal Investigator

R13HL078328     (WEISS, JAMES W)Aug 15, 2004 - Jul 31, 2005
NIH/NHLBI
Eigth International Conference on Sleep and Breathing
Role: Principal Investigator

R01HL075184     (WEISS, JAMES WOODROW)Sep 30, 2003 - May 31, 2008
NIH/NHLBI
Cartoid Mediators of Sympathoexcitation in Sleep Apnea
Role: Principal Investigator

R01HL072648     (WEISS, JAMES WOODROW)Aug 1, 2003 - May 31, 2008
NIH/NHLBI
Time Domains of Sympathetic Activity following Hypoxia
Role: Principal Investigator

P50HL060292     (SAPER, CLIFFORD)Sep 1, 1998 - Aug 31, 2008
NIH/NHLBI
Harvard Center on Sleep Neurobiology and Sleep Apnea (SCOR)
Role: Co-Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang JW, Li AY, Guo QH, Guo YJ, Weiss JW, Ji ES. Endothelin-1 and ET receptors impair left ventricular function by mediated coronary arteries dysfunction in chronic intermittent hypoxia rats. Physiol Rep. 2017 Jan; 5(1). PMID: 28057852.
    View in: PubMed
  2. Hunt BE, Tamisier R, Gilmartin GS, Curley M, Anand A, Weiss JW. Baroreflex responsiveness during ventilatory acclimatization in humans. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1794-801. PMID: 18757487; PMCID: PMC2593498.
  3. Gilmartin GS, Tamisier R, Curley M, Weiss JW. Ventilatory, hemodynamic, sympathetic nervous system, and vascular reactivity changes after recurrent nocturnal sustained hypoxia in humans. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H778-85. PMID: 18539753; PMCID: PMC2519226.
  4. Tamisier R, Hunt BE, Gilmartin GS, Curley M, Anand A, Weiss JW. Hemodynamics and muscle sympathetic nerve activity after 8 h of sustained hypoxia in healthy humans. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3027-35. PMID: 17873026.
    View in: PubMed
  5. Thomas RJ, Tamisier R, Boucher J, Kotlar Y, Vigneault K, Weiss JW, Gilmartin G. Nocturnal hypoxia exposure with simulated altitude for 14 days does not significantly alter working memory or vigilance in humans. Sleep. 2007 Sep; 30(9):1195-203. PMID: 17910391; PMCID: PMC1978402.
  6. Loring SH, Weiss JW. Plateau pressures in the ARDSnet protocol: cause of injury or indication of disease? Am J Respir Crit Care Med. 2007 Jul 01; 176(1):99-100; author reply 100-1. PMID: 17586764.
    View in: PubMed
  7. Weiss JW, Liu MD, Huang J. Physiological basis for a causal relationship of obstructive sleep apnoea to hypertension. Exp Physiol. 2007 Jan; 92(1):21-6. PMID: 17124275.
    View in: PubMed
  8. Gilmartin G, Tamisier R, Anand A, Cunnington D, Weiss JW. Evidence of impaired hypoxic vasodilation after intermediate-duration hypoxic exposure in humans. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2173-80. PMID: 16648184.
    View in: PubMed
  9. Shapiro NI, Howell MD, Talmor D, Lahey D, Ngo L, Buras J, Wolfe RE, Weiss JW, Lisbon A. Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med. 2006 Apr; 34(4):1025-32. PMID: 16484890.
    View in: PubMed
  10. Shapiro NI, Howell MD, Talmor D, Nathanson LA, Lisbon A, Wolfe RE, Weiss JW. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med. 2005 May; 45(5):524-8. PMID: 15855951.
    View in: PubMed
  11. Thomas RJ, Rosen BR, Stern CE, Weiss JW, Kwong KK. Functional imaging of working memory in obstructive sleep-disordered breathing. J Appl Physiol (1985). 2005 Jun; 98(6):2226-34. PMID: 15677733.
    View in: PubMed
  12. Thomas RJ, Daly RW, Weiss JW. Low-concentration carbon dioxide is an effective adjunct to positive airway pressure in the treatment of refractory mixed central and obstructive sleep-disordered breathing. Sleep. 2005 Jan; 28(1):69-77. PMID: 15700722.
    View in: PubMed
  13. Tamisier R, Anand A, Nieto LM, Cunnington D, Weiss JW. Arterial pressure and muscle sympathetic nerve activity are increased after two hours of sustained but not cyclic hypoxia in healthy humans. J Appl Physiol (1985). 2005 Jan; 98(1):343-9. PMID: 15448121.
    View in: PubMed
  14. Tamisier R, Nieto L, Anand A, Cunnington D, Weiss JW. Sustained muscle sympathetic activity after hypercapnic but not hypocapnic hypoxia in normal humans. Respir Physiol Neurobiol. 2004 Jul 20; 141(2):145-55. PMID: 15239965.
    View in: PubMed
  15. Thomas RJ, Terzano MG, Parrino L, Weiss JW. Obstructive sleep-disordered breathing with a dominant cyclic alternating pattern--a recognizable polysomnographic variant with practical clinical implications. Sleep. 2004 Mar 15; 27(2):229-34. PMID: 15124715.
    View in: PubMed
  16. Tamisier R, Norman D, Anand A, Choi Y, Weiss JW. Evidence of sustained forearm vasodilatation after brief isocapnic hypoxia. J Appl Physiol (1985). 2004 May; 96(5):1782-7. PMID: 14766778.
    View in: PubMed
  17. Anand A, Remsburg-Sailor S, Launois SH, Weiss JW. Peripheral vascular resistance increases after termination of obstructive apneas. J Appl Physiol (1985). 2001 Nov; 91(5):2359-65. PMID: 11641381.
    View in: PubMed
  18. Launois SH, Averill N, Abraham JH, Kirby DA, Weiss JW. Cardiovascular responses to nonrespiratory and respiratory arousals in a porcine model. J Appl Physiol (1985). 2001 Jan; 90(1):114-20. PMID: 11133900.
    View in: PubMed
  19. Moy M, Weiss JW, Sparrow D, Israel E Schwartzstein RM. Quality of dyspnea in bronchoconstriction differs from external resistive loads. Am J. Respir Care Med. 2000; 162:451-5.
  20. Remsburg S, Launois SH, Weiss JW. Patients with obstructive sleep apnea have an abnormal peripheral vascular response to hypoxia. J Appl Physiol (1985). 1999 Sep; 87(3):1148-53. PMID: 10484589.
    View in: PubMed
  21. Kesler B, Anand A, Launois SH, Weiss JW. Drug-induced arterial pressure elevation is associated with arousal from NREM sleep in normal volunteers. J Appl Physiol (1985). 1999 Sep; 87(3):897-901. PMID: 10484555.
    View in: PubMed
  22. Weiss JW, Launois SH, Anand A, Garpestad E. Cardiovascular morbidity in obstructive sleep apnea. Prog Cardiovasc Dis. 1999 Mar-Apr; 41(5):367-76. PMID: 10406330.
    View in: PubMed
  23. Launois SH, Abraham JH, Weiss JW, Kirby DA. Patterned cardiovascular responses to sleep and nonrespiratory arousals in a porcine model. J Appl Physiol (1985). 1998 Oct; 85(4):1285-91. PMID: 9760318.
    View in: PubMed
  24. Launois SH, Tsui J, Weiss JW. Respiratory function of velopharyngeal constrictor muscles during wakefulness in normal adults. J Appl Physiol (1985). 1997 Feb; 82(2):584-91. PMID: 9049741.
    View in: PubMed
  25. Lauretano AM, Khosla RK, Richardson G, Matheson J, Weiss JW, Graham C, Fried MP. Efficacy of laser-assisted uvulopalatoplasty. Lasers Surg Med. 1997; 21(2):109-16. PMID: 9261787.
    View in: PubMed
  26. Weiss JW, Remsburg S, Garpestad E, Ringler J, Sparrow D, Parker JA. Hemodynamic consequences of obstructive sleep apnea. Sleep. 1996 Jun; 19(5):388-97. PMID: 8843530.
    View in: PubMed
  27. Launois SH, Remsburg S, Yang WJ, Weiss JW. Relationship between velopharyngeal dimensions and palatal EMG during progressive hypercapnia. J Appl Physiol (1985). 1996 Feb; 80(2):478-85. PMID: 8929587.
    View in: PubMed
  28. Kirby DA, Pinto JM, Weiss JW, Garpestad E, Zinkovska S. Effects of beta adrenergic receptor blockade on hemodynamic changes associated with obstructive sleep apnea. Physiol Behav. 1995 Nov; 58(5):919-23. PMID: 8577888.
    View in: PubMed
  29. Garpestad E, Ringler J, Parker JA, Remsburg S, Weiss JW. Sleep stage influences the hemodynamic response to obstructive apneas. Am J Respir Crit Care Med. 1995 Jul; 152(1):199-203. PMID: 7599824.
    View in: PubMed
  30. Weinberger SE, Weiss JW. Weaning from ventilatory support. N Engl J Med. 1995 Feb 09; 332(6):388-9. PMID: 7824002.
    View in: PubMed
  31. Garpestad E, Parker JA, Katayama H, Lilly J, Yasuda T, Ringler J, Strauss HW, Weiss JW. Decrease in ventricular stroke volume at apnea termination is independent of oxygen desaturation. J Appl Physiol (1985). 1994 Oct; 77(4):1602-8. PMID: 7836175.
    View in: PubMed
  32. Ringler J, Garpestad E, Basner RC, Weiss JW. Systemic blood pressure elevation after airway occlusion during NREM sleep. Am J Respir Crit Care Med. 1994 Oct; 150(4):1062-6. PMID: 7921437.
    View in: PubMed
  33. Weiss JW, Garpestad E, Parker T, Remsburg S, Ringler J. Changes in left ventricular stroke volume during obstructive apneas. Sleep. 1993 Dec; 16(8 Suppl):S39-40. PMID: 8178022.
    View in: PubMed
  34. Pinto JM, Garpestad E, Weiss JW, Bergau DM, Kirby DA. Hemodynamic changes associated with obstructive sleep apnea followed by arousal in a porcine model. J Appl Physiol (1985). 1993 Oct; 75(4):1439-43. PMID: 8282587.
    View in: PubMed
  35. Garpestad E, Katayama H, Parker JA, Ringler J, Lilly J, Yasuda T, Moore RH, Strauss HW, Weiss JW. Stroke volume and cardiac output decrease at termination of obstructive apneas. J Appl Physiol (1985). 1992 Nov; 73(5):1743-8. PMID: 1474046.
    View in: PubMed
  36. Demediuk BH, Manning H, Lilly J, Fencl V, Weinberger SE, Weiss JW, Schwartzstein RM. Dissociation between dyspnea and respiratory effort. Am Rev Respir Dis. 1992 Nov; 146(5 Pt 1):1222-5. PMID: 1443874.
    View in: PubMed
  37. Basner RC, Ringler J, Garpestad E, Schwartzstein RM, Sparrow D, Weinberger SE, Lilly J, Weiss JW. Upper airway anesthesia delays arousal from airway occlusion induced during human NREM sleep. J Appl Physiol (1985). 1992 Aug; 73(2):642-8. PMID: 1399992.
    View in: PubMed
  38. Manning HL, Brown R, Scharf SM, Leith DE, Weiss JW, Weinberger SE, Schwartzstein RM. Ventilatory and P0.1 response to hypercapnia in quadriplegia. Respir Physiol. 1992 Jul; 89(1):97-112. PMID: 1518990.
    View in: PubMed
  39. Garpestad E, Basner RC, Ringler J, Lilly J, Schwartzstein R, Weinberger SE, Weiss JW. Phenylephrine-induced hypertension acutely decreases genioglossus EMG activity in awake humans. J Appl Physiol (1985). 1992 Jan; 72(1):110-5. PMID: 1537703.
    View in: PubMed
  40. Simon PM, Basner RC, Weinberger SE, Fencl V, Weiss JW, Schwartzstein RM. Oral mucosal stimulation modulates intensity of breathlessness induced in normal subjects. Am Rev Respir Dis. 1991 Aug; 144(2):419-22. PMID: 1859070.
    View in: PubMed
  41. Manning HL, Basner R, Ringler J, Rand C, Fencl V, Weinberger SE, Weiss JW, Schwartzstein RM. Effect of chest wall vibration on breathlessness in normal subjects. J Appl Physiol (1985). 1991 Jul; 71(1):175-81. PMID: 1917740.
    View in: PubMed
  42. Findley LJ, Weiss JW, Jabour ER. Drivers with untreated sleep apnea. A cause of death and serious injury. Arch Intern Med. 1991 Jul; 151(7):1451-2. PMID: 2064498.
    View in: PubMed
  43. Basner RC, Ringler J, Schwartzstein RM, Weinberger SE, Weiss JW. Phasic electromyographic activity of the genioglossus increases in normals during slow-wave sleep. Respir Physiol. 1991 Feb; 83(2):189-200. PMID: 2068416.
    View in: PubMed
  44. Ringler J, Basner RC, Shannon R, Schwartzstein R, Manning H, Weinberger SE, Weiss JW. Hypoxemia alone does not explain blood pressure elevations after obstructive apneas. J Appl Physiol (1985). 1990 Dec; 69(6):2143-8. PMID: 2077012.
    View in: PubMed
  45. Simon PM, Schwartzstein RM, Weiss JW, Fencl V, Teghtsoonian M, Weinberger SE. Distinguishable types of dyspnea in patients with shortness of breath. Am Rev Respir Dis. 1990 Nov; 142(5):1009-14. PMID: 2240820.
    View in: PubMed
  46. Basner RC, Ringler J, Berkowitz S, Schwartzstein RM, Weinberger SE, Sparrow D, Weiss JW. Effect of inspired air temperature on genioglossus activity during nose breathing in awake humans. J Appl Physiol (1985). 1990 Sep; 69(3):1098-103. PMID: 2123177.
    View in: PubMed
  47. Schwartzstein RM, Manning HL, Weiss JW, Weinberger SE. Dyspnea: a sensory experience. Lung. 1990; 168(4):185-99. PMID: 2122135.
    View in: PubMed
  48. Weinberger SE, Schwartzstein RM, Weiss JW. Hypercapnia. N Engl J Med. 1989 Nov 02; 321(18):1223-31. PMID: 2677729.
    View in: PubMed
  49. Simon PM, Schwartzstein RM, Weiss JW, Lahive K, Fencl V, Teghtsoonian M, Weinberger SE. Distinguishable sensations of breathlessness induced in normal volunteers. Am Rev Respir Dis. 1989 Oct; 140(4):1021-7. PMID: 2508520.
    View in: PubMed
  50. Schwartzstein RM, Simon PM, Weiss JW, Fencl V, Weinberger SE. Breathlessness induced by dissociation between ventilation and chemical drive. Am Rev Respir Dis. 1989 May; 139(5):1231-7. PMID: 2523682.
    View in: PubMed
  51. Basner RC, Simon PM, Schwartzstein RM, Weinberger SE, Weiss JW. Breathing route influences upper airway muscle activity in awake normal adults. J Appl Physiol (1985). 1989 Apr; 66(4):1766-71. PMID: 2732169.
    View in: PubMed
  52. Simon PM, Pope A, Lahive K, Steinbrook RA, Schwartzstein RM, Weiss JW, Fencl V, Weinberger SE. Naloxone does not alter response to hypercapnia or resistive loading in chronic obstructive pulmonary disease. Am Rev Respir Dis. 1989 Jan; 139(1):134-8. PMID: 2643373.
    View in: PubMed
  53. Lahive KC, Weiss JW, Weinberger SE. Alpha-methyldopa selectively reduces alae nasi activity. Clin Sci (Lond). 1988 May; 74(5):547-51. PMID: 3370922.
    View in: PubMed
  54. Lahive KC, Weiss JW, Weinberger SE. Low dose aminophylline selectively increases upper airway motor activity in normals. Respir Physiol. 1988 May; 72(2):163-70. PMID: 3287534.
    View in: PubMed
  55. Schwartzstein RM, Kelleher M, Weinberger SE, Weiss JW, Drazen JM. Airway effects of monosodium glutamate in subjects with chronic stable asthma. J Asthma. 1987; 24(3):167-72. PMID: 3505530.
    View in: PubMed
  56. Blaustein AS, Risser TA, Weiss JW, Parker JA, Holman BL, McFadden ER. Mechanisms of pulsus paradoxus during resistive respiratory loading and asthma. J Am Coll Cardiol. 1986 Sep; 8(3):529-36. PMID: 3745698.
    View in: PubMed
  57. Rossing TH, Saari AF, Lazarus JM, Weiss JW. The effects of passive CO2 removal on breathing pattern in humans. Respiration. 1986; 49(2):109-13. PMID: 3081976.
    View in: PubMed
  58. Weiss ST, Tager IB, Weiss JW, Munoz A, Speizer FE, Ingram RH. Airways responsiveness in a population sample of adults and children. Am Rev Respir Dis. 1984 Jun; 129(6):898-902. PMID: 6610372.
    View in: PubMed
  59. Weiss ST, Tager IB, Weiss JW, Munoz A, Speizer FE, Ingram RH Jr. . The relationship of physican diagnosed croup or bronchiolitis to the subsequent development of bronchial responsiveness. Chest. 1984; 85S:9-10.
  60. Weiss JW, Rossing TH, McFadden ER, Ingram RH. Relationship between bronchial responsiveness to hyperventilation with cold and methacholine in asthma. J Allergy Clin Immunol. 1983 Aug; 72(2):140-4. PMID: 6350408.
    View in: PubMed
  61. Weiss JW, Rossing TH, Ingram RH. Effect of intermittent mandatory ventilation on respiratory drive and timing. Am Rev Respir Dis. 1983 Jun; 127(6):705-8. PMID: 6407372.
    View in: PubMed
  62. Weiss JW, Drazen JM, McFadden ER, Weller P, Corey EJ, Lewis RA, Austen KF. Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. JAMA. 1983 May 27; 249(20):2814-7. PMID: 6842792.
    View in: PubMed
  63. Griffin M, Weiss JW, Leitch AG, McFadden ER, Corey EJ, Austen KF, Drazen JM. Effects of leukotriene D on the airways in asthma. N Engl J Med. 1983 Feb 24; 308(8):436-9. PMID: 6823253.
    View in: PubMed
  64. Lewis RA, Lee CW, Levine L, Morgan RA, Weiss JW, Drazen JM, Oh H, Hoover D, Corey EJ, Austen KF. Biology of the C-6-sulfidopeptide leukotrienes. Adv Prostaglandin Thromboxane Leukot Res. 1983; 11:15-26. PMID: 6221518.
    View in: PubMed
  65. Johnson TS, White P, Weiss ST, Weiss JW, Weinberger SE. Endobronchial necrobiotic nodule antedating rheumatoid arthritis. Chest. 1982 Aug; 82(2):199-200. PMID: 7094653.
    View in: PubMed
  66. Weiss JW, McFadden ER, Ingram RH. Parenteral vs. inhaled atropine: density dependence of maximal expiratory flow. J Appl Physiol Respir Environ Exerc Physiol. 1982 Aug; 53(2):392-6. PMID: 7118660.
    View in: PubMed
  67. Rossing TH, Weiss JW, Breslin FJ, Ingram RH, McFadden ER. Effects of inhaled sympathomimetics on obstructive response to respiratory heat loss. J Appl Physiol Respir Environ Exerc Physiol. 1982 May; 52(5):1119-23. PMID: 7047469.
    View in: PubMed
  68. Weiss JW, Drazen JM, Coles N, McFadden ER, Weller PF, Corey EJ, Lewis RA, Austen KF. Bronchoconstrictor effects of leukotriene C in humans. Science. 1982 Apr 09; 216(4542):196-8. PMID: 7063880.
    View in: PubMed
  69. Weiss JW, McFadden ER, Ingram RH. Bronchodilatation, lung recoil, and density dependence of maximal expiratory flow. J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr; 52(4):874-8. PMID: 7085421.
    View in: PubMed
  70. Weiss JW, Drazen JM, McFadden ER, Weller PF, Corey EJ, Lewis RA, Austen KF. Comparative bronchoconstrictor effects of histamine, leukotriene C, and leukotriene D in normal human volunteers. Trans Assoc Am Physicians. 1982; 95:30-5. PMID: 7182983.
    View in: PubMed
  71. Weiss ST, Weinberger SE, Weiss JW, Johnson TS. Normal pregnancy and delivery in a woman with severe underlying lung disease. Thorax. 1981 Nov; 36(11):878-9. PMID: 7330815; PMCID: PMC471836.
  72. Weinberger SE, Weiss ST, Weiss JW, Johnson TS. Malignant transudative effusion: misleading results of pleural fluid analysis. Clin Notes Respir Dis. 1981; 20(1):13-5. PMID: 7261491.
    View in: PubMed
  73. Weinberger SE, Weiss ST, Cohen WR, Weiss JW, Johnson TS. Pregnancy and the lung. Am Rev Respir Dis. 1980 Mar; 121(3):559-81. PMID: 6998334.
    View in: PubMed
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