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Lydia Lynch, Ph.D.

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Biography
2008 - 2010
UNESCO-L'Oreal International Women In Science
2009 - 2013
Marie Curie International Fellowship

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB. Distinct iNKT Cell Populations Use IFN? or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. Cell Metab. 2020 Aug 04; 32(2):243-258.e6. PMID: 32516575.
    Citations:    
  2. Clancy-Thompson E, Chen GZ, LaMarche NM, Ali LR, Jeong HJ, Crowley SJ, Boelaars K, Brenner MB, Lynch L, Dougan SK. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019 May 31. PMID: 31152007.
    Citations:    
  3. Clancy-Thompson E, Chen GZ, LaMarche NM, Ali LR, Jeong HJ, Crowley SJ, Boelaars K, Brenner MB, Lynch L, Dougan SK. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019 07 15; 38(14):e101260. PMID: 31304630.
    Citations:    
  4. O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D, Hogan AE. Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses. J Immunol. 2019 06 15; 202(12):3404-3411. PMID: 31076528.
    Citations:    
  5. Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L. Author Correction: ?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nat Immunol. 2019 Mar; 20(3):373. PMID: 30728493.
    Citations:    
  6. Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L. Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nat Immunol. 2018 12; 19(12):1330-1340. PMID: 30420624.
    Citations:    Fields:    
  7. Wu D, Hu D, Chen H, Shi G, Fetahu IS, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian CG, Murphy GF, Adler GK, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 2018 07; 559(7715):637-641. PMID: 30022161.
    Citations: 4     Fields:    
  8. Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L. ?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nat Immunol. 2018 05; 19(5):464-474. PMID: 29670241.
    Citations: 5     Fields:    
  9. Hong S, Song W, Zushin PH, Liu B, Jedrychowski MP, Mina AI, Deng Z, Cabarkapa D, Hall JA, Palmer CJ, Aliakbarian H, Szpyt J, Gygi SP, Tavakkoli A, Lynch L, Perrimon N, Banks AS. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab. 2018 06; 12:25-38. PMID: 29661693.
    Citations:    Fields:    
  10. LaMarche NM, Lynch L. Adipose Dendritic Cells Come Out of Hiding. Cell Metab. 2018 03 06; 27(3):485-486. PMID: 29514060.
    Citations:    Fields:    
  11. Prüss H, Tedeschi A, Thiriot A, Lynch L, Loughhead SM, Stutte S, Mazo IB, Kopp MA, Brommer B, Blex C, Geurtz LC, Liebscher T, Niedeggen A, Dirnagl U, Bradke F, Volz MS, DeVivo MJ, Chen Y, von Andrian UH, Schwab JM. Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex. Nat Neurosci. 2017 Nov; 20(11):1549-1559. PMID: 28920935.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Chang SK, Kohlgruber AC, Mizoguchi F, Michelet X, Wolf BJ, Wei K, Lee PY, Lynch L, Duquette D, Ceperuelo-Mallafré V, Banks AS, Brenner MB. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. J Clin Invest. 2017 Sep 01; 127(9):3300-3312. PMID: 28758901.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L. Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity. Immunity. 2017 02 21; 46(2):273-286. PMID: 28228283.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Kohlgruber AC, LaMarche NM, Lynch L. Adipose tissue at the nexus of systemic and cellular immunometabolism. Semin Immunol. 2016 10; 28(5):431-440. PMID: 27789087.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Lynch L, Hogan AE, Duquette D, Lester C, Banks A, LeClair K, Cohen DE, Ghosh A, Lu B, Corrigan M, Stevanovic D, Maratos-Flier E, Drucker DJ, O'Shea D, Brenner M. iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metab. 2016 09 13; 24(3):510-519. PMID: 27593966.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  16. Longchamp A, Tao M, Bartelt A, Ding K, Lynch L, Hine C, Corpataux JM, Kristal BS, Mitchell JR, Ozaki CK. Surgical injury induces local and distant adipose tissue browning. Adipocyte. 2016 Apr-Jun; 5(2):163-74. PMID: 27386152.
    Citations: 1     Fields:    
  17. Kohlgruber A, Lynch L. Adipose tissue inflammation in the pathogenesis of type 2 diabetes. Curr Diab Rep. 2015 Nov; 15(11):92. PMID: 26374569.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  18. Carolan E, Tobin LM, Mangan BA, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter DC, Doherty DG, Lynch L, O'Shea D, Hogan AE. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol. 2015 Jun 15; 194(12):5775-80. PMID: 25980010.
    Citations: 26     Fields:    Translation:HumansCells
  19. Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB. The transcriptional programs of iNKT cells. Semin Immunol. 2015 Feb; 27(1):26-32. PMID: 25841627.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  20. Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015 Jan; 16(1):85-95. PMID: 25436972.
    Citations: 93     Fields:    Translation:AnimalsCells
  21. Exley MA, Hand L, O'Shea D, Lynch L. Interplay between the immune system and adipose tissue in obesity. J Endocrinol. 2014 Nov; 223(2):R41-8. PMID: 25228503.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  22. Lynch L. Adipose invariant natural killer T cells. Immunology. 2014 Jul; 142(3):337-46. PMID: 24673647.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  23. Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1a-dependent inflammation. Diabetes. 2014 Jun; 63(6):2037-50. PMID: 24458363.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, O'Connell J, O'Shea D. Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia. 2014 Apr; 57(4):781-4. PMID: 24362727.
    Citations: 16     Fields:    Translation:Humans
  25. Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity. 2012 Sep 21; 37(3):574-87. PMID: 22981538.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  26. Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O'Farrelly C, Szekeres-Bartho J. Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy. Am J Reprod Immunol. 2012 Jan; 67(1):9-16. PMID: 21682790.
    Citations: 2     Fields:    Translation:HumansCells
  27. Exley MA, Lynch L, Varghese B, Nowak M, Alatrakchi N, Balk SP. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects. Clin Immunol. 2011 Aug; 140(2):184-95. PMID: 21646050.
    Citations: 17     Fields:    Translation:HumansCells
  28. Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clin Immunol. 2011 Sep; 140(3):229-35. PMID: 21684213.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  29. O'Connell J, Lynch L, Cawood TJ, Kwasnik A, Nolan N, Geoghegan J, McCormick A, O'Farrelly C, O'Shea D. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS One. 2010 Apr 01; 5(4):e9997. PMID: 20376319.
    Citations: 40     Fields:    Translation:HumansCells
  30. O'Donovan A, Hughes BM, Slavich GM, Lynch L, Cronin MT, O'Farrelly C, Malone KM. Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships. Brain Behav Immun. 2010 Oct; 24(7):1074-7. PMID: 20227485.
    Citations: 55     Fields:    Translation:Humans
  31. Nowak M, Lynch L, Yue S, Ohta A, Sitkovsky M, Balk SP, Exley MA. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol. 2010 Mar; 40(3):682-7. PMID: 20039304.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  32. O'Shea D, Cawood TJ, O'Farrelly C, Lynch L. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One. 2010 Jan 25; 5(1):e8660. PMID: 20107494.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  33. Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C. Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity. Eur J Immunol. 2009 Jul; 39(7):1893-901. PMID: 19585513.
    Citations: 84     Fields:    Translation:HumansCells
  34. McGrath E, Ryan EJ, Lynch L, Golden-Mason L, Mooney E, Eogan M, O'Herlihy C, O'Farrelly C. Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility. Am J Reprod Immunol. 2009 Apr; 61(4):265-76. PMID: 19260857.
    Citations: 5     Fields:    Translation:HumansCells
  35. Lynch LA, O'Connell JM, Kwasnik AK, Cawood TJ, O'Farrelly C, O'Shea DB. Are natural killer cells protecting the metabolically healthy obese patient? Obesity (Silver Spring). 2009 Mar; 17(3):601-5. PMID: 19238145.
    Citations: 55     Fields:    Translation:HumansCells
  36. Lynch L, O'Donoghue D, Dean J, O'Sullivan J, O'Farrelly C, Golden-Mason L. Detection and characterization of hemopoietic stem cells in the adult human small intestine. J Immunol. 2006 May 01; 176(9):5199-204. PMID: 16621984.
    Citations: 7     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.