Harvard Catalyst Profiles

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Jeffrey Isaac Zwicker, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21CA231000 (KENNEDY, DANIEL ROBERT) Sep 1, 2019 - Aug 31, 2021
    NIH/NCI
    Response to PQ12 - Using thiol isomerase inhibitors to diminish cancer induced thrombosis
    Role: Co-Principal Investigator
  2. U01HL143365 (ZWICKER, JEFFREY) Aug 1, 2018 - Jul 31, 2023
    NIH/NHLBI
    Biomarkers and mechanisms in cancer associated thrombosis
    Role: Principal Investigator
  3. R34HL135226 (ZWICKER, JEFFREY) Jul 5, 2017 - Jun 30, 2020
    NIH/NHLBI
    Thromboprophylaxis with rosuvastatin following surgery for ovarian cancer
    Role: Principal Investigator
  4. R34HL127156 (ZWICKER, JEFFREY) Feb 10, 2016 - Jan 31, 2019
    NIH/NHLBI
    Risk-adapted thromboprophylaxis of hospitalized cancer patients
    Role: Co-Principal Investigator
  5. U54HL112302 (FURIE, BRUCE) Sep 1, 2012 - Apr 30, 2017
    NIH/NHLBI
    Protein disulfide isomerases: A new class of antithrombotic targets
    Role: Co-Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Patell R, Bogue T, Koshy AG, Bindal P, Merrill M, Aird WC, Bauer KA, Zwicker JI. Post-discharge thrombosis and hemorrhage in patients with COVID-19. Blood. 2020 Aug 07. PMID: 32766883.
    Citations:    
  2. Patell R, Bogue T, Bindal P, Koshy A, Merrill M, Aird WC, Bauer KA, Zwicker JI. Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID-19. J Thromb Haemost. 2020 Jul 21. PMID: 32692862.
    Citations:    
  3. Patell R, Khan AM, Bogue T, Merrill M, Koshy A, Bindal P, Joyce R, Aird WC, Neuberg D, Bauer KA, Zwicker JI. Heparin induced thrombocytopenia antibodies in Covid-19. Am J Hematol. 2020 Jul 13. PMID: 32658337.
    Citations:    
  4. Patell R, Zwicker JI. Inpatient prophylaxis in cancer patients: where is the evidence? Thromb Res. 2020 Jul; 191 Suppl 1:S85-S90. PMID: 32736785.
    Citations:    
  5. Carney BJ, Uhlmann EJ, Puligandla M, Mantia C, Weber GM, Neuberg DS, Zwicker JI. Anticoagulation after intracranial hemorrhage in brain tumors: Risk of recurrent hemorrhage and venous thromboembolism. Res Pract Thromb Haemost. 2020 Jul; 4(5):860-865. PMID: 32685895.
    Citations:    
  6. Stoeckle JH, Bogue T, Zwicker JI. Postpartum haemorrhage in women with mild factor XI deficiency. Haemophilia. 2020 Jul; 26(4):663-666. PMID: 32558038.
    Citations:    
  7. Zwicker JI, Roopkumar J, Puligandla M, Schlechter BL, Sharda AV, Peereboom D, Joyce R, Bockorny B, Neuberg D, Bauer KA, Khorana AA. Dose-adjusted enoxaparin thromboprophylaxis in hospitalized cancer patients: a randomized, double-blinded multicenter phase 2 trial. Blood Adv. 2020 May 26; 4(10):2254-2260. PMID: 32442298.
    Citations:    
  8. Zwicker JI, Wang TF, DeAngelo DJ, Lauw MN, Connors JM, Falanga A, McMasters M, Carrier M. The prevention and management of asparaginase-related venous thromboembolism in adults: Guidance from the SSC on Hemostasis and Malignancy of the ISTH. J Thromb Haemost. 2020 02; 18(2):278-284. PMID: 31999063.
    Citations:    
  9. Wang TF, Zwicker JI, Ay C, Pabinger I, Falanga A, Antic D, Noble S, Khorana AA, Carrier M, Meyer G. The use of direct oral anticoagulants for primary thromboprophylaxis in ambulatory cancer patients: Guidance from the SSC of the ISTH. J Thromb Haemost. 2019 10; 17(10):1772-1778. PMID: 31353841.
    Citations:    
  10. Zwicker JI, Muia J, Dolatshahi L, Westfield LA, Nieters P, Rodrigues A, Hamdan A, Antun AG, Metjian A, Sadler JE. Adjuvant low-dose rituximab and plasma exchange for acquired TTP. Blood. 2019 09 26; 134(13):1106-1109. PMID: 31331919.
    Citations:    
  11. Zwicker JI, Schlechter BL, Stopa JD, Liebman HA, Aggarwal A, Puligandla M, Caughey T, Bauer KA, Kuemmerle N, Wong E, Wun T, McLaughlin M, Hidalgo M, Neuberg D, Furie B, Flaumenhaft R. Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer. JCI Insight. 2019 02 21; 4(4). PMID: 30652973.
    Citations:    Fields:    
  12. Mantia C, Zwicker JI. Anticoagulation in the Setting of Primary and Metastatic Brain Tumors. Cancer Treat Res. 2019; 179:179-189. PMID: 31317488.
    Citations:    
  13. Carney BJ, Uhlmann EJ, Puligandla M, Mantia C, Weber GM, Neuberg DS, Zwicker JI. Intracranial hemorrhage with direct oral anticoagulants in patients with brain tumors. J Thromb Haemost. 2019 01; 17(1):72-76. PMID: 30450803.
    Citations:    Fields:    
  14. Kraaijpoel N, Di Nisio M, Mulder FI, van Es N, Beyer-Westendorf J, Carrier M, Garcia D, Grosso M, Kakkar AK, Mercuri MF, Middeldorp S, Hernandez CR, Santamaria A, Schwocho L, Segers A, Verhamme P, Wang TF, Weitz JI, Zhang G, Zwicker JI, Büller HR, Raskob GE. Clinical Impact of Bleeding in Cancer-Associated Venous Thromboembolism: Results from the Hokusai VTE Cancer Study. Thromb Haemost. 2018 Aug; 118(8):1439-1449. PMID: 30060256.
    Citations:    Fields:    
  15. Samuelson Bannow BR, Lee AYY, Khorana AA, Zwicker JI, Noble S, Ay C, Carrier M. Management of anticoagulation for cancer-associated thrombosis in patients with thrombocytopenia: A systematic review. Res Pract Thromb Haemost. 2018 Oct; 2(4):664-669. PMID: 30349884.
    Citations:    
  16. Samuelson Bannow BT, Lee A, Khorana AA, Zwicker JI, Noble S, Ay C, Carrier M. Management of cancer-associated thrombosis in patients with thrombocytopenia: guidance from the SSC of the ISTH. J Thromb Haemost. 2018 06; 16(6):1246-1249. PMID: 29737593.
    Citations: 1     Fields:    
  17. Stopa JD, Zwicker JI. The intersection of protein disulfide isomerase and cancer associated thrombosis. Thromb Res. 2018 04; 164 Suppl 1:S130-S135. PMID: 29703471.
    Citations:    Fields:    Translation:Humans
  18. Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D, Grosso MA, Kakkar AK, Kovacs MJ, Mercuri MF, Meyer G, Segers A, Shi M, Wang TF, Yeo E, Zhang G, Zwicker JI, Weitz JI, Büller HR. Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism. N Engl J Med. 2018 Feb 15; 378(7):615-624. PMID: 29231094.
    Citations: 24     Fields:    Translation:Humans
  19. Mantia C, Uhlmann EJ, Puligandla M, Weber GM, Neuberg D, Zwicker JI. Predicting the higher rate of intracranial hemorrhage in glioma patients receiving therapeutic enoxaparin. Blood. 2017 06 22; 129(25):3379-3385. PMID: 28468796.
    Citations: 6     Fields:    Translation:Humans
  20. Zwicker JI. Risking thromboembolism: podoplanin and glioma. Blood. 2017 03 30; 129(13):1742-1743. PMID: 28360357.
    Citations: 1     Fields:    Translation:Humans
  21. Stopa JD, Neuberg D, Puligandla M, Furie B, Flaumenhaft R, Zwicker JI. Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation. JCI Insight. 2017 01 12; 2(1):e89373. PMID: 28097231.
    Citations: 6     Fields:    
  22. Rosenblatt J, Stone RM, Uhl L, Neuberg D, Joyce R, Levine JD, Arnason J, McMasters M, Luptakova K, Jain S, Zwicker JI, Hamdan A, Boussiotis V, Steensma DP, DeAngelo DJ, Galinsky I, Dutt PS, Logan E, Bryant MP, Stroopinsky D, Werner L, Palmer K, Coll M, Washington A, Cole L, Kufe D, Avigan D. Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions. Sci Transl Med. 2016 12 07; 8(368):368ra171. PMID: 27928025.
    Citations: 17     Fields:    Translation:HumansCellsPHPublic Health
  23. Zwicker JI. Scattering the spotlight on microparticles. J Thromb Haemost. 2017 01; 15(1):185-186. PMID: 27778450.
    Citations:    Fields:    Translation:HumansCells
  24. Zwicker JI, Carrier M. A meta-analysis of intracranial hemorrhage in patients with brain tumors receiving therapeutic anticoagulation: reply. J Thromb Haemost. 2016 10; 14(10):2082. PMID: 27477626.
    Citations:    Fields:    Translation:Humans
  25. Zwicker JI, Karp Leaf R, Carrier M. A meta-analysis of intracranial hemorrhage in patients with brain tumors receiving therapeutic anticoagulation. J Thromb Haemost. 2016 09; 14(9):1736-40. PMID: 27306689.
    Citations: 5     Fields:    Translation:Humans
  26. Weinstock MJ, Uhlmann EJ, Zwicker JI. Intracranial hemorrhage in cancer patients treated with anticoagulation. Thromb Res. 2016 Apr; 140 Suppl 1:S60-5. PMID: 27067980.
    Citations: 3     Fields:    Translation:Humans
  27. Galinski CN, Zwicker JI, Kennedy DR. Revisiting the mechanistic basis of the French Paradox: Red wine inhibits the activity of protein disulfide isomerase in vitro. Thromb Res. 2016 Jan; 137:169-173. PMID: 26585763.
    Citations:    Fields:    Translation:AnimalsCells
  28. Donato J, Campigotto F, Uhlmann EJ, Coletti E, Neuberg D, Weber GM, Zwicker JI. Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study. Blood. 2015 Jul 23; 126(4):494-9. PMID: 25987658.
    Citations: 11     Fields:    Translation:Humans
  29. Arnason JE, Luptakova K, Rosenblatt J, Tzachanis D, Avigan D, Zwicker JI, Levine J, Kim M, Parker JA, Grant B, Joyce RM. Yttrium-90 ibritumomab tiuxetan followed by rituximab maintenance as treatment for patients with diffuse large B-cell lymphoma are not candidates for autologous stem cell transplant. Acta Haematol. 2015; 133(4):347-53. PMID: 25677780.
    Citations: 1     Fields:    Translation:Humans
  30. Khorana AA, Zwicker JI, Connolly GC, Pabinger I. Prevention of venous thromboembolism in cancer outpatients: guidance from the SSC of the ISTH: reply. J Thromb Haemost. 2015 Feb; 13(2):325-6. PMID: 25408162.
    Citations:    Fields:    Translation:Humans
  31. Shields K, Cumming M, Rios J, Wong MT, Zwicker JI, Stramer SL, Alonso CD. Transfusion-associated Anaplasma phagocytophilum infection in a pregnant patient with thalassemia trait: a case report. Transfusion. 2015 Apr; 55(4):719-25. PMID: 25385549.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  32. Carrier M, Khorana AA, Zwicker JI. The reply. Am J Med. 2014 Oct; 127(10):e13. PMID: 25311068.
    Citations:    Fields:    Translation:HumansPHPublic Health
  33. Khorana AA, Otten HM, Zwicker JI, Connolly GC, Bancel DF, Pabinger I. Prevention of venous thromboembolism in cancer outpatients: guidance from the SSC of the ISTH. J Thromb Haemost. 2014 Nov; 12(11):1928-31. PMID: 25208230.
    Citations: 8     Fields:    Translation:Humans
  34. Zwicker JI, Bauer KA. How long is long enough? Extended anticoagulation for the treatment of cancer-associated deep vein thrombosis. J Clin Oncol. 2014 Nov 10; 32(32):3596-9. PMID: 25267753.
    Citations:    Fields:    Translation:Humans
  35. Flaumenhaft R, Furie B, Zwicker JI. Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):16-23. PMID: 25104801.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  36. Carrier M, Khorana AA, Zwicker JI. The reply. Am J Med. 2014 Jul; 127(7):e35. PMID: 24970611.
    Citations:    Fields:    Translation:HumansPHPublic Health
  37. Zwicker JI, Rojan A, Campigotto F, Rehman N, Funches R, Connolly G, Webster J, Aggarwal A, Mobarek D, Faselis C, Neuberg D, Rickles FR, Wun T, Streiff MB, Khorana AA. Pattern of frequent but nontargeted pharmacologic thromboprophylaxis for hospitalized patients with cancer at academic medical centers: a prospective, cross-sectional, multicenter study. J Clin Oncol. 2014 Jun 10; 32(17):1792-6. PMID: 24799475.
    Citations: 3     Fields:    Translation:Humans
  38. Zwicker JI, Connolly G, Carrier M, Kamphuisen PW, Lee AY. Catheter-associated deep vein thrombosis of the upper extremity in cancer patients: guidance from the SSC of the ISTH. J Thromb Haemost. 2014 May; 12(5):796-800. PMID: 24548519.
    Citations: 6     Fields:    Translation:Humans
  39. Zwicker JI. Unconventional approaches to the prevention of cancer associated thrombosis. Thromb Res. 2014 May; 133 Suppl 2:S44-8. PMID: 24862145.
    Citations: 2     Fields:    Translation:Humans
  40. Carrier M, Khorana AA, Zwicker JI, Noble S, Lee AY. Management of challenging cases of patients with cancer-associated thrombosis including recurrent thrombosis and bleeding: guidance from the SSC of the ISTH: a reply to a rebuttal. J Thromb Haemost. 2014 Jan; 12(1):116-7. PMID: 24406069.
    Citations: 3     Fields:    Translation:Humans
  41. Carrier M, Khorana AA, Moretto P, Le Gal G, Karp R, Zwicker JI. Lack of evidence to support thromboprophylaxis in hospitalized medical patients with cancer. Am J Med. 2014 Jan; 127(1):82-6.e1. PMID: 24384102.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  42. Carrier M, Khorana AA, Zwicker J, Noble S, Lee AY. Management of challenging cases of patients with cancer-associated thrombosis including recurrent thrombosis and bleeding: guidance from the SSC of the ISTH. J Thromb Haemost. 2013 Sep; 11(9):1760-5. PMID: 23809334.
    Citations: 21     Fields:    Translation:Humans
  43. Zwicker JI, Liebman HA, Bauer KA, Caughey T, Campigotto F, Rosovsky R, Mantha S, Kessler CM, Eneman J, Raghavan V, Lenz HJ, Bullock A, Buchbinder E, Neuberg D, Furie B. Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study). Br J Haematol. 2013 Feb; 160(4):530-7. PMID: 23240761.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  44. Carrier M, Khorana AA, Zwicker JI, Lyman GH, Le Gal G, Lee AY. Venous thromboembolism in cancer clinical trials: recommendation for standardized reporting and analysis. J Thromb Haemost. 2012 Dec; 10(12):2599-601. PMID: 23362524.
    Citations: 3     Fields:    Translation:Humans
  45. Mantha S, Karp R, Raghavan V, Terrin N, Bauer KA, Zwicker JI. Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis. BMJ. 2012 Aug 07; 345:e4944. PMID: 22872710.
    Citations: 16     Fields:    Translation:Humans
  46. Campigotto F, Neuberg D, Zwicker JI. Biased estimation of thrombosis rates in cancer studies using the method of Kaplan and Meier. J Thromb Haemost. 2012 Jul; 10(7):1449-51. PMID: 22554355.
    Citations: 8     Fields:    Translation:Humans
  47. Khorana AA, Spyropoulos AC, Zwicker J, Lyman GH, Francis CW. Preventing VTE in Outpatients With Cancer. Chest. 2012 Jul; 142(1):265-266. PMID: 22796860.
    Citations: 1     Fields:    Translation:Humans
  48. Luptakova K, Rosenblatt J, Glotzbecker B, Mills H, Stroopinsky D, Kufe T, Vasir B, Arnason J, Tzachanis D, Zwicker JI, Joyce RM, Levine JD, Anderson KC, Kufe D, Avigan D. Lenalidomide enhances anti-myeloma cellular immunity. Cancer Immunol Immunother. 2013 Jan; 62(1):39-49. PMID: 22733396.
    Citations: 39     Fields:    Translation:HumansCells
  49. Weitz IC, Razavi P, Rochanda L, Zwicker J, Furie B, Manly D, Mackman N, Green R, Liebman HA. Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation. Thromb Res. 2012 Sep; 130(3):361-8. PMID: 22542362.
    Citations: 17     Fields:    Translation:HumansCells
  50. Campigotto F, Neuberg D, Zwicker JI. Accounting for death as a competing risk in cancer-associated thrombosis studies. Thromb Res. 2012 Apr; 129 Suppl 1:S85-7. PMID: 22682141.
    Citations: 2     Fields:    Translation:Humans
  51. Theisen-Toupal J, Rosenthal ES, Kelly E, Zwicker JI, Akuthota P, Roberts DH. Pulmonary zygomycosis in a non-neutropenic patient with myelodysplastic syndrome on lenalidomide. Respir Care. 2012 Jul; 57(7):1175-7. PMID: 22369887.
    Citations: 1     Fields:    Translation:Humans
  52. Zwicker JI, Lacroix R, Dignat-George F, Furie BC, Furie B. Measurement of platelet microparticles. Methods Mol Biol. 2012; 788:127-39. PMID: 22130705.
    Citations: 7     Fields:    Translation:HumansCells
  53. Zwicker JI, Trenor CC, Furie BC, Furie B. Tissue factor-bearing microparticles and thrombus formation. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):728-33. PMID: 21252066.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  54. Zwicker JI. Impedance-based flow cytometry for the measurement of microparticles. Semin Thromb Hemost. 2010 Nov; 36(8):819-23. PMID: 21049382.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  55. Zwicker JI. Predictive value of tissue factor bearing microparticles in cancer associated thrombosis. Thromb Res. 2010 Apr; 125 Suppl 2:S89-91. PMID: 20434015.
    Citations: 18     Fields:    Translation:HumansCells
  56. Mantha S, Bauer KA, Zwicker JI. Low molecular weight heparin to achieve live birth following unexplained pregnancy loss: a systematic review. J Thromb Haemost. 2010 Feb; 8(2):263-8. PMID: 19912516.
    Citations: 4     Fields:    Translation:Humans
  57. Zwicker JI, Liebman HA, Neuberg D, Lacroix R, Bauer KA, Furie BC, Furie B. Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res. 2009 Nov 15; 15(22):6830-40. PMID: 19861441.
    Citations: 101     Fields:    Translation:Humans
  58. Zwicker JI. Tissue factor-bearing microparticles and cancer. Semin Thromb Hemost. 2008 Mar; 34(2):195-8. PMID: 18645925.
    Citations: 8     Fields:    Translation:HumansCells
  59. Freedman RA, Bauer KA, Neuberg DS, Zwicker JI. Timing of postpartum enoxaparin administration and severe postpartum hemorrhage. Blood Coagul Fibrinolysis. 2008 Jan; 19(1):55-9. PMID: 18180616.
    Citations: 1     Fields:    Translation:Humans
  60. Zwicker JI, Furie BC, Furie B. Cancer-associated thrombosis. Crit Rev Oncol Hematol. 2007 May; 62(2):126-36. PMID: 17293122.
    Citations: 32     Fields:    Translation:HumansAnimals
  61. Zwicker JI, Peyvandi F, Palla R, Lombardi R, Canciani MT, Cairo A, Ardissino D, Bernardinelli L, Bauer KA, Lawler J, Mannucci P. The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. Blood. 2006 Aug 15; 108(4):1280-3. PMID: 16684956.
    Citations: 17     Fields:    Translation:HumansCells
  62. Zwicker JI, Uhl L, Huang WY, Shaz BH, Bauer KA. Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2004 Dec; 2(12):2133-7. PMID: 15613017.
    Citations: 34     Fields:    Translation:Humans
  63. Adams AE, Zwicker J, Curiel C, Kadin ME, Falchuk KR, Drews R, Kupper TS. Aggressive cutaneous T-cell lymphomas after TNFalpha blockade. J Am Acad Dermatol. 2004 Oct; 51(4):660-2. PMID: 15389210.
    Citations: 12     Fields:    Translation:Humans
  64. Näär AM, Beaurang PA, Robinson KM, Oliner JD, Avizonis D, Scheek S, Zwicker J, Kadonaga JT, Tjian R. Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. Genes Dev. 1998 Oct 01; 12(19):3020-31. PMID: 9765204.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.