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profileTatjana Claudia Jakobs, M.D.

TitleAssociate Professor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressSchepens Eye Research Institute
20 Staniford Street
Boston MA 02114
Phone6179120205
Fax617/726-5336
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01EY019703     (JAKOBS, TATJANA CLAUDIA)Sep 30, 2009 - Feb 29, 2020
NIH/NEI
Cell Biology of Astrocytes in Optic Nerve Head
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Choi HJ, Wang R, Jakobs TC. Single-Cell Dissociation and Characterization in the Murine Retina and Optic Nerve. Methods Mol Biol. 2018; 1695:311-334. PMID: 29190033.
    View in: PubMed
  2. Sun D, Moore S, Jakobs TC. Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries. J Exp Med. 2017 May 01; 214(5):1411-1430. PMID: 28416649.
    View in: PubMed
  3. Tamm ER, Ethier CR. Biological aspects of axonal damage in glaucoma: A brief review. Exp Eye Res. 2017 04; 157:5-12. PMID: 28223179.
    View in: PubMed
  4. Jakobs TC. Ex Vivo Imaging of the Murine Optic Nerve Head. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):734. PMID: 28152143.
    View in: PubMed
  5. Wang R, Seifert P, Jakobs TC. Astrocytes in the Optic Nerve Head of Glaucomatous Mice Display a Characteristic Reactive Phenotype. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):924-932. PMID: 28170536.
    View in: PubMed
  6. Gao S, Jakobs TC. Mice Homozygous for a Deletion in the Glaucoma Susceptibility Locus INK4 Show Increased Vulnerability of Retinal Ganglion Cells to Elevated Intraocular Pressure. Am J Pathol. 2016 Apr; 186(4):985-1005. PMID: 26883755.
    View in: PubMed
  7. Berry RH, Qu J, John SW, Howell GR, Jakobs TC. Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma. PLoS One. 2015; 10(12):e0144341. PMID: 26637126; PMCID: PMC4670161.
  8. Choi HJ, Sun D, Jakobs TC. Astrocytes in the optic nerve head express putative mechanosensitive channels. Mol Vis. 2015; 21:749-66. PMID: 26236150; PMCID: PMC4502055.
  9. Choi HJ, Sun D, Jakobs TC. Isolation of intact astrocytes from the optic nerve head of adult mice. Exp Eye Res. 2015 Aug; 137:103-10. PMID: 26093274; PMCID: PMC4523456.
  10. Jakobs TC. Differential gene expression in glaucoma. Cold Spring Harb Perspect Med. 2014 Jul 01; 4(7):a020636. PMID: 24985133; PMCID: PMC4066643.
  11. Qu J, Jakobs TC. The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve. PLoS One. 2013; 8(6):e67094. PMID: 23826199; PMCID: PMC3694957.
  12. Sun D, Qu J, Jakobs TC. Reversible reactivity by optic nerve astrocytes. Glia. 2013 Aug; 61(8):1218-35. PMID: 23650091; PMCID: PMC3762692.
  13. Lye-Barthel M, Sun D, Jakobs TC. Morphology of astrocytes in a glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):909-17. PMID: 23322566; PMCID: PMC3564449.
  14. Sun D, Jakobs TC. Structural remodeling of astrocytes in the injured CNS. Neuroscientist. 2012 Dec; 18(6):567-88. PMID: 21982954; PMCID: PMC3713769.
  15. Koizumi A, Jakobs TC, Masland RH. Regular mosaic of synaptic contacts among three retinal neurons. J Comp Neurol. 2011 Feb 01; 519(2):341-57. PMID: 21165978; PMCID: PMC3140001.
  16. Sun D, Lye-Barthel M, Masland RH, Jakobs TC. Structural remodeling of fibrous astrocytes after axonal injury. J Neurosci. 2010 Oct 20; 30(42):14008-19. PMID: 20962222; PMCID: PMC3124820.
  17. Sun D, Lye-Barthel M, Masland RH, Jakobs TC. The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse. J Comp Neurol. 2009 Sep 01; 516(1):1-19. PMID: 19562764; PMCID: PMC2900161.
  18. Jakobs TC, Koizumi A, Masland RH. The spatial distribution of glutamatergic inputs to dendrites of retinal ganglion cells. J Comp Neurol. 2008 Sep 10; 510(2):221-36. PMID: 18623177; PMCID: PMC2566960.
  19. Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SW. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol. 2007 Dec 31; 179(7):1523-37. PMID: 18158332.
    View in: PubMed
  20. Jakobs TC, Ben Y, Masland RH. Expression of mRNA for glutamate receptor subunits distinguishes the major classes of retinal neurons, but is less specific for individual cell types. Mol Vis. 2007 Jun 18; 13:933-48. PMID: 17653033; PMCID: PMC2774459.
  21. Lye MH, Jakobs TC, Masland RH, Koizumi A. Organotypic culture of adult rabbit retina. J Vis Exp. 2007; (3):190. PMID: 18978996; PMCID: PMC2535832.
  22. Koizumi A, Zeck G, Ben Y, Masland RH, Jakobs TC. Organotypic culture of physiologically functional adult mammalian retinas. PLoS One. 2007 Feb 21; 2(2):e221. PMID: 17311097; PMCID: PMC1794165.
  23. Enoki R, Jakobs TC, Koizumi A. Horizontal slice preparation of the retina. J Vis Exp. 2006 Nov 20; (1):108. PMID: 18704185; PMCID: PMC2504459.
  24. Jakobs TC, Libby RT, Ben Y, John SW, Masland RH. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol. 2005 Oct 24; 171(2):313-25. PMID: 16247030; PMCID: PMC2171185.
  25. Lin B, Jakobs TC, Masland RH. Different functional types of bipolar cells use different gap-junctional proteins. J Neurosci. 2005 Jul 13; 25(28):6696-701. PMID: 16014731.
    View in: PubMed
  26. Koizumi A, Jakobs TC, Masland RH. Inward rectifying currents stabilize the membrane potential in dendrites of mouse amacrine cells: patch-clamp recordings and single-cell RT-PCR. Mol Vis. 2004 May 13; 10:328-40. PMID: 15152185.
    View in: PubMed
  27. Jakobs TC, Ben Y, Masland RH. CD15 immunoreactive amacrine cells in the mouse retina. J Comp Neurol. 2003 Oct 20; 465(3):361-71. PMID: 12966561.
    View in: PubMed
  28. Sugawara H, Egashira M, Harada N, Jakobs TC, Yoshiura K, Kishino T, Ohta T, Niikawa N, Matsumoto N. Breakpoint analysis of a familial balanced translocation t(2;8)(q31;p21) associated with mesomelic dysplasia. J Med Genet. 2002 Jul; 39(7):E34. PMID: 12114491; PMCID: PMC1735173.
  29. Jakobs TC, Mentrup B, Schmutzler C, Dreher I, Köhrle J. Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodinase in HepG2 hepatocarcinoma cells. Eur J Endocrinol. 2002 Apr; 146(4):559-66. PMID: 11916626.
    View in: PubMed
  30. Winzer R, Schmutzler C, Jakobs TC, Ebert R, Rendl J, Reiners C, Jakob F, Köhrle J. Reverse transcriptase-polymerase chain reaction analysis of thyrocyte-relevant genes in fine-needle aspiration biopsies of the human thyroid. Thyroid. 1998 Nov; 8(11):981-7. PMID: 9848710.
    View in: PubMed
  31. schmutzler C, Brtko J, Winzer R, Jakobs TC, Meissner-Weigl J, Simon D, Goretzki PE, Köhrle J. Functional retinoid and thyroid hormone receptors in human thyroid-carcinoma cell lines and tissues. Int J Cancer. 1998 May 04; 76(3):368-76. PMID: 9579574.
    View in: PubMed
  32. Dreher I, Jakobs TC, Köhrle J. Cloning and characterization of the human selenoprotein P promoter. Response of selenoprotein P expression to cytokines in liver cells. J Biol Chem. 1997 Nov 14; 272(46):29364-71. PMID: 9361018.
    View in: PubMed
  33. Jakobs TC, Schmutzler C, Meissner J, Köhrle J. The promoter of the human type I 5'-deiodinase gene--mapping of the transcription start site and identification of a DR+4 thyroid-hormone-responsive element. Eur J Biochem. 1997 Jul 01; 247(1):288-97. PMID: 9249039.
    View in: PubMed
  34. Jakobs TC, Koehler MR, Schmutzler C, Glaser F, Schmid M, Köhrle J. Structure of the human type I iodothyronine 5'-deiodinase gene and localization to chromosome 1p32-p33. Genomics. 1997 Jun 01; 42(2):361-3. PMID: 9192862.
    View in: PubMed
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