Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileLino Renan Becerra, Ph.D.

TitleAssociate Professor of Anaesthesia
InstitutionBoston Children's Hospital
DepartmentAnaesthesia
AddressChildren's Hospital
Pain Medicine Division
9 Hope Avenue
Waltham MA 02453
Phone617/355-2303
vCardDownload vCard (login for email)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Mongerson CRL, Jennings RW, Borsook D, Becerra L, Bajic D. Resting-State Functional Connectivity in the Infant Brain: Methods, Pitfalls, and Potentiality. Front Pediatr. 2017; 5:159. PMID: 28856131.
    View in: PubMed
  2. Youssef AM, Ludwick A, Wilcox SL, Lebel A, Peng K, Colon E, Danehy A, Burstein R, Becerra L, Borsook D. In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation. Hum Brain Mapp. 2017 Aug; 38(8):4078-4087. PMID: 28560777.
    View in: PubMed
  3. Becerra L, Bishop J, Barmettler G, Kainz V, Burstein R, Borsook D. Brain network alterations in the inflammatory soup animal model of migraine. Brain Res. 2017 Apr 01; 1660:36-46. PMID: 28167076.
    View in: PubMed
  4. Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM. Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry. Hum Brain Mapp. 2017 Apr; 38(4):2276-2325. PMID: 28145075.
    View in: PubMed
  5. Hodkinson DJ, Veggeberg R, Kucyi A, van Dijk KR, Wilcox SL, Scrivani SJ, Burstein R, Becerra L, Borsook D. Cortico-Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine. eNeuro. 2016 Nov-Dec; 3(6). PMID: 28101529.
    View in: PubMed
  6. Aasted CM, Yücel MA, Steele SC, Peng K, Boas DA, Becerra L, Borsook D. Frontal Lobe Hemodynamic Responses to Painful Stimulation: A Potential Brain Marker of Nociception. PLoS One. 2016; 11(11):e0165226. PMID: 27806119.
    View in: PubMed
  7. Azqueta-Gavaldon M, Schulte-Göcking H, Storz C, Azad S, Reiners A, Borsook D, Becerra L, Kraft E. Basal ganglia dysfunction in complex regional pain syndrome - A valid hypothesis? Eur J Pain. 2017 Mar; 21(3):415-424. PMID: 27805769.
    View in: PubMed
  8. Bajic D, Craig MM, Borsook D, Becerra L. Probing Intrinsic Resting-State Networks in the Infant Rat Brain. Front Behav Neurosci. 2016; 10:192. PMID: 27803653.
    View in: PubMed
  9. Hubbard CS, Becerra L, Smith JH, DeLange JM, Smith RM, Black DF, Welker KM, Burstein R, Cutrer FM, Borsook D. Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Front Hum Neurosci. 2016; 10:497. PMID: 27766076.
    View in: PubMed
  10. Hodkinson DJ, Wilcox SL, Veggeberg R, Noseda R, Burstein R, Borsook D, Becerra L. Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine. J Neurosci. 2016 Jul 27; 36(30):8026-36. PMID: 27466345; PMCID: PMC4961783 [Available on 01/27/17].
  11. Wilcox SL, Veggeberg R, Lemme J, Hodkinson DJ, Scrivani S, Burstein R, Becerra L, Borsook D. Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine. Front Hum Neurosci. 2016; 10:366. PMID: 27507939; PMCID: PMC4960233.
  12. Yücel MA, Selb J, Aasted CM, Lin PY, Borsook D, Becerra L, Boas DA. Mayer waves reduce the accuracy of estimated hemodynamic response functions in functional near-infrared spectroscopy. Biomed Opt Express. 2016 Aug 01; 7(8):3078-88. PMID: 27570699; PMCID: PMC4986815.
  13. Kussman BD, Aasted CM, Yücel MA, Steele SC, Alexander ME, Boas DA, Borsook D, Becerra L. Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias. PLoS One. 2016; 11(7):e0158975. PMID: 27415436; PMCID: PMC4944937.
  14. Hubbard CS, Becerra L, Heinz N, Ludwick A, Rasooly T, Wu R, Johnson A, Schechter NL, Borsook D, Nurko S. Abdominal Pain, the Adolescent and Altered Brain Structure and Function. PLoS One. 2016; 11(5):e0156545. PMID: 27244227; PMCID: PMC4886967.
  15. Borsook D, Linnman C, Faria V, Strassman AM, Becerra L, Elman I. Reward deficiency and anti-reward in pain chronification. Neurosci Biobehav Rev. 2016 Sep; 68:282-297. PMID: 27246519.
    View in: PubMed
  16. George E, Elman I, Becerra L, Berg S, Borsook D. Pain in an era of armed conflicts: Prevention and treatment for warfighters and civilian casualties. Prog Neurobiol. 2016 06; 141:25-44. PMID: 27084355.
    View in: PubMed
  17. Becerra L, Aasted CM, Boas DA, George E, Yücel MA, Kussman BD, Kelsey P, Borsook D. Brain measures of nociception using near-infrared spectroscopy in patients undergoing routine screening colonoscopy. Pain. 2016 Apr; 157(4):840-848. PMID: 26645550; PMCID: PMC4794375 [Available on 04/01/17].
  18. Becerra L, Veggeberg R, Prescot A, Jensen JE, Renshaw P, Scrivani S, Spierings EL, Burstein R, Borsook D. A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin. 2016; 11:588-94. PMID: 27158591; PMCID: PMC4846856.
  19. Kim P, Hinkle C, Zhang R, Becerra L, Borsook D, Simons L. (219) Regional brain structure differences in learning, motivation, and emotion between treatment responders and non-responders in pediatric CRPS. J Pain. 2016 Apr; 17(4S):S30. PMID: 28162449.
    View in: PubMed
  20. Asghar MS, Becerra L, Larsson HB, Borsook D, Ashina M. Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain - An fMRI Study in Healthy Volunteers. PLoS One. 2016; 11(3):e0150334. PMID: 26990646; PMCID: PMC4798403.
  21. Bukhari Q, Borsook D, Rudin M, Becerra L. Random Forest Segregation of Drug Responses May Define Regions of Biological Significance. Front Comput Neurosci. 2016; 10:21. PMID: 27014046; PMCID: PMC4783407.
  22. Simons LE, Erpelding N, Hernandez JM, Serrano P, Zhang K, Lebel AA, Sethna NF, Berde CB, Prabhu SP, Becerra L, Borsook D. Fear and Reward Circuit Alterations in Pediatric CRPS. Front Hum Neurosci. 2015; 9:703. PMID: 26834606; PMCID: PMC4717323.
  23. Becerra L, Schwartzman RJ, Kiefer RT, Rohr P, Moulton EA, Wallin D, Pendse G, Morris S, Borsook D. CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome. Pain Med. 2015 Dec; 16(12):2368-85. PMID: 26745152.
    View in: PubMed
  24. Faria V, Erpelding N, Lebel A, Johnson A, Wolff R, Fair D, Burstein R, Becerra L, Borsook D. The migraine brain in transition: girls vs boys. Pain. 2015 Nov; 156(11):2212-21. PMID: 26172552.
    View in: PubMed
  25. Becerra L, Bishop J, Barmettler G, Xie Y, Navratilova E, Porreca F, Borsook D. Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas. J Neurophysiol. 2016 Jan 01; 115(1):208-17. PMID: 26490291; PMCID: PMC4760506 [Available on 01/01/17].
  26. Hodkinson DJ, Veggeberg R, Wilcox SL, Scrivani S, Burstein R, Becerra L, Borsook D. Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine. PLoS One. 2015; 10(9):e0137971. PMID: 26372461; PMCID: PMC4570777.
  27. Yücel MA, Selb J, Aasted CM, Petkov MP, Becerra L, Borsook D, Boas DA. Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses. Neurophotonics. 2015 Jul; 2(3):035005. PMID: 26835480; PMCID: PMC4717232.
  28. Barakat N, Gorman MP, Benson L, Becerra L, Borsook D. Pain and spinal cord imaging measures in children with demyelinating disease. Neuroimage Clin. 2015; 9:338-47. PMID: 26509120; PMCID: PMC4588416.
  29. Borsook D, Veggeberg R, Erpelding N, Borra R, Linnman C, Burstein R, Becerra L. The Insula: A "Hub of Activity" in Migraine. Neuroscientist. 2016 Dec; 22(6):632-652. PMID: 26290446.
    View in: PubMed
  30. Maleki N, Barmettler G, Moulton EA, Scrivani S, Veggeberg R, Spierings EL, Burstein R, Becerra L, Borsook D. Female migraineurs show lack of insular thinning with age. Pain. 2015 Jul; 156(7):1232-9. PMID: 25775358; PMCID: PMC4474740.
  31. Upadhyay J, Lemme J, Anderson J, Bleakman D, Large T, Evelhoch JL, Hargreaves R, Borsook D, Becerra L. Test-retest reliability of evoked heat stimulation BOLD fMRI. J Neurosci Methods. 2015 Sep 30; 253:38-46. PMID: 26072245.
    View in: PubMed
  32. Borsook D, Kussman B, George E, Becerra L, Burke D. Reply to Letter: "Surgically Induced Neuropathic Pain: Understanding the Perioperative Process". Ann Surg. 2015 Jun; 261(6):e162-3. PMID: 24299687.
    View in: PubMed
  33. Aasted CM, Yücel MA, Cooper RJ, Dubb J, Tsuzuki D, Becerra L, Petkov MP, Borsook D, Dan I, Boas DA. Anatomical guidance for functional near-infrared spectroscopy: AtlasViewer tutorial. Neurophotonics. 2015 Apr; 2(2):020801. PMID: 26157991; PMCID: PMC4478785.
  34. Yücel MA, Aasted CM, Petkov MP, Borsook D, Boas DA, Becerra L. Specificity of hemodynamic brain responses to painful stimuli: a functional near-infrared spectroscopy study. Sci Rep. 2015 Mar 30; 5:9469. PMID: 25820289; PMCID: PMC4377554.
  35. Erpelding N, Simons L, Lebel A, Serrano P, Pielech M, Prabhu S, Becerra L, Borsook D. Rapid treatment-induced brain changes in pediatric CRPS. Brain Struct Funct. 2016 Mar; 221(2):1095-111. PMID: 25515312; PMCID: PMC4470894 [Available on 03/01/17].
  36. Rojas-Mirquez JC, Rodriguez-Zuñiga MJ, Bonilla-Escobar FJ, Garcia-Perdomo HA, Petkov M, Becerra L, Borsook D, Linnman C. Nocebo effect in randomized clinical trials of antidepressants in children and adolescents: systematic review and meta-analysis. Front Behav Neurosci. 2014; 8:375. PMID: 25404901; PMCID: PMC4217505.
  37. Tajerian M, Leu D, Zou Y, Sahbaie P, Li W, Khan H, Hsu V, Kingery W, Huang TT, Becerra L, Clark JD. Brain neuroplastic changes accompany anxiety and memory deficits in a model of complex regional pain syndrome. Anesthesiology. 2014 Oct; 121(4):852-65. PMID: 25093591; PMCID: PMC4175292.
  38. Barmettler G, Brawn J, Maleki N, Scrivani S, Burstein R, Becerra L, Borsook D. A new electronic diary tool for mapping and tracking spatial and temporal head pain patterns in migraine. Cephalalgia. 2015 Apr; 35(5):417-25. PMID: 25143550.
    View in: PubMed
  39. Becerra L, Sava S, Simons LE, Drosos AM, Sethna N, Berde C, Lebel AA, Borsook D. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome. Neuroimage Clin. 2014; 6:347-69. PMID: 25379449; PMCID: PMC4218937.
  40. Simons LE, Pielech M, Erpelding N, Linnman C, Moulton E, Sava S, Lebel A, Serrano P, Sethna N, Berde C, Becerra L, Borsook D. The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome. Pain. 2014 Sep; 155(9):1727-42. PMID: 24861582; PMCID: PMC4157948.
  41. Xie JY, Qu C, Patwardhan A, Ossipov MH, Navratilova E, Becerra L, Borsook D, Porreca F. Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy. Pain. 2014 Aug; 155(8):1659-66. PMID: 24861580; PMCID: PMC4118589.
  42. Moulton EA, Elman I, Becerra LR, Goldstein RZ, Borsook D. The cerebellum and addiction: insights gained from neuroimaging research. Addict Biol. 2014 May; 19(3):317-31. PMID: 24851284; PMCID: PMC4031616.
  43. Moulton EA, Becerra L, Johnson A, Burstein R, Borsook D. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PLoS One. 2014; 9(4):e95508. PMID: 24743801; PMCID: PMC3990690.
  44. Borsook D, Erpelding N, Lebel A, Linnman C, Veggeberg R, Grant PE, Buettner C, Becerra L, Burstein R. Sex and the migraine brain. Neurobiol Dis. 2014 Aug; 68:200-14. PMID: 24662368; PMCID: PMC4171725.
  45. Borsook D, Erpelding N, Becerra L. Losses and gains: chronic pain and altered brain morphology. Expert Rev Neurother. 2013 Nov; 13(11):1221-34. PMID: 24164053.
    View in: PubMed
  46. Erpelding N, Sava S, Simons LE, Lebel A, Serrano P, Becerra L, Borsook D. Habenula functional resting-state connectivity in pediatric CRPS. J Neurophysiol. 2014 Jan; 111(2):239-47. PMID: 24155006; PMCID: PMC3921385.
  47. Borsook D, Aasted CM, Burstein R, Becerra L. Migraine Mistakes: Error Awareness. Neuroscientist. 2014 Jun; 20(3):291-304. PMID: 24047609.
    View in: PubMed
  48. Borsook D, Becerra L, Fava M. Use of functional imaging across clinical phases in CNS drug development. Transl Psychiatry. 2013 Jul 16; 3:e282. PMID: 23860483; PMCID: PMC3731782.
  49. Becerra L, Navratilova E, Porreca F, Borsook D. Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans. J Neurophysiol. 2013 Sep; 110(5):1221-6. PMID: 23785130; PMCID: PMC3763092.
  50. Linnman C, Becerra L, Lebel A, Berde C, Grant PE, Borsook D. Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. PLoS One. 2013; 8(3):e57205. PMID: 23526938; PMCID: PMC3602432.
  51. Borsook D, Edwards R, Elman I, Becerra L, Levine J. Pain and analgesia: the value of salience circuits. Prog Neurobiol. 2013 May; 104:93-105. PMID: 23499729; PMCID: PMC3644802.
  52. Borsook D, Kussman BD, George E, Becerra LR, Burke DW. Surgically induced neuropathic pain: understanding the perioperative process. Ann Surg. 2013 Mar; 257(3):403-12. PMID: 23059501; PMCID: PMC3546123.
  53. Becerra L, Upadhyay J, Chang PC, Bishop J, Anderson J, Baumgartner R, Schwarz AJ, Coimbra A, Wallin D, Nutile L, George E, Maier G, Sunkaraneni S, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Borsook D. Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects. J Pharmacol Exp Ther. 2013 Apr; 345(1):41-51. PMID: 23370795.
    View in: PubMed
  54. Maleki N, Brawn J, Barmettler G, Borsook D, Becerra L. Pain response measured with arterial spin labeling. NMR Biomed. 2013 Jun; 26(6):664-73. PMID: 23319440; PMCID: PMC3634868.
  55. Gear R, Becerra L, Upadhyay J, Bishop J, Wallin D, Pendse G, Levine J, Borsook D. Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI. PLoS One. 2013; 8(1):e50169. PMID: 23341872; PMCID: PMC3540048.
  56. Linnman C, Becerra L, Borsook D. Inflaming the brain: CRPS a model disease to understand neuroimmune interactions in chronic pain. J Neuroimmune Pharmacol. 2013 Jun; 8(3):547-63. PMID: 23188523; PMCID: PMC3596443.
  57. Linnman C, Maleki N, Becerra L, Borsook D. Migraine tweets - what can online behavior tell us about disease? Cephalalgia. 2013 Jan; 33(1):68-9. PMID: 23136208; PMCID: PMC3808841.
  58. Simons LE, Moulton EA, Linnman C, Carpino E, Becerra L, Borsook D. The human amygdala and pain: evidence from neuroimaging. Hum Brain Mapp. 2014 Feb; 35(2):527-38. PMID: 23097300; PMCID: PMC3920543.
  59. Maleki N, Becerra L, Borsook D. Migraine: maladaptive brain responses to stress. Headache. 2012 Oct; 52 Suppl 2:102-6. PMID: 23030541; PMCID: PMC3475609.
  60. Moulton EA, Becerra L, Rosenthal P, Borsook D. An approach to localizing corneal pain representation in human primary somatosensory cortex. PLoS One. 2012; 7(9):e44643. PMID: 22973463; PMCID: PMC3433421.
  61. Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D. Her versus his migraine: multiple sex differences in brain function and structure. Brain. 2012 Aug; 135(Pt 8):2546-59. PMID: 22843414; PMCID: PMC3407427.
  62. Maleki N, Becerra L, Brawn J, McEwen B, Burstein R, Borsook D. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013 Jul; 218(4):903-12. PMID: 22760159; PMCID: PMC3711530.
  63. Maleki N, Becerra L, Brawn J, Bigal M, Burstein R, Borsook D. Concurrent functional and structural cortical alterations in migraine. Cephalalgia. 2012 Jun; 32(8):607-20. PMID: 22623760; PMCID: PMC3846436.
  64. Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ. Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain. Drug Discov Today. 2012 Sep; 17(17-18):964-73. PMID: 22579743.
    View in: PubMed
  65. Moulton EA, Pendse G, Becerra LR, Borsook D. BOLD responses in somatosensory cortices better reflect heat sensation than pain. J Neurosci. 2012 Apr 25; 32(17):6024-31. PMID: 22539862; PMCID: PMC3347471.
  66. Toledo E, Lebel A, Becerra L, Minster A, Linnman C, Maleki N, Dodick DW, Borsook D. The young brain and concussion: imaging as a biomarker for diagnosis and prognosis. Neurosci Biobehav Rev. 2012 Jul; 36(6):1510-31. PMID: 22476089; PMCID: PMC3372677.
  67. Shelton L, Pendse G, Maleki N, Moulton EA, Lebel A, Becerra L, Borsook D. Mapping pain activation and connectivity of the human habenula. J Neurophysiol. 2012 May; 107(10):2633-48. PMID: 22323632; PMCID: PMC3362277.
  68. Elman I, Becerra L, Tschibelu E, Yamamoto R, George E, Borsook D. Yohimbine-induced amygdala activation in pathological gamblers: a pilot study. PLoS One. 2012; 7(2):e31118. PMID: 22319607; PMCID: PMC3271103.
  69. Borsook D, Maleki N, Becerra L, McEwen B. Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load. Neuron. 2012 Jan 26; 73(2):219-34. PMID: 22284178.
    View in: PubMed
  70. Shelton L, Becerra L, Borsook D. Unmasking the mysteries of the habenula in pain and analgesia. Prog Neurobiol. 2012 Feb; 96(2):208-19. PMID: 22270045; PMCID: PMC3465722.
  71. Linnman C, Moulton EA, Barmettler G, Becerra L, Borsook D. Neuroimaging of the periaqueductal gray: state of the field. Neuroimage. 2012 Mar; 60(1):505-22. PMID: 22197740; PMCID: PMC3288184.
  72. Pendse GV, Borsook D, Becerra L. A simple and objective method for reproducible resting state network (RSN) detection in fMRI. PLoS One. 2011; 6(12):e27594. PMID: 22174743; PMCID: PMC3236249.
  73. Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Schwarz AJ, Pendse G, Wallin D, Nutile L, Bishop J, George E, Elman I, Sunkaraneni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine. Neuroimage. 2012 Feb 15; 59(4):3762-73. PMID: 22119647.
    View in: PubMed
  74. Becerra L, Pendse G, Chang PC, Bishop J, Borsook D. Robust reproducible resting state networks in the awake rodent brain. PLoS One. 2011; 6(10):e25701. PMID: 22028788; PMCID: PMC3196498.
  75. Maleki N, Becerra L, Nutile L, Pendse G, Brawn J, Bigal M, Burstein R, Borsook D. Migraine attacks the Basal Ganglia. Mol Pain. 2011 Sep 21; 7:71. PMID: 21936901; PMCID: PMC3192678.
  76. Upadhyay J, Anderson J, Schwarz AJ, Coimbra A, Baumgartner R, Pendse G, George E, Nutile L, Wallin D, Bishop J, Neni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Imaging drugs with and without clinical analgesic efficacy. Neuropsychopharmacology. 2011 Dec; 36(13):2659-73. PMID: 21849979; PMCID: PMC3230490.
  77. Borsook D, Becerra L. How close are we in utilizing functional neuroimaging in routine clinical diagnosis of neuropathic pain? Curr Pain Headache Rep. 2011 Jun; 15(3):223-9. PMID: 21369853.
    View in: PubMed
  78. Borsook D, Hargreaves R, Becerra L. Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery? Expert Opin Drug Discov. 2011 Jun 01; 6(6):597-617. PMID: 21765857.
    View in: PubMed
  79. Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #1: processes and requirements. Drug Discov Today. 2011 Jul; 16(13-14):583-93. PMID: 21635967.
    View in: PubMed
  80. Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practices. Drug Discov Today. 2011 Aug; 16(15-16):671-82. PMID: 21477664.
    View in: PubMed
  81. Moulton EA, Elman I, Pendse G, Schmahmann J, Becerra L, Borsook D. Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images. J Neurosci. 2011 Mar 09; 31(10):3795-804. PMID: 21389234; PMCID: PMC3063442.
  82. Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging. Discov Med. 2011 Mar; 11(58):209-19. PMID: 21447280.
    View in: PubMed
  83. Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions. Discov Med. 2011 Mar; 11(58):197-207. PMID: 21447279.
    View in: PubMed
  84. Maleki N, Becerra L, Upadhyay J, Burstein R, Borsook D. Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia. Hum Brain Mapp. 2012 Jan; 33(1):75-88. PMID: 21337474; PMCID: PMC3711521.
  85. Borsook D, Becerra L. CNS animal fMRI in pain and analgesia. Neurosci Biobehav Rev. 2011 Apr; 35(5):1125-43. PMID: 21126534; PMCID: PMC3076623.
  86. Becerra L, Chang PC, Bishop J, Borsook D. CNS activation maps in awake rats exposed to thermal stimuli to the dorsum of the hindpaw. Neuroimage. 2011 Jan 15; 54(2):1355-66. PMID: 20817102.
    View in: PubMed
  87. Borsook D, George E, Kussman B, Becerra L. Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors. Prog Neurobiol. 2010 Dec; 92(4):601-12. PMID: 20727935.
    View in: PubMed
  88. Borsook D, Becerra L. Using NMR approaches to drive the search for new CNS therapeutics. Curr Opin Investig Drugs. 2010 Jul; 11(7):771-8. PMID: 20571972; PMCID: PMC3010855.
  89. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul; 68(1):81-91. PMID: 20582997; PMCID: PMC2930514.
  90. Moulton EA, Becerra L, Maleki N, Pendse G, Tully S, Hargreaves R, Burstein R, Borsook D. Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States. Cereb Cortex. 2011 Feb; 21(2):435-48. PMID: 20562317; PMCID: PMC3020583.
  91. Upadhyay J, Maleki N, Potter J, Elman I, Rudrauf D, Knudsen J, Wallin D, Pendse G, McDonald L, Griffin M, Anderson J, Nutile L, Renshaw P, Weiss R, Becerra L, Borsook D. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain. 2010 Jul; 133(Pt 7):2098-114. PMID: 20558415; PMCID: PMC2912691.
  92. Pendse GV, Schwarz AJ, Baumgartner R, Coimbra A, Upadhyay J, Borsook D, Becerra L. Robust, unbiased general linear model estimation of phMRI signal amplitude in the presence of variation in the temporal response profile. J Magn Reson Imaging. 2010 Jun; 31(6):1445-57. PMID: 20512898.
    View in: PubMed
  93. George E, Becerra L, Upadhyay J, Schmidt U, Borsook D. Evaluation of novel drugs using fMRI in early-phase clinical trials: safety monitoring. Drug Discov Today. 2010 Aug; 15(15-16):684-9. PMID: 20553959; PMCID: PMC2921954.
  94. Moulton EA, Schmahmann JD, Becerra L, Borsook D. The cerebellum and pain: passive integrator or active participator? Brain Res Rev. 2010 Oct 05; 65(1):14-27. PMID: 20553761; PMCID: PMC2943015.
  95. Borsook D, Upadhyay J, Chudler EH, Becerra L. A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging. Mol Pain. 2010 May 13; 6:27. PMID: 20465845; PMCID: PMC2883978.
  96. Scrivani S, Wallin D, Moulton EA, Cole S, Wasan AD, Lockerman L, Bajwa Z, Upadhyay J, Becerra L, Borsook D. A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study. Pain Med. 2010 Jun; 11(6):920-41. PMID: 20492571.
    View in: PubMed
  97. Borsook D, Sava S, Becerra L. The pain imaging revolution: advancing pain into the 21st century. Neuroscientist. 2010 Apr; 16(2):171-85. PMID: 20400714; PMCID: PMC3370428.
  98. Pendse GV, Baumgartner R, Schwarz AJ, Coimbra A, Borsook D, Becerra L. A statistical framework for optimal design matrix generation with application to fMRI. IEEE Trans Med Imaging. 2010 Sep; 29(9):1573-611. PMID: 20304726.
    View in: PubMed
  99. Becerra L, Harris W, Grant M, George E, Boas D, Borsook D. Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuli. PLoS One. 2009 Nov 24; 4(11):e8016. PMID: 19956637; PMCID: PMC2778627.
  100. Upadhyay J, Pendse G, Anderson J, Schwarz AJ, Baumgartner R, Coimbra A, Bishop J, Knudsen J, George E, Grachev I, Iyengar S, Bleakman D, Hargreaves R, Borsook D, Becerra L. Improved characterization of BOLD responses for evoked sensory stimuli. Neuroimage. 2010 Feb 01; 49(3):2275-86. PMID: 19854280.
    View in: PubMed
  101. Moulton EA, Becerra L, Borsook D. An fMRI case report of photophobia: activation of the trigeminal nociceptive pathway. Pain. 2009 Oct; 145(3):358-63. PMID: 19674842; PMCID: PMC2756998.
  102. Elman I, Lowen S, Frederick BB, Chi W, Becerra L, Pitman RK. Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder. Biol Psychiatry. 2009 Dec 15; 66(12):1083-90. PMID: 19640506.
    View in: PubMed
  103. Prescot A, Becerra L, Pendse G, Tully S, Jensen E, Hargreaves R, Renshaw P, Burstein R, Borsook D. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009 Jun 30; 5:34. PMID: 19566960; PMCID: PMC2714306.
  104. Sava S, Lebel AA, Leslie DS, Drosos A, Berde C, Becerra L, Borsook D. Challenges of functional imaging research of pain in children. Mol Pain. 2009 Jun 16; 5:30. PMID: 19531255; PMCID: PMC2702328.
  105. Pendse G, Borsook D, Becerra L. Enhanced false discovery rate using Gaussian mixture models for thresholding fMRI statistical maps. Neuroimage. 2009 Aug 01; 47(1):231-61. PMID: 19269334; PMCID: PMC2735129.
  106. Moulton EA, Pendse G, Morris S, Aiello-Lammens M, Becerra L, Borsook D. Segmentally arranged somatotopy within the face representation of human primary somatosensory cortex. Hum Brain Mapp. 2009 Mar; 30(3):757-65. PMID: 18266215.
    View in: PubMed
  107. Becerra L, Schwartzman RJ, Kiefer RT, Rohr P, Moulton EA, Wallin D, Pendse G, Morris S, Borsook D. CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome. Pain Med. 2009 Feb 25. PMID: 19254342.
    View in: PubMed
  108. Borsook D, Becerra L. Emotional pain without sensory pain--dream on? Neuron. 2009 Jan 29; 61(2):153-5. PMID: 19186157.
    View in: PubMed
  109. Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008; 3(11):e3799. PMID: 19030105; PMCID: PMC2582961.
  110. Upadhyay J, Knudsen J, Anderson J, Becerra L, Borsook D. Noninvasive mapping of human trigeminal brainstem pathways. Magn Reson Med. 2008 Nov; 60(5):1037-46. PMID: 18956455; PMCID: PMC2597480.
  111. DaSilva AF, Becerra L, Pendse G, Chizh B, Tully S, Borsook D. Colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain. PLoS One. 2008; 3(10):e3396. PMID: 18923647; PMCID: PMC2561059.
  112. Lebel A, Becerra L, Wallin D, Moulton EA, Morris S, Pendse G, Jasciewicz J, Stein M, Aiello-Lammens M, Grant E, Berde C, Borsook D. fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain. 2008 Jul; 131(Pt 7):1854-79. PMID: 18567621.
    View in: PubMed
  113. Borsook D, Bleakman D, Hargreaves R, Upadhyay J, Schmidt KF, Becerra L. A 'BOLD' experiment in defining the utility of fMRI in drug development. Neuroimage. 2008 Aug 15; 42(2):461-6. PMID: 18598770.
    View in: PubMed
  114. Becerra L, Harris W, Joseph D, Huppert T, Boas DA, Borsook D. Diffuse optical tomography of pain and tactile stimulation: activation in cortical sensory and emotional systems. Neuroimage. 2008 Jun; 41(2):252-9. PMID: 18394924; PMCID: PMC2728450.
  115. Becerra L, Borsook D. Signal valence in the nucleus accumbens to pain onset and offset. Eur J Pain. 2008 Oct; 12(7):866-9. PMID: 18226937; PMCID: PMC2581873.
  116. Borsook D, Moulton EA, Tully S, Schmahmann JD, Becerra L. Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects. Cerebellum. 2008; 7(3):252-72. PMID: 18418691.
    View in: PubMed
  117. Borsook D, Moulton EA, Pendse G, Morris S, Cole SH, Aiello-Lammens M, Scrivani S, Becerra LR. Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux). Mol Pain. 2007 Nov 06; 3:34. PMID: 17983481; PMCID: PMC2217520.
  118. Borsook D, Moulton EA, Schmidt KF, Becerra LR. Neuroimaging revolutionizes therapeutic approaches to chronic pain. Mol Pain. 2007 Sep 11; 3:25. PMID: 17848191; PMCID: PMC2048498.
  119. Borsook D, Becerra L. Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic. Curr Pain Headache Rep. 2007 Jun; 11(3):201-7. PMID: 17504647.
    View in: PubMed
  120. Moulton EA, Pendse G, Morris S, Strassman A, Aiello-Lammens M, Becerra L, Borsook D. Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study. Neuroimage. 2007 May 01; 35(4):1586-600. PMID: 17407825; PMCID: PMC2034350.
  121. Becerra L, Morris S, Bazes S, Gostic R, Sherman S, Gostic J, Pendse G, Moulton E, Scrivani S, Keith D, Chizh B, Borsook D. Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J Neurosci. 2006 Oct 18; 26(42):10646-57. PMID: 17050704.
    View in: PubMed
  122. Borsook D, Becerra LR. Breaking down the barriers: fMRI applications in pain, analgesia and analgesics. Mol Pain. 2006 Sep 18; 2:30. PMID: 16982005; PMCID: PMC1592305.
  123. Becerra L, Harter K, Gonzalez RG, Borsook D. Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers. Anesth Analg. 2006 Jul; 103(1):208-16, table of contents. PMID: 16790655.
    View in: PubMed
  124. Negus SS, Vanderah TW, Brandt MR, Bilsky EJ, Becerra L, Borsook D. Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. J Pharmacol Exp Ther. 2006 Nov; 319(2):507-14. PMID: 16751251.
    View in: PubMed
  125. Borsook D, Burstein R, Moulton E, Becerra L. Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache. 2006 Jun; 46 Suppl 1:S32-8. PMID: 16927962.
    View in: PubMed
  126. Borsook D, Becerra L, Hargreaves R. A role for fMRI in optimizing CNS drug development. Nat Rev Drug Discov. 2006 May; 5(5):411-24. PMID: 16604100.
    View in: PubMed
  127. Borsook D, Becerra L, Carlezon WA, Shaw M, Renshaw P, Elman I, Levine J. Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders. Eur J Pain. 2007 Jan; 11(1):7-20. PMID: 16495096.
    View in: PubMed
  128. Aharon I, Becerra L, Becerraa L, Chabris CF, Borsook D, Borsooka D. Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens. Neurosci Lett. 2006 Jan 16; 392(3):159-64. PMID: 16257488.
    View in: PubMed
  129. Borsook D, Becerra L. Functional imaging of pain and analgesia--a valid diagnostic tool? Pain. 2005 Oct; 117(3):247-50. PMID: 16154699.
    View in: PubMed
  130. Borsook D, Burstein R, Becerra L. Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease. J Neurobiol. 2004 Oct; 61(1):107-25. PMID: 15362156.
    View in: PubMed
  131. Borras MC, Becerra L, Ploghaus A, Gostic JM, DaSilva A, Gonzalez RG, Borsook D. fMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers. J Neurophysiol. 2004 Jun; 91(6):2723-33. PMID: 15136603.
    View in: PubMed
  132. Becerra L, Iadarola M, Borsook D. CNS activation by noxious heat to the hand or foot: site-dependent delay in sensory but not emotion circuitry. J Neurophysiol. 2004 Jan; 91(1):533-41. PMID: 14715722.
    View in: PubMed
  133. Borsook D, Becerra L. Pain imaging: future applications to integrative clinical and basic neurobiology. Adv Drug Deliv Rev. 2003 Aug 28; 55(8):967-86. PMID: 12935940.
    View in: PubMed
  134. Borsook D, DaSilva AF, Ploghaus A, Becerra L. Specific and somatotopic functional magnetic resonance imaging activation in the trigeminal ganglion by brush and noxious heat. J Neurosci. 2003 Aug 27; 23(21):7897-903. PMID: 12944520.
    View in: PubMed
  135. Ploghaus A, Becerra L, Borras C, Borsook D. Neural circuitry underlying pain modulation: expectation, hypnosis, placebo. Trends Cogn Sci. 2003 May; 7(5):197-200. PMID: 12757820.
    View in: PubMed
  136. DaSilva AF, Becerra L, Makris N, Strassman AM, Gonzalez RG, Geatrakis N, Borsook D. Somatotopic activation in the human trigeminal pain pathway. J Neurosci. 2002 Sep 15; 22(18):8183-92. PMID: 12223572.
    View in: PubMed
  137. Borsook D, Ploghaus A, Becerra L. Utilizing brain imaging for analgesic drug development. Curr Opin Investig Drugs. 2002 Sep; 3(9):1342-7. PMID: 12498011.
    View in: PubMed
  138. Romero JM, Schaefer PW, Grant PE, Becerra L, González RG. Diffusion MR imaging of acute ischemic stroke. Neuroimaging Clin N Am. 2002 Feb; 12(1):35-53. PMID: 11998252.
    View in: PubMed
  139. Becerra L, Breiter HC, Wise R, Gonzalez RG, Borsook D. Reward circuitry activation by noxious thermal stimuli. Neuron. 2001 Dec 06; 32(5):927-46. PMID: 11738036.
    View in: PubMed
  140. González RG, Cheng LL, Westmoreland SV, Sakaie KE, Becerra LR, Lee PL, Masliah E, Lackner AA. Early brain injury in the SIV-macaque model of AIDS. AIDS. 2000 Dec 22; 14(18):2841-9. PMID: 11153665.
    View in: PubMed
  141. Tracey I, Becerra L, Chang I, Breiter H, Jenkins L, Borsook D, González RG. Noxious hot and cold stimulation produce common patterns of brain activation in humans: a functional magnetic resonance imaging study. Neurosci Lett. 2000 Jul 14; 288(2):159-62. PMID: 10876085.
    View in: PubMed
  142. Becerra LR, Breiter HC, Stojanovic M, Fishman S, Edwards A, Comite AR, Gonzalez RG, Borsook D. Human brain activation under controlled thermal stimulation and habituation to noxious heat: an fMRI study. Magn Reson Med. 1999 May; 41(5):1044-57. PMID: 10332889.
    View in: PubMed
  143. Borsook D, Becerra L, Fishman S, Edwards A, Jennings CL, Stojanovic M, Papinicolas L, Ramachandran VS, Gonzalez RG, Breiter H. Acute plasticity in the human somatosensory cortex following amputation. Neuroreport. 1998 Apr 20; 9(6):1013-7. PMID: 9601659.
    View in: PubMed
  144. Cheng LL, Ma MJ, Becerra L, Ptak T, Tracey I, Lackner A, González RG. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6408-13. PMID: 9177231; PMCID: PMC21063.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Becerra's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_