Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Wade Harper, Ph.D.

Other Positions

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H. The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente. . 2014 Jan; 15(1):7-11. PMID: 24398128.
    Citations:    Translation:HumansCells
  2. Harper JW, Tan MK. Understanding cullin-RING E3 biology through proteomics-based substrate identification. Mol Cell Proteomics. 2012 Dec; 11(12):1541-50. PMID: 22962057.
    Citations: 31     Fields:    Translation:HumansCells
  3. Harper JW, King RW. Stuck in the middle: drugging the ubiquitin system at the e2 step. Cell. 2011 Jun 24; 145(7):1007-9. PMID: 21703444.
    Citations: 3     Fields:    
  4. Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell. 2007 Dec 14; 28(5):739-45. PMID: 18082599.
    Citations: 688     Fields:    Translation:HumansAnimalsCells
  5. Harper JW, Schulman BA. Structural complexity in ubiquitin recognition. Cell. 2006 Mar 24; 124(6):1133-6. PMID: 16564007.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  6. Ayala G, Thompson T, Yang G, Frolov A, Li R, Scardino P, Ohori M, Wheeler T, Harper W. High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res. 2004 Oct 01; 10(19):6572-8. PMID: 15475446.
    Citations: 76     Fields:    Translation:HumansCells
  7. Baumgartner B, Harper JW. Deafening cycle. Nat Cell Biol. 2003 May; 5(5):385-7. PMID: 12724771.
    Citations: 2     Fields:    Translation:AnimalsCells
  8. Wei Y, Jin J, Harper JW. The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain. Mol Cell Biol. 2003 May; 23(10):3669-80. PMID: 12724424.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  9. Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ. Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell. 2003 Mar 07; 112(5):697-709. PMID: 12628189.
    Citations: 32     Fields:    Translation:AnimalsCells
  10. Passmore LA, McCormack EA, Au SW, Paul A, Willison KR, Harper JW, Barford D. Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J. 2003 Feb 17; 22(4):786-96. PMID: 12574115.
    Citations: 86     Fields:    Translation:AnimalsCells
  11. Harper JW, Burton JL, Solomon MJ. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 2002 Sep 01; 16(17):2179-206. PMID: 12208841.
    Citations: 182     Fields:    Translation:HumansAnimalsCells
  12. Nalepa G, Harper JW. Efp: a ring of independence? Nat Med. 2002 Jul; 8(7):661-2. PMID: 12091896.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Jin J, Harper JW. RING finger specificity in SCF-driven protein destruction. Dev Cell. 2002 Jun; 2(6):685-7. PMID: 12062077.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature. 2002 Apr 18; 416(6882):703-9. PMID: 11961546.
    Citations: 547     Fields:    Translation:HumansCells
  15. Leng X, Noble M, Adams PD, Qin J, Harper JW. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol Cell Biol. 2002 Apr; 22(7):2242-54. PMID: 11884610.
    Citations: 32     Fields:    Translation:HumansCells
  16. Harper JW. A phosphorylation-driven ubiquitination switch for cell-cycle control. Trends Cell Biol. 2002 Mar; 12(3):104-7. PMID: 11859016.
    Citations: 17     Fields:    Translation:AnimalsCells
  17. Au SW, Leng X, Harper JW, Barford D. Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. J Mol Biol. 2002 Mar 01; 316(4):955-68. PMID: 11884135.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  18. Pogue BW, Kaufman HB, Zelenchuk A, Harper W, Burke GC, Burke EE, Harper DM. Analysis of acetic acid-induced whitening of high-grade squamous intraepithelial lesions. J Biomed Opt. 2001 Oct; 6(4):397-403. PMID: 11728197.
    Citations: 6     Fields:    Translation:Humans
  19. Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science. 2001 Oct 05; 294(5540):173-7. PMID: 11533444.
    Citations: 301     Fields:    Translation:HumansAnimalsCells
  20. Harper JW. Protein destruction: adapting roles for Cks proteins. Curr Biol. 2001 Jun 05; 11(11):R431-5. PMID: 11516665.
    Citations: 29     Fields:    Translation:Cells
  21. Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature. 2000 Nov 16; 408(6810):381-6. PMID: 11099048.
    Citations: 218     Fields:    Translation:HumansAnimalsCells
  22. Ma T, Van Tine BA, Wei Y, Garrett MD, Nelson D, Adams PD, Wang J, Qin J, Chow LT, Harper JW. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 2000 Sep 15; 14(18):2298-313. PMID: 10995387.
    Citations: 123     Fields:    Translation:HumansCells
  23. Stepanova L, Finegold M, DeMayo F, Schmidt EV, Harper JW. The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues. Mol Cell Biol. 2000 Jun; 20(12):4462-73. PMID: 10825210.
    Citations: 33     Fields:    Translation:Animals
  24. Winston JT, Chu C, Harper JW. Culprits in the degradation of cyclin E apprehended. Genes Dev. 1999 Nov 01; 13(21):2751-7. PMID: 10557204.
    Citations: 17     Fields:    Translation:HumansAnimals
  25. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW. A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21; 9(20):1180-2. PMID: 10531037.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  26. Wang Y, Penfold S, Tang X, Hattori N, Riley P, Harper JW, Cross JC, Tyers M. Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E. Curr Biol. 1999 Oct 21; 9(20):1191-4. PMID: 10531039.
    Citations: 47     Fields:    Translation:AnimalsCells
  27. Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell. 1999 Jul; 4(1):21-33. PMID: 10445024.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  28. Koepp DM, Harper JW, Elledge SJ. How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell. 1999 May 14; 97(4):431-4. PMID: 10338207.
    Citations: 115     Fields:    Translation:Humans
  29. Harper JW, Elledge SJ. Skipping into the E2F1-destruction pathway. Nat Cell Biol. 1999 May; 1(1):E5-7. PMID: 10559870.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  30. Skowyra D, Koepp DM, Kamura T, Conrad MN, Conaway RC, Conaway JW, Elledge SJ, Harper JW. Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science. 1999 Apr 23; 284(5414):662-5. PMID: 10213692.
    Citations: 140     Fields:    Translation:AnimalsCells
  31. Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science. 1999 Apr 23; 284(5414):657-61. PMID: 10213691.
    Citations: 248     Fields:    Translation:AnimalsCells
  32. Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev. 1999 Feb 01; 13(3):270-83. PMID: 9990852.
    Citations: 315     Fields:    Translation:HumansAnimalsCells
  33. Ma T, Zou N, Lin BY, Chow LT, Harper JW. Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):382-7. PMID: 9892642.
    Citations: 59     Fields:    Translation:HumansCells
  34. Zhang P, Wong C, Liu D, Finegold M, Harper JW, Elledge SJ. p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev. 1999 Jan 15; 13(2):213-24. PMID: 9925645.
    Citations: 110     Fields:    Translation:Animals
  35. Zhang P, Wong C, DePinho RA, Harper JW, Elledge SJ. Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev. 1998 Oct 15; 12(20):3162-7. PMID: 9784491.
    Citations: 93     Fields:    Translation:Animals
  36. Connell-Crowley L, Elledge SJ, Harper JW. G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts. Curr Biol. 1998 Jan 01; 8(1):65-8. PMID: 9427630.
    Citations: 29     Fields:    Translation:HumansCells
  37. Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell. 1997 Oct 17; 91(2):209-19. PMID: 9346238.
    Citations: 454     Fields:    Translation:AnimalsCells
  38. Leng X, Connell-Crowley L, Goodrich D, Harper JW. S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation. Curr Biol. 1997 Sep 01; 7(9):709-12. PMID: 9285720.
    Citations: 34     Fields:    Translation:AnimalsCells
  39. Zhang P, Liégeois NJ, Wong C, Finegold M, Hou H, Thompson JC, Silverman A, Harper JW, DePinho RA, Elledge SJ. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature. 1997 May 08; 387(6629):151-8. PMID: 9144284.
    Citations: 206     Fields:    Translation:Animals
  40. Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell. 1996 Jul 26; 86(2):263-74. PMID: 8706131.
    Citations: 507     Fields:    Translation:HumansAnimalsCells
  41. Stepanova L, Leng X, Parker SB, Harper JW. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 1996 Jun 15; 10(12):1491-502. PMID: 8666233.
    Citations: 137     Fields:    Translation:HumansAnimalsCells
  42. Deng C, Zhang P, Harper JW, Elledge SJ, Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995 Aug 25; 82(4):675-84. PMID: 7664346.
    Citations: 554     Fields:    Translation:AnimalsCells
  43. Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 1995 Mar 15; 9(6):650-62. PMID: 7729684.
    Citations: 229     Fields:    Translation:HumansAnimalsCells
  44. Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science. 1995 Feb 17; 267(5200):1024-7. PMID: 7863329.
    Citations: 237     Fields:    Translation:AnimalsCells
  45. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993 Nov 19; 75(4):805-16. PMID: 8242751.
    Citations: 1464     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Harper's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (256)
Co-Authors (5)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.