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Last Name
Institution

James D. Zieske, Ph.D.

TitleAssociate Professor of Ophthalmology
InstitutionSchepens Eye Research Institute
DepartmentOphthalmology
AddressSchepens Eye Research Institute
20 Staniford St
Boston MA 02114
Phone617/912-0282
Fax617/912-0107

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature. 2014 Jul 17; 511(7509):353-7.
    View in: PubMed
  2. Karamichos D, Hutcheon AE, Zieske JD. Reversal of fibrosis by TGF-ß3 in a 3D in vitro model. Exp Eye Res. 2014 Jul; 124:31-6.
    View in: PubMed
  3. Karamichos D, Hutcheon AE, Rich CB, Trinkaus-Randall V, Asara JM, Zieske JD. In vitro model suggests oxidative stress involved in keratoconus disease. Sci Rep. 2014; 4:4608.
    View in: PubMed
  4. Stepp MA, Zieske JD, Trinkaus-Randall V, Kyne BM, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Wounding the cornea to learn how it heals. Exp Eye Res. 2014 Apr; 121:178-93.
    View in: PubMed
  5. Masli S, Sheibani N, Cursiefen C, Zieske J. Matricellular protein thrombospondins: influence on ocular angiogenesis, wound healing and immuneregulation. Curr Eye Res. 2014 Aug; 39(8):759-74.
    View in: PubMed
  6. Karamichos D, Funderburgh ML, Hutcheon AE, Zieske JD, Du Y, Wu J, Funderburgh JL. A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells. PLoS One. 2014 Jan 21; 9(1):e86260.
    View in: PubMed
  7. Karamichos D, Rich CB, Zareian R, Hutcheon AE, Ruberti JW, Trinkaus-Randall V, Zieske JD. TGF-ß3 stimulates stromal matrix assembly by human corneal keratocyte-like cells. Invest Ophthalmol Vis Sci. 2013 Oct; 54(10):6612-9.
    View in: PubMed
  8. Blanco-Mezquita JT, Hutcheon AE, Zieske JD. Role of thrombospondin-1 in repair of penetrating corneal wounds. Invest Ophthalmol Vis Sci. 2013; 54(9):6262-8.
    View in: PubMed
  9. Blanco-Mezquita T, Martinez-Garcia C, Proença R, Zieske JD, Bonini S, Lambiase A, Merayo-Lloves J. Nerve growth factor promotes corneal epithelial migration by enhancing expression of matrix metalloprotease-9. Invest Ophthalmol Vis Sci. 2013 Jun; 54(6):3880-90.
    View in: PubMed
  10. Lucas K, Karamichos D, Mathew R, Zieske JD, Stein-Streilein J. Retinal laser burn-induced neuropathy leads to substance P-dependent loss of ocular immune privilege. J Immunol. 2012 Aug 1; 189(3):1237-42.
    View in: PubMed
  11. Saeidi N, Guo X, Hutcheon AE, Sander EA, Bale SS, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro. Biotechnol Bioeng. 2012 Oct; 109(10):2683-98.
    View in: PubMed
  12. Blanco-Mezquita JT, Hutcheon AE, Stepp MA, Zieske JD. aVß6 integrin promotes corneal wound healing. Invest Ophthalmol Vis Sci. 2011 Oct; 52(11):8505-13.
    View in: PubMed
  13. Karamichos D, Rich CB, Hutcheon AE, Ren R, Saitta B, Trinkaus-Randall V, Zieske JD. Self-assembled matrix by umbilical cord stem cells. J Funct Biomater. 2011; 2(3):213-29.
    View in: PubMed
  14. Pal-Ghosh S, Blanco T, Tadvalkar G, Pajoohesh-Ganji A, Parthasarathy A, Zieske JD, Stepp MA. MMP9 cleavage of the ß4 integrin ectodomain leads to recurrent epithelial erosions in mice. J Cell Sci. 2011 Aug 1; 124(Pt 15):2666-75.
    View in: PubMed
  15. Matsuba M, Hutcheon AE, Zieske JD. Localization of thrombospondin-1 and myofibroblasts during corneal wound repair. Exp Eye Res. 2011 Oct; 93(4):534-40.
    View in: PubMed
  16. Karamichos D, Hutcheon AE, Zieske JD. Transforming growth factor-ß3 regulates assembly of a non-fibrotic matrix in a 3D corneal model. J Tissue Eng Regen Med. 2011 Aug; 5(8):e228-38.
    View in: PubMed
  17. Klocke J, Barcia RN, Heimer S, Cario E, Zieske J, Gilmore MS, Ksander BR, Gregory MS. Spontaneous bacterial keratitis in CD36 knockout mice. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):256-63.
    View in: PubMed
  18. Karamichos D, Guo XQ, Hutcheon AE, Zieske JD. Human corneal fibrosis: an in vitro model. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1382-8.
    View in: PubMed
  19. Ren R, Hutcheon AE, Guo XQ, Saeidi N, Melotti SA, Ruberti JW, Zieske JD, Trinkaus-Randall V. Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3-D cultures. Dev Dyn. 2008 Oct; 237(10):2705-15.
    View in: PubMed
  20. Pal-Ghosh S, Tadvalkar G, Jurjus RA, Zieske JD, Stepp MA. BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds. Exp Eye Res. 2008 Nov; 87(5):478-86.
    View in: PubMed
  21. Ruberti JW, Zieske JD. Prelude to corneal tissue engineering - gaining control of collagen organization. Prog Retin Eye Res. 2008 Sep; 27(5):549-77.
    View in: PubMed
  22. Guo X, Hutcheon AE, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4050-60.
    View in: PubMed
  23. Hutcheon AE, Sippel KC, Zieske JD. Examination of the restoration of epithelial barrier function following superficial keratectomy. Exp Eye Res. 2007 Jan; 84(1):32-8.
    View in: PubMed
  24. Hutcheon AE, Guo XQ, Stepp MA, Simon KJ, Weinreb PH, Violette SM, Zieske JD. Effect of wound type on Smad 2 and 4 translocation. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2362-8.
    View in: PubMed
  25. Netto MV, Mohan RR, Ambrósio R, Hutcheon AE, Zieske JD, Wilson SE. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea. 2005 Jul; 24(5):509-22.
    View in: PubMed
  26. Shurman DL, Glazewski L, Gumpert A, Zieske JD, Richard G. In vivo and in vitro expression of connexins in the human corneal epithelium. Invest Ophthalmol Vis Sci. 2005 Jun; 46(6):1957-65.
    View in: PubMed
  27. Stepp MA, Zieske JD. The corneal epithelial stem cell niche. Ocul Surf. 2005 Jan; 3(1):15-26.
    View in: PubMed
  28. Taneri S, Zieske JD, Azar DT. Evolution, techniques, clinical outcomes, and pathophysiology of LASEK: review of the literature. Surv Ophthalmol. 2004 Nov-Dec; 49(6):576-602.
    View in: PubMed
  29. Guo X, Hutcheon AE, Zieske JD. TAT-mediated protein transduction into human corneal epithelial cells: p15(INK4b) inhibits cell proliferation and stimulates cell migration. Invest Ophthalmol Vis Sci. 2004 Jun; 45(6):1804-11.
    View in: PubMed
  30. Guo X, Hutcheon AE, Zieske JD. Transduction of functionally active TAT fusion proteins into cornea. Exp Eye Res. 2004 May; 78(5):997-1005.
    View in: PubMed
  31. Zieske JD, Francesconi CM, Guo X. Cell cycle regulators at the ocular surface. Exp Eye Res. 2004 Mar; 78(3):447-56.
    View in: PubMed
  32. Zieske JD. Corneal development associated with eyelid opening. Int J Dev Biol. 2004; 48(8-9):903-11.
    View in: PubMed
  33. Stramer BM, Zieske JD, Jung JC, Austin JS, Fini ME. Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4237-46.
    View in: PubMed
  34. Kabosova A, Kramerov AA, Aoki AM, Murphy G, Zieske JD, Ljubimov AV. Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture. Exp Eye Res. 2003 Aug; 77(2):211-7.
    View in: PubMed
  35. Wilson SE, Mohan RR, Hutcheon AE, Mohan RR, Ambrósio R, Zieske JD, Hong J, Lee J. Effect of ectopic epithelial tissue within the stroma on keratocyte apoptosis, mitosis, and myofibroblast transformation. Exp Eye Res. 2003 Feb; 76(2):193-201.
    View in: PubMed
  36. Mohan RR, Hutcheon AE, Choi R, Hong J, Lee J, Mohan RR, Ambrósio R, Zieske JD, Wilson SE. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp Eye Res. 2003 Jan; 76(1):71-87.
    View in: PubMed
  37. Wolosin JM, Schütte M, Zieske JD, Budak MT. Changes in connexin43 in early ocular surface development. Curr Eye Res. 2002 Jun; 24(6):430-8.
    View in: PubMed
  38. Maguen E, Zorapapel NC, Zieske JD, Ninomiya Y, Sado Y, Kenney MC, Ljubimov AV. Extracellular matrix and matrix metalloproteinase changes in human corneas after complicated laser-assisted in situ keratomileusis (LASIK). Cornea. 2002 Jan; 21(1):95-100.
    View in: PubMed
  39. Xu KP, Zoukhri D, Zieske JD, Dartt DA, Sergheraert C, Loing E, Yu FS. A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C603-14.
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  40. Zieske JD. Extracellular matrix and wound healing. Curr Opin Ophthalmol. 2001 Aug; 12(4):237-41.
    View in: PubMed
  41. Zieske JD, Hutcheon AE, Guo X, Chung EH, Joyce NC. TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1465-71.
    View in: PubMed
  42. Zieske JD, Guimarães SR, Hutcheon AE. Kinetics of keratocyte proliferation in response to epithelial debridement. Exp Eye Res. 2001 Jan; 72(1):33-9.
    View in: PubMed
  43. Dartt DA, Rios JD, Kanno H, Rawe IM, Zieske JD, Ralda N, Hodges RR, Zoukhri D, Rios JR. Regulation of conjunctival goblet cell secretion by Ca(2+)and protein kinase C. Exp Eye Res. 2000 Dec; 71(6):619-28.
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  44. Takahashi H, Ohara K, Ohmura T, Takahashi R, Zieske JD. Glucose transporter 1 expression in corneal wound repair under high serum glucose level. Jpn J Ophthalmol. 2000 Sep-Oct; 44(5):470-4.
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  45. Takahashi H, Akiba K, Noguchi T, Ohmura T, Takahashi R, Ezure Y, Ohara K, Zieske JD. Matrix metalloproteinase activity is enhanced during corneal wound repair in high glucose condition. Curr Eye Res. 2000 Aug; 21(2):608-15.
    View in: PubMed
  46. Ríos JD, Forde K, Diebold Y, Lightman J, Zieske JD, Dartt DA. Development of conjunctival goblet cells and their neuroreceptor subtype expression. Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2127-37.
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  47. Zieske JD. Expression of cyclin-dependent kinase inhibitors during corneal wound repair. Prog Retin Eye Res. 2000 May; 19(3):257-70.
    View in: PubMed
  48. Zieske JD, Takahashi H, Hutcheon AE, Dalbone AC. Activation of epidermal growth factor receptor during corneal epithelial migration. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1346-55.
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  49. Francesconi CM, Hutcheon AE, Chung EH, Dalbone AC, Joyce NC, Zieske JD. Expression patterns of retinoblastoma and E2F family proteins during corneal development. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1054-62.
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  50. Chung EH, Hutcheon AE, Joyce NC, Zieske JD. Synchronization of the G1/S transition in response to corneal debridement. Invest Ophthalmol Vis Sci. 1999 Aug; 40(9):1952-8.
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  51. Garrana RM, Zieske JD, Assouline M, Gipson IK. Matrix metalloproteinases in epithelia from human recurrent corneal erosion. Invest Ophthalmol Vis Sci. 1999 May; 40(6):1266-70.
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  52. Ríos JD, Zoukhri D, Rawe IM, Hodges RR, Zieske JD, Dartt DA. Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion. Invest Ophthalmol Vis Sci. 1999 May; 40(6):1102-11.
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  53. Joyce NC, Harris DL, Zieske JD. Mitotic inhibition of corneal endothelium in neonatal rats. Invest Ophthalmol Vis Sci. 1998 Dec; 39(13):2572-83.
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  54. Joyce NC, Zieske JD. Transforming growth factor-beta receptor expression in human cornea. Invest Ophthalmol Vis Sci. 1997 Sep; 38(10):1922-8.
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  55. Hodges RR, Zoukhri D, Sergheraert C, Zieske JD, Dartt DA. Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components. Invest Ophthalmol Vis Sci. 1997 Mar; 38(3):610-9.
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  56. Sugrue SP, Zieske JD. ZO1 in corneal epithelium: association to the zonula occludens and adherens junctions. Exp Eye Res. 1997 Jan; 64(1):11-20.
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  57. Takahashi H, Kaminski AE, Zieske JD. Glucose transporter 1 expression is enhanced during corneal epithelial wound repair. Exp Eye Res. 1996 Dec; 63(6):649-59.
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  58. Fini ME, Parks WC, Rinehart WB, Girard MT, Matsubara M, Cook JR, West-Mays JA, Sadow PM, Burgeson RE, Jeffrey JJ, Raizman MB, Krueger RR, Zieske JD. Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. Am J Pathol. 1996 Oct; 149(4):1287-302.
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  59. Dartt DA, Kessler TL, Chung EH, Zieske JD. Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells. Exp Eye Res. 1996 Jul; 63(1):27-34.
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  60. Joyce NC, Navon SE, Roy S, Zieske JD. Expression of cell cycle-associated proteins in human and rabbit corneal endothelium in situ. Invest Ophthalmol Vis Sci. 1996 Jul; 37(8):1566-75.
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  61. Joyce NC, Meklir B, Joyce SJ, Zieske JD. Cell cycle protein expression and proliferative status in human corneal cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):645-55.
    View in: PubMed
  62. Dartt DA, McCarthy DM, Mercer HJ, Kessler TL, Chung EH, Zieske JD. Localization of nerves adjacent to goblet cells in rat conjunctiva. Curr Eye Res. 1995 Nov; 14(11):993-1000.
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  63. Kessler TL, Mercer HJ, Zieske JD, McCarthy DM, Dartt DA. Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva. Curr Eye Res. 1995 Nov; 14(11):985-92.
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  64. Chung EH, DeGregorio PG, Wasson M, Zieske JD. Epithelial regeneration after limbus-to-limbus debridement. Expression of alpha-enolase in stem and transient amplifying cells. Invest Ophthalmol Vis Sci. 1995 Jun; 36(7):1336-43.
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  65. Wilson SE, He YG, Weng J, Zieske JD, Jester JV, Schultz GS. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells. Exp Eye Res. 1994 Dec; 59(6):665-78.
    View in: PubMed
  66. Zieske JD, Mason VS, Wasson ME, Meunier SF, Nolte CJ, Fukai N, Olsen BR, Parenteau NL. Basement membrane assembly and differentiation of cultured corneal cells: importance of culture environment and endothelial cell interaction. Exp Cell Res. 1994 Oct; 214(2):621-33.
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  67. Trocmé SD, Gleich GJ, Kephart GM, Zieske JD. Eosinophil granule major basic protein inhibition of corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 1994 Jun; 35(7):3051-6.
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  68. Zieske JD. Perpetuation of stem cells in the eye. Eye (Lond). 1994; 8 ( Pt 2):163-9.
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  69. Zieske JD, Wasson M. Regional variation in distribution of EGF receptor in developing and adult corneal epithelium. J Cell Sci. 1993 Sep; 106 ( Pt 1):145-52.
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  70. Gipson IK, Watanabe H, Zieske JD. Corneal wound healing and fibronectin. Int Ophthalmol Clin. 1993; 33(4):149-63.
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  71. Chung EH, Bukusoglu G, Zieske JD. Localization of corneal epithelial stem cells in the developing rat. Invest Ophthalmol Vis Sci. 1992 Jun; 33(7):2199-206.
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  72. Zieske JD, Bukusoglu G, Yankauckas MA, Wasson ME, Keutmann HT. Alpha-enolase is restricted to basal cells of stratified squamous epithelium. Dev Biol. 1992 May; 151(1):18-26.
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  73. Zieske JD, Bukusoglu G, Yankauckas MA. Characterization of a potential marker of corneal epithelial stem cells. Invest Ophthalmol Vis Sci. 1992 Jan; 33(1):143-52.
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  74. Matsubara M, Zieske JD, Fini ME. Mechanism of basement membrane dissolution preceding corneal ulceration. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3221-37.
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  75. Zieske JD, Bukusoglu G. Effect of protease inhibitors on corneal epithelial migration. Invest Ophthalmol Vis Sci. 1991 Jun; 32(7):2073-8.
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  76. Zieske JD, Bukusoglu G, Gipson IK. Enhancement of vinculin synthesis by migrating stratified squamous epithelium. J Cell Biol. 1989 Aug; 109(2):571-6.
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  77. Zieske JD, Higashijima SC, Spurr-Michaud SJ, Gipson IK. Biosynthetic responses of the rabbit cornea to a keratectomy wound. Invest Ophthalmol Vis Sci. 1987 Oct; 28(10):1668-77.
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  78. Zieske JD, Higashijima SC, Gipson IK. Con A- and WGA-binding glycoproteins of stationary and migratory corneal epithelium. Invest Ophthalmol Vis Sci. 1986 Aug; 27(8):1205-10.
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  79. Zieske JD, Gipson IK. Protein synthesis during corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 1986 Jan; 27(1):1-7.
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  80. Zieske JD, Bernstein IA. Epidermal fucosylation of cell surface glycoprotein. Biochem Biophys Res Commun. 1984 Mar 30; 119(3):1028-33.
    View in: PubMed
  81. Zieske JD, Bernstein IA. Molecular changes in the cell surface of differentiating epidermal keratinocytes. Curr Probl Dermatol. 1983; 11:243-51.
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  82. Zieske JD, Bernstein IA. Modification of cell surface glycoprotein: addition of fucosyl residues during epidermal differentiation. J Cell Biol. 1982 Nov; 95(2 Pt 1):626-31.
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  83. Weiss TL, Zieske JD, Bernstein IA. Reversible microsomal binding of hepatic aldolase. Biochim Biophys Acta. 1981 Oct 13; 661(2):221-9.
    View in: PubMed
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