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Richard Hodin, M.D.

TitleProfessor of Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
GRB 504, Surgery
55 Fruit St
Boston MA 02114
Phone617/726-2000
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 Mentoring 
 current student opportunities
Available: 04/30/14, Expires: 07/01/16

We have discovered the that gut enzyme, intestinal alkaline phosphatase (IAP), is an endogenous regulator of the normal intestinal commensal microbiota. Further, oral IAL supplementation in animals treated with antibiotics results in an earlier restoration of the commensal organisms and, hence, prevention of subsequent infection with pathogens. Oral IAP has also been shown to prevent the metabolic syndrome in mice.

The student will have the opportunity to be involved with a translational research project designed to eventually bring oral IAP therapy to patients. The project will involve either basic investigations into how IAP protects us from bacterial products or studies involving human patients and/or samples.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sauk J, Nguyen D, Yajnik V, Khalili H, Konijeti G, Hodin R, Bordeianou L, Shellito P, Sylla P, Korzenik J, Friedman S, Ananthakrishnan AN. Natural history of perianal Crohn's disease after fecal diversion. Inflamm Bowel Dis. 2014 Dec; 20(12):2260-5.
    View in: PubMed
  2. Chen Y, Hodin RA, Pandolfi C, Ruan DT, McKenzie TJ. Hypoglycemia after resection of pheochromocytoma. Surgery. 2014 Dec; 156(6):1404-9.
    View in: PubMed
  3. Dursun A, Hodin R, Bordeianou L. Impact of perineal Crohn's disease on utilization of care in the absence of modifiable predictors of treatment failure. Int J Colorectal Dis. 2014 Dec; 29(12):1535-9.
    View in: PubMed
  4. Hamarneh SR, Mohamed MM, Economopoulos KP, Morrison SA, Phupitakphol T, Tantillo TJ, Gul SS, Gharedaghi MH, Tao Q, Kaliannan K, Narisawa S, Millán JL, van der Wilden GM, Fagenholz PJ, Malo MS, Hodin RA. A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. Ann Surg. 2014 Oct; 260(4):706-15.
    View in: PubMed
  5. Hicks CW, Hodin RA, Savitt L, Bordeianou L. Does intramesorectal excision for ulcerative colitis impact bowel and sexual function when compared with total mesorectal excision? Am J Surg. 2014 Oct; 208(4):499-504.e4.
    View in: PubMed
  6. Shin J, Carr A, Corner GA, Tögel L, Dávaos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM. The Intestinal Epithelial Cell Differentiation Marker Intestinal Alkaline Phosphatase (ALPi) Is Selectively Induced by Histone Deacetylase Inhibitors (HDACi) in Colon Cancer Cells in a Kruppel-like Factor 5 (KLF5)-dependent Manner. J Biol Chem. 2014 Sep 5; 289(36):25306-16.
    View in: PubMed
  7. Morrison SA, Suh H, Hodin RA. The surgical management of thyroid cancer. Rambam Maimonides Med J. 2014 Apr; 5(2):e0008.
    View in: PubMed
  8. Malo MS, Moaven O, Muhammad N, Biswas B, Alam SN, Economopoulos KP, Gul SS, Hamarneh SR, Malo NS, Teshager A, Mohamed MM, Tao Q, Narisawa S, Millán JL, Hohmann EL, Warren HS, Robson SC, Hodin RA. Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. Am J Physiol Gastrointest Liver Physiol. 2014 May 15; 306(10):G826-38.
    View in: PubMed
  9. Alam SN, Yammine H, Moaven O, Ahmed R, Moss AK, Biswas B, Muhammad N, Biswas R, Raychowdhury A, Kaliannan K, Ghosh S, Ray M, Hamarneh SR, Barua S, Malo NS, Bhan AK, Malo MS, Hodin RA. Intestinal alkaline phosphatase prevents antibiotic-induced susceptibility to enteric pathogens. Ann Surg. 2014 Apr; 259(4):715-22.
    View in: PubMed
  10. Hodin R, Lubitz C, Phitayakorn R, Stephen A. Diagnosis and management of pheochromocytoma. Curr Probl Surg. 2014 Apr; 51(4):151-87.
    View in: PubMed
  11. Hodin R, Lubitz C, Phitayakorn R, Stephen A. In brief. Curr Probl Surg. 2014 Apr; 51(4):146-9.
    View in: PubMed
  12. Hicks CW, Hodin RA, Savitt L, Bordeianou L. Does intramesorectal proctectomy with rectal eversion affect postoperative complications compared to standard total mesorectal excision in patients with ulcerative colitis? J Gastrointest Surg. 2014 Feb; 18(2):385-90.
    View in: PubMed
  13. Hicks CW, Hodin RA, Bordeianou L. Semi-urgent surgery in hospitalized patients with severe ulcerative colitis does not increase overall J-pouch complications. Am J Surg. 2014 Feb; 207(2):281-7.
    View in: PubMed
  14. Phitayakorn R, Morales-Garcia D, Wanderer J, Lubitz CC, Gaz RD, Stephen AE, Ehrenfeld JM, Daniels GH, Hodin RA, Parangi S. Surgery for Graves' disease: a 25-year perspective. Am J Surg. 2013 Nov; 206(5):669-73.
    View in: PubMed
  15. McKenzie TJ, Chen Y, Hodin RA, Shikora SA, Hutter MM, Gaz RD, Moore FD, Lubitz CC. Recalcitrant hypocalcemia after thyroidectomy in patients with previous Roux-en-Y gastric bypass. Surgery. 2013 Dec; 154(6):1300-6.
    View in: PubMed
  16. Hodin R, Clark O, Doherty G, Grant C, Heller K, Weigel R. Voice issues and laryngoscopy in thyroid surgery patients. Surgery. 2013 Jul; 154(1):46-7.
    View in: PubMed
  17. Hicks CW, Hodin RA, Bordeianou L. Possible overuse of 3-stage procedures for active ulcerative colitis. JAMA Surg. 2013 Jul; 148(7):658-64.
    View in: PubMed
  18. Kaliannan K, Hamarneh SR, Economopoulos KP, Nasrin Alam S, Moaven O, Patel P, Malo NS, Ray M, Abtahi SM, Muhammad N, Raychowdhury A, Teshager A, Mohamed MM, Moss AK, Ahmed R, Hakimian S, Narisawa S, Millán JL, Hohmann E, Warren HS, Bhan AK, Malo MS, Hodin RA. Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):7003-8.
    View in: PubMed
  19. Moss AK, Hamarneh SR, Mohamed MM, Ramasamy S, Yammine H, Patel P, Kaliannan K, Alam SN, Muhammad N, Moaven O, Teshager A, Malo NS, Narisawa S, Millán JL, Warren HS, Hohmann E, Malo MS, Hodin RA. Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 304(6):G597-604.
    View in: PubMed
  20. Prescott JD, Sadow PM, Hodin RA, Le LP, Gaz RD, Randolph GW, Stephen AE, Parangi S, Daniels GH, Lubitz CC. BRAF V600E status adds incremental value to current risk classification systems in predicting papillary thyroid carcinoma recurrence. Surgery. 2012 Dec; 152(6):984-90.
    View in: PubMed
  21. Nagarkatti SS, Faquin WC, Lubitz CC, Garcia DM, Barbesino G, Ross DS, Hodin RA, Daniels GH, Parangi S. Management of thyroid nodules with atypical cytology on fine-needle aspiration biopsy. Ann Surg Oncol. 2013 Jan; 20(1):60-5.
    View in: PubMed
  22. Hodin R, Angelos P, Carty S, Chen H, Clark O, Doherty G, Duh QY, Evans DB, Heller K, Inabnet W, Kebebew E, Pasieka J, Perrier N, Sturgeon C. No need to abandon unilateral parathyroid surgery. J Am Coll Surg. 2012 Aug; 215(2):297; author reply 297-300.
    View in: PubMed
  23. Lubitz CC, Stephen AE, Hodin RA, Pandharipande P. Preoperative localization strategies for primary hyperparathyroidism: an economic analysis. Ann Surg Oncol. 2012 Dec; 19(13):4202-9.
    View in: PubMed
  24. Salinas H, Dursun A, Konstantinidis I, Nguyen D, Shellito P, Hodin R, Bordeianou L. Does preoperative total parenteral nutrition in patients with ulcerative colitis produce better outcomes? Int J Colorectal Dis. 2012 Nov; 27(11):1479-83.
    View in: PubMed
  25. Lubitz CC, Nagarkatti SS, Faquin WC, Samir AE, Hassan MC, Barbesino G, Ross DS, Randolph GW, Gaz RD, Stephen AE, Hodin RA, Daniels GH, Parangi S. Diagnostic yield of nondiagnostic thyroid nodules is not altered by timing of repeat biopsy. Thyroid. 2012 Jun; 22(6):590-4.
    View in: PubMed
  26. Moaven O, Hodin RA. Chilaiditi syndrome: a rare entity with important differential diagnoses. Gastroenterol Hepatol (N Y). 2012 Apr; 8(4):276-8.
    View in: PubMed
  27. Levack MM, Savitt LR, Berger DL, Shellito PC, Hodin RA, Rattner DW, Goldberg SM, Bordeianou L. Sigmoidectomy syndrome? Patients' perspectives on the functional outcomes following surgery for diverticulitis. Dis Colon Rectum. 2012 Jan; 55(1):10-7.
    View in: PubMed
  28. Nehs MA, Nucera C, Nagarkatti SS, Sadow PM, Morales-Garcia D, Hodin RA, Parangi S. Late intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer. Endocrinology. 2012 Feb; 153(2):985-94.
    View in: PubMed
  29. Yip DT, Hassan M, Pazaitou-Panayiotou K, Ruan DT, Gawande AA, Gaz RD, Moore FD, Hodin RA, Stephen AE, Sadow PM, Daniels GH, Randolph GW, Parangi S, Lubitz CC. Preoperative basal calcitonin and tumor stage correlate with postoperative calcitonin normalization in patients undergoing initial surgical management of medullary thyroid carcinoma. Surgery. 2011 Dec; 150(6):1168-77.
    View in: PubMed
  30. Hodin RA. Ask the doctor. A hospital in the area is advertising robotic surgery. Is it really any better than having a surgeon do the operation? Harv Health Lett. 2011 May; 36(7):1.
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  31. Ebrahimi F, Malo MS, Alam SN, Moss AK, Yammine H, Ramasamy S, Biswas B, Chen KT, Muhammad N, Mostafa G, Warren HS, Hohmann EL, Hodin RA. Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice. J Gastrointest Surg. 2011 May; 15(5):860-9.
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  32. Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, Parangi S. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist. 2011; 16(3):296-309.
    View in: PubMed
  33. Ramasamy S, Nguyen DD, Eston MA, Alam SN, Moss AK, Ebrahimi F, Biswas B, Mostafa G, Chen KT, Kaliannan K, Yammine H, Narisawa S, Millán JL, Warren HS, Hohmann EL, Mizoguchi E, Reinecker HC, Bhan AK, Snapper SB, Malo MS, Hodin RA. Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis. 2011 Feb; 17(2):532-42.
    View in: PubMed
  34. Bordeianou L, Stein SL, Ho VP, Dursun A, Sands BE, Korzenik JR, Hodin RA. Immediate versus tailored prophylaxis to prevent symptomatic recurrences after surgery for ileocecal Crohn's disease? Surgery. 2011 Jan; 149(1):72-8.
    View in: PubMed
  35. Goldfarb M, Gondek S, Hodin R, Parangi S. Resident/fellow assistance in the operating room for endocrine surgery in the era of fellowships. Surgery. 2010 Dec; 148(6):1065-71; discussion 1071-2.
    View in: PubMed
  36. Lubitz CC, Hunter GJ, Hamberg LM, Parangi S, Ruan D, Gawande A, Gaz RD, Randolph GW, Moore FD, Hodin RA, Stephen AE. Accuracy of 4-dimensional computed tomography in poorly localized patients with primary hyperparathyroidism. Surgery. 2010 Dec; 148(6):1129-37; discussion 1137-8.
    View in: PubMed
  37. Nucera C, Lawler J, Hodin R, Parangi S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? Oncotarget. 2010 Dec; 1(8):751-6.
    View in: PubMed
  38. Nehs MA, Nagarkatti S, Nucera C, Hodin RA, Parangi S. Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer. Surgery. 2010 Dec; 148(6):1154-62; discussion 1162.
    View in: PubMed
  39. Malo MS, Alam SN, Mostafa G, Zeller SJ, Johnson PV, Mohammad N, Chen KT, Moss AK, Ramasamy S, Faruqui A, Hodin S, Malo PS, Ebrahimi F, Biswas B, Narisawa S, Millán JL, Warren HS, Kaplan JB, Kitts CL, Hohmann EL, Hodin RA. Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut. 2010 Nov; 59(11):1476-84.
    View in: PubMed
  40. Klos CL, Shellito PC, Rattner DW, Hodin RA, Cusack JC, Bordeianou L, Sylla P, Hong TS, Blaszkowsky L, Ryan DP, Lauwers GY, Chang Y, Berger DL. The effect of neoadjuvant chemoradiation therapy on the prognostic value of lymph nodes after rectal cancer surgery. Am J Surg. 2010 Oct; 200(4):440-5.
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  41. Chen KT, Malo MS, Beasley-Topliffe LK, Poelstra K, Millan JL, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. A role for intestinal alkaline phosphatase in the maintenance of local gut immunity. Dig Dis Sci. 2011 Apr; 56(4):1020-7.
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  42. Mekel M, Nucera C, Hodin RA, Parangi S. Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules. Am J Surg. 2010 Jul; 200(1):136-43.
    View in: PubMed
  43. Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010 Jun 8; 107(23):10649-54.
    View in: PubMed
  44. Chen KT, Malo MS, Moss AK, Zeller S, Johnson P, Ebrahimi F, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G467-75.
    View in: PubMed
  45. Mekel M, Stephen AE, Gaz RD, Randolph GW, Richer S, Perry ZH, Lubitz CC, Nehs MA, Parangi S, Hodin RA. Surgical drains can be safely avoided in lateral neck dissections for papillary thyroid cancer. Am J Surg. 2010 Apr; 199(4):485-90.
    View in: PubMed
  46. Lubitz CC, Faquin WC, Yang J, Mekel M, Gaz RD, Parangi S, Randolph GW, Hodin RA, Stephen AE. Clinical and cytological features predictive of malignancy in thyroid follicular neoplasms. Thyroid. 2010 Jan; 20(1):25-31.
    View in: PubMed
  47. Mekel M, Stephen AE, Gaz RD, Perry ZH, Hodin RA, Parangi S. Thyroid surgery in octogenarians is associated with higher complication rates. Surgery. 2009 Nov; 146(5):913-21.
    View in: PubMed
  48. Bordeianou L, Kunitake H, Shellito P, Hodin R. Preoperative infliximab treatment in patients with ulcerative and indeterminate colitis does not increase rate of conversion to emergent and multistep abdominal surgery. Int J Colorectal Dis. 2010 Mar; 25(3):401-4.
    View in: PubMed
  49. Nucera C, Nehs MA, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, Parangi S. A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid. 2009 Oct; 19(10):1077-84.
    View in: PubMed
  50. Bordeianou L, Hodin R. Total proctocolectomy with ileoanal J-pouch reconstruction utilizing the hand-assisted laparoscopic approach. J Gastrointest Surg. 2009 Dec; 13(12):2314-20.
    View in: PubMed
  51. Henneman D, Chang Y, Hodin RA, Berger DL. Effect of laparoscopy on the indications for adrenalectomy. Arch Surg. 2009 Mar; 144(3):255-9; discussion 259.
    View in: PubMed
  52. Nucera C, Goldfarb M, Hodin R, Parangi S. Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E). Biochim Biophys Acta. 2009 Apr; 1795(2):152-61.
    View in: PubMed
  53. Hodin RS. Optimal timing of surgery for inflammatory bowel diseases. J Gastrointest Surg. 2008 Dec; 12(12):2149.
    View in: PubMed
  54. Kunitake H, Hodin R, Shellito PC, Sands BE, Korzenik J, Bordeianou L. Perioperative treatment with infliximab in patients with Crohn's disease and ulcerative colitis is not associated with an increased rate of postoperative complications. J Gastrointest Surg. 2008 Oct; 12(10):1730-6; discussion 1736-7.
    View in: PubMed
  55. Hodin R. By the way, doctor. I heard that human growth hormone can help people after surgery. Is that true? Harv Health Lett. 2008 May; 33(7):5.
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  56. Goldberg RF, Austen WG, Zhang X, Munene G, Mostafa G, Biswas S, McCormack M, Eberlin KR, Nguyen JT, Tatlidede HS, Warren HS, Narisawa S, Millán JL, Hodin RA. Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci U S A. 2008 Mar 4; 105(9):3551-6.
    View in: PubMed
  57. Kaplan GG, McCarthy EP, Ayanian JZ, Korzenik J, Hodin R, Sands BE. Impact of hospital volume on postoperative morbidity and mortality following a colectomy for ulcerative colitis. Gastroenterology. 2008 Mar; 134(3):680-7.
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  58. Hodin RA. Gnothi se auton: SUS Presidential Address. Surgery. 2007 Aug; 142(2):127-35.
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  59. Stephen AE, Roth SI, Fardo DW, Finkelstein DM, Randolph GW, Gaz RD, Hodin RA. Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas. Arch Surg. 2007 Apr; 142(4):381-6.
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  60. Bordeianou L, Hodin R. Controversies in the surgical management of sigmoid diverticulitis. J Gastrointest Surg. 2007 Apr; 11(4):542-8.
    View in: PubMed
  61. Malo MS, Biswas S, Abedrapo MA, Yeh L, Chen A, Hodin RA. The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression. DNA Cell Biol. 2006 Dec; 25(12):684-95.
    View in: PubMed
  62. Hutter MM, Rowell KS, Devaney LA, Sokal SM, Warshaw AL, Abbott WM, Hodin RA. Identification of surgical complications and deaths: an assessment of the traditional surgical morbidity and mortality conference compared with the American College of Surgeons-National Surgical Quality Improvement Program. J Am Coll Surg. 2006 Nov; 203(5):618-24.
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  63. Stephen AE, Hodin RA. Neuroendocrine tumors of the pancreas, excluding gastrinoma. Surg Oncol Clin N Am. 2006 Jul; 15(3):497-510.
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  64. Malo MS, Mozumder M, Chen A, Mostafa G, Zhang XB, Hodin RA. pFRL7: an ideal vector for eukaryotic promoter analysis. Anal Biochem. 2006 Mar 15; 350(2):307-9.
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  65. Malo MS, Mozumder M, Zhang XB, Biswas S, Chen A, Bai LC, Merchant JL, Hodin RA. Intestinal alkaline phosphatase gene expression is activated by ZBP-89. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G737-46.
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  66. Archer SY, Johnson J, Kim HJ, Ma Q, Mou H, Daesety V, Meng S, Hodin RA. The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 289(4):G696-703.
    View in: PubMed
  67. Malo MS, Pushpakaran P, Hodin RA. A 'Swinging Cradle' model for in vitro classification of different types of response elements of a nuclear receptor. Biochem Biophys Res Commun. 2005 Nov 18; 337(2):490-7.
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  68. Hamzaoglu I, Hodin RA. Perianal problems in patients with ulcerative colitis. Inflamm Bowel Dis. 2005 Sep; 11(9):856-9.
    View in: PubMed
  69. Bordeianou L, Hodin RA. Expanding the role of strictureplasty: can resections be made obsolete? Inflamm Bowel Dis. 2005 Sep; 11(9):861-2.
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  70. Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nosé V, Li C, Stiles CD. A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet. 2005 Jul; 1(1):72-80.
    View in: PubMed
  71. Alkhoury F, Malo MS, Mozumder M, Mostafa G, Hodin RA. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G285-90.
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  72. Hall JF, Hodin R. Restorative proctocolectomy: fertile ground for technical improvements? Inflamm Bowel Dis. 2005 Feb; 11(2):207-8.
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  73. Grikscheit TC, Siddique A, Ochoa ER, Srinivasan A, Alsberg E, Hodin RA, Vacanti JP. Tissue-engineered small intestine improves recovery after massive small bowel resection. Ann Surg. 2004 Nov; 240(5):748-54.
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  74. Malo MS, Zhang W, Alkhoury F, Pushpakaran P, Abedrapo MA, Mozumder M, Fleming E, Siddique A, Henderson JW, Hodin RA. Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element. Mol Endocrinol. 2004 Aug; 18(8):1941-62.
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  75. Partridge SK, Hodin RA. Small bowel adenocarcinoma at a strictureplasty site in a patient with Crohn's disease: report of a case. Dis Colon Rectum. 2004 May; 47(5):778-81.
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  76. Malo MS, Abedrapo M, Chen A, Mozumder M, Pushpakaran P, Alkhoury F, Zhang W, Fleming E, Hodin RA. Improved eukaryotic promoter-detection vector carrying two luciferase reporter genes. Biotechniques. 2003 Dec; 35(6):1150-2, 1154.
    View in: PubMed
  77. Siddique A, Malo MS, Ocuin LM, Hinnebusch BF, Abedrapo MA, Henderson JW, Zhang W, Mozumder M, Yang VW, Hodin RA. Convergence of the thyroid hormone and gut-enriched Krüppel-like factor pathways in the context of enterocyte differentiation. J Gastrointest Surg. 2003 Dec; 7(8):1053-61; discussion 1061.
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  78. Siewert B, Raptopoulos V, Liu SI, Hodin RA, Davis RB, Rosen MP. CT predictors of failed laparoscopic appendectomy. Radiology. 2003 Nov; 229(2):415-20.
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  79. Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, Abedrapo MA, Chen X, Yang VW, Hodin RA. Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol. 2004 Jan; 286(1):G23-30.
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  80. Hodin R. By the way, doctor. My mother recently had her gallbladder removed. The doctors say there are "surgical clips" in her. Are they supposed to be there and could they be the reason she is having pains in her side? Harv Health Lett. 2003 Jun; 28(8):8.
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  81. Hinnebusch BF, Henderson JW, Siddique A, Malo MS, Zhang W, Abedrapo MA, Hodin RA. Transcriptional activation of the enterocyte differentiation marker intestinal alkaline phosphatase is associated with changes in the acetylation state of histone H3 at a specific site within its promoter region in vitro. J Gastrointest Surg. 2003 Feb; 7(2):237-44; discussion 244-5.
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  82. Hodin R, Abedrapo M. Perhaps we can, but should we? Inflamm Bowel Dis. 2002 Sep; 8(5):372-3.
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  83. Hinnebusch BF, Ma Q, Henderson JW, Siddique A, Archer SY, Hodin RA. Enterocyte response to ischemia is dependent on differentiation state. J Gastrointest Surg. 2002 May-Jun; 6(3):403-9.
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  84. Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA. The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr. 2002 May; 132(5):1012-7.
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  85. Liu SI, Siewert B, Raptopoulos V, Hodin RA. Factors associated with conversion to laparotomy in patients undergoing laparoscopic appendectomy. J Am Coll Surg. 2002 Mar; 194(3):298-305.
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  86. Hodin R. The value of sestamibi scans. Surgery. 2002 Feb; 131(2):238-9.
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  87. Duda RB, Kang SS, Archer SY, Meng S, Hodin RA. American ginseng transcriptionally activates p21 mRNA in breast cancer cell lines. J Korean Med Sci. 2001 Dec; 16 Suppl:S54-60.
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  88. Greene AK, Hodin RA. Laparoscopic splenectomy for massive splenomegaly using a Lahey bag. Am J Surg. 2001 Jun; 181(6):543-6.
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  89. Archer SY, Johnson JJ, Kim HJ, Hodin RA. p21 gene regulation during enterocyte differentiation. J Surg Res. 2001 Jun 1; 98(1):4-8.
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  90. Wu JT, Archer SY, Hinnebusch B, Meng S, Hodin RA. Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. Am J Physiol Gastrointest Liver Physiol. 2001 Mar; 280(3):G482-90.
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  91. Meng S, Badrinarain J, Sibley E, Fang R, Hodin R. Thyroid hormone and the d-type cyclins interact in regulating enterocyte gene transcription. J Gastrointest Surg. 2001 Jan-Feb; 5(1):49-55.
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  92. Greene AK, Michetti P, Peppercorn MA, Hodin RA. Laparoscopically assisted ileocolectomy for Crohn's disease through a pfannenstiel incision. Am J Surg. 2000 Sep; 180(3):238-40.
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  93. Rayan SS, Hodin RA. Short-stay laparoscopic adrenalectomy. Surg Endosc. 2000 Jun; 14(6):568-72.
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  94. Hodin R. Maintaining gut homeostasis: the butyrate-NF-kappaB connection. Gastroenterology. 2000 Apr; 118(4):798-801.
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  95. Greene AK, Mowschenson P, Hodin RA. Is sestamibi-guided parathyroidectomy really cost-effective? Surgery. 1999 Dec; 126(6):1036-40; discussion 1040-1.
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  96. Farokhzad OC, Sagar GD, Mun EC, Sicklick JK, Lotz M, Smith JA, Song JC, O'Brien TC, Sharma CP, Kinane TB, Hodin RA, Matthews JB. Protein kinase C activation downregulates the expression and function of the basolateral Na+/K+/2Cl(-) cotransporter. J Cell Physiol. 1999 Dec; 181(3):489-98.
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  97. Hodin RA. Gut permeability in Crohn's disease: the chicken/egg question revisited Inflamm Bowel Dis. 1999 Nov; 5(4):311-2.
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  98. Chavez AM, Menconi MJ, Hodin RA, Fink MP. Cytokine-induced intestinal epithelial hyperpermeability: role of nitric oxide. Crit Care Med. 1999 Oct; 27(10):2246-51.
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  99. Meng S, Wu JT, Archer SY, Hodin RA. Short-chain fatty acids and thyroid hormone interact in regulating enterocyte gene transcription. Surgery. 1999 Aug; 126(2):293-8.
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  100. Unno N, Hodin RA, Fink MP. Acidic conditions exacerbate interferon-gamma-induced intestinal epithelial hyperpermeability: role of peroxynitrous acid. Crit Care Med. 1999 Aug; 27(8):1429-36.
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  101. Chavez AM, Morin MJ, Unno N, Fink MP, Hodin RA. Acquired interferon gamma responsiveness during Caco-2 cell differentiation: effects on iNOS gene expression. Gut. 1999 May; 44(5):659-65.
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  102. Kim JH, Meng S, Shei A, Hodin RA. A novel Sp1-related cis element involved in intestinal alkaline phosphatase gene transcription. Am J Physiol. 1999 Apr; 276(4 Pt 1):G800-7.
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  103. Archer SY, Hodin RA. Histone acetylation and cancer. Curr Opin Genet Dev. 1999 Apr; 9(2):171-4.
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  104. Nguyen DB, Silen W, Hodin RA. Interval appendectomy in the laparoscopic era. J Gastrointest Surg. 1999 Mar-Apr; 3(2):189-93.
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  105. Hoenig SJ, Hodin RA, Novak G, Cohn WE. Videoscopic harvest of the inferior epigastric artery. Ann Thorac Surg. 1999 Feb; 67(2):565-6.
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  106. Nguyen DB, Silen W, Hodin RA. Appendectomy in the pre- and postlaparoscopic eras. J Gastrointest Surg. 1999 Jan-Feb; 3(1):67-73.
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  107. Archer S, Meng S, Wu J, Johnson J, Tang R, Hodin R. Butyrate inhibits colon carcinoma cell growth through two distinct pathways. Surgery. 1998 Aug; 124(2):248-53.
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  108. Morin MJ, Unno N, Hodin RA, Fink MP. Differential expression of inducible nitric oxide synthase messenger RNA along the longitudinal and crypt-villus axes of the intestine in endotoxemic rats. Crit Care Med. 1998 Jul; 26(7):1258-64.
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  109. Archer SY, Meng S, Shei A, Hodin RA. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):6791-6.
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  110. Matthews JB, Hassan I, Meng S, Archer SY, Hrnjez BJ, Hodin RA. Na-K-2Cl cotransporter gene expression and function during enterocyte differentiation. Modulation of Cl- secretory capacity by butyrate. J Clin Invest. 1998 May 15; 101(10):2072-9.
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  111. Unno N, Wang H, Menconi MJ, Tytgat SH, Larkin V, Smith M, Morin MJ, Chavez A, Hodin RA, Fink MP. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology. 1997 Oct; 113(4):1246-57.
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  112. Hodin RA, Shei A, Meng S. Transcriptional activation of the human villin gene during enterocyte differentiation. J Gastrointest Surg. 1997 Sep-Oct; 1(5):433-8; discussion 438.
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  113. Hodin RA, Silen WW. Detection and management of parathyroid tumors. Curr Opin Oncol. 1997 Jan; 9(1):75-8.
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  114. Hodin RA, Shei A, Morin M, Meng S. Thyroid hormone and the gut: selective transcriptional activation of a villus-enterocyte marker. Surgery. 1996 Aug; 120(2):138-43.
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  115. Saldinger PF, Matthews JB, Mowschenson PM, Hodin RA. Stapled laparoscopic splenectomy: initial experience. J Am Coll Surg. 1996 May; 182(5):459-61.
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  116. Hodin RA, Meng S, Archer S, Tang R. Cellular growth state differentially regulates enterocyte gene expression in butyrate-treated HT-29 cells. Cell Growth Differ. 1996 May; 7(5):647-53.
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  117. Mowschenson PM, Hodin RA. Outpatient thyroid and parathyroid surgery: a prospective study of feasibility, safety, and costs. Surgery. 1995 Dec; 118(6):1051-3; discussion 1053-4.
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  118. Hodin RA, Chamberlain SM, Meng S. Pattern of rat intestinal brush-border enzyme gene expression changes with epithelial growth state. Am J Physiol. 1995 Aug; 269(2 Pt 1):C385-91.
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  119. Hodin RA, Saldinger P, Meng S. Small bowel adaptation: counterregulatory effects of epidermal growth factor and somatostatin on the program of early gene expression. Surgery. 1995 Aug; 118(2):206-10; discussion 210-1.
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  120. Hodin RA, Meng S, Shei A. Differential cloning of novel intestine-specific genes whose expression is altered under conditions of villus atrophy. J Surg Res. 1995 Jul; 59(1):115-20.
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  121. Mowschenson PM, Hodin RA, Wang HH, Upton M, Silen W. Fine-needle aspiration of normal thyroid tissue may result in the misdiagnosis of microfollicular lesions. Surgery. 1994 Dec; 116(6):1006-9.
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  122. Hodin RA, Meng S, Chamberlain SM. Thyroid hormone responsiveness is developmentally regulated in the rat small intestine: a possible role for the alpha-2 receptor variant. Endocrinology. 1994 Aug; 135(2):564-8.
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  123. Hodin RA, Meng S, Shei A. Bombesin maintains enterocyte phenotype in fasted rats. Surgery. 1994 Aug; 116(2):426-31.
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  124. Hodin RA, Meng S, Nguyen D. Immediate-early gene expression in EGF-stimulated intestinal epithelial cells. J Surg Res. 1994 Jun; 56(6):500-4.
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  125. Hodin RA, Graham JR, Meng S, Upton MP. Temporal pattern of rat small intestinal gene expression with refeeding. Am J Physiol. 1994 Jan; 266(1 Pt 1):G83-9.
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  126. Hupart KH, Hodin RA, Lazar MA, Shapiro LE, Chin WW, Surks MI. c-erb-A mRNA correlates with T3-receptor levels in liver and pituitary of tumor rats. Thyroid. 1993; 3(1):55-8.
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  127. Hodin RA, Chamberlain SM, Upton MP. Thyroid hormone differentially regulates rat intestinal brush border enzyme gene expression. Gastroenterology. 1992 Nov; 103(5):1529-36.
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  128. Lazar MA, Hodin RA, Cardona G, Chin WW. Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription. J Biol Chem. 1990 Aug 5; 265(22):12859-63.
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  129. Hodin RA, Lazar MA, Chin WW. Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone. J Clin Invest. 1990 Jan; 85(1):101-5.
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  130. Lazar MA, Hodin RA, Chin WW. Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7771-4.
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  131. Hodin RA, Lazar MA, Chin WW. The pituitary-specific form of rat c-erbA is a biologically active thyroid hormone receptor. Curr Surg. 1989 Jul-Aug; 46(4):298-301.
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  132. Hodin RA, Lazar MA, Wintman BI, Darling DS, Koenig RJ, Larsen PR, Moore DD, Chin WW. Identification of a thyroid hormone receptor that is pituitary-specific. Science. 1989 Apr 7; 244(4900):76-9.
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  133. Lazar MA, Hodin RA, Darling DS, Chin WW. A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Cell Biol. 1989 Mar; 9(3):1128-36.
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  134. Koenig RJ, Lazar MA, Hodin RA, Brent GA, Larsen PR, Chin WW, Moore DD. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature. 1989 Feb 16; 337(6208):659-61.
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  135. Lazar MA, Hodin RA, Darling DS, Chin WW. Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone. Mol Endocrinol. 1988 Oct; 2(10):893-901.
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  136. Kreisman NR, Hodin RA, Rosenthal M, Sick TJ. Role of pulmonary edema in phasic changes of cerebral oxygenation during serial seizures. Brain Res. 1987 Aug 11; 417(2):335-42.
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  137. Kreisman NR, Hodin RA, Brizzee BL, Rosenthal M, Sick TJ, Busto R, Ginsberg MD. Seizure-associated pulmonary edema and cerebral oxygenation in the rat. J Appl Physiol (1985). 1987 Feb; 62(2):658-67.
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