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Grace Chan, Ph.D., M.D.

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Biography
Harvard CollegeBA
Johns Hopkins School of Public HealthMPH
Harvard Medical SchoolMD
Boston Children's HospitalResidency
Johns Hopkins School of Public HealthPhD
International Centre of Diarrheal Disease Research, BangladeshPost-doc

Overview
Dr. Chan’s work focuses on global perinatal and pediatric epidemiology. She leads the HaSET research program for maternal and child health. Together with colleagues, she has established a field site in rural Ethiopia with a cohort of women and their children.

Ongoing research projects and interests focus on:
- Surveillance of maternal and child morbidity and mortality to improve disease estimates
- Risk prediction and causal modeling for pregnancy complications and adverse birth outcomes
- Development and testing of newborn care packages to improve survival of preterm and low-birth weight babies
- Etiologies of neonatal sepsis and antimicrobial resistance

Dr. Chan also serves as an attending physician in the Division of Medical Critical Care at Boston Children’s Hospital. She is also an honorary faculty member at St Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. She has mentored students and fellows as an academic advisor and dissertation committee member.

Mentoring
Available: 01/01/21, Expires: 05/31/22

Our HaSET (“happiness” in Amharic) for Mothers and Children research program works closely with partners in Ethiopia to generate evidence to improve maternal and child health programs and policies.

We are engaged in multiple studies to understand the causes of morbidity and mortality among pregnant women and children, to discover and test interventions to advance survival, and to deliver known cost-effective interventions:

  • Unaddressed morbidities remain a major cause of persistently high newborn and infant mortality. Our maternal and child health morbidity and mortality surveillance study, covering a population of 16 villages and ~80,000 people in rural Ethiopia, aims to describe the distribution of diseases among pregnant/postpartum women and their children.
  • The case-fatality among preterm newborns in Ethiopia is approximately 25%. Through an adaptive intervention study design, we are developing and testing iterative delivery models to improve KMC coverage in Ethiopia so that 80% of all preterm babies receive this life-saving intervention in a catchment of 1,000,000 people.
  • Neonatal infections account for approximately 23.4% of the world’s 3.1 million annual neonatal deaths. To better target antibiotic therapy and develop preventive interventions, we are conducting a prospective birth cohort of 5000 mother/newborns to identify etiologies of neonatal sepsis, antibiotic resistance patterns, and the association between maternal colonization and neonatal sepsis in Ethiopia.

Nested within the studies are research opportunities for students, including secondary data analysis or potential primary data collection in Ethiopia.

Maternal and Childhood Mortality Surveillance in Ethiopa
Soma Weiss, 01/02/19 - 05/28/20

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bekele D, Hunegnaw BM, Bekele C, Van Wickle K, Tadesse F, Goddard FGB, Mohammed Y, Unninayar S, Chan GJ. Cohort Profile: The Birhan Health and Demographic Surveillance System. Int J Epidemiol. 2021 Nov 09. PMID: 34751768.
    Citations:    Fields:    
  2. Chan GJ, Hunegnaw BM, Van Wickle K, Mohammed Y, Hunegnaw M, Bekele C, Goddard FGB, Tadesse F, Bekele D. Birhan maternal and child health cohort: a study protocol. BMJ Open. 2021 09 28; 11(9):e049692. PMID: 34588249.
    Citations:    Fields:    Translation:Humans
  3. Baye E, Abate FW, Eglovitch M, Shiferie F, Olson IE, Shifraw T, Kidane WT, Yibeltal K, Tsegaye S, Derebe MM, Isanaka S, Wylie BJ, Molina RL, Chan GJ, Worku A, Mullany LC, Worku A, Berhane Y, Lee ACC. Effect of birthweight measurement quality improvement on low birthweight prevalence in rural Ethiopia. Popul Health Metr. 2021 09 22; 19(1):35. PMID: 34551768.
    Citations:    Fields:    Translation:Humans
  4. Mony PK, Tadele H, Gobezayehu AG, Chan GJ, Kumar A, Mazumder S, Beyene SA, Jayanna K, Kassa DH, Mohammed HA, Estifanos AS, Kumar P, Jadaun AS, Hailu Abay T, Washington M, W/Gebriel F, Alamineh L, Fikre A, Kumar A, Trikha S, Ashebir Gebregizabher F, Kar A, Bilal SM, Belew ML, Debere MK, Krishna R, Dalpath SK, Amare SY, Mohan HL, Brune T, Sibley LM, Tariku A, Sahu A, Kumar T, Hadush MY, Gowda PD, Aziz K, Duguma D, Singh PK, Darmstadt GL, Agarwal R, Gebremariam DS, Martines J, Portela A, Jaiswal HV, Bahl R, Rao Pn S, Tadesse BT, Cranmer JN, Hailemariam D, Kumar V, Bhandari N, Medhanyie AA. Scaling up Kangaroo Mother Care in Ethiopia and India: a multi-site implementation research study. BMJ Glob Health. 2021 09; 6(9). PMID: 34518203.
    Citations: 1     Fields:    Translation:Humans
  5. Thomson KM, Dyer C, Liu F, Sands K, Portal E, Carvalho MJ, Barrell M, Boostrom I, Dunachie S, Farzana R, Ferreira A, Frayne F, Hassan B, Jones E, Jones L, Mathias J, Milton R, Rees J, Chan GJ, Bekele D, Mahlet A, Basu S, Nandy RK, Saha B, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Syed NU, Mazarati JB, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, van Hasselt JGC, Walsh TR. Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS). Lancet Infect Dis. 2021 12; 21(12):1677-1688. PMID: 34384533.
    Citations: 2     Fields:    Translation:HumansCells
  6. Solomon S, Akeju O, Odumade OA, Ambachew R, Gebreyohannes Z, Van Wickle K, Abayneh M, Metaferia G, Carvalho MJ, Thomson K, Sands K, Walsh TR, Milton R, Goddard FGB, Bekele D, Chan GJ. Prevalence and risk factors for antimicrobial resistance among newborns with gram-negative sepsis. PLoS One. 2021; 16(8):e0255410. PMID: 34343185.
    Citations: 1     Fields:    Translation:HumansCells
  7. Chan GJ, Daniel J, Getnet M, Kennedy M, Olowojesiku R, Hunegnaw BM, Unninayar S, Taddesse L, and Bekele D. Gaps in maternal, newborn, and child health research: a scoping review of 72 years in Ethiopia. Journal of Global Health Reports. 2021; 5:e2021033. View Publication.
  8. Sands K, Carvalho MJ, Portal E, Thomson K, Dyer C, Akpulu C, Andrews R, Ferreira A, Gillespie D, Hender T, Hood K, Mathias J, Milton R, Nieto M, Taiyari K, Chan GJ, Bekele D, Solomon S, Basu S, Chattopadhyay P, Mukherjee S, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Muhammad A, Mazarati JB, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, Walsh TR. Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low- and middle-income countries. Nat Microbiol. 2021 04; 6(4):512-523. PMID: 33782558.
    Citations: 16     Fields:    Translation:HumansCells
  9. Chan GJ, Getnet M, Olowojesiku R, Min-Swe T, Hunegnaw B, Bekele D. Scoping review protocol on maternal, newborn and child health research in Ethiopia. BMJ Open. 2020 07 02; 10(7):e034307. PMID: 32616486.
    Citations:    Fields:    Translation:Humans
  10. Medhanyie AA, Alemu H, Asefa A, Beyene SA, Gebregizabher FA, Aziz K, Bhandari N, Beyene H, Brune T, Chan G, Cranmer JN, Darmstadt G, Duguma D, Fikre A, Andualem BG, Gobezayehu AG, Mariam DH, Abay TH, Mohan HL, Jadaun A, Jayanna K, Kajal FNU, Kar A, Krishna R, Kumar A, Kumar V, Madhur TK, Belew ML, M R, Martines J, Mazumder S, Amin H, Mony PK, Muleta M, Pileggi-Castro C, Pn Rao S, Estifanos AS, Sibley LM, Singhal N, Tadele H, Tariku A, Lemango ET, Tadesse BT, Upadhyay R, Worku B, Hadush MY, Bahl R. Kangaroo Mother Care implementation research to develop models for accelerating scale-up in India and Ethiopia: study protocol for an adequacy evaluation. BMJ Open. 2019 11 21; 9(11):e025879. PMID: 31753865.
    Citations: 5     Fields:    Translation:Humans
  11. Uwemedimo OT, Lewis TP, Essien EA, Chan GJ, Nsona H, Kruk ME, Leslie HH. Distribution and determinants of pneumonia diagnosis using Integrated Management of Childhood Illness guidelines: a nationally representative study in Malawi. BMJ Glob Health. 2018; 3(2):e000506. PMID: 29662688.
    Citations: 15     Fields:    
  12. Chan G, Bergelson I, Smith ER, Skotnes T, Wall S. Barriers and enablers of kangaroo mother care implementation from a health systems perspective: a systematic review. Health Policy Plan. 2017 Dec 01; 32(10):1466-1475. PMID: 28973515.
    Citations: 27     Fields:    Translation:Humans
  13. Chan GJ, Bergelson I, Smith ER, Skotnes T, Wall S. Barriers and enablers of kangaroo mother care implementation from a health systems perspective: a systematic review. Health Policy and Planning. 2017. View Publication.
  14. Bekele D, Ahmed M, Ibrahim A, Kedir S, Chan G. Profile and outcomes of women with pregnancy-related acute kidney injury requiring dialysis at a center in Ethiopia. Int J Gynaecol Obstet. 2017 Aug; 138(2):138-141. PMID: 28485834.
    Citations:    Fields:    Translation:Humans
  15. Smith ER, Bergelson I, Constantian S, Valsangkar B, Chan GJ. Barriers and enablers of health system adoption of kangaroo mother care: a systematic review of caregiver perspectives. BMC Pediatr. 2017 01 25; 17(1):35. PMID: 28122592.
    Citations: 24     Fields:    Translation:Humans
  16. Mosha D, Liu E, Hertzmark E, Chan G, Sudfeld C, Masanja H, Fawzi W. Dietary iron and calcium intakes during pregnancy are associated with lower risk of prematurity, stillbirth and neonatal mortality among women in Tanzania. Public Health Nutr. 2017 03; 20(4):678-686. PMID: 27819215.
    Citations: 9     Fields:    Translation:Humans
  17. Chan GJ, Silverman M, Zaman M, Murillo-Chaves A, Mahmud A, Baqui AH, Boyd TK. Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh. J Perinatol. 2016 12; 36(12):1039-1044. PMID: 27629373.
    Citations: 2     Fields:    Translation:Humans
  18. Chan GJ, Valsangkar B, Kajeepeta S, Boundy EO, Wall S. What is kangaroo mother care? Systematic review of the literature. J Glob Health. 2016 Jun; 6(1):010701. PMID: 27231546.
    Citations: 32     Fields:    Translation:Humans
  19. Muhihi A, Sudfeld CR, Smith ER, Noor RA, Mshamu S, Briegleb C, Bakari M, Masanja H, Fawzi W, Chan GJ. Risk factors for small-for-gestational-age and preterm births among 19,269 Tanzanian newborns. BMC Pregnancy Childbirth. 2016 05 17; 16:110. PMID: 27183837.
    Citations: 21     Fields:    Translation:Humans
  20. Boundy EO, Dastjerdi R, Spiegelman D, Fawzi WW, Missmer SA, Lieberman E, Kajeepeta S, Wall S, Chan GJ. Kangaroo Mother Care and Neonatal Outcomes: A Meta-analysis. Pediatrics. 2016 Jan; 137(1). PMID: 26702029.
    Citations: 108     Fields:    Translation:Humans
  21. Chan GJ, Labar AS, Wall S, Atun R. Kangaroo mother care: a systematic review of barriers and enablers. Bull World Health Organ. 2016 Feb 01; 94(2):130-141J. PMID: 26908962.
    Citations: 42     Fields:    Translation:Humans
  22. Reisman J, Martineau N, Kairuki A, Mponzi V, Meda AR, Isangula KG, Thomas E, Plotkin M, Chan GJ, Davids L, Msemo G, Azayo M, Nelson BD. Validation of a novel tool for assessing newborn resuscitation skills among birth attendants trained by the Helping Babies Breathe program. Int J Gynaecol Obstet. 2015 Nov; 131(2):196-200. PMID: 26283225.
    Citations: 10     Fields:    Translation:Humans
  23. Chan GJ, Lee AC, Baqui AH, Tan J, Black RE. Prevalence of early-onset neonatal infection among newborns of mothers with bacterial infection or colonization: a systematic review and meta-analysis. BMC Infect Dis. 2015 Mar 07; 15:118. PMID: 25886298.
    Citations: 19     Fields:    Translation:HumansPHPublic Health
  24. Chan GJ, Stuart EA, Zaman M, Mahmud AA, Baqui AH, Black RE. The effect of intrapartum antibiotics on early-onset neonatal sepsis in Dhaka, Bangladesh: a propensity score matched analysis. BMC Pediatr. 2014 Apr 17; 14:104. PMID: 24742087.
    Citations: 2     Fields:    Translation:Humans
  25. Flynn JT, Ng DK, Chan GJ, Samuels J, Furth S, Warady B, Greenbaum LA. The effect of abnormal birth history on ambulatory blood pressure and disease progression in children with chronic kidney disease. J Pediatr. 2014 Jul; 165(1):154-162.e1. PMID: 24698454.
    Citations: 16     Fields:    Translation:Humans
  26. Chan GJ, Modak JK, Mahmud AA, Baqui AH, Black RE, Saha SK. Maternal and neonatal colonization in Bangladesh: prevalences, etiologies and risk factors. J Perinatol. 2013 Dec; 33(12):971-6. PMID: 23989196.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  27. Chan GJ, Lee AC, Baqui AH, Tan J, Black RE. Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis. PLoS Med. 2013 Aug; 10(8):e1001502. PMID: 23976885.
    Citations: 44     Fields:    Translation:HumansPHPublic Health
  28. Chan GJ, Baqui AH, Modak JK, Murillo-Chaves A, Mahmud AA, Boyd TK, Black RE, Saha SK. Early-onset neonatal sepsis in Dhaka, Bangladesh: risk associated with maternal bacterial colonisation and chorioamnionitis. Trop Med Int Health. 2013 Sep; 18(9):1057-1064. PMID: 23822861.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  29. Chan GJ, Parco KB, Sihombing ME, Tredwell SP, O'Rourke EJ. Improving health services to displaced persons in Aceh, Indonesia: a balanced scorecard. Bull World Health Organ. 2010 Sep 01; 88(9):709-12. PMID: 20865077.
    Citations: 8     Fields:    Translation:Humans
  30. Chan GJ, Moulton LH, Becker S, Muñoz A, Black RE. Non-specific effects of diphtheria tetanus pertussis vaccination on child mortality in Cebu, The Philippines. Int J Epidemiol. 2007 Oct; 36(5):1022-9. PMID: 17646186.
    Citations: 6     Fields:    Translation:Humans
  31. Glass RJ, Chan G, Rentz D. Cognitive impairment screening in second offense DUI programs. J Subst Abuse Treat. 2000 Dec; 19(4):369-73. PMID: 11166501.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.