Richard Hodin, M.D.
|Title||Professor of Surgery|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
GRB 504, Surgery
55 Fruit St
Boston MA 02114
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Available: 04/30/14, Expires: 07/01/16
We have discovered the that gut enzyme, intestinal alkaline phosphatase (IAP), is an endogenous regulator of the normal intestinal commensal microbiota. Further, oral IAL supplementation in animals treated with antibiotics results in an earlier restoration of the commensal organisms and, hence, prevention of subsequent infection with pathogens. Oral IAP has also been shown to prevent the metabolic syndrome in mice.
The student will have the opportunity to be involved with a translational research project designed to eventually bring oral IAP therapy to patients. The project will involve either basic investigations into how IAP protects us from bacterial products or studies involving human patients and/or samples.
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