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profileDemetrios Vavvas, M.D.,PH.D.

TitleAssociate Professor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infrm
c/o Faculty Services
243 Charles St
Boston MA 02114
Phone617/573-6874
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tian B, Maidana DE, Dib B, Miller JB, Bouzika P, Miller JW, Vavvas DG, Lin H. miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. PLoS One. 2016; 11(8):e0160887. PMID: 27505139.
    View in: PubMed
  2. Yonekawa Y, Wu WC, Kusaka S, Robinson J, Tsujioka D, Kang KB, Shapiro MJ, Padhi TR, Jain L, Sears JE, Kuriyan AE, Berrocal AM, Quiram PA, Gerber AE, Paul Chan RV, Jonas KE, Wong SC, Patel CK, Abbey AM, Spencer R, Blair MP, Chang EY, Papakostas TD, Vavvas DG, Sisk RA, Ferrone PJ, Henderson RH, Olsen KR, Hartnett ME, Chau FY, Mukai S, Murray TG, Thomas BJ, Meza PA, Drenser KA, Trese MT, Capone A. Immediate Sequential Bilateral Pediatric Vitreoretinal Surgery: An International Multicenter Study. Ophthalmology. 2016 Aug; 123(8):1802-8. PMID: 27221737.
    View in: PubMed
  3. Miller JB, Yonekawa Y, Eliott D, Kim IK, Kim LA, Loewenstein JI, Sobrin L, Young LH, Mukai S, Vavvas DG. Long-term Follow-up and Outcomes in Traumatic Macular Holes. Am J Ophthalmol. 2016 Jun; 166:206-7. PMID: 27084591.
    View in: PubMed
  4. Stryjewski TP, Papakostas TD, Vavvas D. Proliferative Hypertensive Retinopathy. JAMA Ophthalmol. 2016 Mar 1; 134(3):345-6. PMID: 26767543.
    View in: PubMed
  5. Papakostas TD, Vavvas D, Eliott D, Kim LA. Reply to 'Comment on: Intravitreal aflibercept for macular oedema secondary to central retinal vein occlusion in patients with prior treatment with bevacizumab or ranibizmab'. Eye (Lond). 2016 May; 30(5):766-7. PMID: 26869157.
    View in: PubMed
  6. Vavvas DG, Daniels AB, Kapsala ZG, Goldfarb JW, Ganotakis E, Loewenstein JI, Young LH, Gragoudas ES, Eliott D, Kim IK, Tsilimbaris MK, Miller JW. Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment. EBioMedicine. 2016 Mar; 5:198-203. PMID: 27077128.
    View in: PubMed
  7. Kumase F, Takeuchi K, Morizane Y, Suzuki J, Matsumoto H, Kataoka K, Al-Moujahed A, Maidana DE, Miller JW, Vavvas DG. AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-?B Pathway in RAW264.7 Macrophages. PLoS One. 2016; 11(1):e0147279. PMID: 26799633.
    View in: PubMed
  8. Modjtahedi BS, Bose N, Papakostas TD, Morse L, Vavvas DG, Kishan AU. Lipids and Diabetic Retinopathy. Semin Ophthalmol. 2016; 31(1-2):10-8. PMID: 26959124.
    View in: PubMed
  9. Lin H, Yue Y, Maidana DE, Bouzika P, Atik A, Matsumoto H, Miller JW, Vavvas DG. Drug Delivery Nanoparticles: Toxicity Comparison in Retinal Pigment Epithelium and Retinal Vascular Endothelial Cells. Semin Ophthalmol. 2016; 31(1-2):1-9. PMID: 26959123.
    View in: PubMed
  10. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
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  11. Murakami Y, Ikeda Y, Nakatake S, Miller JW, Vavvas DG, Sonoda KH, Ishibashi T. Necrotic cone photoreceptor cell death in retinitis pigmentosa. Cell Death Dis. 2015; 6:e2038. PMID: 26720347.
    View in: PubMed
  12. Papakostas TD, Jakobiec FA, Stagner AM, Vavvas D. Unusual focal remnant of the tunica vasculosa lentis. Clin Experiment Ophthalmol. 2016 Apr; 44(3):203-5. PMID: 26348530.
    View in: PubMed
  13. Tsilimbaris MK, Vavvas DG, Bechrakis NE. Myopic foveoschisis: an ectatic retinopathy, not a schisis. Eye (Lond). 2016 Feb; 30(2):328-9. PMID: 26584797.
    View in: PubMed
  14. Matsumoto H, Murakami Y, Kataoka K, Notomi S, Mantopoulos D, Trichonas G, Miller JW, Gregory MS, Ksander BR, Marshak-Rothstein A, Vavvas DG. Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium. Cell Death Dis. 2015; 6:e1986. PMID: 26583327; PMCID: PMC4670938.
  15. Papakostas TD, Lim L, van Zyl T, Miller JB, Modjtahedi BS, Andreoli CM, Wu D, Young LH, Kim IK, Vavvas DG, Esmaili DD, Husain D, Eliott D, Kim LA. Intravitreal aflibercept for macular oedema secondary to central retinal vein occlusion in patients with prior treatment with bevacizumab or ranibizumab. Eye (Lond). 2016 Jan; 30(1):79-84. PMID: 26449196.
    View in: PubMed
  16. Patel AV, Papakostas TD, Vavvas DG. Under the Guise of Retinitis. JAMA Ophthalmol. 2015 Oct 1; 133(10):1205-6. PMID: 26226191.
    View in: PubMed
  17. Maidana DE, Tsoka P, Tian B, Dib B, Matsumoto H, Kataoka K, Lin H, Miller JW, Vavvas DG. A Novel ImageJ Macro for Automated Cell Death Quantitation in the Retina. Invest Ophthalmol Vis Sci. 2015 Oct 1; 56(11):6701-8. PMID: 26469755; PMCID: PMC4611955 [Available on 04/01/16].
  18. Sandhu H, Vavvas D. Bilateral tractional retinal detachment in a patient with hemolytic-uremic syndrome. J AAPOS. 2015 Oct; 19(5):484-6. PMID: 26486040.
    View in: PubMed
  19. Miller JB, Yonekawa Y, Eliott D, Kim IK, Kim LA, Loewenstein JI, Sobrin L, Young LH, Mukai S, Vavvas DG. Long-term Follow-up and Outcomes in Traumatic Macular Holes. Am J Ophthalmol. 2015 Dec; 160(6):1255-1258.e1. PMID: 26393438.
    View in: PubMed
  20. Zygoura V, Papavasileiou E, Vavvas DG, Cortis D, Eleftheriadis H, Jackson TL. Real-world treatment of diabetic macular oedema: a comparison of combined ranibizumab plus macular LASER with macular LASER monotherapy. Hell J Nucl Med. 2015 Sep-Dec; 18 Suppl 1:33-41. PMID: 26665210.
    View in: PubMed
  21. Dib B, Lin H, Maidana DE, Tian B, Miller JB, Bouzika P, Miller JW, Vavvas DG. Mitochondrial DNA has a pro-inflammatory role in AMD. Biochim Biophys Acta. 2015 Nov; 1853(11 Pt A):2897-906. PMID: 26305120.
    View in: PubMed
  22. Sweigard JH, Matsumoto H, Smith KE, Kim LA, Paschalis EI, Okonuki Y, Castillejos A, Kataoka K, Hasegawa E, Yanai R, Husain D, Lambris JD, Vavvas D, Miller JW, Connor KM. Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. Sci Transl Med. 2015 Jul 22; 7(297):297ra116. PMID: 26203084.
    View in: PubMed
  23. Lim LS, Ng WY, Wong D, Wong E, Yeo I, Ang CL, Kim L, Vavvas D, Lee SY. Prognostic factor analysis of vitrectomy for myopic foveoschisis. Br J Ophthalmol. 2015 Dec; 99(12):1639-43. PMID: 26137989.
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  24. Gupta R, Vavvas D, Asaad WF. Case records of the Massachusetts General Hospital. Case 15-2015. A 27-year-old man with a nail in the eye. N Engl J Med. 2015 May 14; 372(20):1945-52. PMID: 25970053.
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  25. Kataoka K, Matsumoto H, Kaneko H, Notomi S, Takeuchi K, Sweigard JH, Atik A, Murakami Y, Connor KM, Terasaki H, Miller JW, Vavvas DG. Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis. 2015; 6:e1731. PMID: 25906154; PMCID: PMC4650542.
  26. Papakostas TD, Chee YE, Vavvas D. Posterior nodular scleritis. JAMA Ophthalmol. 2015 Jan; 133(1):e141801. PMID: 25569317.
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  27. Brodowska K, Theodoropoulou S, Meyer Zu Hörste M, Paschalis EI, Takeuchi K, Scott G, Ramsey DJ, Kiernan E, Hoang M, Cichy J, Miller JW, Gragoudas ES, Vavvas DG. Effects of metformin on retinoblastoma growth in vitro and in vivo. Int J Oncol. 2014 Dec; 45(6):2311-24. PMID: 25215935; PMCID: PMC4215581.
  28. Hasegawa E, Sweigard H, Husain D, Olivares AM, Chang B, Smith KE, Birsner AE, D'Amato RJ, Michaud NA, Han Y, Vavvas DG, Miller JW, Haider NB, Connor KM. Characterization of a spontaneous retinal neovascular mouse model. PLoS One. 2014; 9(9):e106507. PMID: 25188381; PMCID: PMC4154693.
  29. Miller JB, Papakostas TD, Vavvas DG. Complications of emulsified silicone oil after retinal detachment repair. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):312-8. PMID: 25325856.
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  30. Chan CY, Papakostas TD, Vavvas DG. Choroidal changes associated with bruch membrane pathology in pseudoxanthoma elasticum. Am J Ophthalmol. 2014 Sep; 158(3):644. PMID: 25132250.
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  31. Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR. LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014 Sep; 17(9):1190-7. PMID: 25086610.
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  32. Chee Yee C, Papakostas TD, Vavvas DG. Quantitative assessment of central retinal thickness in recurrent neovascular age-related macular degeneration. Br J Ophthalmol. 2014 Sep; 98(9):1308. PMID: 24997184.
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  33. Kim LA, Amarnani D, Gnanaguru G, Tseng WA, Vavvas DG, D'Amore PA. Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms. Invest Ophthalmol Vis Sci. 2014 Aug; 55(8):4747-58. PMID: 24994868; PMCID: PMC4122018.
  34. Miller JB, Kim LA, Wu DM, Vavvas DG, Eliott D, Husain D. Ocriplasmin for treatment of stage 2 macular holes: early clinical results. Ophthalmic Surg Lasers Imaging Retina. 2014 Jul-Aug; 45(4):293-7. PMID: 25037011; PMCID: PMC4342757.
  35. Hu Y, Lin H, Dib B, Atik A, Bouzika P, Lin C, Yan Y, Tang S, Miller JW, Vavvas DG. Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-?B pathway. Discov Med. 2014 Jul-Aug; 18(97):7-14. PMID: 25091484.
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  36. Chan CY, Papakostas TD, Vavvas DG. Evaluating choroidal thickness in diabetic retinopathy. Clin Ophthalmol. 2014; 8:1185-6. PMID: 25028530; PMCID: PMC4077862.
  37. Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM. Cytochrome P450-generated metabolites derived from ?-3 fatty acids attenuate neovascularization. Proc Natl Acad Sci U S A. 2014 Jul 1; 111(26):9603-8. PMID: 24979774; PMCID: PMC4084420.
  38. Matsumoto H, Murakami Y, Kataoka K, Lin H, Connor KM, Miller JW, Zhou D, Avruch J, Vavvas DG. Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment. Cell Death Dis. 2014; 5:e1269. PMID: 24874741; PMCID: PMC4047884.
  39. Matsumoto H, Kataoka K, Tsoka P, Connor KM, Miller JW, Vavvas DG. Strain difference in photoreceptor cell death after retinal detachment in mice. Invest Ophthalmol Vis Sci. 2014 Jul; 55(7):4165-74. PMID: 24854853; PMCID: PMC4089419.
  40. Brodowska K, Al-Moujahed A, Marmalidou A, Meyer Zu Horste M, Cichy J, Miller JW, Gragoudas E, Vavvas DG. The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp Eye Res. 2014 Jul; 124:67-73. PMID: 24837142; PMCID: PMC4135181.
  41. Chan CY, Papakostas TD, Vavvas D. Evaluation of choroidal thickness among patients with oculocutaneous albinism. Br J Ophthalmol. 2014 Aug; 98(8):1135. PMID: 24814965.
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  42. Al-Moujahed A, Nicolaou F, Brodowska K, Papakostas TD, Marmalidou A, Ksander BR, Miller JW, Gragoudas E, Vavvas DG. Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Invest Ophthalmol Vis Sci. 2014 Jul; 55(7):4175-85. PMID: 24781943; PMCID: PMC4089421.
  43. Cade F, Paschalis EI, Regatieri CV, Vavvas DG, Dana R, Dohlman CH. Alkali burn to the eye: protection using TNF-a inhibition. Cornea. 2014 Apr; 33(4):382-9. PMID: 24488127.
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  44. Takeuchi K, Yanai R, Kumase F, Morizane Y, Suzuki J, Kayama M, Brodowska K, Nakazawa M, Miller JW, Connor KM, Vavvas DG. EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. PLoS One. 2014; 9(3):e91849. PMID: 24647208; PMCID: PMC3960138.
  45. Papakostas TD, Jakobiec FA, Mantagos J, Rashid A, Fay A, Vavvas DG. Idiopathic dacryoadenitis mimicking a primary intraocular tumour in a young girl. Clin Experiment Ophthalmol. 2014 Nov; 42(8):785-8. PMID: 24533840.
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  46. Patel M, Vavvas DG. Spontaneous resolution of a postvitrectomy macular hole retinal detachment. Retin Cases Brief Rep. 2014; 8(3):161-3. PMID: 25372428.
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  47. Shoni M, Lui KO, Vavvas DG, Muto MG, Berkowitz RS, Vlahos N, Ng SW. Protein kinases and associated pathways in pluripotent state and lineage differentiation. Curr Stem Cell Res Ther. 2014; 9(5):366-87. PMID: 24998240.
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  48. Matsumoto H, Miller JW, Vavvas DG. Retinal detachment model in rodents by subretinal injection of sodium hyaluronate. J Vis Exp. 2013; (79). PMID: 24056325; PMCID: PMC3864357.
  49. Ramsey DJ, Ramsey KM, Vavvas DG. Genetic advances in ophthalmology: the role of melanopsin-expressing, intrinsically photosensitive retinal ganglion cells in the circadian organization of the visual system. Semin Ophthalmol. 2013 Sep-Nov; 28(5-6):406-21. PMID: 24010846.
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  50. Murakami Y, Notomi S, Hisatomi T, Nakazawa T, Ishibashi T, Miller JW, Vavvas DG. Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res. 2013 Nov; 37:114-40. PMID: 23994436; PMCID: PMC3871865.
  51. Murakami Y, Matsumoto H, Roh M, Giani A, Kataoka K, Morizane Y, Kayama M, Thanos A, Nakatake S, Notomi S, Hisatomi T, Ikeda Y, Ishibashi T, Connor KM, Miller JW, Vavvas DG. Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death Differ. 2014 Feb; 21(2):270-7. PMID: 23954861; PMCID: PMC3890945.
  52. Patel M, Vavvas DG. Fundus autofluorescence in ampiginous choroiditis. Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug; 44(4):393-7. PMID: 23883534.
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  53. Takeuchi K, Morizane Y, Kamami-Levy C, Suzuki J, Kayama M, Cai W, Miller JW, Vavvas DG. AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells. J Biol Chem. 2013 Jul 12; 288(28):20581-91. PMID: 23723070; PMCID: PMC3711322.
  54. Yonekawa Y, Andreoli C, Miller JB, Loewenstein JI, Sobrin L, Eliott D, Vavvas DG, Miller JW, Kim IK. Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration. Am J Ophthalmol. 2013 Jul; 156(1):29-35.e2. PMID: 23668679.
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  55. Vavvas DG. Anti-VEGF in retinopathy of prematurity, need to titrate. Invest Ophthalmol Vis Sci. 2013 Mar; 54(3). PMID: 23519043.
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  56. Stryjewski TP, Vavvas DG. Genetic correlates of proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2013 Mar; 54(3). PMID: 23463022.
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  57. Theodoropoulou S, Brodowska K, Kayama M, Morizane Y, Miller JW, Gragoudas ES, Vavvas DG. Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis. PLoS One. 2013; 8(1):e52852. PMID: 23300996; PMCID: PMC3536763.
  58. Chee YE, Patel MM, Vavvas DG. Retinal detachment after open-globe injury. Int Ophthalmol Clin. 2013; 53(4):79-92. PMID: 24088935.
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  59. Miller JB, Yonekawa Y, Eliott D, Vavvas DG. A review of traumatic macular hole: diagnosis and treatment. Int Ophthalmol Clin. 2013; 53(4):59-67. PMID: 24088933.
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  60. Papakostas TD, Yonekawa Y, Skondra D, Vavvas DG. Traumatic chorioretinal rupture (sclopetaria). Int Ophthalmol Clin. 2013; 53(4):119-25. PMID: 24088938.
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  61. Huckfeldt RM, Vavvas DG. Neuroprotection for retinal detachment. Int Ophthalmol Clin. 2013; 53(4):105-17. PMID: 24088937.
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  62. Moysidis SN, Thanos A, Vavvas DG. Mechanisms of inflammation in proliferative vitreoretinopathy: from bench to bedside. Mediators Inflamm. 2012; 2012:815937. PMID: 23049173; PMCID: PMC3463807.
  63. Gologorsky D, Thanos A, Vavvas D. Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy. Mediators Inflamm. 2012; 2012:629452. PMID: 23028203; PMCID: PMC3457666.
  64. Skondra D, Papakostas T, Vavvas DG. Enhanced depth imaging optical coherence tomography in age-related macular degeneration. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):209-12. PMID: 23163278.
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  65. Skondra D, Papakostas TD, Hunter R, Vavvas DG. Near infrared autofluorescence imaging of retinal diseases. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):202-8. PMID: 23163277.
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  66. Murakami Y, Matsumoto H, Roh M, Suzuki J, Hisatomi T, Ikeda Y, Miller JW, Vavvas DG. Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Proc Natl Acad Sci U S A. 2012 Sep 4; 109(36):14598-603. PMID: 22908283; PMCID: PMC3437885.
  67. Roh M, Zhang Y, Murakami Y, Thanos A, Lee SC, Vavvas DG, Benowitz LI, Miller JW. Etanercept, a widely used inhibitor of tumor necrosis factor-a (TNF-a), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS One. 2012; 7(7):e40065. PMID: 22802951; PMCID: PMC3388998.
  68. Suzuki J, Yoshimura T, Simeonova M, Takeuchi K, Murakami Y, Morizane Y, Miller JW, Sobrin L, Vavvas DG. Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2012; 53(7):4158-69. PMID: 22562518; PMCID: PMC3392008.
  69. Hisatomi T, Nakao S, Murakami Y, Noda K, Nakazawa T, Notomi S, Connolly E, She H, Almulki L, Ito Y, Vavvas DG, Ishibashi T, Miller JW. The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. Am J Pathol. 2012 Jul; 181(1):53-61. PMID: 22613025; PMCID: PMC3388154.
  70. Thanos A, Vavvas D, Young LH, Foster CS. Choroidal neovascular membrane formation and retinochoroidopathy in a patient with systemic langerhans cell histiocytosis: a case report and review of the literature. Case Rep Ophthalmol. 2012 Jan; 3(1):128-35. PMID: 23002392; PMCID: PMC3448115.
  71. Thanos A, Morizane Y, Murakami Y, Giani A, Mantopoulos D, Kayama M, Roh MI, Michaud N, Pawlyk B, Sandberg M, Young LH, Miller JW, Vavvas DG. Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol. 2012 May; 180(5):1917-27. PMID: 22429967; PMCID: PMC3349832.
  72. Chen L, Miller JW, Vavvas D, Kim IK. Anti-vascular endothelial growth factor monotherapy versus combination treatment with photodynamic therapy for subfoveal choroidal neovascularization secondary to causes other than age-related macular degeneration. Retina. 2011 Nov; 31(10):2078-83. PMID: 21691258.
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  73. Mantopoulos D, Murakami Y, Comander J, Thanos A, Roh M, Miller JW, Vavvas DG. Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. PLoS One. 2011; 6(9):e24245. PMID: 21961034; PMCID: PMC3178513.
  74. Suzuki J, Manola A, Murakami Y, Morizane Y, Takeuchi K, Kayama M, Miller JW, Sobrin L, Vavvas DG. Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2011 Aug; 52(9):6565-71. PMID: 21775660.
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  75. Giani A, Thanos A, Roh MI, Connolly E, Trichonas G, Kim I, Gragoudas E, Vavvas D, Miller JW. In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3880-7. PMID: 21296820.
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  76. Roh MI, Murakami Y, Thanos A, Vavvas DG, Miller JW. Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3825-31. PMID: 21310909; PMCID: PMC3109058.
  77. Murakami Y, Miller JW, Vavvas DG. RIP kinase-mediated necrosis as an alternative mechanisms of photoreceptor death. Oncotarget. 2011 Jun; 2(6):497-509. PMID: 21670490; PMCID: PMC3248194.
  78. Salehi-Had H, Roh MI, Giani A, Hisatomi T, Nakao S, Kim IK, Gragoudas ES, Vavvas D, Guccione S, Miller JW. Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization. PLoS One. 2011; 6(4):e18864. PMID: 21559527; PMCID: PMC3084713.
  79. Nakazawa T, Kayama M, Ryu M, Kunikata H, Watanabe R, Yasuda M, Kinugawa J, Vavvas D, Miller JW. Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1384-91. PMID: 21402953; PMCID: PMC3101673.
  80. Morizane Y, Thanos A, Takeuchi K, Murakami Y, Kayama M, Trichonas G, Miller J, Foretz M, Viollet B, Vavvas DG. AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts. J Biol Chem. 2011 May 6; 286(18):16030-8. PMID: 21402702; PMCID: PMC3091212.
  81. Kayama M, Nakazawa T, Thanos A, Morizane Y, Murakami Y, Theodoropoulou S, Abe T, Vavvas D, Miller JW. Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. Am J Pathol. 2011 Mar; 178(3):1080-91. PMID: 21356360; PMCID: PMC3069883.
  82. Trichonas G, Murakami Y, Thanos A, Morizane Y, Kayama M, Debouck CM, Hisatomi T, Miller JW, Vavvas DG. Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21695-700. PMID: 21098270; PMCID: PMC3003048.
  83. Seyedahmadi BJ, Vavvas D. In vivo high-resolution retinal imaging using adaptive optics. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):186-91. PMID: 21090998.
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  84. Vavvas D, Kim I, Lane AM, Chaglassian A, Mukai S, Gragoudas E. Posterior uveal melanoma in young patients treated with proton beam therapy. Retina. 2010 Sep; 30(8):1267-71. PMID: 20224468.
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  85. Rhéaume MA, Vavvas D. Pharmacologic vitreolysis. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):295-302. PMID: 21091015.
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  86. Kiss S, Vavvas D. Intraoperative switch to a temporal surgical approach in 23- and 25-gauge microcannula-based sutureless transconjunctival vitrectomy. Open Ophthalmol J. 2010; 4:12-4. PMID: 21270948; PMCID: PMC3027078.
  87. Theodoropoulou S, Kolovou PE, Morizane Y, Kayama M, Nicolaou F, Miller JW, Gragoudas E, Ksander BR, Vavvas DG. Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. FASEB J. 2010 Aug; 24(8):2620-30. PMID: 20371623; PMCID: PMC2909289.
  88. Trichonas G, Manola A, Morizane Y, Thanos A, Koufomichali X, Papakostas TD, Montezuma S, Young L, Miller JW, Gragoudas E, Vavvas D. A novel nonradioactive method to evaluate vascular barrier breakdown and leakage. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1677-82. PMID: 19875655.
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  89. Papakostas TD, Pieretti-Vanmarcke R, Nicolaou F, Thanos A, Trichonas G, Koufomichali X, Anago K, Donahoe PK, Teixeira J, MacLaughlin DT, Vavvas D. Development of an efficiently cleaved, bioactive, highly pure FLAG-tagged recombinant human Mullerian Inhibiting Substance. Protein Expr Purif. 2010 Mar; 70(1):32-8. PMID: 19755162; PMCID: PMC3581853.
  90. Vavvas D, Brodowska K. Images in clinical medicine. Traumatic bleb. N Engl J Med. 2009 Jul 9; 361(2):e2. PMID: 19587336.
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  91. Savar A, Vavvas D. Optical coherence tomography appearance of a retinal artery macroaneurysm. Ophthalmic Surg Lasers Imaging. 2009 Jul-Aug; 40(4):403-4. PMID: 19634746.
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  92. Rouvas AA, Papakostas TD, Vavvas D, Vergados I, Moschos MM, Kotsolis A, Ladas ID. Intravitreal ranibizumab, intravitreal ranibizumab with PDT, and intravitreal triamcinolone with PDT for the treatment of retinal angiomatous proliferation: a prospective study. Retina. 2009 Apr; 29(4):536-44. PMID: 19190547.
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  93. Montezuma SR, Vavvas D, Miller JW. Review of the ocular angiogenesis animal models. Semin Ophthalmol. 2009 Mar-Apr; 24(2):52-61. PMID: 19373687.
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  94. Andreoli CM, Andreoli MT, Kloek CE, Ahuero AE, Vavvas D, Durand ML. Low rate of endophthalmitis in a large series of open globe injuries. Am J Ophthalmol. 2009 Apr; 147(4):601-608.e2. PMID: 19181306.
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  95. Vavvas D, Huynh N, Pasquale L, Berson EL. Progressive hydroxychloroquine toxicity mimicking low-tension glaucoma after discontinuation of the drug. Acta Ophthalmol. 2010 Feb; 88(1):156-7. PMID: 18937815.
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  96. Kiss S, Vavvas D. 25-gauge transconjunctival sutureless pars plana vitrectomy for the removal of retained lens fragments and intraocular foreign bodies. Retina. 2008 Oct; 28(9):1346-51. PMID: 18685539.
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  97. Vavvas D, D'Amico DJ. Pegaptanib (Macugen): treating neovascular age-related macular degeneration and current role in clinical practice. Ophthalmol Clin North Am. 2006 Sep; 19(3):353-60. PMID: 16935210.
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  98. Vavvas D, Fay A, Watkins L. Two cases of orbital lymphangioma associated with vascular abnormalities of the retina and iris. Ophthalmology. 2004 Jan; 111(1):189-92. PMID: 14711734.
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  99. Vavvas D, Gragoudas ES, Hatton MP. Preface. Int Ophthalmol Clin. 2004; 44(3):xiii. PMID: 15211188.
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  100. Vavvas D, Foster CS. Immunomodulatory medications in uveitis. Int Ophthalmol Clin. 2004; 44(3):187-203. PMID: 15211185.
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  101. Vavvas D, Azar NF, Azar DT. Mechanisms of disease: cataracts. Ophthalmol Clin North Am. 2002 Mar; 15(1):49-60. PMID: 12064081.
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  102. Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res. 2001; 56:127-55. PMID: 11237210.
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  103. Dean D, Daugaard JR, Young ME, Saha A, Vavvas D, Asp S, Kiens B, Kim KH, Witters L, Richter EA, Ruderman N. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes. 2000 Aug; 49(8):1295-300. PMID: 10923628.
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  104. Saha AK, Laybutt DR, Dean D, Vavvas D, Sebokova E, Ellis B, Klimes I, Kraegen EW, Shafrir E, Ruderman NB. Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. Am J Physiol. 1999 Jun; 276(6 Pt 1):E1030-7. PMID: 10362615.
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  105. Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol. 1999 Jan; 276(1 Pt 1):E1-E18. PMID: 9886945.
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  106. Vavvas D, Li X, Avruch J, Zhang XF. Identification of Nore1 as a potential Ras effector. J Biol Chem. 1998 Mar 6; 273(10):5439-42. PMID: 9488663.
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  107. Ruderman NB, Saha AK, Vavvas D, Kurowski T, Laybutt DR, Schmitz-Peiffer C, Biden T, Kraegen EW. Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity. Adv Exp Med Biol. 1998; 441:263-70. PMID: 9781332.
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  108. Ruderman NB, Saha AK, Vavvas D, Heydrick SJ, Kurowski TG. Lipid abnormalities in muscle of insulin-resistant rodents. The malonyl CoA hypothesis. Ann N Y Acad Sci. 1997 Sep 20; 827:221-30. PMID: 9329757.
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  109. Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A, Kemp BE, Witters LA, Ruderman NB. Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. J Biol Chem. 1997 May 16; 272(20):13255-61. PMID: 9148944.
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  110. Saha AK, Vavvas D, Kurowski TG, Apazidis A, Witters LA, Shafrir E, Ruderman NB. Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol. 1997 Apr; 272(4 Pt 1):E641-8. PMID: 9142886.
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  111. Luo Z, Tzivion G, Belshaw PJ, Vavvas D, Marshall M, Avruch J. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature. 1996 Sep 12; 383(6596):181-5. PMID: 8774885.
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