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profileMichael John McGeachie, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Channing Division of Network Medicine
181 Longwood Ave
Boston MA 02115
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Blighe K, Chawes BL, Kelly RS, Mirzakhani H, McGeachie M, Litonjua AA, Weiss ST, Lasky-Su JA. Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y. Am J Clin Nutr. 2017 Oct; 106(4):1092-1099. PMID: 28835366.
    View in: PubMed
  2. Busch R, Hobbs BD, Zhou J, Castaldi PJ, McGeachie MJ, Hardin ME, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Tal-Singer R, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Paré PD, Levy RD, Rennard SI, Beaty TH, Hokanson J, Silverman EK, Cho MH. Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. Am J Respir Cell Mol Biol. 2017 07; 57(1):35-46. PMID: 28170284.
    View in: PubMed
  3. McGeachie MJ. Childhood asthma is a risk factor for the development of chronic obstructive pulmonary disease. Curr Opin Allergy Clin Immunol. 2017 Apr; 17(2):104-109. PMID: 28118239.
    View in: PubMed
  4. McGeachie MJ, Davis JS, Kho AT, Dahlin A, Sordillo JE, Sun M, Lu Q, Weiss ST, Tantisira KG. Asthma remission: Predicting future airways responsiveness using an miRNA network. J Allergy Clin Immunol. 2017 Aug; 140(2):598-600.e8. PMID: 28238746.
    View in: PubMed
  5. McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 Dec 15; 194(12):1465-1474. PMID: 27367781.
    View in: PubMed
  6. Kelly RS, Croteau-Chonka DC, Dahlin A, Mirzakhani H, Wu AC, Wan ES, McGeachie MJ, Qiu W, Sordillo JE, Al-Garawi A, Gray KJ, McElrath TF, Carey VJ, Clish CB, Litonjua AA, Weiss ST, Lasky-Su JA. Integration of metabolomic and transcriptomic networks in pregnant women reveals biological pathways and predictive signatures associated with preeclampsia. Metabolomics. 2017 Jan; 13(1). PMID: 28596717.
    View in: PubMed
  7. McGeachie MJ, Clemmer GL, Croteau-Chonka DC, Castaldi PJ, Cho MH, Sordillo JE, Lasky-Su JA, Raby BA, Tantisira KG, Weiss ST. Whole genome prediction and heritability of childhood asthma phenotypes. Immun Inflamm Dis. 2016 Dec; 4(4):487-496. PMID: 27980782.
    View in: PubMed
  8. Kelly RS, Dahlin A, McGeachie MJ, Qiu W, Sordillo J, Wan ES, Wu AC, Lasky-Su J. Asthma Metabolomics and the Potential for Integrative Omics in Research and the Clinic. Chest. 2017 Feb; 151(2):262-277. PMID: 27776981.
    View in: PubMed
  9. Sordillo JE, Zhou Y, McGeachie MJ, Ziniti J, Lange N, Laranjo N, Savage JR, Carey V, O'Connor G, Sandel M, Strunk R, Bacharier L, Zeiger R, Weiss ST, Weinstock G, Gold DR, Litonjua AA. Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART). J Allergy Clin Immunol. 2017 Feb; 139(2):482-491.e14. PMID: 27746239.
    View in: PubMed
  10. Weiss ST, McGeachie MJ. Decline in Lung Function in Childhood Asthma. N Engl J Med. 2016 Aug 18; 375(7):e13. PMID: 27532852.
    View in: PubMed
  11. McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Weiss ST, Strunk RC. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med. 2016 May 12; 374(19):1842-1852. PMID: 27168434; PMCID: PMC5032024 [Available on 11/12/16].
  12. McGeachie MJ, Sordillo JE, Gibson T, Weinstock GM, Liu YY, Gold DR, Weiss ST, Litonjua A. Longitudinal Prediction of the Infant Gut Microbiome with Dynamic Bayesian Networks. Sci Rep. 2016 Feb 08; 6:20359. PMID: 26853461; PMCID: PMC4745046.
  13. Croteau-Chonka DC, Rogers AJ, Raj T, McGeachie MJ, Qiu W, Ziniti JP, Stubbs BJ, Liang L, Martinez FD, Strunk RC, Lemanske RF, Liu AH, Stranger BE, Carey VJ, Raby BA. Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation. PLoS One. 2015; 10(10):e0140758. PMID: 26474488; PMCID: PMC4608673.
  14. Dahlin A, Denny J, Roden DM, Brilliant MH, Ingram C, Kitchner TE, Linneman JG, Shaffer CM, Weeke P, Xu H, Kubo M, Tamari M, Clemmer GL, Ziniti J, McGeachie MJ, Tantisira KG, Weiss ST, Wu AC. CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids. Immun Inflamm Dis. 2015 Dec; 3(4):350-9. PMID: 26734457; PMCID: PMC4693729.
  15. McGeachie MJ, Wu AC, Tse SM, Clemmer GL, Sordillo J, Himes BE, Lasky-Su J, Chase RP, Martinez FD, Weeke P, Shaffer CM, Xu H, Denny JC, Roden DM, Panettieri RA, Raby BA, Weiss ST, Tantisira KG. CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies. J Allergy Clin Immunol. 2015 Dec; 136(6):1503-1510. PMID: 26073756.
    View in: PubMed
  16. McGeachie MJ, Dahlin A, Qiu W, Croteau-Chonka DC, Savage J, Wu AC, Wan ES, Sordillo JE, Al-Garawi A, Martinez FD, Strunk RC, Lemanske RF, Liu AH, Raby BA, Weiss S, Clish CB, Lasky-Su JA. The metabolomics of asthma control: a promising link between genetics and disease. Immun Inflamm Dis. 2015 Sep; 3(3):224-38. PMID: 26421150; PMCID: PMC4578522.
  17. Clemmer GL, Wu AC, Rosner B, McGeachie MJ, Litonjua AA, Tantisira KG, Weiss ST. Measuring the corticosteroid responsiveness endophenotype in asthmatic patients. J Allergy Clin Immunol. 2015 Aug; 136(2):274-81.e8. PMID: 25951964; PMCID: PMC4530065.
  18. Sordillo JE, Kelly R, Bunyavanich S, McGeachie M, Qiu W, Croteau-Chonka DC, Soto-Quiros M, Avila L, Celedón JC, Brehm JM, Weiss ST, Gold DR, Litonjua AA. Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity. J Allergy Clin Immunol. 2015 Oct; 136(4):885-92.e2. PMID: 25913104; PMCID: PMC4763940.
  19. McGeachie MJ, Clemmer GL, Lasky-Su J, Dahlin A, Raby BA, Weiss ST. Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases. Genom Data. 2014 Dec 01; 2:202-211. PMID: 25838990.
    View in: PubMed
  20. Chhibber A, Kroetz DL, Tantisira KG, McGeachie M, Cheng C, Plenge R, Stahl E, Sadee W, Ritchie MD, Pendergrass SA. Genomic architecture of pharmacological efficacy and adverse events. Pharmacogenomics. 2014 Dec; 15(16):2025-48. PMID: 25521360; PMCID: PMC4308414.
  21. Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10. PMID: 25315895; PMCID: PMC4806382.
  22. Naidoo D, Wu AC, Brilliant MH, Denny J, Ingram C, Kitchner TE, Linneman JG, McGeachie MJ, Roden DM, Shaffer CM, Shah A, Weeke P, Weiss ST, Xu H, Medina MW. A polymorphism in HLA-G modifies statin benefit in asthma. Pharmacogenomics J. 2015 Jun; 15(3):272-7. PMID: 25266681; PMCID: PMC4379135.
  23. McGeachie MJ, Chang HH, Weiss ST. CGBayesNets: conditional Gaussian Bayesian network learning and inference with mixed discrete and continuous data. PLoS Comput Biol. 2014 Jun; 10(6):e1003676. PMID: 24922310; PMCID: PMC4055564.
  24. Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM. Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One. 2014; 9(1):e87538. PMID: 24498130; PMCID: PMC3907548.
  25. McGeachie MJ, Stahl EA, Himes BE, Pendergrass SA, Lima JJ, Irvin CG, Peters SP, Ritchie MD, Plenge RM, Tantisira KG. Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. Pharmacogenet Genomics. 2013 Jun; 23(6):324-8. PMID: 23532052; PMCID: PMC3767309.
  26. McGeachie MJ, Wu AC, Chang HH, Lima JJ, Peters SP, Tantisira KG. Predicting inhaled corticosteroid response in asthma with two associated SNPs. Pharmacogenomics J. 2013 Aug; 13(4):306-11. PMID: 22641026; PMCID: PMC3434304.
  27. McGeachie M, Doyle J. The Local Geometry of Multiattribute Tradeoff Preferences. Artif Intell. 2011 May 01; 175(7-8):1122-1152. PMID: 21528018.
    View in: PubMed
  28. McGeachie M, Doyle J. The Local Geometry of Multiattribute Tradeoff Preferences. Artificial Intelligence. 2011; 175(7):1122-1152.
  29. Chang HH, McGeachie M. Phenotype prediction by integrative network analysis of SNP and gene expression microarrays. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:6849-52. PMID: 22255912; PMCID: PMC3343740.
  30. Chang HH, McGeachie M, Alterovitz G, Ramoni MF. Mapping transcription mechanisms from multimodal genomic data. BMC Bioinformatics. 2010 Oct 28; 11 Suppl 9:S2. PMID: 21044360; PMCID: PMC2967743.
  31. McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF. Integrative predictive model of coronary artery calcification in atherosclerosis. Circulation. 2009 Dec 15; 120(24):2448-54. PMID: 19948975; PMCID: PMC2810344.
  32. McGeachie M. Recompiling Utility Functions in a Changing World. Proceedings of the 2005 AAAI Spring Symposium: Challenges to Decision Support in a Changing World, California, USA. 2005; 80-85.
  33. McGeachie M. Intl Joint Conference on AI (2005) Multidisciplinary Workshop on Advances in Preference Handling. Integrating Tradeoffs Preferences with Arbitrary Ceteris Paribus Preferences. 2005.
  34. McGeachie M, Doyle J. Utility Functions for Ceteris Paribus Preferences. Computational Intelligence: Special Issue on Preferences in AI. 2004; 20(2):158-217.
  35. McGeachie MJ, Doyle J. Proc AAAI First Workshop on Preferences in Artificial Intelligence. Utility Functions for Ceteris Paribus Preferences. 2002.
  36. McGeachie MJ, Doyle J. Proc AAAI Eighteenth National Conference on Artificial Intelligence. Efficient Utility Functions for Ceteris Paribus Preferences. 2002; 279-284.
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