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Elena F. Brachtel, M.D.

TitleAssistant Professor of Pathology
InstitutionMassachusetts General Hospital
DepartmentPathology
AddressMassachusetts General Hospital
Pathology, Warren 219
55 Fruit St
Boston MA 02114
Phone617/726-2967
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 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Dong F, Irshad H, Oh EY, Lerwill MF, Brachtel EF, Jones NC, Knoblauch NW, Montaser-Kouhsari L, Johnson NB, Rao LK, Faulkner-Jones B, Wilbur DC, Schnitt SJ, Beck AH. Computational pathology to discriminate benign from malignant intraductal proliferations of the breast. PLoS One. 2014; 9(12):e114885.
    View in: PubMed
  2. Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DA. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014 Jul 11; 345(6193):216-20.
    View in: PubMed
  3. Wang Y, Li W, Patel SS, Cong J, Zhang N, Sabbatino F, Liu X, Qi Y, Huang P, Lee H, Taghian A, Li JJ, DeLeo AB, Ferrone S, Epperly MW, Ferrone CR, Ly A, Brachtel EF, Wang X. Blocking the formation of radiation-induced breast cancer stem cells. Oncotarget. 2014 Jun 15; 5(11):3743-55.
    View in: PubMed
  4. Camp MS, Coopey SB, Tang R, Colwell A, Specht M, Greenup RA, Gadd MA, Brachtel E, Austen WG, Smith BL. Management of Positive Sub-areolar/Nipple Duct Margins in Nipple-Sparing Mastectomies. Breast J. 2014 Jul; 20(4):402-7.
    View in: PubMed
  5. Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK. Hypermutable DNA chronicles the evolution of human colon cancer. Proc Natl Acad Sci U S A. 2014 May 6; 111(18):E1889-98.
    View in: PubMed
  6. Corben AD, Abi-Raad R, Popa I, Teo CH, Macklin EA, Koerner FC, Taghian AG, Brachtel EF. Pathologic response and long-term follow-up in breast cancer patients treated with neoadjuvant chemotherapy: a comparison between classifications and their practical application. Arch Pathol Lab Med. 2013 Aug; 137(8):1074-82.
    View in: PubMed
  7. Kerr SE, Schnabel CA, Sullivan PS, Zhang Y, Huang VJ, Erlander MG, Brachtel EF, Dry SM. A 92-gene cancer classifier predicts the site of origin for neuroendocrine tumors. Mod Pathol. 2014 Jan; 27(1):44-54.
    View in: PubMed
  8. Patel MM, Lefebvre DR, Lee NG, Brachtel E, Rizzo J, Freitag SK. Gaze-evoked amaurosis from orbital breast carcinoma metastasis. Ophthal Plast Reconstr Surg. 2013 Jul-Aug; 29(4):e98-e101.
    View in: PubMed
  9. Tang R, Coopey SB, Buckley JM, Aftreth OP, Fernandez LJ, Brachtel EF, Michaelson JS, Gadd MA, Specht MC, Koerner FC, Smith BL. A pilot study evaluating shaved cavity margins with micro-computed tomography: a novel method for predicting lumpectomy margin status intraoperatively. Breast J. 2013 Sep-Oct; 19(5):485-9.
    View in: PubMed
  10. Yeshi MM, Tambouret RH, Brachtel EF. Fine-needle aspiration cytology in Ethiopia. Arch Pathol Lab Med. 2013 Jun; 137(6):791-7.
    View in: PubMed
  11. Tang R, Buckley JM, Fernandez L, Coopey S, Aftreth O, Michaelson J, Saksena M, Lei L, Specht M, Gadd M, Yagi Y, Rafferty E, Brachtel E, Smith BL. Micro-computed tomography (Micro-CT): a novel approach for intraoperative breast cancer specimen imaging. Breast Cancer Res Treat. 2013 Jun; 139(2):311-6.
    View in: PubMed
  12. Ozkumur E, Shah AM, Ciciliano JC, Emmink BL, Miyamoto DT, Brachtel E, Yu M, Chen PI, Morgan B, Trautwein J, Kimura A, Sengupta S, Stott SL, Karabacak NM, Barber TA, Walsh JR, Smith K, Spuhler PS, Sullivan JP, Lee RJ, Ting DT, Luo X, Shaw AT, Bardia A, Sequist LV, Louis DN, Maheswaran S, Kapur R, Haber DA, Toner M. Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med. 2013 Apr 3; 5(179):179ra47.
    View in: PubMed
  13. Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, Concannon KF, Donaldson MC, Sequist LV, Brachtel E, Sgroi D, Baselga J, Ramaswamy S, Toner M, Haber DA, Maheswaran S. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 2013 Feb 1; 339(6119):580-4.
    View in: PubMed
  14. Kerr SE, Schnabel CA, Sullivan PS, Zhang Y, Singh V, Carey B, Erlander MG, Highsmith WE, Dry SM, Brachtel EF. Multisite validation study to determine performance characteristics of a 92-gene molecular cancer classifier. Clin Cancer Res. 2012 Jul 15; 18(14):3952-60.
    View in: PubMed
  15. Pashtan IM, Recht A, Ancukiewicz M, Brachtel E, Abi-Raad RF, D'Alessandro HA, Levy A, Wo JY, Hirsch AE, Kachnic LA, Goldberg S, Specht M, Gadd M, Smith BL, Powell SN, Taghian AG. External beam accelerated partial-breast irradiation using 32 gy in 8 twice-daily fractions: 5-year results of a prospective study. Int J Radiat Oncol Biol Phys. 2012 Nov 1; 84(3):e271-7.
    View in: PubMed
  16. Malon C, Brachtel E, Cosatto E, Graf HP, Kurata A, Kuroda M, Meyer JS, Saito A, Wu S, Yagi Y. Mitotic figure recognition: agreement among pathologists and computerized detector. Anal Cell Pathol (Amst). 2012; 35(2):97-100.
    View in: PubMed
  17. Brachtel E, Yagi Y. Digital imaging in pathology--current applications and challenges. J Biophotonics. 2012 Apr; 5(4):327-35.
    View in: PubMed
  18. Collins LC, Marotti JD, Gelber S, Cole K, Ruddy K, Kereakoglow S, Brachtel EF, Schapira L, Come SE, Winer EP, Partridge AH. Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Res Treat. 2012 Feb; 131(3):1061-6.
    View in: PubMed
  19. Mordes DA, Brachtel EF. Cytopathology of subacute thyroiditis. Diagn Cytopathol. 2012 May; 40(5):433-4.
    View in: PubMed
  20. Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2760-5.
    View in: PubMed
  21. Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011 Aug 18; 476(7360):346-50.
    View in: PubMed
  22. Takahashi F, Chiba N, Tajima K, Hayashida T, Shimada T, Takahashi M, Moriyama H, Brachtel E, Edelman EJ, Ramaswamy S, Maheswaran S. Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib. Oncogene. 2011 Jul 7; 30(27):3084-95.
    View in: PubMed
  23. Muss HB, D'Alessandro HA, Brachtel EF. Case records of the Massachusetts General Hospital. Case 15-2010. An 85-year-old woman with mammographically detected early breast cancer. N Engl J Med. 2010 May 20; 362(20):1921-8.
    View in: PubMed
  24. Boutrus R, Abi-Raad R, Niemierko A, Brachtel EF, Rizk L, Kelada A, Taghian AG. Does lymphovascular invasion predict regional nodal failure in breast cancer patients with zero to three positive lymph nodes treated with conserving surgery and radiotherapy? Implications for regional radiation. Int J Radiat Oncol Biol Phys. 2010 Nov 1; 78(3):793-8.
    View in: PubMed
  25. Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco Md, Wijendran V, Shioda T, Sgroi D, Donahoe PK, Maheswaran S. HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1100-5.
    View in: PubMed
  26. Brachtel EF, Rusby JE, Michaelson JS, Chen LL, Muzikansky A, Smith BL, Koerner FC. Occult nipple involvement in breast cancer: clinicopathologic findings in 316 consecutive mastectomy specimens. J Clin Oncol. 2009 Oct 20; 27(30):4948-54.
    View in: PubMed
  27. Yu M, Smolen GA, Zhang J, Wittner B, Schott BJ, Brachtel E, Ramaswamy S, Maheswaran S, Haber DA. A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. Genes Dev. 2009 Aug 1; 23(15):1737-42.
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  28. Rusby JE, Brachtel EF, Othus M, Michaelson JS, Koerner FC, Smith BL. Development and validation of a model predictive of occult nipple involvement in women undergoing mastectomy. Br J Surg. 2008 Nov; 95(11):1356-61.
    View in: PubMed
  29. Rusby JE, Kirstein LJ, Brachtel EF, Michaelson JS, Koerner FC, Smith BL. Nipple-sparing mastectomy: lessons from ex vivo procedures. Breast J. 2008 Sep-Oct; 14(5):464-70.
    View in: PubMed
  30. Winer EP, Harris JR, Smith BL, D'Alessandro HA, Brachtel EF. Case records of the Massachusetts General Hospital. Case 32-2007. A 62-year-old woman with a second breast cancer. N Engl J Med. 2007 Oct 18; 357(16):1640-8.
    View in: PubMed
  31. Rusby JE, Brachtel EF, Taghian A, Michaelson JS, Koerner FC, Smith BL. George Peters Award. Microscopic anatomy within the nipple: implications for nipple-sparing mastectomy. Am J Surg. 2007 Oct; 194(4):433-7.
    View in: PubMed
  32. Brachtel EF, Iafrate AJ, Mark EJ, Deshpande V. Cytomorphological correlates of epidermal growth factor receptor mutations in lung carcinoma. Diagn Cytopathol. 2007 May; 35(5):257-62.
    View in: PubMed
  33. Rusby JE, Brachtel EF, Michaelson JS, Koerner FC, Smith BL. Breast duct anatomy in the human nipple: three-dimensional patterns and clinical implications. Breast Cancer Res Treat. 2007 Dec; 106(2):171-9.
    View in: PubMed
  34. Kawakubo H, Brachtel E, Hayashida T, Yeo G, Kish J, Muzikansky A, Walden PD, Maheswaran S. Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein. Cancer Res. 2006 Jul 15; 66(14):7075-82.
    View in: PubMed
  35. Michaels PJ, Brachtel EF, Bounds BC, Brugge WR, Pitman MB. Intraductal papillary mucinous neoplasm of the pancreas: cytologic features predict histologic grade. Cancer. 2006 Jun 25; 108(3):163-73.
    View in: PubMed
  36. Oliva E, Sarrió D, Brachtel EF, Sánchez-Estévez C, Soslow RA, Moreno-Bueno G, Palacios J. High frequency of beta-catenin mutations in borderline endometrioid tumours of the ovary. J Pathol. 2006 Apr; 208(5):708-13.
    View in: PubMed
  37. Brachtel EF, Sánchez-Estevez C, Moreno-Bueno G, Prat J, Palacios J, Oliva E. Distinct molecular alterations in complex endometrial hyperplasia (CEH) with and without immature squamous metaplasia (squamous morules). Am J Surg Pathol. 2005 Oct; 29(10):1322-9.
    View in: PubMed
  38. Ryan DP, Fernandez-del Castillo C, Willett CG, Brugge WR, Sahani D, Brachtel EF. Case records of the Massachusetts General Hospital. Case 20-2005. A 58-year-old man with locally advanced pancreatic cancer. N Engl J Med. 2005 Jun 30; 352(26):2734-41.
    View in: PubMed
  39. Krakauer EL, Zhu AX, Bounds BC, Sahani D, McDonald KR, Brachtel EF. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 6-2005. A 58-year-old man with esophageal cancer and nausea, vomiting, and intractable hiccups. N Engl J Med. 2005 Feb 24; 352(8):817-25.
    View in: PubMed
  40. Siegler G, Meyer B, Dawson C, Brachtel E, Lennerz J, Koch C, Kremmer E, Niedobitek E, Gonnella R, Pilch BZ, Young LS, Niedobitek G. Expression of tumor necrosis factor receptor-associated factor 1 in nasopharyngeal carcinoma: possible upregulation by Epstein-Barr virus latent membrane protein 1. Int J Cancer. 2004 Nov 1; 112(2):265-72.
    View in: PubMed
  41. Kawakubo H, Carey JL, Brachtel E, Gupta V, Green JE, Walden PD, Maheswaran S. Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer. Oncogene. 2004 Oct 28; 23(50):8310-9.
    View in: PubMed
  42. Heussinger N, Büttner M, Ott G, Brachtel E, Pilch BZ, Kremmer E, Niedobitek G. Expression of the Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) in EBV-associated nasopharyngeal carcinoma. J Pathol. 2004 Jun; 203(2):696-9.
    View in: PubMed
  43. Harisinghani MG, Dixon WT, Saksena MA, Brachtel E, Blezek DJ, Dhawale PJ, Torabi M, Hahn PF. MR lymphangiography: imaging strategies to optimize the imaging of lymph nodes with ferumoxtran-10. Radiographics. 2004 May-Jun; 24(3):867-78.
    View in: PubMed
  44. Hoshiya Y, Gupta V, Kawakubo H, Brachtel E, Carey JL, Sasur L, Scott A, Donahoe PK, Maheswaran S. Mullerian inhibiting substance promotes interferon gamma-induced gene expression and apoptosis in breast cancer cells. J Biol Chem. 2003 Dec 19; 278(51):51703-12.
    View in: PubMed
  45. Brachtel EF, Pilch BZ, Khettry U, Zembowicz A, Faquin WC. Fine-needle aspiration biopsy of a cystic pleomorphic adenoma with extensive adnexa-like differentiation: differential diagnostic pitfall with mucoepidermoid carcinoma. Diagn Cytopathol. 2003 Feb; 28(2):100-3.
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  46. Brachtel EF, Mascola JR, Wear DJ, Ehrenberg PK, Dayhoff DE, Sanders-Buell E, Michael NL, Frankel SS. Demonstration of de novo HIV type 1 production by detection of multiply spliced and unspliced HIV type 1 RNA in paraffin-embedded tonsils. AIDS Res Hum Retroviruses. 2002 Jul 20; 18(11):785-90.
    View in: PubMed
  47. Wu SJ, Grouard-Vogel G, Sun W, Mascola JR, Brachtel E, Putvatana R, Louder MK, Filgueira L, Marovich MA, Wong HK, Blauvelt A, Murphy GS, Robb ML, Innes BL, Birx DL, Hayes CG, Frankel SS. Human skin Langerhans cells are targets of dengue virus infection. Nat Med. 2000 Jul; 6(7):816-20.
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  48. Grundmann T, Brachtel E, Kehrl W. [Fistula between the trachea and innominate artery--a rare complication following tracheostenosis treatment with silastic tubes]. Laryngorhinootologie. 1999 Feb; 78(2):91-6.
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  49. Brachtel EF, Washiyama M, Johnson GD, Tenner-Racz K, Racz P, MacLennan IC. Differences in the germinal centres of palatine tonsils and lymph nodes. Scand J Immunol. 1996 Mar; 43(3):239-47.
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  50. Tenner-Racz K, Brachtel E, Racz P. [Histologic classification of HIV-1 induced lymphadenopathy. Current results on the pathogenesis of germinal center changes]. Verh Dtsch Ges Pathol. 1991; 75:69-79.
    View in: PubMed
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