Richard Hodin, M.D.
|Title||Professor of Surgery|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
GRB 504, Surgery
55 Fruit St
Boston MA 02114
Available: 04/30/14, Expires: 07/01/16
We have discovered the that gut enzyme, intestinal alkaline phosphatase (IAP), is an endogenous regulator of the normal intestinal commensal microbiota. Further, oral IAL supplementation in animals treated with antibiotics results in an earlier restoration of the commensal organisms and, hence, prevention of subsequent infection with pathogens. Oral IAP has also been shown to prevent the metabolic syndrome in mice.
The student will have the opportunity to be involved with a translational research project designed to eventually bring oral IAP therapy to patients. The project will involve either basic investigations into how IAP protects us from bacterial products or studies involving human patients and/or samples.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.