Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Joan Elaine Stein-Streilein, PH.D.

TitleAssociate Professor of Ophthalmology
InstitutionSchepens Eye Research Institute
DepartmentOphthalmology
AddressSchepens Eye Research Inst.
2 West
20 Staniford St
Boston MA 02114
Phone617/912-7494
Fax617/912-0105
vCardDownload vCard (login for email)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Hsu SM, Mathew R, Taylor AW, Stein-Streilein J. Ex-vivo tolerogenic F4/80? antigen-presenting cells (APC) induce efferent CD8? regulatory T cell-dependent suppression of experimental autoimmune uveitis. Clin Exp Immunol. 2014 Apr; 176(1):37-48.
    View in: PubMed
  2. Stein-Streilein J, Caspi RR. Immune privilege and the philosophy of immunology. Front Immunol. 2014; 5:110.
    View in: PubMed
  3. Stein-Streilein J. Mechanisms of immune privilege in the posterior eye. Int Rev Immunol. 2013 Feb; 32(1):42-56.
    View in: PubMed
  4. Lucas K, Karamichos D, Mathew R, Zieske JD, Stein-Streilein J. Retinal laser burn-induced neuropathy leads to substance P-dependent loss of ocular immune privilege. J Immunol. 2012 Aug 1; 189(3):1237-42.
    View in: PubMed
  5. Retraction. Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth. J Exp Med. 2011 Nov 21; 208(12):2561.
    View in: PubMed
  6. Manrique SZ, Correa MA, Hoelzinger DB, Dominguez AL, Mirza N, Lin HH, Stein-Streilein J, Gordon S, Lustgarten J. Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth. J Exp Med. 2011 Jul 4; 208(7):1485-99.
    View in: PubMed
  7. Niederkorn JY, Stein-Streilein J. History and physiology of immune privilege. Ocul Immunol Inflamm. 2010 Jan; 18(1):19-23.
    View in: PubMed
  8. Lin HH, Stacey M, Stein-Streilein J, Gordon S. F4/80: the macrophage-specific adhesion-GPCR and its role in immunoregulation. Adv Exp Med Biol. 2010; 706:149-56.
    View in: PubMed
  9. Qiao H, Lucas K, Stein-Streilein J. Retinal laser burn disrupts immune privilege in the eye. Am J Pathol. 2009 Feb; 174(2):414-22.
    View in: PubMed
  10. Stein-Streilein J. Immune regulation and the eye. Trends Immunol. 2008 Nov; 29(11):548-54.
    View in: PubMed
  11. Watte CM, Nakamura T, Lau CH, Ortaldo JR, Stein-Streilein J. Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance. J Leukoc Biol. 2008 Apr; 83(4):928-35.
    View in: PubMed
  12. Sonoda KH, Nakamura T, Young HA, Hart D, Carmeliet P, Stein-Streilein J. NKT cell-derived urokinase-type plasminogen activator promotes peripheral tolerance associated with eye. J Immunol. 2007 Aug 15; 179(4):2215-22.
    View in: PubMed
  13. Nowak M, Stein-Streilein J. Invariant NKT cells and tolerance. Int Rev Immunol. 2007 Jan-Apr; 26(1-2):95-119.
    View in: PubMed
  14. Stein-Streilein J, Watte C. Cross talk among cells promoting anterior chamber-associated immune deviation. Chem Immunol Allergy. 2007; 92:115-30.
    View in: PubMed
  15. Zhang-Hoover J, Stein-Streilein J. Therapies based on principles of ocular immune privilege. Chem Immunol Allergy. 2007; 92:317-27.
    View in: PubMed
  16. Stein-Streilein J, Taylor AW. An eye's view of T regulatory cells. J Leukoc Biol. 2007 Mar; 81(3):593-8.
    View in: PubMed
  17. Sugita S, Keino H, Futagami Y, Takase H, Mochizuki M, Stein-Streilein J, Streilein JW. B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5376-84.
    View in: PubMed
  18. Keino H, Masli S, Sasaki S, Streilein JW, Stein-Streilein J. CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1533-42.
    View in: PubMed
  19. Keino H, Takeuchi M, Kezuka T, Hattori T, Usui M, Taguchi O, Streilein JW, Stein-Streilein J. Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1047-55.
    View in: PubMed
  20. Zhang-Hoover J, Finn P, Stein-Streilein J. Modulation of ovalbumin-induced airway inflammation and hyperreactivity by tolerogenic APC. J Immunol. 2005 Dec 1; 175(11):7117-24.
    View in: PubMed
  21. Maruyama K, Ii M, Cursiefen C, Jackson DG, Keino H, Tomita M, Van Rooijen N, Takenaka H, D'Amore PA, Stein-Streilein J, Losordo DW, Streilein JW. Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest. 2005 Sep; 115(9):2363-72.
    View in: PubMed
  22. Nakamura T, Terajewicz A, Stein-Streilein J. Mechanisms of peripheral tolerance following intracameral inoculation are independent of IL-13 or STAT6. J Immunol. 2005 Aug 15; 175(4):2643-6.
    View in: PubMed
  23. Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J. The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med. 2005 May 16; 201(10):1615-25.
    View in: PubMed
  24. Stein-Streilein J. A privileged view of NKT cells and peripheral tolerance through the eye. Ocul Immunol Inflamm. 2005 Apr-Jun; 13(2-3):111-7.
    View in: PubMed
  25. Faunce DE, Terajewicz A, Stein-Streilein J. Cutting edge: in vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis. J Immunol. 2004 Feb 15; 172(4):1991-5.
    View in: PubMed
  26. Zhang-Hoover J, Stein-Streilein J. Tolerogenic APC generate CD8+ T regulatory cells that modulate pulmonary interstitial fibrosis. J Immunol. 2004 Jan 1; 172(1):178-85.
    View in: PubMed
  27. Stein-Streilein J. Invariant NKT cells as initiators, licensors, and facilitators of the adaptive immune response. J Exp Med. 2003 Dec 15; 198(12):1779-83.
    View in: PubMed
  28. Nakamura T, Sonoda KH, Faunce DE, Gumperz J, Yamamura T, Miyake S, Stein-Streilein J. CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site. J Immunol. 2003 Aug 1; 171(3):1266-71.
    View in: PubMed
  29. Katagiri K, Zhang-Hoover J, Mo JS, Stein-Streilein J, Streilein JW. Using tolerance induced via the anterior chamber of the eye to inhibit Th2-dependent pulmonary pathology. J Immunol. 2002 Jul 1; 169(1):84-9.
    View in: PubMed
  30. Faunce DE, Stein-Streilein J. NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in tolerance. J Immunol. 2002 Jul 1; 169(1):31-8.
    View in: PubMed
  31. Sonoda KH, Stein-Streilein J. CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance. Eur J Immunol. 2002 Mar; 32(3):848-57.
    View in: PubMed
  32. Stein-Streilein J, Streilein JW. Anterior chamber associated immune deviation (ACAID): regulation, biological relevance, and implications for therapy. Int Rev Immunol. 2002 Mar-Jun; 21(2-3):123-52.
    View in: PubMed
  33. Sonoda KH, Stein-Streilein J. Ocular immune privilege and CD1d-reactive natural killer T cells. Cornea. 2002 Mar; 21(2 Suppl 1):S33-8.
    View in: PubMed
  34. Sonoda KH, Taniguchi M, Stein-Streilein J. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. J Immunol. 2002 Feb 15; 168(4):2028-34.
    View in: PubMed
  35. Zhang-Hoover J, Sutton A, Stein-Streilein J. CD40/CD40 ligand interactions are critical for elicitation of autoimmune-mediated fibrosis in the lung. J Immunol. 2001 Mar 1; 166(5):3556-63.
    View in: PubMed
  36. Silverman ES, De Sanctis GT, Boyce J, Maclean JA, Jiao A, Green FH, Grasemann H, Faunce D, Fitzmaurice G, Shi GP, Stein-Streilein J, Milbrandt J, Collins T, Drazen JM. The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):778-85.
    View in: PubMed
  37. Faunce DE, Sonoda KH, Stein-Streilein J. MIP-2 recruits NKT cells to the spleen during tolerance induction. J Immunol. 2001 Jan 1; 166(1):313-21.
    View in: PubMed
  38. Sonoda KH, Faunce DE, Taniguchi M, Exley M, Balk S, Stein-Streilein J. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J Immunol. 2001 Jan 1; 166(1):42-50.
    View in: PubMed
  39. Zhang-Hoover J, Sutton A, van Rooijen N, Stein-Streilein J. A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis. Immunology. 2000 Dec; 101(4):501-11.
    View in: PubMed
  40. Stein-Streilein J, Sonoda KH, Faunce D, Zhang-Hoover J. Regulation of adaptive immune responses by innate cells expressing NK markers and antigen-transporting macrophages. J Leukoc Biol. 2000 Apr; 67(4):488-94.
    View in: PubMed
  41. Streilein JW, Stein-Streilein J. Does innate immune privilege exist? J Leukoc Biol. 2000 Apr; 67(4):479-87.
    View in: PubMed
  42. Sonoda KH, Exley M, Snapper S, Balk SP, Stein-Streilein J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med. 1999 Nov 1; 190(9):1215-26.
    View in: PubMed
  43. De Sanctis GT, MacLean JA, Qin S, Wolyniec WW, Grasemann H, Yandava CN, Jiao A, Noonan T, Stein-Streilein J, Green FH, Drazen JM. Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. J Clin Invest. 1999 Feb; 103(4):507-15.
    View in: PubMed
  44. Asea A, Stein-Streilein J. Signalling through NK1.1 triggers NK cells to die but induces NK T cells to produce interleukin-4. Immunology. 1998 Feb; 93(2):296-305.
    View in: PubMed
  45. Del Moral T, Goldberg RN, Urbon J, Suguihara C, Martinez O, Stein-Streilein J, Feuer WJ, Bancalari E. Effects of treatment with pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet. Pediatr Res. 1996 Sep; 40(3):469-74.
    View in: PubMed
  46. D'Orazio JA, Stein-Streilein J. Human natural killer (NK) cells present staphylococcal enterotoxin B (SEB) to T lymphocytes. Clin Exp Immunol. 1996 May; 104(2):366-73.
    View in: PubMed
  47. D'Orazio JA, Cole BC, Stein-Streilein J. Mycoplasma arthritidis mitogen up-regulates human NK cell activity. Infect Immun. 1996 Feb; 64(2):441-7.
    View in: PubMed
  48. D'Orazio JA, Burke GW, Stein-Streilein J. Staphylococcal enterotoxin B activates purified NK cells to secrete IFN-gamma but requires T lymphocytes to augment NK cytotoxicity. J Immunol. 1995 Feb 1; 154(3):1014-23.
    View in: PubMed
  49. Hu H, Stein-Streilein J. Hapten-immune pulmonary interstitial fibrosis (HIPIF) in mice requires both CD4+ and CD8+ T lymphocytes. J Leukoc Biol. 1993 Nov; 54(5):414-22.
    View in: PubMed
  50. Stein-Streilein J, Phipps RP. Horses and zebras. Reg Immunol. 1993 May-Aug; 5(3-4):127-33.
    View in: PubMed
  51. Kimura R, Hu H, Stein-Streilein J. Tolerance to hapten prevents specific delayed type hypersensitivity and pulmonary interstitial fibrosis in the mouse model. Chest. 1993 Feb; 103(2 Suppl):122S-124S.
    View in: PubMed
  52. Kimura R, Hu H, Stein-Streilein J. Delayed-type hypersensitivity responses regulate collagen deposition in the lung. Immunology. 1992 Dec; 77(4):550-5.
    View in: PubMed
  53. Kimura R, Hu H, Stein-Streilein J. Immunological tolerance to hapten prevents subsequent induction of hapten-immune pulmonary interstitial fibrosis (HIPIF). Cell Immunol. 1992 Dec; 145(2):351-8.
    View in: PubMed
  54. Stein-Streilein J, Salter-Cid L, Roberts B, Altman NH. Persistent pulmonary interstitial fibrosis, induced by immune response to TNP, is associated with altered mRNA procollagen type I:III ratio. Reg Immunol. 1992 Nov-Dec; 4(6):391-400.
    View in: PubMed
  55. Garcia H, Salter-Cid L, Stein-Streilein J. Persistent interleukin-2 activity and molecular evidence for expression of lymphotoxin in the hapten-immune model for pulmonary interstitial fibrosis. Am J Respir Cell Mol Biol. 1992 Jan; 6(1):22-8.
    View in: PubMed
  56. Liu H, Alder JD, Steiner BM, Stein-Streilein J, Lim L, Schell RF. Role of L3T4+ and 38+ T-cell subsets in resistance against infection with Treponema pallidum subsp. pertenue in hamsters. Infect Immun. 1991 Feb; 59(2):529-36.
    View in: PubMed
  57. Peacock JS, Tan J, Guffee J, Stein-Streilein J. Monovalent Fab fragments of D7.5 monoclonal antibody activate intracellular Ca2+ mobilization and secretion of cytolytic factors by thymus cells. J Leukoc Biol. 1991 Jan; 49(1):90-7.
    View in: PubMed
  58. Stein-Streilein J, Guffee J, Ramos M, Pitchenik AE. Spontaneous lymphokine activated killer (LAK) activity in bronchoalveolar lavage cells from patients with bronchogenic carcinoma. Reg Immunol. 1989 Nov-Dec; 2(6):370-5.
    View in: PubMed
  59. Stein-Streilein J, Guffee J. Monoclonal antibodies (G1.4, D7.5) induce secretion of lytic factors from natural killer and T lymphocytes. J Leukoc Biol. 1989 Sep; 46(3):199-213.
    View in: PubMed
  60. Moas CM, Evans DA, Stein-Streilein J, Ganjei P, Pitchenik AE. Cresyl violet: a rapid, simple, easily interpretable stain for detecting Pneumocystis carinii in sputum. South Med J. 1989 Aug; 82(8):957-9.
    View in: PubMed
  61. Stein-Streilein J, Guffee J. A common trigger molecule (TrgS) for secretion of lytic factor is expressed on cells that participate in non-MHC restricted cellular cytotoxicity. Transplant Proc. 1989 Feb; 21(1 Pt 1):105-7.
    View in: PubMed
  62. Stein-Streilein J. Immunobiology of lymphocytes in the lung. Reg Immunol. 1988 Sep-Oct; 1(2):128-36.
    View in: PubMed
  63. Stein-Streilein J, Guffee J, Fan W. Locally and systemically derived natural killer cells participate in defense against intranasally inoculated influenza virus. Reg Immunol. 1988 Sep-Oct; 1(2):100-5.
    View in: PubMed
  64. Colsky AS, Stein-Streilein J, Peacock JS. Surrogate receptor-mediated cellular cytotoxicity. A method for "custom designing" killer cells of desired target specificity. J Immunol. 1988 Apr 15; 140(8):2515-9.
    View in: PubMed
  65. Pitchenik AE, Guffee J, Stein-Streilein J. Lung natural killer and interleukin-2 activity in lung cancer. A pulmonary compartment of augmented natural killer activity occurs in patients with bronchogenic carcinoma. Am Rev Respir Dis. 1987 Dec; 136(6):1327-32.
    View in: PubMed
  66. Stein-Streilein J, Zakarija M, Papic M, McKenzie JM. Hyperthyroxinemic mice have reduced natural killer cell activity. Evidence for a defective trigger mechanism. J Immunol. 1987 Oct 1; 139(7):2502-7.
    View in: PubMed
  67. Stein-Streilein J, Lipscomb MF, Fisch H, Whitney PL. Pulmonary interstitial fibrosis induced in hapten-immune hamsters. Am Rev Respir Dis. 1987 Jul; 136(1):119-23.
    View in: PubMed
  68. Papic M, Stein-Streilein J, Zakarija M, McKenzie JM, Guffee J, Fletcher MA. Suppression of peripheral blood natural killer cell activity by excess thyroid hormone. J Clin Invest. 1987 Feb; 79(2):404-8.
    View in: PubMed
  69. Stein-Streilein J, Guffee J. In vivo treatment of mice and hamsters with antibodies to asialo GM1 increases morbidity and mortality to pulmonary influenza infection. J Immunol. 1986 Feb 15; 136(4):1435-41.
    View in: PubMed
  70. Mann DW, Sonnenfeld G, Stein-Streilein J. Pulmonary compartmentalization of interferon and natural killer cell activity. Proc Soc Exp Biol Med. 1985 Nov; 180(2):224-30.
    View in: PubMed
  71. Stein-Streilein J, Witte PL, Streilein JW, Guffee J. Local cellular defenses in influenza-infected lungs. Cell Immunol. 1985 Oct 15; 95(2):234-46.
    View in: PubMed
  72. Witte PL, Stein-Streilein J, Streilein JW. Description of phenotypically distinct T-lymphocyte subsets which mediate helper/DTH and cytotoxic functions in the Syrian hamster. J Immunol. 1985 May; 134(5):2908-15.
    View in: PubMed
  73. Stein-Streilein J, Bennett M, Mann D, Kumar V. Natural killer cells in mouse lung: surface phenotype, target preference, and response to local influenza virus infection. J Immunol. 1983 Dec; 131(6):2699-704.
    View in: PubMed
  74. Lipscomb MF, Yeakel-Houlihan D, Lyons CR, Gleason RR, Stein-Streilein J. Persistence of influenza as an immunogen in pulmonary antigen-presenting cells. Infect Immun. 1983 Dec; 42(3):965-72.
    View in: PubMed
  75. Stein-Streilein J. Allergic contact dermatitis induced by intratracheal administration of hapten. J Immunol. 1983 Oct; 131(4):1748-53.
    View in: PubMed
  76. Lipscomb MF, Lyons CR, O'Hara RM, Stein-Streilein J. The antigen-induced selective recruitment of specific T lymphocytes to the lung. J Immunol. 1982 Jan; 128(1):111-5.
    View in: PubMed
  77. Streilein JW, Phillips JT, Stein-Streilein J, Proia DA, Duncan WR. Biochemical characterization of Syrian hamster cell surface alloantigens. III. Hamster alloantisera immunoprecipitate class II-like, but not class I-like, molecules. Transplantation. 1981 Aug; 32(2):106-10.
    View in: PubMed
  78. Stein-Streilein J, Lipscomb MF, Hart DA, Darden A. Graft-versus-host reaction in the lung. Transplantation. 1981 Jul; 32(1):38-44.
    View in: PubMed
  79. Stein-Streilein J, Hart DA. Isolation of characterization of hamster alpha 2 macroglobulin. Adv Exp Med Biol. 1981; 134:111-9.
    View in: PubMed
  80. Hart DA, Stein-Streilein J. Hamster lymphoid cell responses in vitro. Adv Exp Med Biol. 1981; 134:7-22.
    View in: PubMed
  81. Stein-Streilein J, Lipscomb MF, Hart DA. Immune responses related to the hamster lung. Adv Exp Med Biol. 1981; 134:191-204.
    View in: PubMed
  82. Stein-Streilein J, Hart DA. Effect of route of immunization on development of antibody-forming cells in hilar lymph nodes. Infect Immun. 1980 Nov; 30(2):391-6.
    View in: PubMed
  83. Stein-Streilein J, Hart DA. Exogenous protease promotes specific antibody forming cell response in vitro. Cell Immunol. 1980 Sep 1; 54(2):284-92.
    View in: PubMed
  84. Stein-Streilein J, Hart DA. In vitro development of a primary antibody response with lymph node cells. Cell Immunol. 1979 Jun; 45(1):241-8.
    View in: PubMed
  85. Stein-Streilein J, Frazier JL, Gross GN, Hart DA. Splenic influence on the development of a local pulmonary immune response. Infect Immun. 1979 Apr; 24(1):139-44.
    View in: PubMed
  86. Stein-Streilein J, Gross GN, Hart DA. Comparison of intratracheal and intravenous inoculation of sheep erythrocytes in the induction of local and systemic immune responses. Infect Immun. 1979 Apr; 24(1):145-50.
    View in: PubMed
  87. Nelles M, Stein-Streilein J, Hart D, Proia R, Streilein JW. Characterization of a Syrian hamster plasma cell tumor. Prog Exp Tumor Res. 1979; 24:414-23.
    View in: PubMed
  88. Stein-Streilein J, Hart DA. Role of alpha globulins in nonspecific regulation of the immune response: possible mechanisms for external and internal signals. Fed Proc. 1978 May 15; 37(7):2042-4.
    View in: PubMed
  89. Hart DA, Stein-Streilein J, Eidels L. Mitogenic activation of hamster lymphoid cells. Fed Proc. 1978 May 15; 37(7):2039-41.
    View in: PubMed
  90. Streilein JW, Stein-Streilein J. Allogeneic reactions, "adjuvant effect" and response to weak transplantation antigens in hamsters. Fed Proc. 1978 May 15; 37(7):2052-4.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Stein-Streilein's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department