Kip Connor, Ph.D.
|Title||Assistant Professor of Ophthalmology|
|Institution||Massachusetts Eye and Ear Infirmary|
|Address||Massachusetts Eye & Ear Infrm|
243 Charles St
Boston MA 02114
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Available: 05/28/14, Expires: 08/31/15
Pathological neovascularization is a hallmark of numerous vascular diseases. Since the balance between neovessel formation and regression determines severity, modulating neovessel growth is highly desirable. Vascular regression coincides with a spike in immune activity; we therefore hypothesize (and pilot studies suggest) that pathologic vessel regression may be mediated, in part, through the complement system, an integral part of innate immunity. The complement system is an intricate immune surveillance system that is able to discriminate between healthy host tissue, diseased host tissue, apoptotic cells and foreign invaders and is able to modulate the elimination and repair of host tissue accordingly.
Students will work to define the role of the complement system in a mouse model of oxygen induced retinopathy (a model for neovascular disease). Students will have to be comfortable working with animals (previous experience with mice is a plus).
Characterizing the role of the complement system in vascular regression in a mouse model of retinopathy
Summer, 06/17/13 - 08/16/13
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