Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Kip Connor, Ph.D.

TitleAssistant Professor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infrm
Ophthalmology
243 Charles St
Boston MA 02114
vCardDownload vCard (login for email)

 Mentoring 
 current student opportunities
Available: 05/28/14, Expires: 08/31/15

Pathological neovascularization is a hallmark of numerous vascular diseases. Since the balance between neovessel formation and regression determines severity, modulating neovessel growth is highly desirable. Vascular regression coincides with a spike in immune activity; we therefore hypothesize (and pilot studies suggest) that pathologic vessel regression may be mediated, in part, through the complement system, an integral part of innate immunity. The complement system is an intricate immune surveillance system that is able to discriminate between healthy host tissue, diseased host tissue, apoptotic cells and foreign invaders and is able to modulate the elimination and repair of host tissue accordingly.

Students will work to define the role of the complement system in a mouse model of oxygen induced retinopathy (a model for neovascular disease). Students will have to be comfortable working with animals (previous experience with mice is a plus).

 completed student projects
Characterizing the role of the complement system in vascular regression in a mouse model of retinopathy
Summer, 06/17/13 - 08/16/13

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Sampson JF, Hasegawa E, Mulki L, Suryawanshi A, Jiang S, Chen WS, Rabinovich GA, Connor KM, Panjwani N. Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response. PLoS One. 2015; 10(6):e0130772.
    View in: PubMed
  2. Kataoka K, Matsumoto H, Kaneko H, Notomi S, Takeuchi K, Sweigard JH, Atik A, Murakami Y, Connor KM, Terasaki H, Miller JW, Vavvas DG. Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis. 2015; 6:e1731.
    View in: PubMed
  3. Mulki L, Sweigard JH, Connor KM. Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay. J Vis Exp. 2014; (94).
    View in: PubMed
  4. Hasegawa E, Sweigard H, Husain D, Olivares AM, Chang B, Smith KE, Birsner AE, D'Amato RJ, Michaud NA, Han Y, Vavvas DG, Miller JW, Haider NB, Connor KM. Characterization of a spontaneous retinal neovascular mouse model. PLoS One. 2014; 9(9):e106507.
    View in: PubMed
  5. Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM. Cytochrome P450-generated metabolites derived from ?-3 fatty acids attenuate neovascularization. Proc Natl Acad Sci U S A. 2014 Jul 1; 111(26):9603-8.
    View in: PubMed
  6. Matsumoto H, Murakami Y, Kataoka K, Lin H, Connor KM, Miller JW, Zhou D, Avruch J, Vavvas DG. Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment. Cell Death Dis. 2014; 5:e1269.
    View in: PubMed
  7. Matsumoto H, Kataoka K, Tsoka P, Connor KM, Miller JW, Vavvas DG. Strain difference in photoreceptor cell death after retinal detachment in mice. Invest Ophthalmol Vis Sci. 2014 Jul; 55(7):4165-74.
    View in: PubMed
  8. Sweigard JH, Yanai R, Gaissert P, Saint-Geniez M, Kataoka K, Thanos A, Stahl GL, Lambris JD, Connor KM. The alternative complement pathway regulates pathological angiogenesis in the retina. FASEB J. 2014 Jul; 28(7):3171-82.
    View in: PubMed
  9. Takeuchi K, Yanai R, Kumase F, Morizane Y, Suzuki J, Kayama M, Brodowska K, Nakazawa M, Miller JW, Connor KM, Vavvas DG. EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. PLoS One. 2014; 9(3):e91849.
    View in: PubMed
  10. Adini I, Ghosh K, Adini A, Chi ZL, Yoshimura T, Benny O, Connor KM, Rogers MS, Bazinet L, Birsner AE, Bielenberg DR, D'Amato RJ. Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest. 2014 Jan 2; 124(1):425-36.
    View in: PubMed
  11. Murakami Y, Matsumoto H, Roh M, Giani A, Kataoka K, Morizane Y, Kayama M, Thanos A, Nakatake S, Notomi S, Hisatomi T, Ikeda Y, Ishibashi T, Connor KM, Miller JW, Vavvas DG. Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death Differ. 2014 Feb; 21(2):270-7.
    View in: PubMed
  12. Saint-Geniez M, Jiang A, Abend S, Liu L, Sweigard H, Connor KM, Arany Z. PGC-1a regulates normal and pathological angiogenesis in the retina. Am J Pathol. 2013 Jan; 182(1):255-65.
    View in: PubMed
  13. Yanai R, Thanos A, Connor KM. Complement involvement in neovascular ocular diseases. Adv Exp Med Biol. 2012; 946:161-83.
    View in: PubMed
  14. Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 9; 3(69):69ra12.
    View in: PubMed
  15. Stahl A, Sapieha P, Connor KM, Sangiovanni JP, Chen J, Aderman CM, Willett KL, Krah NM, Dennison RJ, Seaward MR, Guerin KI, Hua J, Smith LE. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010 Aug 20; 107(4):495-500.
    View in: PubMed
  16. Stahl A, Connor KM, Sapieha P, Chen J, Dennison RJ, Krah NM, Seaward MR, Willett KL, Aderman CM, Guerin KI, Hua J, Löfqvist C, Hellström A, Smith LE. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2813-26.
    View in: PubMed
  17. Connor KM, Krah NM, Dennison RJ, Aderman CM, Chen J, Guerin KI, Sapieha P, Stahl A, Willett KL, Smith LE. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4(11):1565-73.
    View in: PubMed
  18. Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8.
    View in: PubMed
  19. Stahl A, Connor KM, Sapieha P, Willett KL, Krah NM, Dennison RJ, Chen J, Guerin KI, Smith LE. Computer-aided quantification of retinal neovascularization. Angiogenesis. 2009; 12(3):297-301.
    View in: PubMed
  20. Adini A, Fainaru O, Udagawa T, Connor KM, Folkman J, D'Amato RJ. Matrigel cytometry: a novel method for quantifying angiogenesis in vivo. J Immunol Methods. 2009 Mar 15; 342(1-2):78-81.
    View in: PubMed
  21. Lofqvist C, Willett KL, Aspegren O, Smith AC, Aderman CM, Connor KM, Chen J, Hellstrom A, Smith LE. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1831-7.
    View in: PubMed
  22. Chen J, Connor KM, Aderman CM, Willett KL, Aspegren OP, Smith LE. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1329-35.
    View in: PubMed
  23. Chen J, Connor KM, Aderman CM, Smith LE. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb; 118(2):526-33.
    View in: PubMed
  24. Connor KM, Hempel N, Nelson KK, Dabiri G, Gamarra A, Belarmino J, Van De Water L, Mian BM, Melendez JA. Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Cancer Res. 2007 Nov 1; 67(21):10260-7.
    View in: PubMed
  25. Chen J, Connor KM, Smith LE. Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. J Clin Invest. 2007 Oct; 117(10):2758-62.
    View in: PubMed
  26. Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LE. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-73.
    View in: PubMed
  27. Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10589-94.
    View in: PubMed
  28. Connor, K.M., Aderman, C.M, Chen, J., Higuchi, A., SanGiovanni, J.-P., Chew, E.Y., Carper, D., Salem, N., Smith, L.E.H. Dietary omega-3 Long-Chain Polyunsaturated Fatty Acids Protect Against Pathological Retinal Neovascularization Through Modulation of Microglial Derived TNF-alpha. The Association for Research in Vision and Ophthalmology Annual Meeting. 2007.
  29. Lofqvist, C, Chen, C, Connor, K.M., Smith, A.C.H, Aderman, C.M, Liu, N, Pintar, J.E, Ludwig, T, Hellstrom, A, Smith, L.E.H. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. PNAS. 2007; 104(25):10589-94.
  30. Connor, K.M., Aderman, C.M., Chen, J., Higuchi, A., SanGiovanni, J-P., Serhan, C.N., Smith, L.E.H. . Increasing dietary omega-3 PUFA reduces pathological angiogenesis via regulation of local resolvins, protectins and TNF-alpha. Society for Free Radical Biology and Medicine 13th Annual Meeting. 2006.
  31. Dasgupta J, Subbaram S, Connor KM, Rodriguez AM, Tirosh O, Beckman JS, Jourd'Heuil D, Melendez JA. Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006 Jul-Aug; 8(7-8):1295-305.
    View in: PubMed
  32. Connor, K.M., Aderman, C.M, Chen, SanGiovanni, J.-P., Chew, E.Y., Carper, D., Salem, N., Smith, L.E.H. . Dietary and Pharmalogic intervention in Proliferative Retinopathy. The Association for Research in Vision and Ophthalmology Annual Meeting. 2006.
  33. Nelson KK, Subbaram S, Connor KM, Dasgupta J, Ha XF, Meng TC, Tonks NK, Melendez JA. Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs. J Biol Chem. 2006 May 19; 281(20):14100-10.
    View in: PubMed
  34. Smith, L.E. and Connor, K.M. . A Radical Twist in Lipid Mediated Vascular Death. Nature Medicine. 2005; 11(12):1276-6.
  35. Smith LE, Connor KM. A radically twisted lipid regulates vascular death. Nat Med. 2005 Dec; 11(12):1275-6.
    View in: PubMed
  36. Kip M Connor. Manganese Superoxide Dismutase Regulates the Malignant Phenotype through the Production of Mitochondrial Derived Hydrogen Peroxide. 2005.
  37. Connor, K.M., Sita Subbaram, Kevin J. Regan, Kristin K. Nelson, Joseph E. Mazurkiewicz, Peter J. Bartholomew, Andrew E. Aplin, Yu-Tzu Tai, Julio Aguirre-Ghiso, Sonia C. Flores and J. Andres Melendez. Sod2-derived H2O2 Regulates the Angiogenic Phenotype via PTEN Oxidation. Journal of Biological Chemistry. 2005; 280(17):16916-24.
  38. Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT, Aguirre-Ghiso J, Flores SC, Melendez JA. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem. 2005 Apr 29; 280(17):16916-24.
    View in: PubMed
  39. Connor, K.M., Mazurkiewicz J.E., Melendez, J.A. . Mitochondrial-derived H2O2 mediates the cellular redistribution of phosphoinositides. Society for Free Radical Biology and Medicine 11th Annual Meeting. 2004.
  40. Connor, K.M., Regan K., Nelson, K., Goswami, P., Melendez, J.A. . Hydrogen Peroxide Regulates the PI3K Signaling Cascade via Oxidation of the Tumor Suppressor PTEN. American Association for Cancer Research. 2004.
  41. Connor, K.M., Nelson, K.K., Melendez, J.A. . Mitochondrial-derived Hydrogen Peroxide Regulates PI3K Signaling via PTEN Oxidation. Society for Free Radical Biology and Medicine 10th Annual Meeting. 2003.
  42. Connor, K.M., Nelson, K.K., Goswami, Prabat, Melendez, J.A. . Sod2-Derrived Hydrogen Peroxide Regulates the PI3K Signaling Cascade. Pathobiology of Cancer Workshop, AACR. 2003.
  43. Connor, K.M., Nelson, K.K., Regan, Kevin J., Lotz, S.A., Goswami, P., Melendez, J.A. . Potential Mechanism for the Catalase-dependent Inhibition of Tumor Growth. 9th Annual Meeting of the Oxygen Society. 2002.
  44. Connor, K.M., Rodriguez, A.M., Bennett, J.A., Melendez, J.A. . Inhibition of Tumor Growth by the expression of Mitochondrial Catalase: The Role of Hydrogen Peroxide in Regulating Caspase Activation. 8th Annual Meeting of The Oxygen Society. 2001.
  45. Miller J, Connor K. Going to the dogs ... for help. Nursing. 2000 Nov; 30(11):65-7.
    View in: PubMed
  46. Connor K, Miller J. Help from our animal friends. Nurs Manage. 2000 Jul; 31(7):42-6.
    View in: PubMed
  47. Connor K, Miller J. Animal-assisted therapy: an in-depth look. Dimens Crit Care Nurs. 2000 May-Jun; 19(3):20-6.
    View in: PubMed
  48. Cheng YC, Grill S, Derse D, Chen JY, Caradonna SJ, Connor K. Mode of action of phosphonoformate as an anti-herpes simplex virus agent. Biochim Biophys Acta. 1981 Jan 29; 652(1):90-8.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Connor's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_