Harvard Catalyst Profiles

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Yu-Hua Tseng, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK122808 (TSENG, YU-HUA) Apr 1, 2020 - Jan 31, 2024
    Role of brown fat-derived specialized pro-resolving lipid mediators in inflammation and metabolism
    Role: Principal Investigator
  2. R01DK102898 (TSENG, YU-HUA) Jul 3, 2015 - May 31, 2020
    Fibroblast Growth Factor and Energy Metabolism
    Role: Principal Investigator
  3. R01DK077097 (TSENG, YU-HUA) Dec 1, 2006 - Mar 31, 2012
    Regulation of human brown and beige adipocyte differentiation and function
    Role: Principal Investigator
  4. R21DK070722 (TSENG, YU-HUA) Apr 1, 2005 - Mar 31, 2007
    Role of BMPs on Brown Adipogenesis and Thermogenesis
    Role: Principal Investigator
  5. F32DK010183 (TSENG, YU-HUA) Mar 1, 2001
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chiu WC, Chiang JY, Juang JM, Wu CK, Tsai CT, Tseng YZ, Su MJ, Chiang FT. Reduction of blood pressure elevation by losartan in spontaneously hypertensive rats through suppression of LARG expression in vascular smooth muscle cells. J Formos Med Assoc. 2020 Jan; 119(1 Pt 1):164-172. PMID: 30962047.
    Citations:    Fields:    Translation:AnimalsCells
  2. Townsend KL, Madden CJ, Blaszkiewicz M, McDougall L, Tupone D, Lynes MD, Mishina Y, Yu P, Morrison SF, Tseng YH. Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A. Endocrinology. 2017 12 01; 158(12):4233-4245. PMID: 29040444.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Shamsi F, Zhang H, Tseng YH. MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure. Front Endocrinol (Lausanne). 2017; 8:205. PMID: 28878735.
    Citations: 5     
  4. Hiraike Y, Waki H, Yu J, Nakamura M, Miyake K, Nagano G, Nakaki R, Suzuki K, Kobayashi H, Yamamoto S, Sun W, Aoyama T, Hirota Y, Ohno H, Oki K, Yoneda M, White AP, Tseng YH, Cypess AM, Larsen TJ, Jespersen NZ, Scheele C, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T. NFIA co-localizes with PPAR? and transcriptionally controls the brown fat gene program. Nat Cell Biol. 2017 Sep; 19(9):1081-1092. PMID: 28812581.
    Citations: 9     Fields:    Translation:AnimalsCells
  5. Lynes MD, Tseng YH. Deciphering adipose tissue heterogeneity. Ann N Y Acad Sci. 2018 01; 1411(1):5-20. PMID: 28763833.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  6. Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH. Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570265.
    Citations: 6     Fields:    
  7. Hou Y, Kitaguchi T, Kriszt R, Tseng YH, Raghunath M, Suzuki M. Ca2+-associated triphasic pH changes in mitochondria during brown adipocyte activation. Mol Metab. 2017 08; 6(8):797-808. PMID: 28752044.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP, Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sudhaharan T, Ishiwata S, Lane EB, Chang YT, Tseng YH, Suzuki M, Raghunath M. Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes. Sci Rep. 2017 05 03; 7(1):1383. PMID: 28469146.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May; 23(5):631-637. PMID: 28346411.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  10. Shamsi F, Tseng YH. Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines. Methods Mol Biol. 2017; 1566:77-85. PMID: 28244042.
    Citations: 4     Fields:    Translation:HumansCells
  11. Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 2016 09 13; 24(3):420-433. PMID: 27626200.
    Citations: 19     Fields:    Translation:AnimalsCells
  12. Gao F, McDaniel J, Chen EY, Rockwell H, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA. Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry. Metabolites. 2016 Aug 17; 6(3). PMID: 27548241.
    Citations: 8     
  13. Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O'Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y, Tseng YH. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance. Diabetologia. 2016 08; 59(8):1769-77. PMID: 27209464.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling. Biochem Biophys Res Commun. 2016 Feb 19; 470(4):783-91. PMID: 26801556.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Ashcroft F, Pearce E, Partridge L, Suomalainen A, Brunet A, Schulze A, Tseng YH, Sethi JK, Reue K, Kingwell B, McNally E, Cnop M, Hevener AL, Diano S. Women in Metabolism: Part 3. Cell Metab. 2015 Dec 01; 22(6):949-53. PMID: 26636490.
    Citations:    Fields:    Translation:Humans
  16. Unser AM, Mooney B, Corr DT, Tseng YH, Xie Y. 3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials. 2016 Jan; 75:123-134. PMID: 26496384.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Zhang H, Guan M, Townsend KL, Huang TL, An D, Yan X, Xue R, Schulz TJ, Winnay J, Mori M, Hirshman MF, Kristiansen K, Tsang JS, White AP, Cypess AM, Goodyear LJ, Tseng YH. MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1a signaling network. . 2015 Oct; 16(10):1378-93. PMID: 26303948.
    Citations: 32     Translation:HumansAnimalsCells
  18. Zhang X, Tian Y, Zhang H, Kavishwar A, Lynes M, Brownell AL, Sun H, Tseng YH, Moore A, Ran C. Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Sci Rep. 2015 Aug 13; 5:13116. PMID: 26269357.
    Citations: 14     Fields:    Translation:AnimalsCells
  19. Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med. 2015 Jul; 21(7):760-8. PMID: 26076036.
    Citations: 68     Fields:    Translation:HumansCells
  20. Lynes MD, Tseng YH. The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation. Genes Dis. 2015 Jun; 2(2):164-172. PMID: 26491708.
    Citations: 5     
  21. Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015 Apr; 21(4):389-94. PMID: 25774848.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  22. Lynes MD, Schulz TJ, Pan AJ, Tseng YH. Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development. Endocrinology. 2015 May; 156(5):1637-47. PMID: 25625589.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH, Goodyear LJ. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes. 2015 Jun; 64(6):2002-14. PMID: 25605808.
    Citations: 81     Fields:    Translation:Animals
  24. Lynes MD, Tseng YH. Unwiring the transcriptional heat circuit. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14318-9. PMID: 25261553.
    Citations: 2     Fields:    Translation:AnimalsCells
  25. Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med. 2014 Jul 30; 6(247):247ra103. PMID: 25080478.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  26. Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1a. Cell. 2014 Jul 03; 158(1):69-83. PMID: 24995979.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  27. Huang P, Schulz TJ, Beauvais A, Tseng YH, Gussoni E. Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signalling. Nat Commun. 2014 Jun 05; 5:4063. PMID: 24898859.
    Citations: 11     Fields:    Translation:AnimalsCells
  28. Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis. Cell. 2014 Jan 30; 156(3):440-55. PMID: 24485453.
    Citations: 120     Fields:    Translation:AnimalsCells
  29. Mwangi SM, Nezami BG, Obukwelu B, Anitha M, Marri S, Fu P, Epperson MF, Le NA, Shanmugam M, Sitaraman SV, Tseng YH, Anania FA, Srinivasan S. Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2014 Mar; 306(6):G515-25. PMID: 24458024.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle. Stem Cell Reports. 2014 Jan 14; 2(1):92-106. PMID: 28039752.
  31. Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle. Stem Cell Reports. 2014 Jan 14; 2(1):92-106. PMID: 24678452.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  32. Townsend KL, Tseng YH. Brown fat fuel utilization and thermogenesis. Trends Endocrinol Metab. 2014 Apr; 25(4):168-77. PMID: 24389130.
    Citations: 72     Fields:    Translation:HumansAnimals
  33. Lau AM, Tseng YH, Schulz TJ. Adipogenic fate commitment of muscle-derived progenitor cells: isolation, culture, and differentiation. Methods Mol Biol. 2014; 1213:229-43. PMID: 25173387.
    Citations: 3     Fields:    Translation:AnimalsCells
  34. Cypess AM, Doyle AN, Sass CA, Huang TL, Mowschenson PM, Rosen HN, Tseng YH, Palmer EL, Kolodny GM. Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT. J Nucl Med. 2013 Nov; 54(11):1896-901. PMID: 24071505.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  35. Schulz TJ, Tseng YH. Systemic control of brown fat thermogenesis: integration of peripheral and central signals. Ann N Y Acad Sci. 2013 Oct; 1302:35-41. PMID: 24111913.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  36. Schulz TJ, Tseng YH. Brown adipose tissue: development, metabolism and beyond. Biochem J. 2013 Jul 15; 453(2):167-78. PMID: 23805974.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  37. Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013 May; 19(5):635-9. PMID: 23603815.
    Citations: 237     Fields:    Translation:HumansAnimalsCells
  38. Ziogas DC, Gras-Miralles B, Mustafa S, Geiger BM, Najarian RM, Nagel JM, Flier SN, Popov Y, Tseng YH, Kokkotou E. Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2013 May 15; 304(10):G876-84. PMID: 23538494.
    Citations: 3     Fields:    Translation:AnimalsCells
  39. Schulz TJ, Huang P, Huang TL, Xue R, McDougall LE, Townsend KL, Cypess AM, Mishina Y, Gussoni E, Tseng YH. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature. 2013 Mar 21; 495(7441):379-83. PMID: 23485971.
    Citations: 153     Fields:    Translation:AnimalsCells
  40. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26. PMID: 23291629.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  41. Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. p62 links ß-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest. 2013 Jan; 123(1):469-78. PMID: 23257354.
    Citations: 49     Fields:    Translation:AnimalsCells
  42. Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, Hitchcox KM, Markan KR, Nakano K, Hirshman MF, Tseng YH, Goodyear LJ. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest. 2013 Jan; 123(1):215-23. PMID: 23221344.
    Citations: 292     Fields:    Translation:Animals
  43. Chiu WC, Juang JM, Chang SN, Wu CK, Tsai CT, Tseng CD, Tseng YZ, Su MJ, Chiang FT. Differential baseline expression and angiotensin II-stimulation of leukemia-associated RhoGEF in vascular smooth muscle cells of spontaneously hypertensive rats. Int J Nanomedicine. 2012; 7:5929-39. PMID: 23233801.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Chiu WC, Juang JM, Chang SN, Wu CK, Tsai CT, Tseng YZ, Chiang FT. Angiotensin II regulates the LARG/RhoA/MYPT1 axis in rat vascular smooth muscle in vitro. Acta Pharmacol Sin. 2012 Dec; 33(12):1502-10. PMID: 23123644.
    Citations: 5     Fields:    Translation:AnimalsCells
  45. Townsend KL, An D, Lynes MD, Huang TL, Zhang H, Goodyear LJ, Tseng YH. Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antioxid Redox Signal. 2013 Jul 20; 19(3):243-57. PMID: 22938691.
    Citations: 25     Fields:    Translation:AnimalsCells
  46. Macotela Y, Emanuelli B, Mori MA, Gesta S, Schulz TJ, Tseng YH, Kahn CR. Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes. 2012 Jul; 61(7):1691-9. PMID: 22596050.
    Citations: 107     Fields:    Translation:AnimalsCells
  47. Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, Zhang H, He TC, Kokkotou E, Tseng YH. Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J. 2012 May; 26(5):2187-96. PMID: 22331196.
    Citations: 38     Fields:    Translation:AnimalsCells
  48. Fujiwara K, Hasegawa K, Ohkumo T, Miyoshi H, Tseng YH, Yoshikawa K. Necdin controls proliferation of white adipocyte progenitor cells. PLoS One. 2012; 7(1):e30948. PMID: 22292082.
    Citations: 17     Fields:    Translation:AnimalsCells
  49. Townsend K, Tseng YH. Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential. Adipocyte. 2012 Jan 01; 1(1):13-24. PMID: 23700507.
    Citations: 40     Fields:    
  50. Cypess AM, Zhang H, Schulz TJ, Huang TL, Espinoza DO, Kristiansen K, Unterman TG, Tseng YH. Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology. 2011 Oct; 152(10):3680-9. PMID: 21862615.
    Citations: 18     Fields:    Translation:AnimalsCells
  51. Juang JM, Phan WL, Chen PC, Lai LP, Tsai MH, Lin JW, Cheng PH, Chiu WY, Cheng BW, Hwang JJ, Tseng CD, Hsu KL, Tseng YZ, Lin JL, Chiang FT. Brugada-type electrocardiogram in the Taiwanese population--is it a risk factor for sudden death? J Formos Med Assoc. 2011 Apr; 110(4):230-8. PMID: 21540005.
    Citations: 7     Fields:    Translation:Humans
  52. Schleinitz D, Klöting N, Böttcher Y, Wolf S, Dietrich K, Tönjes A, Breitfeld J, Enigk B, Halbritter J, Körner A, Schön MR, Jenkner J, Tseng YH, Lohmann T, Dressler M, Stumvoll M, Blüher M, Kovacs P. Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity. PLoS One. 2011 Feb 02; 6(2):e16155. PMID: 21311592.
    Citations: 20     Fields:    Translation:Humans
  53. Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, Shadrach JL, Cerletti M, McDougall LE, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland JL, Wagers AJ, Tseng YH. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):143-8. PMID: 21173238.
    Citations: 195     Fields:    Translation:HumansAnimalsCells
  54. Dai DF, Hwang JJ, Chen CL, Chiang FT, Lin JL, Hsu KL, Tseng CD, Tseng YZ. Effect of physical activity on the prevalence of metabolic syndrome and left ventricular hypertrophy in apparently healthy adults. J Formos Med Assoc. 2010 Oct; 109(10):716-24. PMID: 20970068.
    Citations: 7     Fields:    Translation:Humans
  55. Zhang H, Schulz TJ, Espinoza DO, Huang TL, Emanuelli B, Kristiansen K, Tseng YH. Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis. Mol Cell Biol. 2010 Sep; 30(17):4224-33. PMID: 20584981.
    Citations: 30     Fields:    Translation:AnimalsCells
  56. Tseng YH, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov. 2010 Jun; 9(6):465-82. PMID: 20514071.
    Citations: 201     Fields:    Translation:HumansCells
  57. Boucher J, Tseng YH, Kahn CR. Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem. 2010 May 28; 285(22):17235-45. PMID: 20360006.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  58. Yeih DF, Yeh HI, Lin LY, Tsay YG, Chiang FT, Tseng CD, Tseng YZ. Enhanced activity and subcellular redistribution of myocardial hexokinase after acute myocardial infarction. Int J Cardiol. 2011 May 19; 149(1):74-9. PMID: 20060179.
    Citations: 2     Fields:    Translation:AnimalsCells
  59. Schulz TJ, Tseng YH. Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):523-31. PMID: 19896888.
    Citations: 52     Fields:    Translation:HumansAnimals
  60. Wang WC, Chen HJ, Tseng YH, Lai YC. Identification of somatic mutations in the von Hippel-Lindau (VHL) gene in a patient with renal cell carcinoma. J Formos Med Assoc. 2009 Nov; 108(11):886-93. PMID: 19933033.
    Citations: 2     Fields:    Translation:Humans
  61. Böttcher Y, Unbehauen H, Klöting N, Ruschke K, Körner A, Schleinitz D, Tönjes A, Enigk B, Wolf S, Dietrich K, Koriath M, Scholz GH, Tseng YH, Dietrich A, Schön MR, Kiess W, Stumvoll M, Blüher M, Kovacs P. Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes. 2009 Sep; 58(9):2119-28. PMID: 19502417.
    Citations: 35     Fields:    Translation:Humans
  62. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009 Apr 09; 360(15):1509-17. PMID: 19357406.
    Citations: 1258     Fields:    Translation:HumansCells
  63. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008 Aug 21; 454(7207):1000-4. PMID: 18719589.
    Citations: 366     Fields:    Translation:AnimalsCells
  64. Tsai CT, Lai LP, Hwang JJ, Chen WP, Chiang FT, Hsu KL, Tseng CD, Tseng YZ, Lin JL. Renin-angiotensin system component expression in the HL-1 atrial cell line and in a pig model of atrial fibrillation. J Hypertens. 2008 Mar; 26(3):570-82. PMID: 18300870.
    Citations: 9     Fields:    Translation:AnimalsCells
  65. Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E. Substance P as a novel anti-obesity target. Gastroenterology. 2008 Mar; 134(3):747-55. PMID: 18325388.
    Citations: 13     Fields:    Translation:Animals
  66. Krüger M, Kratchmarova I, Blagoev B, Tseng YH, Kahn CR, Mann M. Dissection of the insulin signaling pathway via quantitative phosphoproteomics. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2451-6. PMID: 18268350.
    Citations: 89     Fields:    Translation:AnimalsCells
  67. Tsai CT, Lai LP, Kuo KT, Hwang JJ, Hsieh CS, Hsu KL, Tseng CD, Tseng YZ, Chiang FT, Lin JL. Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling. Circulation. 2008 Jan 22; 117(3):344-55. PMID: 18172037.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  68. Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE. Rad GTPase deficiency leads to cardiac hypertrophy. Circulation. 2007 Dec 18; 116(25):2976-2983. PMID: 18056528.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  69. Gesta S, Tseng YH, Kahn CR. Developmental origin of fat: tracking obesity to its source. Cell. 2007 Oct 19; 131(2):242-56. PMID: 17956727.
    Citations: 445     Fields:    Translation:HumansAnimalsCells
  70. Huang YS, Wang SM, Hsu KL, Tseng YZ, Wu JC. Mechanism of oleic acid-induced myofibril disassembly in rat cardiomyocytes. J Cell Biochem. 2007 Oct 15; 102(3):638-49. PMID: 17428005.
    Citations: 1     Fields:    Translation:AnimalsCells
  71. Dai DF, Chiang FT, Lin JL, Huang LY, Chen CL, Chang CJ, Lai LP, Hsu KL, Tseng CD, Tseng YZ, Hwang JJ. Human C-reactive protein (CRP) gene 1059G>C polymorphism is associated with plasma CRP concentration in patients receiving coronary angiography. J Formos Med Assoc. 2007 May; 106(5):347-54. PMID: 17561469.
    Citations: 5     Fields:    Translation:Humans
  72. Tsai CT, Wang DL, Chen WP, Hwang JJ, Hsieh CS, Hsu KL, Tseng CD, Lai LP, Tseng YZ, Chiang FT, Lin JL. Angiotensin II increases expression of alpha1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element-binding protein-dependent pathway in HL-1 myocytes. Circ Res. 2007 May 25; 100(10):1476-85. PMID: 17463319.
    Citations: 25     Fields:    Translation:AnimalsCells
  73. Dai DF, Lin JW, Kao JH, Hsu CN, Chiang FT, Lin JL, Chou YH, Hsu KL, Tseng CD, Tseng YZ, Hwang JJ. The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events. J Clin Endocrinol Metab. 2007 Jul; 92(7):2532-7. PMID: 17426096.
    Citations: 5     Fields:    Translation:Humans
  74. Mouche S, Mkaddem SB, Wang W, Katic M, Tseng YH, Carnesecchi S, Steger K, Foti M, Meier CA, Muzzin P, Kahn CR, Ogier-Denis E, Szanto I. Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation. Biochim Biophys Acta. 2007 Jul; 1773(7):1015-27. PMID: 17553579.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  75. Tsai CT, Hwang JJ, Chiang FT, Tseng CD, Lin JL, Tseng YZ, Lai LP. ATP-binding cassette transporter A1 gene I823M polymorphism affects plasma high-density lipoprotein cholesterol level and modifies the effect of low high-density lipoprotein cholesterol on the risk of coronary artery disease. Cardiology. 2007; 107(4):321-8. PMID: 17268197.
    Citations: 4     Fields:    Translation:Humans
  76. Tseng YZ. Applications of 24-hour noninvasive ambulatory blood pressure monitoring. J Formos Med Assoc. 2006 Dec; 105(12):955-63. PMID: 17185237.
    Citations: 2     Fields:    Translation:Humans
  77. Juang JM, Chern YR, Tsai CT, Chiang FT, Lin JL, Hwang JJ, Hsu KL, Tseng CD, Tseng YZ, Lai LP. The association of human connexin 40 genetic polymorphisms with atrial fibrillation. Int J Cardiol. 2007 Mar 02; 116(1):107-12. PMID: 16814413.
    Citations: 26     Fields:    Translation:HumansCells
  78. Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005 Aug 12; 122(3):337-49. PMID: 16096055.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  79. Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7(6):601-11. PMID: 15895078.
    Citations: 75     Fields:    Translation:AnimalsCells
  80. Tseng YZ, Chiang FT, Hsu KL, Lo HM, Tseng CD, Lin JL, Hwang JJ, Lai LP. Low frequency of target organ damage in Taiwanese with white coat hypertension. J Formos Med Assoc. 2005 May; 104(5):327-32. PMID: 15959599.
    Citations:    Fields:    Translation:Humans
  81. Fu M, Zhang J, Tseng YH, Cui T, Zhu X, Xiao Y, Mou Y, De Leon H, Chang MM, Hamamori Y, Kahn CR, Chen YE. Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration. Circulation. 2005 Mar 01; 111(8):1071-7. PMID: 15710763.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  82. Huang YS, Tseng YZ, Wu JC, Wang SM. Mechanism of oleic acid-induced gap junctional disassembly in rat cardiomyocytes. J Mol Cell Cardiol. 2004 Sep; 37(3):755-66. PMID: 15350848.
    Citations: 5     Fields:    Translation:AnimalsCells
  83. Ueki K, Kondo T, Tseng YH, Kahn CR. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10422-7. PMID: 15240880.
    Citations: 111     Fields:    Translation:AnimalsCells
  84. Yang KT, Pan SF, Chien CL, Hsu SM, Tseng YZ, Wang SM, Wu ML. Mitochondrial Na+ overload is caused by oxidative stress and leads to activation of the caspase 3- dependent apoptotic machinery. FASEB J. 2004 Sep; 18(12):1442-4. PMID: 15231730.
    Citations: 6     Fields:    Translation:Cells
  85. Lin LY, Hwang JJ, Lai LP, Chan HL, Du CC, Tseng YZ, Lin JL. Restoration of heart rate turbulence by titrated beta-blocker therapy in patients with advanced congestive heart failure: positive correlation with enhanced vagal modulation of heart rate. J Cardiovasc Electrophysiol. 2004 Jul; 15(7):752-6. PMID: 15250856.
    Citations: 7     Fields:    Translation:Humans
  86. Lai LP, Lin JL, Lin JM, Du CC, Tseng YZ, Huang SK. Use of double-potential barrier to identify functional isthmus at the cavotricuspid isthmus for facilitating catheter ablation of isthmus-dependent atrial flutter. J Cardiovasc Electrophysiol. 2004 Apr; 15(4):396-401. PMID: 15089986.
    Citations:    Fields:    Translation:HumansPHPublic Health
  87. Tsai CT, Lai LP, Lin JL, Chiang FT, Hwang JJ, Ritchie MD, Moore JH, Hsu KL, Tseng CD, Liau CS, Tseng YZ. Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation. 2004 Apr 06; 109(13):1640-6. PMID: 15023884.
    Citations: 76     Fields:    Translation:HumansCells
  88. Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR. Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol. 2004 Mar; 24(5):1918-29. PMID: 14966273.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  89. Lai LP, Lin JL, Lin CS, Yeh HM, Tsay YG, Lee CF, Lee HH, Chang ZF, Hwang JJ, Su MJ, Tseng YZ, Huang SK. Functional genomic study on atrial fibrillation using cDNA microarray and two-dimensional protein electrophoresis techniques and identification of the myosin regulatory light chain isoform reprogramming in atrial fibrillation. J Cardiovasc Electrophysiol. 2004 Feb; 15(2):214-23. PMID: 15028053.
    Citations: 10     Fields:    Translation:AnimalsCells
  90. Cohen SE, Tseng YH, Michael MD, Kahn CR. Effects of insulin-sensitising agents in mice with hepatic insulin resistance. Diabetologia. 2004 Mar; 47(3):407-411. PMID: 14730378.
    Citations: 5     Fields:    Translation:Animals
  91. Lo HM, Hsu KL, Lin FY, Tseng YZ. Implications of prolonged pause in patients with chronic atrial fibrillation with mitral valve disease undergoing atrial compartment operation. J Formos Med Assoc. 2003 Nov; 102(11):762-7. PMID: 14724721.
    Citations: 1     Fields:    Translation:Humans
  92. Tai YT, Podar K, Catley L, Tseng YH, Akiyama M, Shringarpure R, Burger R, Hideshima T, Chauhan D, Mitsiades N, Richardson P, Munshi NC, Kahn CR, Mitsiades C, Anderson KC. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. Cancer Res. 2003 Sep 15; 63(18):5850-8. PMID: 14522909.
    Citations: 55     Fields:    Translation:HumansCells
  93. Lai LP, Tsai CC, Su MJ, Lin JL, Chen YS, Tseng YZ, Huang SK. Atrial fibrillation is associated with accumulation of aging-related common type mitochondrial DNA deletion mutation in human atrial tissue. Chest. 2003 Feb; 123(2):539-44. PMID: 12576378.
    Citations: 13     Fields:    Translation:HumansCells
  94. Tseng YH, Ueki K, Kriauciunas KM, Kahn CR. Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. J Biol Chem. 2002 Aug 30; 277(35):31601-11. PMID: 12082100.
    Citations: 32     Fields:    Translation:AnimalsCells
  95. Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol. 2002 Feb; 22(3):965-77. PMID: 11784871.
    Citations: 91     Fields:    Translation:AnimalsCells
  96. Tsai CT, Hwang JJ, Lai LP, Chiang FT, Tseng YZ. IRS-1 Gly971Arg variant is not a new risk factor for coronary artery disease in the Taiwanese population. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):194. PMID: 11788483.
    Citations: 1     Fields:    Translation:Humans
  97. Tseng YH, Vicent D, Zhu J, Niu Y, Adeyinka A, Moyers JS, Watson PH, Kahn CR. Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23. Cancer Res. 2001 Mar 01; 61(5):2071-9. PMID: 11280768.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  98. Zhu J, Tseng YH, Kantor JD, Rhodes CJ, Zetter BR, Moyers JS, Kahn CR. Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14911-8. PMID: 10611312.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  99. Tseng YH, Schuler LA. Transcriptional regulation of interleukin-1beta gene by interleukin-1beta itself is mediated in part by Oct-1 in thymic stromal cells. J Biol Chem. 1998 May 15; 273(20):12633-41. PMID: 9575225.
    Citations: 4     Fields:    Translation:AnimalsCells
  100. Tseng YH, Kessler MA, Schuler LA. Regulation of interleukin (IL)-1alpha, IL-1beta, and IL-6 expression by growth hormone and prolactin in bovine thymic stromal cells. Mol Cell Endocrinol. 1997 Apr 04; 128(1-2):117-27. PMID: 9140083.
    Citations: 6     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.