Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Bruce Furie, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Cls 903
330 Brookline Ave
Boston MA 02215
Phone617/735-4002
Fax617/735-4000
vCardDownload vCard (login for email)

 Mentoring 
 completed student projects
The role of CD74 in blocking apoptosis during cancer
Summer, 06/15/09 - 08/07/09

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Flaumenhaft R, Furie B, Zwicker JI. Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):16-23.
    View in: PubMed
  2. Proulle V, Furie RA, Merrill-Skoloff G, Furie BC, Furie B. Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS. Blood. 2014 Jul 24; 124(4):611-22.
    View in: PubMed
  3. Furie B, Flaumenhaft R. Thiol isomerases in thrombus formation. Circ Res. 2014 Mar 28; 114(7):1162-73.
    View in: PubMed
  4. Furie B. Do pharmacogenetics have a role in the dosing of vitamin k antagonists? N Engl J Med. 2013 Dec 12; 369(24):2345-6.
    View in: PubMed
  5. Zwicker JI, Liebman HA, Bauer KA, Caughey T, Campigotto F, Rosovsky R, Mantha S, Kessler CM, Eneman J, Raghavan V, Lenz HJ, Bullock A, Buchbinder E, Neuberg D, Furie B. Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study). Br J Haematol. 2013 Feb; 160(4):530-7.
    View in: PubMed
  6. Furie B, Furie BC. Formation of the clot. Thromb Res. 2012 Oct; 130 Suppl 1:S44-6.
    View in: PubMed
  7. Fuster V, Bhatt DL, Califf RM, Michelson AD, Sabatine MS, Angiolillo DJ, Bates ER, Cohen DJ, Coller BS, Furie B, Hulot JS, Mann KG, Mega JL, Musunuru K, O'Donnell CJ, Price MJ, Schneider DJ, Simon DI, Weitz JI, Williams MS, Hoots WK, Rosenberg YD, Hasan AA. Guided antithrombotic therapy: current status and future research direction: report on a National Heart, Lung and Blood Institute working group. Circulation. 2012 Sep 25; 126(13):1645-62.
    View in: PubMed
  8. Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of ß3 integrins. Blood. 2012 Jul 19; 120(3):647-55.
    View in: PubMed
  9. Jasuja R, Passam FH, Kennedy DR, Kim SH, van Hessem L, Lin L, Bowley SR, Joshi SS, Dilks JR, Furie B, Furie BC, Flaumenhaft R. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. J Clin Invest. 2012 Jun 1; 122(6):2104-13.
    View in: PubMed
  10. Weitz IC, Razavi P, Rochanda L, Zwicker J, Furie B, Manly D, Mackman N, Green R, Liebman HA. Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation. Thromb Res. 2012 Sep; 130(3):361-8.
    View in: PubMed
  11. Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest. 2012 Feb 1; 122(2):558-68.
    View in: PubMed
  12. Zwicker JI, Lacroix R, Dignat-George F, Furie BC, Furie B. Measurement of platelet microparticles. Methods Mol Biol. 2012; 788:127-39.
    View in: PubMed
  13. Kroh HK, Panizzi P, Tchaikovski S, Baird TR, Wei N, Krishnaswamy S, Tans G, Rosing J, Furie B, Furie BC, Bock PE. Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo. J Biol Chem. 2011 Jul 1; 286(26):23345-56.
    View in: PubMed
  14. Zwicker JI, Trenor CC, Furie BC, Furie B. Tissue factor-bearing microparticles and thrombus formation. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):728-33.
    View in: PubMed
  15. Arad A, Proulle V, Furie RA, Furie BC, Furie B. ß2-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model. Blood. 2011 Mar 24; 117(12):3453-9.
    View in: PubMed
  16. Lin Z, Jiang L, Yuan C, Jensen JK, Zhang X, Luo Z, Furie BC, Furie B, Andreasen PA, Huang M. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J Biol Chem. 2011 Mar 4; 286(9):7027-32.
    View in: PubMed
  17. Atkinson BT, Jasuja R, Chen VM, Nandivada P, Furie B, Furie BC. Laser-induced endothelial cell activation supports fibrin formation. Blood. 2010 Nov 25; 116(22):4675-83.
    View in: PubMed
  18. Jasuja R, Furie B, Furie BC. Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo. Blood. 2010 Nov 25; 116(22):4665-74.
    View in: PubMed
  19. Lu SX, Holland AM, Na IK, Terwey TH, Alpdogan O, Bautista JL, Smith OM, Suh D, King C, Kochman A, Hubbard VM, Rao UK, Yim N, Liu C, Laga AC, Murphy G, Jenq RR, Zakrzewski JL, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink MR. Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease. J Immunol. 2010 Aug 1; 185(3):1912-9.
    View in: PubMed
  20. Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J Biol Chem. 2010 Mar 19; 285(12):8824-9.
    View in: PubMed
  21. Barthel SR, Wiese GK, Cho J, Opperman MJ, Hays DL, Siddiqui J, Pienta KJ, Furie B, Dimitroff CJ. Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19491-6.
    View in: PubMed
  22. Zwicker JI, Liebman HA, Neuberg D, Lacroix R, Bauer KA, Furie BC, Furie B. Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res. 2009 Nov 15; 15(22):6830-40.
    View in: PubMed
  23. Furie B. Pathogenesis of thrombosis. Hematology Am Soc Hematol Educ Program. 2009; 255-8.
    View in: PubMed
  24. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008 Aug 28; 359(9):938-49.
    View in: PubMed
  25. Ngo JC, Huang M, Roth DA, Furie BC, Furie B. Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure. 2008 Apr; 16(4):597-606.
    View in: PubMed
  26. Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M. Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. Nat Struct Mol Biol. 2008 Apr; 15(4):422-3.
    View in: PubMed
  27. Cho J, Furie BC, Coughlin SR, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest. 2008 Mar; 118(3):1123-31.
    View in: PubMed
  28. Panicot-Dubois L, Thomas GM, Furie BC, Furie B, Lombardo D, Dubois C. Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans. J Clin Invest. 2007 Dec; 117(12):3708-19.
    View in: PubMed
  29. Lin L, Huai Q, Huang M, Furie B, Furie BC. Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII. J Mol Biol. 2007 Aug 17; 371(3):717-24.
    View in: PubMed
  30. Dubois C, Panicot-Dubois L, Gainor JF, Furie BC, Furie B. Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest. 2007 Apr; 117(4):953-60.
    View in: PubMed
  31. Zhu A, Sun H, Raymond RM, Furie BC, Furie B, Bronstein M, Kaufman RJ, Westrick R, Ginsburg D. Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 2007 Jun 15; 109(12):5270-5.
    View in: PubMed
  32. Zwicker JI, Furie BC, Furie B. Cancer-associated thrombosis. Crit Rev Oncol Hematol. 2007 May; 62(2):126-36.
    View in: PubMed
  33. Harakawa N, Shigeta A, Wato M, Merrill-Skoloff G, Furie BC, Furie B, Okazaki T, Domae N, Miyasaka M, Hirata T. P-selectin glycoprotein ligand-1 mediates L-selectin-independent leukocyte rolling in high endothelial venules of peripheral lymph nodes. Int Immunol. 2007 Mar; 19(3):321-9.
    View in: PubMed
  34. Vandendries ER, Hamilton JR, Coughlin SR, Furie B, Furie BC. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A. 2007 Jan 2; 104(1):288-92.
    View in: PubMed
  35. Hansson K, Thämlitz AM, Furie B, Furie BC, Stenflo J. A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide. Biochemistry. 2006 Oct 24; 45(42):12828-39.
    View in: PubMed
  36. Czerwiec E, Kalume DE, Roepstorff P, Hambe B, Furie B, Furie BC, Stenflo J. Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile. FEBS J. 2006 Jun; 273(12):2779-88.
    View in: PubMed
  37. Furie BC, Furie B. Tissue factor pathway vs. collagen pathway for in vivo platelet activation. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):135-8.
    View in: PubMed
  38. Furie B, Furie BC. Cancer-associated thrombosis. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):177-81.
    View in: PubMed
  39. Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M. Structure of human urokinase plasminogen activator in complex with its receptor. Science. 2006 Feb 3; 311(5761):656-9.
    View in: PubMed
  40. Dubois C, Panicot-Dubois L, Merrill-Skoloff G, Furie B, Furie BC. Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo. Blood. 2006 May 15; 107(10):3902-6.
    View in: PubMed
  41. Furie B, Furie BC. Thrombus formation in a living mouse. Pathophysiol Haemost Thromb. 2006; 35(1-2):1-4.
    View in: PubMed
  42. Furie B, Furie BC. Thrombus formation in vivo. J Clin Invest. 2005 Dec; 115(12):3355-62.
    View in: PubMed
  43. Gross PL, Furie BC, Merrill-Skoloff G, Chou J, Furie B. Leukocyte-versus microparticle-mediated tissue factor transfer during arteriolar thrombus development. J Leukoc Biol. 2005 Dec; 78(6):1318-26.
    View in: PubMed
  44. Falati S, Patil S, Gross PL, Stapleton M, Merrill-Skoloff G, Barrett NE, Pixton KL, Weiler H, Cooley B, Newman DK, Newman PJ, Furie BC, Furie B, Gibbins JM. Platelet PECAM-1 inhibits thrombus formation in vivo. Blood. 2006 Jan 15; 107(2):535-41.
    View in: PubMed
  45. Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ. PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol. 2005 Aug 29; 170(5):837-45.
    View in: PubMed
  46. Engelhardt B, Kempe B, Merfeld-Clauss S, Laschinger M, Furie B, Wild MK, Vestweber D. P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice. J Immunol. 2005 Jul 15; 175(2):1267-75.
    View in: PubMed
  47. Brown MA, Begley GS, Czerwiec E, Stenberg LM, Jacobs M, Kalume DE, Roepstorff P, Stenflo J, Furie BC, Furie B. Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation. Biochemistry. 2005 Jun 28; 44(25):9150-9.
    View in: PubMed
  48. Furie B. P-selectin and blood coagulation: it's not only about inflammation any more. Arterioscler Thromb Vasc Biol. 2005 May; 25(5):877-8.
    View in: PubMed
  49. Sim D, Flaumenhaft R, Furie B, Furie B. Interactions of platelets, blood-borne tissue factor, and fibrin during arteriolar thrombus formation in vivo. Microcirculation. 2005 Apr-May; 12(3):301-11.
    View in: PubMed
  50. Sathish JG, Falati S, Croce K, Crump C, Furie BC, Furie B, Poole AW. Antibody cross-linking of human platelet P-selectin induces calcium entry by a mechanism dependent upon Fcgamma receptor IIA. Thromb Haemost. 2004 Sep; 92(3):598-605.
    View in: PubMed
  51. Vandendries ER, Furie BC, Furie B. Role of P-selectin and PSGL-1 in coagulation and thrombosis. Thromb Haemost. 2004 Sep; 92(3):459-66.
    View in: PubMed
  52. Chou J, Mackman N, Merrill-Skoloff G, Pedersen B, Furie BC, Furie B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood. 2004 Nov 15; 104(10):3190-7.
    View in: PubMed
  53. Hansson K, Furie B, Furie BC, Stenflo J. Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern. Biochem Biophys Res Commun. 2004 Jul 9; 319(4):1081-7.
    View in: PubMed
  54. Schenone M, Furie BC, Furie B. The blood coagulation cascade. Curr Opin Hematol. 2004 Jul; 11(4):272-7.
    View in: PubMed
  55. Hansson K, Ma X, Eliasson L, Czerwiec E, Furie B, Furie BC, Rorsman P, Stenflo J. The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J Biol Chem. 2004 Jul 30; 279(31):32453-63.
    View in: PubMed
  56. Grant MA, Hansson K, Furie BC, Furie B, Stenflo J, Rigby AC. The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M. J Biol Chem. 2004 Jul 30; 279(31):32464-73.
    View in: PubMed
  57. Furie B, Furie BC. Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation. Trends Mol Med. 2004 Apr; 10(4):171-8.
    View in: PubMed
  58. Huang M, Furie BC, Furie B. Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. J Biol Chem. 2004 Apr 2; 279(14):14338-46.
    View in: PubMed
  59. Celi A, Lorenzet R, Furie BC, Furie B. Microparticles and a P-selectin-mediated pathway of blood coagulation. Dis Markers. 2004; 20(6):347-52.
    View in: PubMed
  60. Falati S, Gross PL, Merrill-Skoloff G, Sim D, Flaumenhaft R, Celi A, Furie BC, Furie B. In vivo models of platelet function and thrombosis: study of real-time thrombus formation. Methods Mol Biol. 2004; 272:187-97.
    View in: PubMed
  61. Tchernychev B, Furie B, Furie BC. Peritoneal macrophages express both P-selectin and PSGL-1. J Cell Biol. 2003 Dec 8; 163(5):1145-55.
    View in: PubMed
  62. Sim DS, Merrill-Skoloff G, Furie BC, Furie B, Flaumenhaft R. Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels. Blood. 2004 Mar 15; 103(6):2127-34.
    View in: PubMed
  63. Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC. Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol. 2003 Sep; 10(9):751-6.
    View in: PubMed
  64. Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B, Booth SL, Volpe JJ, Rosenberg PA. Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci. 2003 Jul 2; 23(13):5816-26.
    View in: PubMed
  65. Blostein MD, Furie BC, Rajotte I, Furie B. The Gla domain of factor IXa binds to factor VIIIa in the tenase complex. J Biol Chem. 2003 Aug 15; 278(33):31297-302.
    View in: PubMed
  66. Falati S, Liu Q, Gross P, Merrill-Skoloff G, Chou J, Vandendries E, Celi A, Croce K, Furie BC, Furie B. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med. 2003 Jun 2; 197(11):1585-98.
    View in: PubMed
  67. Katayama Y, Hidalgo A, Furie BC, Vestweber D, Furie B, Frenette PS. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. Blood. 2003 Sep 15; 102(6):2060-7.
    View in: PubMed
  68. Furie B, Furie BC. Real time in vivo imaging of tissue factor-induced thrombus formation. Pathophysiol Haemost Thromb. 2003; 33 Suppl 1:26-7.
    View in: PubMed
  69. Czerwiec E, Begley GS, Bronstein M, Stenflo J, Taylor K, Furie BC, Furie B. Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile. Eur J Biochem. 2002 Dec; 269(24):6162-72.
    View in: PubMed
  70. Hirata T, Furie BC, Furie B. P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin. J Immunol. 2002 Oct 15; 169(8):4307-13.
    View in: PubMed
  71. Falati S, Gross P, Merrill-Skoloff G, Furie BC, Furie B. Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med. 2002 Oct; 8(10):1175-81.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Furie's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_