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Darlene Ann Dartt, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13EY028021 (DARTT, DARLENE A) May 1, 2017 - Apr 30, 2018
    NIH/NEI
    Sixth Military Vision Symposium on Ocular and Vision Injury
    Role: Principal Investigator
  2. R01EY022415 (DARTT, DARLENE A) May 1, 2012 - Apr 30, 2016
    NIH/NEI
    Conjunctival Goblet Cell NLRP3 Inflammasome in Ocular Surface Bacterial Infection
    Role: Principal Investigator
  3. R21EY020992 (DARTT, DARLENE A) Sep 1, 2010 - Aug 31, 2012
    NIH/NEI
    Lacrimal Gland Regeneration:Identification and Isolation of Progenitor Cells
    Role: Principal Investigator
  4. R01EY019470 (DARTT, DARLENE A) May 1, 2009 - Dec 31, 2023
    NIH/NEI
    Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution
    Role: Principal Investigator
  5. P20RR020753 (DARTT, DARLENE A) Sep 24, 2004 - Jul 31, 2009
    NIH/NCRR
    Planning Grant:Research on Blinding Eye Diseases (RMI)
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Botten N, Hodges RR, Li D, Bair JA, Shatos MA, Utheim TP, Serhan CN, Dartt DA. Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells. FASEB J. 2019 Apr 23; fj201802467R. PMID: 31013438.
    Citations:    
  2. Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Hua Y, Eidet JR, Stojanovic A, Dartt DA, Utheim TP. Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients. Curr Eye Res. 2019 Apr 06; 1-7. PMID: 30955380.
    Citations:    
  3. Tiedemann D, Mouhammad ZA, Utheim TP, Dartt DA, Heegaard S, Petrovski G, Kolko M. Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment. J Glaucoma. 2019 Apr; 28(4):325-333. PMID: 30585937.
    Citations:    Fields:    
  4. Utheim OA, Pasovic L, Raeder S, Eidet JR, Fostad IG, Sehic A, Roald B, de la Paz MF, Lyberg T, Dartt DA, Utheim TP. Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells. PLoS One. 2019; 14(3):e0212524. PMID: 30861002.
    Citations:    
  5. Adil MY, Xiao J, Olafsson J, Chen X, Lagali NS, Ræder S, Utheim ØA, Dartt DA, Utheim TP. Meibomian Gland Morphology Is a Sensitive Early Indicator of Meibomian Gland Dysfunction. Am J Ophthalmol. 2019 Apr; 200:16-25. PMID: 30578784.
    Citations:    Fields:    
  6. Kaye R, Botten N, Lippestad M, Li D, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells. Exp Eye Res. 2019 03; 180:53-62. PMID: 30513286.
    Citations:    Fields:    
  7. Tatematsu Y, Khan Q, Blanco T, Bair JA, Hodges RR, Masli S, Dartt DA. Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves. Int J Mol Sci. 2018 Oct 16; 19(10). PMID: 30332778.
    Citations:    Fields:    Translation:AnimalsCells
  8. Shen J, Xiao R, Bair J, Wang F, Vandenberghe LH, Dartt D, Baranov P, Ng YSE. Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study. Cell Death Dis. 2018 Oct 03; 9(10):1018. PMID: 30282966.
    Citations:    Fields:    
  9. Saban DR, Hodges RR, Mathew R, Reyes NJ, Yu C, Kaye R, Swift W, Botten N, Serhan CN, Dartt DA. Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model. Mucosal Immunol. 2019 01; 12(1):145-153. PMID: 30279513.
    Citations:    Fields:    
  10. Momtazi L, Dartt DA, Nilsen O, Eidet JR. Molecular layer deposition builds biocompatible substrates for epithelial cells. J Biomed Mater Res A. 2018 Dec; 106(12):3090-3098. PMID: 30194710.
    Citations:    Fields:    
  11. Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Lagali N, Stojanovic A, Dartt DA, Utheim TP. Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort. Curr Eye Res. 2018 12; 43(12):1465-1470. PMID: 30183390.
    Citations:    Fields:    
  12. García-Posadas L, Hodges RR, Diebold Y, Dartt DA. Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators. Sci Rep. 2018 Aug 15; 8(1):12162. PMID: 30111832.
    Citations:    Fields:    
  13. Utheim OA, Lyberg T, Eidet JR, Raeder S, Sehic A, Roald B, Messelt E, de la Paz MF, Dartt DA, Utheim TP. Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency. Sci Rep. 2018 Jul 12; 8(1):10502. PMID: 30002380.
    Citations:    Fields:    
  14. He M, Lippestad M, Li D, Hodges RR, Utheim TP, Dartt DA. Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2018 07 02; 59(8):3543-3553. PMID: 30025103.
    Citations:    Fields:    
  15. Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca2+ in cultured rat conjunctival goblet cells. Exp Eye Res. 2018 08; 173:64-72. PMID: 29702100.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Landsend ECS, Utheim ØA, Pedersen HR, Aass HCD, Lagali N, Dartt DA, Baraas RC, Utheim TP. The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction. Invest Ophthalmol Vis Sci. 2018 04 01; 59(5):2197-2204. PMID: 29801153.
    Citations:    Fields:    Translation:Humans
  17. Landsend ECS, Pedersen HR, Utheim ØA, Xiao J, Adil MY, Tashbayev B, Lagali N, Dartt DA, Baraas RC, Utheim TP. Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia. Br J Ophthalmol. 2019 Jan; 103(1):119-124. PMID: 29519880.
    Citations:    Fields:    
  18. Bhattacharya S, García-Posadas L, Hodges RR, Makarenkova HP, Masli S, Dartt DA. Alteration in nerves and neurotransmitter stimulation of lacrimal gland secretion in the TSP-1-/- mouse model of aqueous deficiency dry eye. Mucosal Immunol. 2018 07; 11(4):1138-1148. PMID: 29445135.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Li D, Hodges RR, Bispo P, Gilmore MS, Gregory-Ksander M, Dartt DA. Neither non-toxigenic Staphylococcus aureus nor commensal S. epidermidi activates NLRP3 inflammasomes in human conjunctival goblet cells. BMJ Open Ophthalmol. 2017; 2(1):e000101. PMID: 29354725.
    Citations:    
  20. Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4530-4544. PMID: 28892824.
    Citations: 1     Fields:    Translation:AnimalsCells
  21. Jackson CJ, Reppe S, Eidet JR, Eide L, Tønseth KA, Bergersen LH, Dartt DA, Griffith M, Utheim TP. Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets. Sci Rep. 2017 08 15; 7(1):8206. PMID: 28811665.
    Citations:    Fields:    
  22. Belmonte C, Nichols JJ, Cox SM, Brock JA, Begley CG, Bereiter DA, Dartt DA, Galor A, Hamrah P, Ivanusic JJ, Jacobs DS, McNamara NA, Rosenblatt MI, Stapleton F, Wolffsohn JS. TFOS DEWS II pain and sensation report. Ocul Surf. 2017 07; 15(3):404-437. PMID: 28736339.
    Citations: 8     Fields:    Translation:AnimalsCells
  23. Islam R, Eidet JR, Badian RA, Lippestad M, Messelt E, Griffith M, Dartt DA, Utheim TP. Tissue Harvesting Site and Culture Medium Affect Attachment, Growth, and Phenotype of Ex Vivo Expanded Oral Mucosal Epithelial Cells. Sci Rep. 2017 04 06; 7(1):674. PMID: 28386069.
    Citations:    Fields:    Translation:AnimalsCells
  24. Fostad IG, Eidet JR, Lagali NS, Dartt DA, Ræder S, Messelt EB, Utheim TP. Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy. Microsc Microanal. 2017 02; 23(1):88-96. PMID: 28162126.
    Citations:    Fields:    Translation:HumansCells
  25. English JT, Norris PC, Hodges RR, Dartt DA, Serhan CN. Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics. Prostaglandins Leukot Essent Fatty Acids. 2017 02; 117:17-27. PMID: 28237084.
    Citations: 14     Fields:    Translation:Humans
  26. Hodges RR, Li D, Shatos MA, Serhan CN, Dartt DA. Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells. Sci Rep. 2016 11 08; 6:36124. PMID: 27824117.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  27. He M, Storr-Paulsen T, Wang AL, Ghezzi CE, Wang S, Fullana M, Karamichos D, Utheim TP, Islam R, Griffith M, Islam MM, Hodges RR, Wnek GE, Kaplan DL, Dartt DA. Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6134-6146. PMID: 27832279.
    Citations: 1     Fields:    Translation:HumansCells
  28. Shatos MA, Hodges RR, Morinaga M, McNay DE, Islam R, Bhattacharya S, Li D, Turpie B, Makarenkova HP, Masli S, Utheim TP, Dartt DA. Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1-/- mice, a model of dry eye. Exp Eye Res. 2016 Dec; 153:27-41. PMID: 27697548.
    Citations: 2     Fields:    Translation:AnimalsCells
  29. Gromova A, Voronov DA, Yoshida M, Thotakura S, Meech R, Dartt DA, Makarenkova HP. Lacrimal Gland Repair Using Progenitor Cells. Stem Cells Transl Med. 2016 Aug 15. PMID: 27526700.
    Citations:    
  30. Gromova A, Voronov DA, Yoshida M, Thotakura S, Meech R, Dartt DA, Makarenkova HP. Lacrimal Gland Repair Using Progenitor Cells. Stem Cells Transl Med. 2017 01; 6(1):88-98. PMID: 28170196.
    Citations: 10     Fields:    
  31. Ryan DS, Bower KS, Sia RK, Shatos MA, Howard RS, Mines MJ, Stutzman RD, Dartt DA. Goblet cell response after photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg. 2016 08; 42(8):1181-9. PMID: 27531295.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  32. Hodges RR, Dartt DA. Signaling Pathways of Purinergic Receptors and Their Interactions with Cholinergic and Adrenergic Pathways in the Lacrimal Gland. J Ocul Pharmacol Ther. 2016 10; 32(8):490-497. PMID: 27463365.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  33. Fostad IG, Eidet JR, Utheim TP, Ræder S, Lagali NS, Messelt EB, Dartt DA. Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility. PLoS One. 2016; 11(5):e0155214. PMID: 27148875.
    Citations: 3     Fields:    Translation:Humans
  34. Hodges RR, Li D, Shatos MA, Bair JA, Lippestad M, Serhan CN, Dartt DA. Lipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion. Mucosal Immunol. 2017 01; 10(1):46-57. PMID: 27072607.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. Utheim TP, Islam R, Fostad IG, Eidet JR, Sehic A, Olstad OK, Dartt DA, Messelt EB, Griffith M, Pasovic L. Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes. PLoS One. 2016; 11(3):e0152526. PMID: 27023475.
    Citations: 1     Fields:    Translation:HumansCells
  36. García-Posadas L, Contreras-Ruiz L, Soriano-Romaní L, Dartt DA, Diebold Y. Conjunctival Goblet Cell Function: Effect of Contact Lens Wear and Cytokines. Eye Contact Lens. 2016 Mar; 42(2):83-90. PMID: 26067396.
    Citations: 1     Fields:    Translation:HumansCells
  37. Eidet JR, Dartt DA, Utheim TP. Concise Review: Comparison of Culture Membranes Used for Tissue Engineered Conjunctival Epithelial Equivalents. J Funct Biomater. 2015 Dec 11; 6(4):1064-84. PMID: 26690486.
    Citations: 2     
  38. Bower KS, Sia RK, Ryan DS, Mines MJ, Dartt DA. Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: Manifestations, incidence, and predictive factors. J Cataract Refract Surg. 2015 Dec; 41(12):2624-34. PMID: 26796443.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  39. Makarenkova HP, Dartt DA. Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair. Curr Mol Biol Rep. 2015 Sep 01; 1(3):115-123. PMID: 26688786.
    Citations: 8     
  40. García-Posadas L, Hodges RR, Li D, Shatos MA, Storr-Paulsen T, Diebold Y, Dartt DA. Interaction of IFN-? with cholinergic agonists to modulate rat and human goblet cell function. Mucosal Immunol. 2016 Jan; 9(1):206-17. PMID: 26129651.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  41. Islam R, Jackson C, Eidet JR, Messelt EB, Corraya RM, Lyberg T, Griffith M, Dartt DA, Utheim TP. Effect of Storage Temperature on Structure and Function of Cultured Human Oral Keratinocytes. PLoS One. 2015; 10(6):e0128306. PMID: 26052937.
    Citations: 4     Fields:    Translation:HumansCells
  42. Utheim O, Islam R, Lyberg T, Roald B, Eidet JR, de la Paz MF, Dartt DA, Raeder S, Utheim TP. Serum-free and xenobiotic-free preservation of cultured human limbal epithelial cells. PLoS One. 2015; 10(3):e0118517. PMID: 25734654.
    Citations: 4     Fields:    Translation:HumansCells
  43. Dartt DA, Masli S. Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation. Curr Opin Allergy Clin Immunol. 2014 Oct; 14(5):464-70. PMID: 25061855.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  44. Sanderson J, Dartt DA, Trinkaus-Randall V, Pintor J, Civan MM, Delamere NA, Fletcher EL, Salt TE, Grosche A, Mitchell CH. Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland. Exp Eye Res. 2014 Oct; 127:270-9. PMID: 25151301.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  45. Eidet JR, Utheim ØA, Islam R, Lyberg T, Messelt EB, Dartt DA, Utheim TP. The impact of storage temperature on the morphology, viability, cell number and metabolism of cultured human conjunctival epithelium. Curr Eye Res. 2015 Jan; 40(1):30-9. PMID: 24750037.
    Citations: 5     Fields:    Translation:HumansCells
  46. Contreras-Ruiz L, Ryan DS, Sia RK, Bower KS, Dartt DA, Masli S. Polymorphism in THBS1 gene is associated with post-refractive surgery chronic ocular surface inflammation. Ophthalmology. 2014 Jul; 121(7):1389-97. PMID: 24679443.
    Citations: 10     Fields:    Translation:HumansCells
  47. Contreras-Ruiz L, Ghosh-Mitra A, Shatos MA, Dartt DA, Masli S. Modulation of conjunctival goblet cell function by inflammatory cytokines. Mediators Inflamm. 2013; 2013:636812. PMID: 24453426.
    Citations: 22     Fields:    Translation:AnimalsCells
  48. Dartt DA, Willcox MD. Complexity of the tear film: importance in homeostasis and dysfunction during disease. Exp Eye Res. 2013 Dec; 117:1-3. PMID: 24280033.
    Citations: 8     Fields:    Translation:Humans
  49. Stapleton F, Marfurt C, Golebiowski B, Rosenblatt M, Bereiter D, Begley C, Dartt D, Gallar J, Belmonte C, Hamrah P, Willcox M. The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology. Invest Ophthalmol Vis Sci. 2013 Oct 18; 54(11):TFOS71-97. PMID: 24058137.
    Citations: 16     Fields:    Translation:Humans
  50. McGilligan VE, Gregory-Ksander MS, Li D, Moore JE, Hodges RR, Gilmore MS, Moore TC, Dartt DA. Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS One. 2013; 8(9):e74010. PMID: 24040145.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  51. Li D, Shatos MA, Hodges RR, Dartt DA. Role of PKCa activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013 Aug 21; 54(8):5661-74. PMID: 23882690.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  52. Hodges RR, Dartt DA. Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins. Exp Eye Res. 2013 Dec; 117:62-78. PMID: 23954166.
    Citations: 19     Fields:    Translation:Humans
  53. Engelsvold DH, Utheim TP, Olstad OK, Gonzalez P, Eidet JR, Lyberg T, Trøseid AM, Dartt DA, Raeder S. miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. Exp Eye Res. 2013 Oct; 115:189-98. PMID: 23872359.
    Citations: 14     Fields:    Translation:Humans
  54. Li D, Jiao J, Shatos MA, Hodges RR, Dartt DA. Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013 Apr 23; 54(4):2872-84. PMID: 23518767.
    Citations: 8     Fields:    Translation:AnimalsCells
  55. Li D, Hodges RR, Jiao J, Carozza RB, Shatos MA, Chiang N, Serhan CN, Dartt DA. Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. Mucosal Immunol. 2013 Nov; 6(6):1119-30. PMID: 23462912.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  56. Saban DR, Calder V, Kuo CH, Reyes NJ, Dartt DA, Ono SJ, Niederkorn JY. New twists to an old story: novel concepts in the pathogenesis of allergic eye disease. Curr Eye Res. 2013 Mar; 38(3):317-30. PMID: 23281793.
    Citations: 9     Fields:    Translation:HumansCells
  57. Li D, Carozza RB, Shatos MA, Hodges RR, Dartt DA. Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2012 Oct 05; 53(11):6928-38. PMID: 22956601.
    Citations: 8     Fields:    Translation:AnimalsCells
  58. Fostad IG, Eidet JR, Shatos MA, Utheim TP, Utheim OA, Raeder S, Dartt DA. Biopsy harvesting site and distance from the explant affect conjunctival epithelial phenotype ex vivo. Exp Eye Res. 2012 Nov; 104:15-25. PMID: 23022405.
    Citations: 4     Fields:    Translation:AnimalsCells
  59. Hodges RR, Bair JA, Carozza RB, Li D, Shatos MA, Dartt DA. Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res. 2012 Oct; 103:99-113. PMID: 22975404.
    Citations: 20     Fields:    Translation:AnimalsCells
  60. Hayashi D, Li D, Hayashi C, Shatos M, Hodges RR, Dartt DA. Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):2993-3003. PMID: 22467574.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  61. Eidet JR, Fostad IG, Shatos MA, Utheim TP, Utheim ØA, Raeder S, Dartt DA. Effect of biopsy location and size on proliferative capacity of ex vivo expanded conjunctival tissue. Invest Ophthalmol Vis Sci. 2012 May 14; 53(6):2897-903. PMID: 22491407.
    Citations: 6     Fields:    Translation:AnimalsCells
  62. Shatos MA, Haugaard-Kedstrom L, Hodges RR, Dartt DA. Isolation and characterization of progenitor cells in uninjured, adult rat lacrimal gland. Invest Ophthalmol Vis Sci. 2012 May 14; 53(6):2749-59. PMID: 22427571.
    Citations: 15     Fields:    Translation:AnimalsCells
  63. Ohtomo K, Shatos MA, Vrouvlianis J, Li D, Hodges RR, Dartt DA. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Invest Ophthalmol Vis Sci. 2011 Dec 16; 52(13):9503-15. PMID: 22039237.
    Citations: 11     Fields:    Translation:AnimalsCells
  64. Eidet JR, Utheim OA, Raeder S, Dartt DA, Lyberg T, Carreras E, Huynh TT, Messelt EB, Louch WE, Roald B, Utheim TP. Effects of serum-free storage on morphology, phenotype, and viability of ex vivo cultured human conjunctival epithelium. Exp Eye Res. 2012 Jan; 94(1):109-16. PMID: 22154551.
    Citations: 12     Fields:    Translation:HumansCells
  65. Moore JE, Vasey GT, Dartt DA, McGilligan VE, Atkinson SD, Grills C, Lamey PJ, Leccisotti A, Frazer DG, Moore TC. Effect of tear hyperosmolarity and signs of clinical ocular surface pathology upon conjunctival goblet cell function in the human ocular surface. Invest Ophthalmol Vis Sci. 2011 Aug 03; 52(9):6174-80. PMID: 21519030.
    Citations: 8     Fields:    Translation:HumansCells
  66. Dartt DA, Hodges RR. Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion. Invest Ophthalmol Vis Sci. 2011 Jul 29; 52(8):5720-9. PMID: 21685341.
    Citations: 5     Fields:    Translation:AnimalsCells
  67. Dartt DA. Tear lipocalin: structure and function. Ocul Surf. 2011 Jul; 9(3):126-38. PMID: 21791187.
    Citations: 20     Fields:    Translation:HumansCells
  68. Hodges RR, Vrouvlianis J, Scott R, Dartt DA. Identification of P2X3 and P2X7 purinergic receptors activated by ATP in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 17; 52(6):3254-63. PMID: 21421865.
    Citations: 10     Fields:    Translation:Animals
  69. Dartt DA, Hodges RR. Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 01; 52(6):3381-90. PMID: 21421880.
    Citations: 12     Fields:    Translation:AnimalsCells
  70. Hodges RR, Guilbert E, Shatos MA, Natarajan V, Dartt DA. Phospholipase D1, but not D2, regulates protein secretion via Rho/ROCK in a Ras/Raf-independent, MEK-dependent manner in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2199-210. PMID: 21212180.
    Citations: 5     Fields:    Translation:Animals
  71. Dartt DA, Hodges RR, Li D, Shatos MA, Lashkari K, Serhan CN. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. J Immunol. 2011 Apr 01; 186(7):4455-66. PMID: 21357260.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  72. Funaki C, Hodges RR, Dartt DA. Identification of the Raf-1 signaling pathway used by cAMP to inhibit p42/p44 MAPK in rat lacrimal gland acini: role in potentiation of protein secretion. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6321-8. PMID: 20671279.
    Citations: 7     Fields:    Translation:AnimalsCells
  73. Turpie B, Yoshimura T, Gulati A, Rios JD, Dartt DA, Masli S. Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. Am J Pathol. 2009 Sep; 175(3):1136-47. PMID: 19700744.
    Citations: 39     Fields:    Translation:AnimalsCells
  74. Hodges RR, Vrouvlianis J, Shatos MA, Dartt DA. Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2009 Dec; 50(12):5681-9. PMID: 19608535.
    Citations: 12     Fields:    Translation:AnimalsCells
  75. Dartt DA. Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res. 2009 May; 28(3):155-77. PMID: 19376264.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  76. Shatos MA, Hodges RR, Bair JA, Lashkari K, Dartt DA. Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1619-25. PMID: 19074803.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  77. Rocha EM, Alves M, Rios JD, Dartt DA. The aging lacrimal gland: changes in structure and function. Ocul Surf. 2008 Oct; 6(4):162-74. PMID: 18827949.
    Citations: 19     Fields:    Translation:Humans
  78. Shatos MA, Hodges RR, Oshi Y, Bair JA, Zoukhri D, Kublin C, Lashkari K, Dartt DA. Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):614-20. PMID: 18824739.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  79. Moore JE, Graham JE, Goodall EA, Dartt DA, Leccisotti A, McGilligan VE, Moore TC. Concordance between common dry eye diagnostic tests. Br J Ophthalmol. 2009 Jan; 93(1):66-72. PMID: 18782801.
    Citations: 10     Fields:    Translation:Humans
  80. Shatos MA, Gu J, Hodges RR, Lashkari K, Dartt DA. ERK/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture. Invest Ophthalmol Vis Sci. 2008 Aug; 49(8):3351-9. PMID: 18421078.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  81. Ríos JD, Shatos MA, Urashima H, Dartt DA. Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells. Exp Eye Res. 2008 Apr; 86(4):629-36. PMID: 18295205.
    Citations: 11     Fields:    Translation:AnimalsCells
  82. Konomi K, Chen LL, Tarko RS, Scally A, Schaumberg DA, Azar D, Dartt DA. Preoperative characteristics and a potential mechanism of chronic dry eye after LASIK. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):168-74. PMID: 18172089.
    Citations: 19     Fields:    Translation:HumansCells
  83. Graham JE, Moore JE, Jiru X, Moore JE, Goodall EA, Dooley JS, Hayes VE, Dartt DA, Downes CS, Moore TC. Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5616-23. PMID: 18055811.
    Citations: 40     Fields:    Translation:HumansCells
  84. Gu J, Chen L, Shatos MA, Rios JD, Gulati A, Hodges RR, Dartt DA. Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation. Exp Eye Res. 2008 Feb; 86(2):322-34. PMID: 18155194.
    Citations: 17     Fields:    Translation:AnimalsCells
  85. Hodges RR, Horikawa Y, Rios JD, Shatos MA, Dartt DA. Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells. Exp Eye Res. 2007 Dec; 85(6):836-44. PMID: 17919561.
    Citations: 13     Fields:    Translation:AnimalsCells
  86. Funaki C, Hodges RR, Dartt DA. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. Am J Physiol Cell Physiol. 2007 Nov; 293(5):C1551-60. PMID: 17687004.
    Citations: 8     Fields:    Translation:AnimalsCells
  87. Collins JF, Dartt DA, Dana R. Mist delivery of eye medication to the anterior segment. Am J Ophthalmol. 2007 Jul; 144(1):137-9. PMID: 17601439.
    Citations:    Fields:    Translation:Humans
  88. Ríos JD, Ghinelli E, Gu J, Hodges RR, Dartt DA. Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation. Invest Ophthalmol Vis Sci. 2007 Apr; 48(4):1543-51. PMID: 17389483.
    Citations: 8     Fields:    Translation:AnimalsCells
  89. Diebold Y, Chen LL, Tepavcevic V, Ferdman D, Hodges RR, Dartt DA. Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome. Exp Eye Res. 2007 Mar; 84(3):500-12. PMID: 17208228.
    Citations: 4     Fields:    Translation:AnimalsCells
  90. Hodges RR, Rios JD, Vrouvlianis J, Ota I, Zoukhri D, Dartt DA. Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3352-9. PMID: 16877402.
    Citations: 8     Fields:    Translation:AnimalsCells
  91. Chen L, Hodges RR, Funaki C, Zoukhri D, Gaivin RJ, Perez DM, Dartt DA. Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C946-56. PMID: 16760267.
    Citations: 14     Fields:    Translation:AnimalsCells
  92. Ríos JD, Shatos M, Urashima H, Tran H, Dartt DA. OPC-12759 increases proliferation of cultured rat conjunctival goblet cells. Cornea. 2006 Jun; 25(5):573-81. PMID: 16783146.
    Citations: 12     Fields:    Translation:AnimalsCells
  93. Hodges RR, Shatos MA, Tarko RS, Vrouvlianis J, Gu J, Dartt DA. Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2005 Aug; 46(8):2781-9. PMID: 16043851.
    Citations: 11     Fields:    Translation:AnimalsCells
  94. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez SF. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. PMID: 15930141.
    Citations: 13     Fields:    Translation:Animals
  95. Ríos JD, Horikawa Y, Chen LL, Kublin CL, Hodges RR, Dartt DA, Zoukhri D. Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response. Exp Eye Res. 2005 Apr; 80(4):477-91. PMID: 15781275.
    Citations: 31     Fields:    Translation:AnimalsCells
  96. Chen LL, Johansson JK, Hodges RR, Zoukhri D, Ghinelli E, Rios JD, Dartt DA. Differential effects of the EGF family of growth factors on protein secretion, MAPK activation, and intracellular calcium concentration in rat lacrimal gland. Exp Eye Res. 2005 Mar; 80(3):379-89. PMID: 15721620.
    Citations: 5     Fields:    Translation:Animals
  97. Jiao J, Huang X, Feit-Leithman RA, Neve RL, Snider W, Dartt DA, Chen DF. Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J. 2005 Mar 09; 24(5):1068-78. PMID: 15719013.
    Citations: 35     Fields:    Translation:AnimalsCells
  98. Hodges RR, Raddassi I, Zoukhri D, Toker A, Kazlauskas A, Dartt DA. Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):3974-81. PMID: 15505044.
    Citations: 9     Fields:    Translation:AnimalsCells
  99. Dartt DA. Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes. Ocul Surf. 2004 Apr; 2(2):76-91. PMID: 17216081.
    Citations: 16     Fields:    
  100. Dartt DA. Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion. Exp Eye Res. 2004 Mar; 78(3):337-45. PMID: 15106911.
    Citations: 12     Fields:    Translation:HumansCells
  101. Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP. VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):368-74. PMID: 14744874.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  102. Dartt DA. Control of mucin production by ocular surface epithelial cells. Exp Eye Res. 2004 Feb; 78(2):173-85. PMID: 14729350.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  103. Sohn UD, Park JH, Lee TS, Shin CY, Jeong JH, Kim JH, Je HD, Dartt DA, Zoukhri D, Choi HC, Lee KY. Differential regulation by Ca(2+) of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter. Auton Autacoid Pharmacol. 2003 Oct-Dec; 23(5-6):307-17. PMID: 15255815.
    Citations: 1     Fields:    Translation:AnimalsCells
  104. Lee-Kwon W, Kim JH, Choi JW, Kawano K, Cha B, Dartt DA, Zoukhri D, Donowitz M. Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1527-36. PMID: 12954600.
    Citations: 43     Fields:    Translation:AnimalsCells
  105. Ghinelli E, Johansson J, Ríos JD, Chen LL, Zoukhri D, Hodges RR, Dartt DA. Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2003 Aug; 44(8):3352-7. PMID: 12882781.
    Citations: 9     Fields:    Translation:Animals
  106. Horikawa Y, Shatos MA, Hodges RR, Zoukhri D, Rios JD, Chang EL, Bernardino CR, Rubin PA, Dartt DA. Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2535-44. PMID: 12766054.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  107. Shatos MA, Ríos JD, Horikawa Y, Hodges RR, Chang EL, Bernardino CR, Rubin PA, Dartt DA. Isolation and characterization of cultured human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2477-86. PMID: 12766046.
    Citations: 29     Fields:    Translation:HumansCells
  108. Tepavcevic V, Hodges RR, Zoukhri D, Dartt DA. Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2003 Mar; 44(3):1075-81. PMID: 12601032.
    Citations: 7     Fields:    Translation:AnimalsCells
  109. Joussen AM, Poulaki V, Mitsiades N, Stechschulte SU, Kirchhof B, Dartt DA, Fong GH, Rudge J, Wiegand SJ, Yancopoulos GD, Adamis AP. VEGF-dependent conjunctivalization of the corneal surface. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):117-23. PMID: 12506063.
    Citations: 18     Fields:    Translation:AnimalsCells
  110. Hodges RR, Dartt DA. Regulatory pathways in lacrimal gland epithelium. Int Rev Cytol. 2003; 231:129-96. PMID: 14713005.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  111. Kanno H, Horikawa Y, Hodges RR, Zoukhri D, Shatos MA, Rios JD, Dartt DA. Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C988-98. PMID: 12620895.
    Citations: 32     Fields:    Translation:AnimalsCells
  112. Xu KP, Dartt DA, Yu FS. EGF-induced ERK phosphorylation independent of PKC isozymes in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2002 Dec; 43(12):3673-9. PMID: 12454035.
    Citations: 10     Fields:    Translation:HumansCells
  113. Dartt DA. Regulation of mucin and fluid secretion by conjunctival epithelial cells. Prog Retin Eye Res. 2002 Nov; 21(6):555-76. PMID: 12433377.
    Citations: 30     Fields:    Translation:AnimalsCells
  114. Ota I, Zoukhri D, Hodges RR, Rios JD, Tepavcevic V, Raddassi I, Chen LL, Dartt DA. Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C168-78. PMID: 12388118.
    Citations: 13     Fields:    Translation:AnimalsCells
  115. Ríos JD, Ferdman D, Tepavcevic V, Hodges R, Zoukhri D, Dartt DA. Role of Ca2+ and protein kinase C in cholinergic, and alpha1-adrenergic agonists and EGF stimulated mitogen-activated protein kinase activity in lacrimal gland. Adv Exp Med Biol. 2002; 506(Pt A):185-90. PMID: 12613906.
    Citations:    Fields:    Translation:AnimalsCells
  116. Shatos MA, Kano H, Rubin P, Garza G, Dartt DA. Isolation and characterization of human goblet cells in vitro: regulation of proliferation and activation of mitogen-activated protein kinase by EGF and carbachol. Adv Exp Med Biol. 2002; 506(Pt A):301-5. PMID: 12613924.
    Citations: 2     Fields:    Translation:HumansCells
  117. Dartt DA, Kanno H, Rios J, Zoukhri D. Role of mitogen-activated protein kinase in cholinergic stimulation of conjunctival goblet cell secretion. Adv Exp Med Biol. 2002; 506(Pt A):297-300. PMID: 12613923.
    Citations:    Fields:    Translation:AnimalsCells
  118. Hodges RR, Kazlauskas A, Toker A, Dartt DA. Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion. Adv Exp Med Biol. 2002; 506(Pt A):237-41. PMID: 12613914.
    Citations: 1     Fields:    Translation:AnimalsCells
  119. Dartt DA. Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors. Exp Eye Res. 2001 Dec; 73(6):741-52. PMID: 11846506.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  120. Diebold Y, Ríos JD, Hodges RR, Rawe I, Dartt DA. Presence of nerves and their receptors in mouse and human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2270-82. PMID: 11527940.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  121. Ang RT, Dartt DA, Tsubota K. Dry eye after refractive surgery. Curr Opin Ophthalmol. 2001 Aug; 12(4):318-22. PMID: 11507347.
    Citations: 27     Fields:    Translation:Humans
  122. Xu KP, Zoukhri D, Zieske JD, Dartt DA, Sergheraert C, Loing E, Yu FS. A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C603-14. PMID: 11443060.
    Citations: 7     Fields:    Translation:HumansCells
  123. Shatos MA, Rios JD, Tepavcevic V, Kano H, Hodges R, Dartt DA. Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1455-64. PMID: 11381047.
    Citations: 35     Fields:    Translation:AnimalsCells
  124. Dartt DA, Rios JD, Kanno H, Rawe IM, Zieske JD, Ralda N, Hodges RR, Zoukhri D, Rios JR. Regulation of conjunctival goblet cell secretion by Ca(2+)and protein kinase C. Exp Eye Res. 2000 Dec; 71(6):619-28. PMID: 11095914.
    Citations: 11     Fields:    Translation:AnimalsCells
  125. Graham MA, Rawe I, Dartt DA, Joyce NC. Protein kinase C regulation of corneal endothelial cell proliferation and cell cycle. Invest Ophthalmol Vis Sci. 2000 Dec; 41(13):4124-32. PMID: 11095605.
    Citations: 5     Fields:    Translation:AnimalsCells
  126. Ríos JD, Forde K, Diebold Y, Lightman J, Zieske JD, Dartt DA. Development of conjunctival goblet cells and their neuroreceptor subtype expression. Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2127-37. PMID: 10892854.
    Citations: 7     Fields:    Translation:AnimalsCells
  127. Zoukhri D, Hodges RR, Sergheraert C, Dartt DA. Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):386-92. PMID: 10670466.
    Citations: 6     Fields:    Translation:AnimalsCells
  128. Thiam K, Loing E, Zoukhri D, Rommens C, Hodges R, Dartt D, Verwaerde C, Auriault C, Gras-Masse H, Sergheraert C. Direct evidence of cytoplasmic delivery of PKC-alpha, -epsilon and -zeta pseudosubstrate lipopeptides: study of their implication in the induction of apoptosis. FEBS Lett. 1999 Oct 15; 459(3):285-90. PMID: 10526151.
    Citations: 3     Fields:    Translation:HumansCells
  129. Ríos JD, Zoukhri D, Rawe IM, Hodges RR, Zieske JD, Dartt DA. Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion. Invest Ophthalmol Vis Sci. 1999 May; 40(6):1102-11. PMID: 10235543.
    Citations: 22     Fields:    Translation:AnimalsCells
  130. Zoukhri D, Hodges RR, Rawe IM, Dartt DA. Ca2+ signaling by cholinergic and alpha1-adrenergic agonists is up-regulated in lacrimal and submandibular glands in a murine model of Sjögren's syndrome. Clin Immunol Immunopathol. 1998 Nov; 89(2):134-40. PMID: 9787115.
    Citations: 9     Fields:    Translation:AnimalsCells
  131. Zoukhri D, Hodges RR, Dartt DA. Lacrimal gland innervation is not altered with the onset and progression of disease in a murine model of Sjögren's syndrome. Clin Immunol Immunopathol. 1998 Nov; 89(2):126-33. PMID: 9787114.
    Citations: 11     Fields:    Translation:AnimalsCells
  132. Zoukhri D, Hodges RR, Sergheraert C, Dartt DA. Lacrimal gland functions are differentially controlled by protein kinase C isoforms. Ann N Y Acad Sci. 1998 Apr 15; 842:217-20. PMID: 9599315.
    Citations: 1     Fields:    Translation:Animals
  133. Dartt DA, Hodges RR, Zoukhri D. Signal transduction pathways activated by cholinergic and alpha 1-adrenergic agonists in the lacrimal gland. Adv Exp Med Biol. 1998; 438:113-21. PMID: 9634873.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  134. Hodges RR, Zoukhri D, Lightman JP, Dartt DA. Identification and cellular localization of the components of the VIP signaling pathway in the lacrimal gland. Adv Exp Med Biol. 1998; 438:169-76. PMID: 9634882.
    Citations: 3     Fields:    Translation:AnimalsCells
  135. Zoukhri D, Hodges RR, Sergheraert C, Dartt DA. Protein kinase C isoforms differentially control lacrimal gland functions. Adv Exp Med Biol. 1998; 438:181-6. PMID: 9634884.
    Citations: 1     Fields:    Translation:Animals
  136. Zoukhri D, Hodges RR, Willert S, Dartt DA. Immunolocalization of lacrimal gland PKC isoforms. Effect of phorbol esters and cholinergic agonists on their cellular distribution. J Membr Biol. 1997 May 15; 157(2):169-75. PMID: 9151658.
    Citations: 9     Fields:    Translation:Animals
  137. Hodges RR, Zoukhri D, Sergheraert C, Zieske JD, Dartt DA. Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components. Invest Ophthalmol Vis Sci. 1997 Mar; 38(3):610-9. PMID: 9071214.
    Citations: 10     Fields:    Translation:AnimalsCells
  138. Sohn UD, Zoukhri D, Dartt D, Sergheraert C, Harnett KM, Behar J, Biancani P. Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle. Mol Pharmacol. 1997 Mar; 51(3):462-70. PMID: 9058601.
    Citations: 8     Fields:    Translation:Animals
  139. Zoukhri D, Hodges RR, Sergheraert C, Toker A, Dartt DA. Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion. Am J Physiol. 1997 Jan; 272(1 Pt 1):C263-9. PMID: 9038832.
    Citations: 13     Fields:    Translation:AnimalsCells
  140. Dartt DA, Kessler TL, Chung EH, Zieske JD. Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells. Exp Eye Res. 1996 Jul; 63(1):27-34. PMID: 8983961.
    Citations: 9     Fields:    Translation:Animals
  141. Dartt DA, Hodges RR, Zoukhri D, Mircheff AK. Protein phosphorylation in Golgi, endosomal, and endoplasmic reticulum membrane fractions of lacrimal gland. Curr Eye Res. 1996 Feb; 15(2):157-64. PMID: 8670724.
    Citations:    Fields:    Translation:AnimalsCells
  142. Kessler TL, Mercer HJ, Zieske JD, McCarthy DM, Dartt DA. Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva. Curr Eye Res. 1995 Nov; 14(11):985-92. PMID: 8585937.
    Citations: 23     Fields:    Translation:AnimalsCells
  143. Dartt DA, McCarthy DM, Mercer HJ, Kessler TL, Chung EH, Zieske JD. Localization of nerves adjacent to goblet cells in rat conjunctiva. Curr Eye Res. 1995 Nov; 14(11):993-1000. PMID: 8585938.
    Citations: 13     Fields:    Translation:AnimalsCells
  144. Zoukhri D, Dartt DA. Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium. Am J Physiol. 1995 Mar; 268(3 Pt 1):C713-20. PMID: 7900776.
    Citations: 8     Fields:    Translation:AnimalsCells
  145. Zoukhri D, Hodges RR, Dicker DM, Dartt DA. Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion. FEBS Lett. 1994 Aug 29; 351(1):67-72. PMID: 8076696.
    Citations: 4     Fields:    Translation:AnimalsCells
  146. Dartt DA, Rose PE, Dicker DM, Ronco LV, Hodges RR. Alpha 1-adrenergic agonist-stimulated protein secretion in rat exorbital lacrimal gland acini. Exp Eye Res. 1994 Apr; 58(4):423-9. PMID: 7925679.
    Citations: 2     Fields:    Translation:Animals
  147. Dartt DA. Regulation of tear secretion. Adv Exp Med Biol. 1994; 350:1-9. PMID: 8030459.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  148. Hodges RR, Dicker DM, Dartt DA. Role of protein kinase C in alpha 1-adrenergic and cholinergic agonist stimulated protein secretion. Adv Exp Med Biol. 1994; 350:147-50. PMID: 8030467.
    Citations: 1     Fields:    Translation:AnimalsCells
  149. Kessler TL, Dartt DA. Neural stimulation of conjunctival goblet cell mucous secretion in rats. Adv Exp Med Biol. 1994; 350:393-8. PMID: 7913285.
    Citations: 3     Fields:    Translation:AnimalsCells
  150. Hodges RR, Dicker DM, Rose PE, Dartt DA. Alpha 1-adrenergic and cholinergic agonists use separate signal transduction pathways in lacrimal gland. Am J Physiol. 1992 Jun; 262(6 Pt 1):G1087-96. PMID: 1319686.
    Citations: 13     Fields:    Translation:AnimalsCells
  151. Gilbard JP, Rossi SR, Heyda KG, Dartt DA. Stimulation of tear secretion and treatment of dry-eye disease with 3-isobutyl-1-methylxanthine. Arch Ophthalmol. 1991 May; 109(5):672-6. PMID: 1709002.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  152. Dartt DA, Dicker DM, Ronco LV, Kjeldsen IM, Hodges RR, Murphy SA. Lacrimal gland inositol trisphosphate isomer and inositol tetrakisphosphate production. Am J Physiol. 1990 Aug; 259(2 Pt 1):G274-81. PMID: 2382726.
    Citations: 10     Fields:    Translation:AnimalsCells
  153. Gilbard JP, Rossi SR, Heyda KG, Dartt DA. Stimulation of tear secretion by topical agents that increase cyclic nucleotide levels. Invest Ophthalmol Vis Sci. 1990 Jul; 31(7):1381-8. PMID: 2365569.
    Citations: 7     Fields:    Translation:AnimalsCells
  154. Rossi SR, Dartt DA, Gilbard JP. Eledoisin and lacrimal secretion in the rabbit. Curr Eye Res. 1990 Mar; 9(3):273-6. PMID: 2347204.
    Citations: 2     Fields:    Translation:Animals
  155. Dartt DA. Signal transduction and control of lacrimal gland protein secretion: a review. Curr Eye Res. 1989 Jun; 8(6):619-36. PMID: 2545411.
    Citations: 19     Fields:    Translation:AnimalsCells
  156. Dartt DA, Baker AK, Rose PE, Murphy SA, Ronco LV, Unser MF. Role of cyclic AMP and Ca2+ in potentiation of rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci. 1988 Nov; 29(11):1732-8. PMID: 2846462.
    Citations: 5     Fields:    Translation:Animals
  157. Dartt DA, Ronco LV, Murphy SA, Unser MF. Effect of phorbol esters on rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci. 1988 Nov; 29(11):1726-31. PMID: 3182205.
    Citations: 3     Fields:    Translation:Animals
  158. Gilbard JP, Dartt DA, Rood RP, Rossi SR, Gray KL, Donowitz M. Increased tear secretion in pancreatic cholera: a newly recognized symptom in an experiment of nature. Am J Med. 1988 Oct; 85(4):552-4. PMID: 2845780.
    Citations: 1     Fields:    Translation:Humans
  159. Dartt DA, Matkin C, Gray K. Comparison of proteins in lacrimal gland fluid secreted in response to different stimuli. Invest Ophthalmol Vis Sci. 1988 Jun; 29(6):991-5. PMID: 3372172.
    Citations: 1     Fields:    Translation:Animals
  160. Lechleiter JD, Dartt DA, Brehm P. Vasoactive intestinal peptide activates Ca2(+)-dependent K+ channels through a cAMP pathway in mouse lacrimal cells. Neuron. 1988 May; 1(3):227-35. PMID: 2856094.
    Citations: 13     Fields:    Translation:Animals
  161. Dartt DA, Mircheff AK, Donowitz M, Sharp GW. Ca2+ - and cAMP-induced protein phosphorylation in lacrimal gland basolateral membranes. Am J Physiol. 1988 Apr; 254(4 Pt 1):G543-51. PMID: 2833116.
    Citations:    Fields:    Translation:AnimalsCells
  162. Dartt DA, Shulman M, Gray KL, Rossi SR, Matkin C, Gilbard JP. Stimulation of rabbit lacrimal gland secretion with biologically active peptides. Am J Physiol. 1988 Mar; 254(3 Pt 1):G300-6. PMID: 3348396.
    Citations: 1     Fields:    Translation:Animals
  163. Dartt DA, Rose PE, Joshi VM, Donowitz M, Sharp GW. Role of calcium in cholinergic stimulation of lacrimal gland protein secretion. Curr Eye Res. 1985 Apr; 4(4):475-83. PMID: 4017636.
    Citations: 3     Fields:    Translation:AnimalsCells
  164. Dartt DA, Baker AK, Vaillant C, Rose PE. Vasoactive intestinal polypeptide stimulation of protein secretion from rat lacrimal gland acini. Am J Physiol. 1984 Nov; 247(5 Pt 1):G502-9. PMID: 6093581.
    Citations: 16     Fields:    Translation:Animals
  165. Dartt DA, Donowitz M, Joshi VJ, Mathieu RS, Sharp GW. Cyclic nucleotide-dependent enzyme secretion in the rat lacrimal gland. J Physiol. 1984 Jul; 352:375-84. PMID: 6205148.
    Citations: 3     Fields:    Translation:Animals
  166. Gilbard JP, Dartt DA. Changes in rabbit lacrimal gland fluid osmolarity with flow rate. Invest Ophthalmol Vis Sci. 1982 Dec; 23(6):804-6. PMID: 7141824.
    Citations: 6     Fields:    Translation:Animals
  167. Dartt DA, Guerina VJ, Donowitz M, Taylor L, Sharp GW. Ca2+- and calmodulin-dependent protein phosphorylation in rat lacrimal gland. Biochem J. 1982 Mar 15; 202(3):799-802. PMID: 7092845.
    Citations: 1     Fields:    Translation:AnimalsCells
  168. Dartt DA, Møller M, Poulsen JH. Lacrimal gland electrolyte and water secretion in the rabbit: localization and role of (Na+ + K+)-activated ATPase. J Physiol. 1981 Dec; 321:557-69. PMID: 6461755.
    Citations: 22     Fields:    Translation:Animals
  169. Dartt DA, Torp-Pedersen C, Thorn NA. Effects of Ca2+ and calmodulin on cyclic nucleotide metabolism in neurosecretosomes isolated from ox neurohypophyses. Brain Res. 1981 Jan 05; 204(1):121-8. PMID: 6113872.
    Citations: 2     Fields:    Translation:AnimalsCells
  170. Gratzl M, Torp-Pedersen C, Dartt D, Treiman M, Thorn NA. Isolation and characterization of secretory vesicles from bovine neurohypophyses. Hoppe Seylers Z Physiol Chem. 1980 Nov; 361(11):1615-28. PMID: 6256277.
    Citations: 10     Fields:    Translation:AnimalsCells
  171. Dartt DA, Knox I, Palau A, Botelho SY. Proteins in fluids from individual orbital glands and in tears. Invest Ophthalmol Vis Sci. 1980 Nov; 19(11):1342-7. PMID: 7429769.
    Citations: 4     Fields:    Translation:Animals
  172. Botelho SY, Dartt DA. Effect of calcium antagonism or chelation on rabbit lacrimal gland secretion and membrane potentials. J Physiol. 1980 Jul; 304:397-403. PMID: 6777483.
    Citations: 6     Fields:    Translation:Animals
  173. Dartt Da, Torp-Pedersen C, Thorn NA. Effects of Ca2+ and calmodulin on enzymes of cyclic nucleotide metabolism in ox neurohypophyseal secretosomes. Ann N Y Acad Sci. 1980; 356:369-70. PMID: 6112949.
    Citations:    Fields:    Translation:AnimalsCells
  174. Dartt DA, Botelho SY. Protein in rabbit lacrimal gland fluid. Invest Ophthalmol Vis Sci. 1979 Nov; 18(11):1207-9. PMID: 511463.
    Citations: 3     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.